KEGG   ENZYME: 2.5.1.125
Entry
EC 2.5.1.125                Enzyme                                 
Name
7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase;
Fur7
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranyl-diphosphate:2-O,3-dimethylflaviolin geranyltransferase (7-O-geranyl-2-O,3-dimethylflaviolin-forming)
Reaction(IUBMB)
geranyl diphosphate + 2-O,3-dimethylflaviolin = diphosphate + 7-O-geranyl-2-O,3-dimethylflaviolin [RN:R11087]
Reaction(KEGG)
R11087
Substrate
geranyl diphosphate [CPD:C00341];
2-O,3-dimethylflaviolin [CPD:C21001]
Product
diphosphate [CPD:C00013];
7-O-geranyl-2-O,3-dimethylflaviolin [CPD:C21003]
Comment
The enzyme is involved in furaquinocin biosynthesis in the bacterium Streptomyces sp. KO-3988. It catalyses the transfer of a geranyl group to 2-O,3-dimethylflaviolin to yield 7-O-geranyl-2-O,3-dimethylflaviolin and 6-linalyl-2-O,3-dimethylflaviolin (cf. EC 2.5.1.124, 6-linalyl-2-O,3-dimethylflaviolin synthase) in a 1:10 ratio.
History
EC 2.5.1.125 created 2014
Orthology
K21341  6-linalyl-2-O,3-dimethylflaviolin/7-geranyloxy-5-hydroxy-2-methoxy-3-methylnaphthalene-1,4-dione synthase
Genes
SDVBN159_7948
SQZFQU76_00200 FQU76_33540
SPADDVK44_34335
SMOBJ7W19_27640
SROIIAG44_38270
SXTKPP03845_300034(ppzP_1) KPP03845_300071(ppzP_2)
ABRYNYE86_28205
ACTQOG417_42660
KBUQ4V64_43050
MSAGGCM10017556_12000
MENOJiend_53560
MCHLPVK74_09525
PSUUPsuf_091250 Psuf_091420
 » show all
Reference
1  [PMID:20937800]
  Authors
Kumano T, Tomita T, Nishiyama M, Kuzuyama T
  Title
Functional characterization of the promiscuous prenyltransferase responsible for furaquinocin biosynthesis: identification of a physiological polyketide substrate and its prenylated reaction products.
  Journal
J Biol Chem 285:39663-71 (2010)
DOI:10.1074/jbc.M110.153957
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.125
IUBMB Enzyme Nomenclature: 2.5.1.125
ExPASy - ENZYME nomenclature database: 2.5.1.125
BRENDA, the Enzyme Database: 2.5.1.125
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