Entry
Name
carboxynorspermidine decarboxylase;
carboxyspermidine decarboxylase;
CANSDC;
VC1623 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
carboxynorspermidine carboxy-lyase (bis(3-aminopropyl)amine-forming)
Reaction(IUBMB)
(1) carboxynorspermidine = bis(3-aminopropyl)amine + CO2 [RN:
R09082 ];
(2) carboxyspermidine = spermidine + CO2 [RN:
R09081 ]
Reaction(KEGG)
Substrate
carboxynorspermidine [CPD:
C18174 ];
carboxyspermidine [CPD:
C18172 ]
Product
Comment
A pyridoxal 5'-phosphate enzyme. Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae [1]. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro [3].
History
EC 4.1.1.96 created 2012
Pathway
ec00330 Arginine and proline metabolism
Orthology
K13747 carboxynorspermidine decarboxylase
Genes
PDAG : 4362423_00506(nspC)
VAU : VANGNB10_cI1168(nspC)
VPL : SA104470976_01355(nspC)
PPRC : PFLCHA0_c35790(nspC)
PFW : PF1751_v1c30140(nspC)
PSYC : DABAL43B_1233(nspC)
SALH : HMF8227_02644(nspC)
MESL : KKZ03_00640 KKZ03_08080(nspC)
GAI : IMCC3135_13130(nspC)
OAI : OLEAN_C07020 OLEAN_C24180
BPM : BURPS1710b_A0479(nspC)
LMIR : NCTC12852_02063(lysA_2)
BTRM : SAMEA390648701673(nspC)
NIY : FQ775_07435 FQ775_11415
SMEL : SM2011_b21631(nspC)
ALF : CFBP5473_18730(nspC)
AVV : RvVAT039_41560(nspC)
AVF : RvVAR031_34050(nspC)
ASAL : CFBP5507_18170(nspC)
RPUS : CFBP5875_20340(nspC)
ALEG : CFBP4996_21910(nspC)
NEN : NCHU2750_24250(nspC)
LAS : CLIBASIA_03140(nspC)
BIO : BR141012304_10215(nspC)
BHS : BM1374165_01703(nspC)
BBK : BARBAKC583_0029(nspC)
BTX : BM1374166_02313(nspC)
SINL : DSM14862_00723(nspC)
SPSE : SULPSESMR1_01760(nspC)
RMM : ROSMUCSMR3_00536(nspC)
LVS : LOKVESSMR4R_01076(nspC)
SBIN : SBA_ch1_25010(nspC)
SFLA : SPHFLASMR4Y_00833(nspC)
HPO : HMPREF4655_20224(nspC)
HPX : HMPREF0462_0021(nspC)
HPUL : NCTC13154_01461(nspC)
CJV : MTVDSCj20_1479(nspC)
CFV : CFVI03293_0337(nspC)
CAMP : CFT03427_0347(nspC)
CCOC : CCON33237_0326(nspC)
CLR : UPTC16701_0349(nspC)
CLM : UPTC16712_0351(nspC)
CAMR : CAQ16704_0364(nspC)
CHV : CHELV3228_0136(nspC)
CPIN : CPIN18020_0993(nspC)
CAMZ : CVIC12175_0272(nspC)
GBN : GEOBRER4_12810(nspC)
PPOR : JCM14722_30430(nspC)
PPQ : PPSQR21_017270(lysA)
COHN : KCTCHS21_60370(nspC)
SNC : HMPREF0837_11565(nspC)
ECEC : NCTC12421_00670(lysA_1)
CLO : HMPREF0868_0010(nspC)
BPRO : PMF13cell1_03257(nspC)
BLUI : Blut17040_10370(nspC)
CBAR : PATL70BA_2247(nspC)
MANA : MAMMFC1_00820(nspC)
PRUN : PCC7821_03671(yeaW)
NSPH : BDGGKGIB_04046(suoC)
DEIN : DAAJ005_13900(nspC)
LSZ : JCM16776_1156(nspC) JCM16776_1391
BTHO : Btheta7330_02258(nspC)
BCEL : BcellWH2_00463(nspC)
BFC : BacF7301_19485(nspC)
PCAG : NCTC12856_00358(lysA)
PMZ : HMPREF0659_A6683(nspC)
PDN : HMPREF9137_1228(nspC)
PSEZ : HME7025_01356(nspC)
» show all
Taxonomy
Reference
Authors
Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ
Title
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.
Journal
Sequence
Reference
Authors
Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA
Title
Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
Journal
Sequence
Reference
Authors
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ
Title
Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.96
ExPASy - ENZYME nomenclature database: 4.1.1.96
LinkDB
All DBs