KEGG ENZYME: 2.1.1.243

ENZYME: 2.1.1.243

Entry

EC 2.1.1.243                Enzyme

Name

5-guanidino-2-oxopentanoate (3R)-methyltransferase;
mrsA (gene name);
argN (gene name);
2-ketoarginine methyltransferase;
S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:5-guanidino-2-oxopentanoate (3R)-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + (3R)-5-guanidino-3-methyl-2-oxopentanoate [RN:R09939]

Reaction(KEGG)

R09939

Substrate

S-adenosyl-L-methionine [CPD:C00019];
5-guanidino-2-oxopentanoate [CPD:C03771]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(3R)-5-guanidino-3-methyl-2-oxopentanoate [CPD:C20234]

Comment

The enzyme is involved in production of the rare amino acid (3R)-3-methyl-L-arginine. The compound is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas savastanoi pv. glycinea. Other bacteria incorporate the compound into more complex compounds such as the peptidyl nucleoside antibiotic arginomycin.

History

EC 2.1.1.243 created 2012, modified 2024

Orthology

K16215

2-ketoarginine methyltransferase

Genes

XTH:	G4Q83_12690

PSB:

Psyr_0118

PSKU:

KUIN1_01120

THAT:

H3N35_27155

BMAE:

DM78_1594

BPS:

BPSL1723

BPM:	BURPS1710b_2150

BPL:	BURPS1106A_2014

BPD:	BURPS668_1994

BPR:	GBP346_A2040

BPSE:

BDL_243

BPSM:

BBQ_1583

BPSU:

BBN_1708

BPSD:

BBX_2180

BPZ:	BP1026B_I1676

BPQ:	BPC006_I2061

BPK:

BBK_3207

BPSH:

DR55_2815

BPSA:

BBU_418

BPSO:

X996_2438

BUT:

X994_885

BOK:	DM82_5248 DM82_5333

BOC:	BG90_5276 BG90_5361

BUU:	WS70_22980

BGD:	bgla_1g16380

BGO:

BM43_2864

ACHR:

C2U31_27130

AAV:

Aave_3704

CCRO:

CMC5_053790

NBR:	O3I_018980

NOZ:	DMB37_02715

SBH:

SBI_00619

STRM:

M444_32675

SLAU:

SLA_6023

SRJ:

SRO_1605

SGF:	HEP81_01791(mrsA)

SCOE:

CP976_29250

SGK:	PET44_31115

NEC:	KGD82_24770

ACTQ:

OG417_15810

NOA:	BKM31_13715

KBS:	EPA93_13985

» show all

Reference

1 [PMID:20190091]

Authors

Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D

Title

Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.

Journal

Appl Environ Microbiol 76:2500-8 (2010)
DOI:10.1128/AEM.00666-09

Sequence

[psb:Psyr_0118]

Reference

2 [PMID:24907335]

Authors

Feng J, Wu J, Gao J, Xia Z, Deng Z, He X.

Title

Biosynthesis of the beta-methylarginine residue of peptidyl nucleoside arginomycin in Streptomyces arginensis NRRL 15941.

Journal

Appl Environ Microbiol 80:5021-7 (2014)
DOI:10.1128/AEM.01172-14

Sequence

[ag:AGG35704]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.243

IUBMB Enzyme Nomenclature:

2.1.1.243

ExPASy - ENZYME nomenclature database:

2.1.1.243

BRENDA, the Enzyme Database:

2.1.1.243

LinkDB

DBGET integrated database retrieval system