KEGG ENZYME: 2.1.1.323

ENZYME: 2.1.1.323

Entry

EC 2.1.1.323                Enzyme

Name

(-)-pluviatolide 4-O-methyltransferase;
OMT3 (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(-)-pluviatolide 4-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + (-)-pluviatolide = S-adenosyl-L-homocysteine + (-)-bursehernin [RN:R11230]

Reaction(KEGG)

R11230

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(-)-pluviatolide [CPD:C21191]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(-)-bursehernin [CPD:C21183]

Comment

The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.

History

EC 2.1.1.323 created 2016

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K21203

(-)-pluviatolide 4-O-methyltransferase

Reference

1 [PMID:26359402]

Authors

Lau W, Sattely ES

Title

Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.

Journal

Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202

Sequence

[ag:ALG05119]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.323

IUBMB Enzyme Nomenclature:

2.1.1.323

ExPASy - ENZYME nomenclature database:

2.1.1.323

BRENDA, the Enzyme Database:

2.1.1.323

LinkDB

DBGET integrated database retrieval system