Entry
Name
deoxyribonuclease IV;
deoxyribonuclease IV (phage-T4-induced) (misleading);
endodeoxyribonuclease IV (phage T4-induced) (misleading);
E. coli endonuclease IV;
endodeoxyribonuclease (misleading);
redoxyendonuclease;
deoxriboendonuclease (misleading);
endonuclease II;
endonuclease IV;
DNA-adenine-transferase;
nfo (gene name)
Class
Hydrolases;
Acting on ester bonds;
Endodeoxyribonucleases producing 5'-phosphomonoesters
BRITE hierarchy
Reaction(IUBMB)
Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products
Comment
The enzyme is an apurinic/apyrimidinic (AP) site endonuclease that primes DNA repair synthesis at AP sites. It specifically cleaves the DNA backbone at AP sites and also removes 3' DNA-blocking groups such as 3' phosphates, 3' phosphoglycolates, and 3' alpha,beta-unsaturated aldehydes that arise from oxidative base damage and the activity of combined glycosylase/lyase enzymes. It is also the only known repair enzyme that is able to cleave the DNA backbone 5' of the oxidative lesion alpha-deoxyadenosine. The enzyme has a strong preference for single-stranded DNA.
History
EC 3.1.21.2 created 1972 as EC 3.1.4.30, transferred 1978 to EC 3.1.21.2, modified 2014
Orthology
K21525 Autographiviridae endonuclease I
Genes
ECOO : ECRM13514_2921(nfo)
ECOH : ECRM13516_2861(nfo)
EDJ : ECDH1ME8569_2095(nfo)
REE : electrica_01551(nfo)
RTG : NCTC13098_02113(nfo)
CLAP : NCTC11466_01390(nfo)
KIE : NCTC12125_00487(nfo)
AHN : NCTC12129_01677(nfo_1) NCTC12129_01678(nfo_2)
METY : MRY16398_16980(nfo)
PSHI : SAMEA2665130_1071(nfo)
YPI : YpsIP31758_2675(nfo)
SFJ : SAMEA4384070_3339(nfo)
SOF : NCTC11214_03498(nfo)
EHD : ERCIPSTX3056_374(nfo)
BAPF : BUMPF009_CDS00458(nfo)
BAPG : BUMPG002_CDS00459(nfo)
BAPU : BUMPUSDA_CDS00457(nfo)
BAPW : BUMPW106_CDS00458(nfo)
TPTY : NCTC11468_02440(nfo)
PHEI : NCTC12003_01639(nfo)
LRI : NCTC12151_01324(nfo)
ALIG : NCTC10568_01164(nfo)
VAU : VANGNB10_cI2136c(nfo)
VPL : SA104470976_00463(nfo)
SCAA : TUM17387_11610(nfo)
HAXI : HAALTHF_40560n(nfo)
AEL : NCTC12917_01966(nfo)
CFF : CFF8240_1550 CFF8240_1670
CFT : CFF04554_1561 CFF04554_1672(nfo)
CFV : CFVI03293_1575 CFVI03293_1694(nfo)
CFX : CFV97608_1683 CFV97608_1797(nfo)
CAMP : CFT03427_1509 CFT03427_1622(nfo)
CFP : CR44_07650 CR44_08240
CCOC : CCON33237_0176(nfo)
CPIN : CPIN18020_1577(nfo)
CAMZ : CVIC12175_0016(nfo)
PPOR : JCM14722_18430(nfo)
BAZ : BAMTA208_12895(nvfo)
BFD : NCTC4823_01661(nfo_1) NCTC4823_01828(nfo_2)
BCOH : BC6307_11375 BC6307_15500
BKW : BkAM31D_05495(nfo_1) BkAM31D_06710(nfo_2)
BON : A361_12690 A361_21005
CSUA : IM538_14395 IM538_17330
ASED : IRT44_13110 IRT44_18690
HMN : HM131_09390 HM131_18745
HNZ : P9989_03405 P9989_12805
HSHI : MUO14_00250 MUO14_01825
HAMY : MUO15_01770 MUO15_03320
VIR : X953_07785 X953_09760
VIL : CFK37_13940 CFK37_15190
VNE : CFK40_09365 CFK40_11465
FAR : ABE41_005765 ABE41_013045
FEC : QNH15_06850 QNH15_15490
AQT : FN924_09310 FN924_10790
NDT : L1999_18655 L1999_21710
NCM : QNK12_19160 QNK12_23155
MEBZ : LPC09_14890 LPC09_17595
AIA : AWH56_000245 AWH56_023635
BLEN : NCTC4824_01682(nfo_1) NCTC4824_02121(nfo_2)
SFOR : QNH23_04000 QNH23_04910
PUK : PU629_07780 PU629_11670
SAUT : SAI1T1_2011290(nfo)
SAUJ : SAI2T2_1011310(nfo)
SAUK : SAI3T3_1011290(nfo)
SAUQ : SAI4T8_1011300(nfo)
SAUV : SAI7S6_1011310(nfo)
SAUW : SAI5S5_1011260(nfo)
SAUX : SAI6T6_1011270(nfo)
SAUY : SAI8T7_1011300(nfo)
SDP : NCTC12225_01450(nfo)
SPIC : SAMEA4384060_1391(nfo)
SSH : NCTC13712_01554(nfo)
SSIM : SAMEA4384339_1448(nfo)
SSTE : SAMEA4384403_1206(nfo)
MCAK : MCCS_14930(nfo_1) MCCS_15320(nfo_2)
LMOC : LMOSLCC5850_1509(nfo)
LMW : LMOSLCC2755_1454(nfo)
LMX : LMOSLCC2372_1511(nfo)
LMZ : LMOSLCC2482_1504(nfo)
LMON : LMOSLCC2376_1405(nfo)
LMOS : LMOSLCC7179_1421(nfo)
LMOO : LMOSLCC2378_1465(nfo)
LMOY : LMOSLCC2479_1510(nfo)
LMOT : LMOSLCC2540_1528(nfo)
LMOA : LMOATCC19117_1458(nfo)
LGZ : NCTC10812_01401(nfo)
GMO : NCTC11323_00616(nfo)
GHA : NCTC10459_01140(nfo)
BBE : BBR47_03200(nfo) BBR47_21870
BLR : BRLA_c014990 BRLA_c035360
BFM : BP422_06180 BP422_27115
BAGR : BA6348_00965 BA6348_18140
BRW : GOP56_00425 GOP56_09765
BCHS : JNE38_09550 JNE38_11520
BCOP : JD108_08310 JD108_13710
BPAB : PSE45_01960 PSE45_10790
BHUI : LOK74_05080 LOK74_11335
BAYD : BSPP4475_06365 BSPP4475_12400
BBOR : RFB14_03645 RFB14_15990
BRUM : NDK47_09685 NDK47_16465
PJD : Pjdr2_1252 Pjdr2_2634
GYM : GYMC10_2376 GYMC10_5224
PPM : PPSC2_06545(nfo1) PPSC2_13680(nfo3)
PPO : PPM_1238(nfo1) PPM_2685(nfo3)
PPOL : X809_07000 X809_30080
PPQ : PPSQR21_013380(nfo) PPSQR21_027200
PPOY : RE92_05340 RE92_23055
PMS : KNP414_00658 KNP414_02941
PMQ : PM3016_3181 PM3016_575
PTA : HPL003_14735 HPL003_20145
PSAB : PSAB_05865 PSAB_14015
PDU : PDUR_07250 PDUR_15685
PBD : PBOR_07115 PBOR_20285
PGM : PGRAT_06890 PGRAT_17390
POD : PODO_05810 PODO_16905
PAEN : P40081_07200 P40081_20630
PAEF : R50345_06205 R50345_14870 R50345_17000
PAEQ : R50912_06375 R50912_18910
PSTE : PSTEL_06945 PSTEL_15635
PAEA : R70723_05875 R70723_18185
PAEE : R70331_05885 R70331_17150
PAEH : H70357_06700 H70357_20220
PAEJ : H70737_06050 H70737_14230 H70737_16755
PBJ : VN24_02875 VN24_24085
PIH : UB51_07230 UB51_16565
PRI : PRIO_1472(nfo1) PRIO_3831(nfo3)
PSON : JI735_15440 JI735_26215
PPEO : ABE82_06670 ABE82_14140
PNP : IJ22_20990 IJ22_38010
POW : IJ21_25470 IJ21_41310
PXL : BS614_11055 BS614_21325
PYG : AWM70_02285 AWM70_08600
PSWU : SY83_08745 SY83_17920
PDH : B9T62_01215 B9T62_14580
PIB : BBD41_02995 BBD41_19790
PKB : B4V02_11370 B4V02_18530
PAIH : ASL14_04890 ASL14_25710
PVO : PVOR_14464 PVOR_28084
PLW : D5F53_03885 D5F53_17760
PLEN : EIM92_15460 EIM92_20760
PPSC : EHS13_16495 EHS13_26770
PLUT : EI981_11295 EI981_21860 EI981_28395
PALB : EJC50_21495 EJC50_27335
PCHI : PC41400_05615 PC41400_12760 PC41400_13190
PBK : Back11_12420(nfo_1) Back11_61260(nfo_2)
PPRT : ET464_06195 ET464_10300
PBAC : HUB98_03555 HUB98_23755
PRZ : GZH47_22260 GZH47_29475
PLYC : GXP70_17955 GXP70_24200
PSOP : KP014_09865 KP014_19075
PTRI : KDC22_06065 KDC22_18530
PALO : E6C60_2048 E6C60_3268
PCEL : HUB94_14775 HUB94_22365
PTJ : JRJ22_05080 JRJ22_15010
PALR : HGI30_06730 HGI30_10990
PTHI : NDS46_17130 NDS46_24100
PUI : PUW25_06175 PUW25_16220
PMAH : PTQ21_12450 PTQ21_20500 PTQ21_24290
PDY : QJQ58_04900 QJQ58_28035
PMAE : LMZ02_13270 LMZ02_20275
PWN : QNH46_07165 QNH46_13315
PSPN : L1F29_06295 L1F29_19620
PPOG : QPK24_05580 QPK24_15570
PAUN : MJA45_15955 MJA45_22620
PPAB : KET34_07670 KET34_16390 KET34_21055
PKP : SK3146_00794(nfo_1) SK3146_03137(nfo_2)
TCO : Theco_0611 Theco_1736
COH : EAV92_08435 EAV92_14435
COHN : KCTCHS21_14770(nfo_1) KCTCHS21_30650(nfo_2)
CCHL : FPL14_20970 FPL14_28025
CHEB : HH215_04660 HH215_22365 HH215_32375
EFU : HMPREF0351_12000(nfo)
ECEC : NCTC12421_00886(nfo)
CCHV : BTM20_04000 BTM20_07535
CSEP : CP523_00050 CP523_11300
CCOH : SAMEA4530647_1531(nfo)
CGEL : psyc5s11_06350(nfo)
CTAG : LL095_16920 LL095_16925
CINT : HZF06_10890 HZF06_15385
PFAA : MM59RIKEN_17360(nfo)
VCOP : MM50RIKEN_17750(nfo)
DDH : Desde_1724 Desde_3122
SAY : TPY_1693(nfo) TPY_2499(nfo)
SAP : Sulac_1893 Sulac_3253
STHR : BXT84_06945 BXT84_14650
BPRO : PMF13cell1_04418(nfo_2)
LACY : A4V08_17715 A4V08_36170
CSCI : HDCHBGLK_02695(nfo)
CHYL : CE91St63_22450(nfo)
ARF : AR1Y2_0667 AR1Y2_1065
ANR : Ana3638_02705 Ana3638_22880
PDF : CD630DERM_05600(nfo)
PHAR : NCTC13077_01221(nfo)
PIV : NCTC13079_00055(nfo)
VDN : NCTC11831_01485(nfo)
DHO : Dia5BBH33_15280(nfo)
SRI : SELR_pSRC101720(nfo)
PFAC : PFJ30894_01392(nfo)
AARG : Aargi30884_04880(nfo)
ABSI : A9CBEGH2_06250(nfo)
FIT : Fi14EGH31_17770(nfo)
MMYI : mycmycITA_00106(nfo)
MCAR : MCCPILRI181_00074(nfo)
HVU : HPAVJP_2410 HPAVJP_2450
PML : ATP_00027(nfo) ATP_00471(nfo)
AHK : NCTC10172_00190(nfo)
AAXA : NCTC10138_00993(nfo)
MTAB : MTABA_v1c03690(nfo)
MCOL : MCOLE_v1c03470(nfo)
EFR : EFREU_v1c00170(nfo) EFREU_v1c03190(nfo) EFREU_v1c04310(nfo)
SSYR : SSYRP_v1c04280(nfo)
STAI : STAIW_v1c06070(nfo)
SAPI : SAPIS_v1c05770(nfo)
SSAB : SSABA_v1c04950(nfo)
SATR : SATRI_v1c07000(nfo)
SERI : SERIO_v1c06710(nfo)
SCOU : SCORR_v1c04880(nfo)
SPRN : S100390_v1c04780(nfo)
SPIT : STU14_v1c04780(nfo)
STAB : STABA_v1c05780(nfo)
SMOO : SMONO_v1c04190(nfo)
SALX : SALLE_v1c05030(nfo)
SCHI : SCHIN_v1c06730(nfo)
SPLT : SPLAT_v1c03770(nfo)
MNU : NCTC10166_00315(nfo)
MOE : NCTC10151_00748(nfo_2)
MGLY : NCTC10194_00254(nfo)
MCOU : NCTC10179_00368(nfo)
MCOM : NCTC10178_00484(nfo)
MPU : MYPU_6210(MYPU_6210)
MEDW : NCTC10132_00325(nfo)
MGAL : NCTC10186_00221(nfo)
MCIT : NCTC10181_00911(nfo)
MMAU : NCTC10168_00095(nfo)
MMEL : NCTC10153_00392(nfo)
MCOB : NCTC10184_00087(nfo)
MALA : NCTC10135_00597(nfo)
MSAI : NCTC10113_01102(nfo_2)
MOB : NCTC10112_00213(nfo)
MGAC : HFMG06CAA_2917(nfo)
MGAN : HFMG08NCA_2747(nfo)
MGNC : HFMG96NCA_2962(nfo)
EGD : GS424_014275 GS424_014280
AHAT : ADCFC_07150(nfo_1) ADCFC_22680(nfo_2)
MBAI : MB901379_00855(end)
MHEK : JMUB5695_03926(nfo)
MKY : IWGMT90018_09920(nfo)
MPHL : MPHLCCUG_01259(end)
MAUU : NCTC10437_01044(nfo)
MFLV : NCTC10271_04149(nfo)
NFR : ERS450000_05259(nfo)
NOZ : DMB37_14050 DMB37_19270
NAD : NCTC11293_05963(nfo)
NWL : NWFMUON74_13150(nfo)
NSPU : IFM12276_08990(nfo)
RCR : NCTC10994_01389(nfo)
SLE : sle_50270(sle_50270)
SGM : GCM10017557_60850(nfo)
STUI : GCM10017668_17610(nfo)
SXT : KPP03845_102358(nfo)
SANT : QR300_03895 QR300_31335
OCP : NF557_00815 NF557_07300
PAUS : NCTC13651_00078(nfo)
NDK : I601_1245(end) I601_2704(nfo)
NOI : FCL41_06160 FCL41_16625
NOO : FE634_13735 FE634_21115
NSN : EXE58_00245 EXE58_08170
NMES : H9L09_01050 H9L09_08885
NAQU : ENKNEFLB_01547(nfo) ENKNEFLB_04460(end)
NRO : K8W59_05665 K8W59_19990
NCQ : K6T13_10805 K6T13_17180
NPC : KUV85_03095 KUV85_13375
NPS : KRR39_11970 KRR39_20255
NMAR : HPC71_07875 HPC71_20700
NFC : KG111_10945 KG111_17935
MUZ : H4N58_02850 H4N58_07755
NBT : KLP28_02345 KLP28_06920
KSL : OG809_11045 OG809_30955
ACTW : F7P10_20725 F7P10_36510
AGRA : AGRA3207_004148 AGRA3207_006778
ACIR : OG979_04475 OG979_18540
SPIQ : OHA34_24005 OHA34_35640
ACTQ : OG417_01750 OG417_19700
NOA : BKM31_28630 BKM31_46155
NOW : GBF35_17890 GBF35_51420
NCX : Nocox_14905(nfo) Nocox_42355(end)
NGN : LCN96_17910 LCN96_55955
NFS : OIE67_28680 OIE67_47520
MHAI : OHB01_09795 OHB01_23730
BSD : BLASA_2145(nfo) BLASA_5049
BLAP : MVA48_06305 MVA48_16515
MMAR : MODMU_3506(nfo) MODMU_5569(nfo)
STP : Strop_3254 Strop_4557
MAU : Micau_4510 Micau_6268
MICB : MicB006_3508 MicB006_6280
MTUA : CSH63_02130 CSH63_26290
MICH : FJK98_23975 FJK98_32830
MTEM : GCE86_16910 GCE86_25425
MCAB : HXZ27_22880 HXZ27_31575
MSAG : GCM10017556_07420(nfo) GCM10017556_25750(nfo)
VMA : VAB18032_04320 VAB18032_26986
MCRA : ID554_13635 ID554_23780
VER : HUT12_24475 HUT12_31970
MENO : Jiend_28760(nfo_1) Jiend_45490(nfo_2)
MCHL : PVK74_12660 PVK74_20895
MFEU : H1D33_06755 H1D33_28195
MPRN : Q3V37_07120 Q3V37_15740
MHAW : RMN56_11850 RMN56_20525
ASE : ACPL_1702(nfo) ACPL_8347(end)
AMS : AMIS_14730 AMIS_80930
ACTN : L083_1965(nfo) L083_8183(end)
ACTS : ACWT_1580 ACWT_8214
AIH : Aiant_42460(nfo_1) Aiant_60350(nfo_2)
ACTR : Asp14428_25840(nfo_1) Asp14428_47490(nfo_2)
ACTL : L3i22_016470(nfo) L3i22_107010(nfo)
ASIC : Q0Z83_072600 Q0Z83_088520
AOU : ACTOB_001661 ACTOB_008741
PLK : CIK06_20585 CIK06_28815
PLAB : C6361_17840 C6361_34605
PLAT : C6W10_26475 C6W10_30220
PFLA : Pflav_070270(nfo) Pflav_090180 Pflav_090190
PSUU : Psuf_032710(nfo_1) Psuf_053090(nfo_2)
ATL : Athai_41310(nfo_1) Athai_64230(nfo_2)
ASER : Asera_11210(nfo_1) Asera_33240(nfo_2)
PRY : Prubr_04300(nfo_1) Prubr_25240(nfo_2)
CATI : CS0771_13360(nfo_1) CS0771_74060(nfo_2)
DVC : Dvina_44420 Dvina_53695
DFU : Dfulv_39240 Dfulv_48210
DROS : Drose_29630 Drose_38205
DAUR : Daura_42890 Daura_51285
DMAT : Dmats_39015 Dmats_48090
NHY : JQS43_08220 JQS43_25705
CCAZ : COUCH_01175 COUCH_29995
BALA : DSM104299_02554(nfo)
ABIW : Abiwalacus_09410(nfo)
PPIO : CE91St28_00890(nfo)
GAU : GAU_2163(nfo) GAU_3071
GPH : GEMMAAP_11295 GEMMAAP_15675
GGR : HKW67_03270 HKW67_20515
BTHO : Btheta7330_03341(nfo)
BCEL : BcellWH2_04572(nfo)
PSOE : CE91St14_22430(nfo)
COPR : Cop2CBH44_09060(nfo)
CFAS : Cfast33896_07110(nfo)
FPE : Ferpe_0690 Ferpe_1305
CDES : C0J27_01550 C0J27_03300
VPM : KG892_03035 KG892_05470
MEHF : MmiHf6_18170(nfo_2)
MEES : MmiEs2_10250(nfo_1)
MCHK : MchiMG62_06710 MchiMG62_07680(nfo)
MFK : E2N92_06075 E2N92_06565
HSU : HLASF_0311 HLASF_0542
HSF : HLASA_0310 HLASA_0539
HAHS : HSRCO_0520(nfo) HSRCO_0866(nfo2)
NSAL : HWV07_13555 HWV07_16385
HME : HFX_0550(xthA) HFX_6012(xthA)
HAQ : DU484_05845 DU484_07860 DU484_07975
HAJ : DU500_06315 DU500_08025
TVO : TVG0169833(TVG0169833) TVG1022523(TVG1022523)
FAC : FACI_IFERC01G0382 FACI_IFERC01G1102
TAR : TALC_01383 TALC_01547
MAX : MMALV_07140 MMALV_14800
MER : MMINT_08520 MMINT_16590
MEAR : Mpt1_c00390 Mpt1_c14230(nfo2)
MEUZ : KRP56_00190 KRP56_07185
MARC : AR505_0028 AR505_0178
NCV : NCAV_0118(nfo) NCAV_0495
LOKI : Lokiarch_47130(nfo_2)
» show all
Taxonomy
Reference
Authors
Friedberg EC, Goldthwait DA.
Title
Endonuclease II of E. coli. I. Isolation and purification.
Journal
Reference
Authors
Friedberg EC, Hadi SM, Goldthwait DA.
Title
Endonuclease II of Escherichia coli. II. Enzyme properties and studies on the degradation of alkylated and native deoxyribonucleic acid.
Journal
J Biol Chem 244:5879-89 (1969)
Reference
Authors
Hadi SM, Goldthwait DA.
Title
Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid.
Journal
Reference
Authors
Cunningham RP, Saporito SM, Spitzer SG, Weiss B
Title
Endonuclease IV (nfo) mutant of Escherichia coli.
Journal
Reference
Authors
Ide H, Tedzuka K, Shimzu H, Kimura Y, Purmal AA, Wallace SS, Kow YW
Title
Alpha-deoxyadenosine, a major anoxic radiolysis product of adenine in DNA, is a substrate for Escherichia coli endonuclease IV.
Journal
Reference
Authors
Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA
Title
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.21.2
ExPASy - ENZYME nomenclature database: 3.1.21.2
LinkDB
All DBs