KEGG   ENZYME: 5.4.99.63
Entry
EC 5.4.99.63                Enzyme                                 
Name
ethylmalonyl-CoA mutase;
Ecm
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
(2R)-ethylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB)
(2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA [RN:R09292]
Reaction(KEGG)
R09292
Substrate
(2R)-ethylmalonyl-CoA [CPD:C20238]
Product
(2S)-methylsuccinyl-CoA [CPD:C18324]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires adenosylcobalamin for activity.
History
EC 5.4.99.63 created 2015
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
Orthology
K14447  ethylmalonyl-CoA mutase
Genes
KAK: Kalk_01785
ALKM: NKI27_11395
ASEM: NNL22_07750
OME: OLMES_2175
GPB: HDN1F_15990(smbA)
APP: CAP2UW1_2499
PLA: Plav_1625
KMN: HW532_10490
RBS: RHODOSMS8_02644(scpA)
BOP: AXW83_14150
BOS: BSY19_4455
BVV: BHK69_28685
BOI: BLM15_27815
BOF: FQV39_17330
XAU: Xaut_1197
XDI: EZH22_01050
AZC: AZC_0992
MEA: Mex_1p0180(ecm)
MDI: METDI0163(ecm)
MEX: Mext_0290
MCH: Mchl_0334
MPO: Mpop_0366
MZA: B2G69_08710
MRD: Mrad2831_1106
MET: M446_0036
MNO: Mnod_0038
MOR: MOC_1330
META: Y590_00905
MAQU: Maq22A_1p32005(meaA)
MPHY: MCBMB27_00697
MEE: DA075_05080
METD: C0214_01275
METX: A3862_25065
METS: DK389_18850
METI: DK427_18530
MMES: MMSR116_22780
MTEA: DK419_07960
MIND: mvi_52660
MOG: MMB17_10640
RHJ: HZY79_04305
CHEL: AL346_09690
CDQ: BOQ54_02765
HDN: Hden_0218
HDT: HYPDE_23653
HMC: HYPMC_0095(ecm)
HNI: W911_17410
RVA: Rvan_1142
RLAC: QMO75_08255
FIL: BN1229_v1_1371(meaA)
FIY: BN1229_v1_1370(meaA)
RHZ: RHPLAN_11770
MCG: GL4_3338
METG: HT051_02990
BVR: BVIR_89
BLAG: BLTE_34290
MSC: BN69_1950
MBRY: B1812_17295
MROS: EHO51_15485
MHEY: H2LOC_019260
MPAR: F7D14_06260
MIWA: SS37A_03150
MTW: CQW49_20150
MECQ: MSC49_02790
PLEO: OHA_1_02830(meaA)
HDI: HDIA_3962(scpA_2)
PSIN: CAK95_11855
NOH: G5V57_10415
RBM: TEF_03475
PSF: PSE_0116(mutB)
PPHR: APZ00_07820
LAP: ACP90_02775
LABR: CHH27_17720
LABP: FJ695_06480
LABT: FIU93_08400(scpA1)
LAGG: B0E33_14255
RPOP: K1718_03850
SIW: GH266_11595
PHR: C6569_14510
PSTG: E8M01_09075
PAQT: E8L99_11580
CCR: CC_3081
CCS: CCNA_03177
CAK: Caul_0836
CSE: Cseg_3643
CHQ: AQ619_02915
CMB: CSW64_02215
CFH: C1707_03485
CAUF: CSW63_19575
TSV: DSM104635_01212(scpA_1)
SIL: SPO0368
SIT: TM1040_3106
RUA: D1823_12095
RUT: FIU92_01400(scpA1)
RCON: K3740_01530
JAN: Jann_0797
RDE: RD1_1635(mutB)
RLI: RLO149_c030730(mutB2)
RPON: G3256_15270
DSH: Dshi_2855(mutB)
PGA: PGA1_c03840(mutB)
PGL: PGA2_c03390(mutB)
PGD: Gal_03117
PHP: PhaeoP97_02971(mutB)
PPIC: PhaeoP14_00302(mutB)
PHQ: D1820_14780
OAT: OAN307_c41380(mutB2)
OAR: OA238_c04410(mutB1)
OTM: OSB_04900(mutB)
OCT: FTO60_13710
LMD: METH_03400
LEJ: ETW24_04235
LAQU: R2C4_13550
LEV: ETW23_15965
LCAE: K3721_03520
RED: roselon_01711
CID: P73_3853
CMAR: IMCC12053_3008
CEH: CEW89_10030
MALG: MALG_02725
CON: TQ29_02505
YPAC: CEW88_11100
YAN: AYJ57_04480
TPRO: Ga0080559_TMP1108
PABY: Ga0080574_TMP3168
SUAM: BOO69_13595
SULZ: C1J03_18105
SULI: C1J05_18030
SULD: B5M07_05045
SPOT: G6548_04215
SMED: JNX03_18130
SINL: DSM14862_02474(mutB)
SFAV: PL335_11785
SUAL: KDD17_02235
SDUB: R1T39_14865
SPSE: SULPSESMR1_00407(scpA)
TOM: BWR18_01110
RMM: ROSMUCSMR3_01834(scpA)
ROK: RAK1035_1351
RID: RIdsm_00119(scpA_1)
ROM: EI983_03065
ROH: FIU89_18790(scpA3)
RPEL: N7U68_09855
AHT: ANTHELSMS3_02143
SAGU: CDO87_04305
THAA: CFI11_20745
OCD: FHY55_05945
ROT: FIV09_01475(scpA1)
RMH: LVO79_01135
MALU: KU6B_41670(MeaA)
TGL: HFZ77_08330
TMD: KUV46_08240
HAT: RC74_09415
PALX: GQA70_04875
LSAL: KBK07_01480
LALG: LentiSH36_00622(mutB)
TRY: QF118_18595
MARU: FIU81_04175(mutB)
RMAI: MACH21_04620(MeaA)
RSP: RSP_0961(MeaA)
RSH: Rsph17029_2621
RSQ: Rsph17025_3008
RSK: RSKD131_2353
CAZT: LV780_12825
RCP: RCAP_rcc03241(mutB)
RHP: LPB142_14600
RBL: B6K69_07525
FYT: QF092_18065
PDE: Pden_3875
PAMI: JCM7686_1037
PYE: A6J80_12665
PCON: B0A89_06935
PZH: CX676_11120
PARO: CUV01_03090
PAMN: JCM7685_2154
PMUT: DPM13_11120
PARR: EOJ32_14930
PAAK: FIU66_03195
PKD: F8A10_08035
PPAN: ESD82_06405
PLIA: E4191_03285
PSAN: HGN31_12035
PMAU: CP157_00623(mutB)
PMEH: JWJ88_03145
PSEW: JHW44_03810
PSAP: JHX88_04430
PFIS: JHX87_08935
PAEX: JHW48_12340
PSTL: JHW45_04620
PALP: JHW40_09130
PVER: E3U25_03755
PFEO: E3U26_19280
PTP: RCA23_c09170(mcmA1)
RSU: NHU_00738
RHM: B5V46_04545
RHC: RGUI_0611
RMB: K529_020835
TSCO: R1T40_12655
DAA: AKL17_0910
DON: BSK21_00875
RBZ: B9057_00660
THW: BMG03_18270
TEC: AKL02_018630
LVS: LOKVESSMR4R_02788(mutB)
RBG: BG454_09815
GEH: HYN69_12825
GFU: KM031_13360
TAW: EI545_06890
SALO: EF888_18455
SEDI: EBB79_02315
PPSO: QPJ95_04630
BOO: E2K80_01925
PSEB: EOK75_09455
PPRU: FDP22_03525
PAED: G5B38_14090
MON: G8E03_01705
PAMO: BAR1_15105
POZ: I0K15_10705
PALW: PSAL_018860(ecm)
PSHQ: F3W81_20345
PGV: SL003B_0357
CACT: HZ995_03600
THAS: C6Y53_10575
HDH: G5B40_19125
CMAG: CBW24_14090
GCE: KYE46_04140
NSM: JO391_13160
ACRO: K3J57_10555
SINR: O5O51_13230
AALK: LGT41_0001995
AMYL: QBD29_12735
AMAQ: GO499_14280
RHOC: QTA57_01965
PBAE: P8S53_09415
FAQ: G5B39_05190
RBX: I3V23_06925
HNE: HNE_3115
HBA: Hbal_0291
CBOT: ATE48_04280
HBC: AEM38_09250
SKT: IGS68_10665
SMUC: JL100_016565
SROE: JL101_014990
RRU: Rru_A3062
RRF: F11_15685
MGY: MGMSRv2__2673(yliK)
MGRY: MSR1_36930(scpA_3)
MAGX: XM1_1238
MAGN: WV31_14305
FER: FNB15_00560
DEX: HWD60_01565
DVN: HQ394_14995
MAG: amb0310
HTQ: FRZ44_46210
HADH: FRZ61_44140
TXI: TH3_17590
THAC: CSC3H3_16680
TII: DY252_04215
THAI: IT893_16595
TLU: R1T41_05145
TTB: MACH01_32640
MAGQ: MGMAQ_3101
VSU: P3M64_11865
TMO: TMO_0118(meaA)
ECOG: FIV45_15320
SNEA: NBZ79_17905
EUZ: DVS28_a3923
RANT: RHODO2019_03895
SCO: SCO6472(SC9C7.08c)
SALB: XNR_0457
SMA: SAVERM_1912(meaA1)
SGR: SGR_1171
SGB: WQO_29555
SFI: SFUL_6326
SANL: KZO11_31640
SGRF: SGFS_030180
SCYE: R2B67_04495
SCB: SCAB_17631
SSX: SACTE_5659
SVL: Strvi_2500
SHY: SHJG_7433
SHO: SHJGH_7193
SRC: M271_13260
SMAL: SMALA_6100
SSOI: I1A49_34350
SFA: Sfla_0906
SBH: SBI_02837
SVE: SVEN_6306
SDV: BN159_1953(meaA)
SALS: SLNWT_0465
STRP: F750_5948
SCI: B446_29765
SLV: SLIV_06065(meaA)
SGU: SGLAU_27250(meaA)
SVT: SVTN_30765
STRE: GZL_02324
SCW: TU94_27470
SLD: T261_1718
SLC: SL103_24365
STRM: M444_27575
STRC: AA958_28640
SAMB: SAM23877_6066(meaA)
SPRI: SPRI_1331
SCZ: ABE83_04725
SCX: AS200_10825
SRW: TUE45_07074(mutB_2)
STRF: ASR50_29035
SLE: sle_13030(sle_13030)
SRN: A4G23_04916(scpA_5)
SPAV: Spa2297_26925
STRT: A8713_26355
SCLF: BB341_03680
SGS: AVL59_13885
STSI: A4E84_33265
SKY: D0C37_03825
SALW: CP975_29940
SGM: GCM10017557_14290
SCAD: DN051_09615
SPHW: NFX46_11070
SLS: SLINC_6871
SNR: SNOUR_10730(meaA)
SALU: DC74_6486
SALL: SAZ_33455
SPLU: LK06_027855
STRD: NI25_06040
SNW: BBN63_05340
SAUO: BV401_34295
SSIA: A7J05_06525
SVU: B1H20_30385
SPUN: BFF78_09065
SGV: B1H19_32465
SLAU: SLA_6260
SALF: SMD44_07017(ecm)
SALJ: SMD11_1339(ecm)
SLX: SLAV_08025(mutB1)
STRO: STRMOE7_31095
SFK: KY5_6786c
SNZ: DC008_28370
SGE: DWG14_01739(scpA_1)
SRJ: SRO_1426
SLK: SLUN_32570
SGD: ELQ87_06720
SQZ: FQU76_28250
SCYA: EJ357_38670
SAST: CD934_04585
SNQ: CP978_27095
STIR: DDW44_26345
SKA: CP970_06745
SGZ: C0216_10220
SVN: CP980_06485
SNK: CP967_03940
SHAW: CEB94_34115
SRK: FGW37_26430
SFIC: EIZ62_05460
SGAL: CP966_29710
SSPO: DDQ41_27615
SVR: CP971_08935
SPAD: DVK44_29745
SFY: GFH48_09630
SAQU: EJC51_37840
SGF: HEP81_01392
SCAV: CVT27_29035
SSEO: D0Z67_24050
SBY: H7H31_05445
SRIM: CP984_07150
SSUB: CP968_06980
SPHV: F9278_39480
SCIN: CP977_28230
SFUG: CNQ36_27175
SPAC: B1H29_06760
STSU: B7R87_28640
SCHA: CP983_08260
SGX: H4W23_31950
SCOE: CP976_35270
SBAT: G4Z16_04715
SSPB: CP982_33015
SNF: JYK04_06749(mutB_2)
SPLA: CP981_31655
SBRO: GQF42_34500
STUI: GCM10017668_58320
SATA: C5746_34335
SCHF: IPT68_30320
SHUN: DWB77_01616(scpA_1)
SCYG: S1361_32250(scpA6)
SFEU: IM697_30280
SLIA: HA039_05420
SDW: K7C20_30095
SVD: CP969_31020
SCAL: I6J39_30190
SAUH: SU9_028720
SFB: CP974_26295
SMOB: J7W19_26400
SPRA: CP972_29690
SPEU: CGZ69_30575
SROI: IAG44_07410
SXN: IAG42_06405
SGJ: IAG43_27265
SHK: J2N69_31305
SANU: K7396_06915
STRY: EQG64_30320
SDD: D9753_06040
SACT: DMT42_31225
SGOB: test1122_23250
SINE: KI385_35825
SLF: JEQ17_10575
SDEC: L3078_37525
SAOV: G3H79_06005
SDUR: M4V62_09170
SYAN: NRK68_28080
SRUG: F0345_25090
SAKB: K1J60_07750
STAA: LDH80_08495
SNIG: HEK616_47030
SVIO: HWN34_03180
SCAE: IHE65_07985
STUB: MMF93_27330
SSPN: LXH13_31695
SCIR: STRCI_006605
SXT: KPP03845_105977(mutB_2)
SLON: LGI35_34445
SDRZ: NEH16_04240
STUD: STRTU_001168
STEE: F3L20_13730
SENG: OJ254_28095
SGK: PET44_26100
SANT: QR300_11060
SYUN: MOV08_10530
SARG: HKX69_05555
SJN: RI060_07360
SCYN: N8I84_32175
SOV: QZH56_05545
SFIY: F0344_03865
SHAU: K9S39_10770
SKG: KJK29_05560
SCOA: QU709_07145
SLAI: P8A22_05565
SROC: RGF97_04315
SFP: QUY26_06975
SCHG: NRO40_24745
STTN: BSL84_27870
SINN: ABB07_06450
STRZ: OYE22_05255
SCT: SCAT_4858(meaA)
SCY: SCATT_48520
KSK: KSE_56500(meaA)
KAB: B7C62_31665
KAU: B6264_03995
KIT: CFP65_5573
KIS: HUT16_26330
STRI: C7M71_024010
YIA: LO772_12030
STRH: GXP74_30640
ABRY: NYE86_24200
AGLA: OIE69_10750
ICA: Intca_2425
ARS: ADJ73_15700
JTE: ASJ30_04295
JLI: EXU32_10505
JME: EEW87_010525
JAY: H7A72_04265
JCR: O9K63_00740
TEH: GKE56_08435
PHW: G7075_02710
TED: U5C87_19870
AUS: IPK37_01675
NCA: Noca_1772
NDK: I601_3918(mutB_2)
NOY: EXE57_05100
NOI: FCL41_11305
NOO: FE634_09195
NBE: Back2_04490
NANO: G5V58_14510
NMES: H9L09_15850
NARO: CFH99_09950
NAQU: ENKNEFLB_01864(mutB_2)
NRO: K8W59_11225
NOQ: LN652_20100
NCQ: K6T13_05870
NPC: KUV85_07875
NPS: KRR39_03630
NMAR: HPC71_14910
NFC: KG111_11470
PSIM: KR76_10535
AER: AERYTH_06740
AEZ: C3E78_12405
AEB: C6I20_10395
AEF: GEV26_12445
ASEZ: H9L21_10400
ADB: NP095_10595
AWN: NQV15_13080
MUZ: H4N58_05980
SGRG: L0C25_02485
NBT: KLP28_14750
KFL: Kfla_5026
KQI: F1D05_07480
KSL: OG809_41255
FRA: Francci3_2169
FRE: Franean1_1034
FAL: FRAAL5921(meaA)
FSY: FsymDg_3836
FRI: FraEuI1c_0946
GOB: Gobs_4128
BSD: BLASA_3911(mutB)
BLAP: MVA48_21090
AMD: AMED_7761
AMN: RAM_39870
AMM: AMES_7643
AMZ: B737_7643
AOI: AORI_6548(ecm)
AJA: AJAP_06220(meaA)
AMQ: AMETH_1366(mutB)
AMYC: CU254_31230
AMYB: BKN51_26185
AAB: A4R43_22310
AMYY: YIM_06440(scpA1)
AORI: SD37_07695
AACD: LWP59_06670
APRT: MUY14_45410
AROO: NQK81_33095
ATHM: L1857_09475
PDX: Psed_1691
PSEA: WY02_10790
PSEE: FRP1_03360
PSEH: XF36_19370
PSEQ: AD006_10970
PECQ: AD017_18800
PHH: AFB00_04680
PAUT: Pdca_54640
PBRO: HOP40_14510
PPEL: H6H00_13985
SESP: BN6_73420(meaA)
SSYI: EKG83_40960
KAL: KALB_7597
KUT: JJ691_90040
KBU: Q4V64_45335
KPHY: AOZ06_46245
LED: BBK82_20750
ALO: CRK59015
PMAD: BAY61_25430
ACTU: Actkin_05108(scpA_3)
CROS: N8J89_35150
ACTY: OG774_11765
UME: RM788_18105
STP: Strop_3621
SAQ: Sare_4003
MAU: Micau_5116
MIL: ML5_3195
MICB: MicB006_4135
MTUA: CSH63_32095
MTEM: GCE86_20210
MCAB: HXZ27_25790
MSAG: GCM10017556_13680
MCHL: PVK74_15850
MFEU: H1D33_01100
MPRN: Q3V37_12330
MHAW: RMN56_17265
PSUU: Psuf_019490
CATI: CS0771_21810
DVC: Dvina_07405
DFU: Dfulv_06855
DROS: Drose_07215
DAUR: Daura_06785
DMAT: Dmats_06930
CAI: Caci_1226
EKE: EK0264_16435
JTL: M6D93_07695
JCY: M6B22_19755
ABAI: IMCC26256_11178
BSOL: FSW04_11595
BALA: DSM104299_01919(ecm)
CWO: Cwoe_4193
PARN: NBH00_07265
SBAE: DSM104329_01837(ecm)
PBAJ: LRS13_14255
TALU: JDY09_03285
AFO: Afer_0223
AYM: YM304_38140(meaA)
ATQ: GH723_16475
AQZ: KSP35_16915
IAM: HC251_22650
IMA: PO878_20385
DHI: LH044_12360
TBH: Tbon_06985
TFLA: O0235_07630
LIL: LB_074(sbm)
LIE: LIF_B059(sbm)
LIC: LIC_20058(mcm2)
LIS: LIL_20066(mcm1)
LBJ: LBJ_4062(meaA)
LBL: LBL_4062(meaA)
LBI: LEPBI_II0044(mcm2)
LBF: LBF_4043(meaA)
LST: LSS_18738
LAJ: A0128_19665
LMAY: DPV73_18965
LKM: EFP84_19380
LWL: FHG68_19780
LKB: LPTSP3_g37080(mcm2_1)
LNO: MAL08_18090
LKR: FH602_00460
TPX: Turpa_0280
 » show all
Reference
1  [PMID:18819910]
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
  Sequence
[rsp:RSP_0961]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.63
IUBMB Enzyme Nomenclature: 5.4.99.63
ExPASy - ENZYME nomenclature database: 5.4.99.63
BRENDA, the Enzyme Database: 5.4.99.63
LinkDB

DBGET integrated database retrieval system