KEGG ENZYME: 2.7.8.45

ENZYME: 2.7.8.45

Entry

EC 2.7.8.45                 Enzyme

Name

teichoic acid glycerol-phosphate transferase;
tarF (gene name) (ambiguous);
teichoic acid glycerol-phosphate primase

Class

Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups

Sysname

CDP-glycerol:4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol glycerophosphotransferase

Reaction(IUBMB)

CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11612 R12868]

Reaction(KEGG)

R11612 R12868(G)

Substrate

CDP-glycerol [CPD:C00513];
4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21464]

Product

CDP [CPD:C00112];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]

Comment

Involved in the biosynthesis of teichoic acid linkage units in the cell walls of some bacteria such as Staphylococcus aureus. This enzyme adds a second glycerol unit to the disaccharide linker of the teichoic acid. cf. EC 2.7.8.12, teichoic acid poly(glycerol phosphate) polymerase.

History

EC 2.7.8.45 created 2017

Pathway

ec00552

Teichoic acid biosynthesis

Orthology

K21591

teichoic acid glycerol-phosphate transferase

Genes

ECQ:	ECED1_2383

BSEL:

RHD99_00905

YFR:

AW19_2176

YKR:

CH54_3610

XPO:

XPG1_3611

ASY:	AUT07_00140(tagF)

MSU:	MS0659(tagB)

SACZ:

AOT14_19650

VHR:	AL538_10705

VAQ:	FIV01_00160(tagF1) FIV01_00165(tagF2)

PPR:	PBPRA2683 PBPRA2700

PGB:	H744_2c2863 H744_2c2866

GHO:	AL542_04975

PPUU:

PputUW4_03542

SSE:

Ssed_2954

SJA:	SJ2017_1421

SPSW:

Sps_03695

SMAI:

EXU30_17220

COZ:	A3Q34_09475

COV:	EKO29_15330

CBER:

B5D82_09540

LAL:	AT746_12870

FPH:

Fphi_1473

FPI:

BF30_1738

FPX:

KU46_1834

TZO:	THMIRHAT_08400

HCS:	FF32_16315

HSV:	HNO53_00800

HCAM:

I4484_00940

HSX:	HNO51_00805

ATW:	C0099_11620

DDE:

Dde_0439

DVM:

DvMF_1840

BSY:	I653_17405

BSX:	C663_3460(ggaB1)

BHT:	DIC78_13225

BMOJ:

HC660_34590

BTHU:

YBT1518_29660

BVJ:	I5776_16315

SA0244

SAV:

SAV0254

SAW:

SAHV_0253

SAH:	SaurJH1_0245

SAJ:	SaurJH9_0239

SAM:

MW0230

SAS:

SAS0231

SAR:

SAR0251

SAC:

SACOL0239

SAX:	USA300HOU_0265(tagF)

SAA:	SAUSA300_0248

SAO:	SAOUHSC_00223

SAE:

NWMN_0188

SAD:

SAAV_0222

SUU:	M013TW_0235

SUV:	SAVC_01010

SUE:

SAOV_0193

SUJ:	SAA6159_00231

SUK:	SAA6008_00228(tarF)

SUC:

ECTR2_215

SUT:	SAT0131_00247

SUQ:	HMPREF0772_10248

SUZ:

MS7_0244

SUD:	ST398NM01_0267

SUX:	SAEMRSA15_02130

SUW:	SATW20_02560(tarF)

SUG:

SAPIG0267

SUF:	SARLGA251_02180(tarF)

SAUA:

SAAG_00735

SAUE:

RSAU_000198(tagF)

SAUN:

SAKOR_00233

SAUS:

SA40_0212(tarF)

SAUU:

SA957_0227(tarF)

SAUG:

SA268_0224(tarF)

SAUZ:

SAZ172_0257

SAUT:

SAI1T1_2001950

SAUJ:

SAI2T2_1001950

SAUK:

SAI3T3_1001950

SAUQ:

SAI4T8_1001950

SAUV:

SAI7S6_1001950

SAUW:

SAI5S5_1001940

SAUX:

SAI6T6_1001950

SAUY:

SAI8T7_1001950

SAUF:

X998_0230

SAB:

SAB0193

SUY:	SA2981_0254

SAUB:

C248_0242

SAUM:

BN843_2530

SAUC:

CA347_261

SAUR:

SABB_01598(tagF)

SAUI:

AZ30_01275

SAUD:

CH52_04455

SAMS:

NI36_01170

SUH:	SAMSHR1132_02220

SSH:	NCTC13712_00200(tagF_2)

SSIM:

SAMEA4384339_0215(tagF_4)

SROT:

ML435_01085

PRT:	AUC31_12615

LPB:	SH83_04920

LPX:	ASU28_00370

LRU:	HMPREF0538_20101

LSA:	LCA_1576(tagB)

VHY:	G7082_02250

VFV:	K5K99_13420

VLC:	G314FT_20750(tarF)

SMAN:

C12CBH8_18810

PHX:	KGNDJEFE_00744(tarF)

HALS:

D7D81_02040

ERH:

ERH_1440

ERS:	K210_05635

MAZA:

NFX31_05885

LEO:	AMK43_07405

MPW:

MPR_1602

SHYR:

LA303_09580

CABY:

Cabys_1821 Cabys_1831

METC:

MTCT_0287

» show all

Reference

1 [PMID:18215769]

Authors

Brown S, Zhang YH, Walker S

Title

A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.

Journal

Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011

Sequence

[sao:SAOUHSC_00223]

Reference

2 [PMID:21035733]

Authors

Brown S, Meredith T, Swoboda J, Walker S

Title

Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.

Journal

Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017

Other DBs

ExplorEnz - The Enzyme Database:

2.7.8.45

IUBMB Enzyme Nomenclature:

2.7.8.45

ExPASy - ENZYME nomenclature database:

2.7.8.45

BRENDA, the Enzyme Database:

2.7.8.45

LinkDB

DBGET integrated database retrieval system