KEGG ENZYME: 6.3.2.24

ENZYME: 6.3.2.24

Entry

EC 6.3.2.24                 Enzyme

Name

tyrosine---arginine ligase;
tyrosyl-arginine synthase;
kyotorphin synthase;
kyotorphin-synthesizing enzyme;
kyotorphin synthetase

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)

Sysname

L-tyrosine:L-arginine ligase (AMP-forming)

Reaction(IUBMB)

ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine [RN:R00735]

Reaction(KEGG)

Substrate

ATP [CPD:C00002];
L-tyrosine [CPD:C00082];
L-arginine [CPD:C00062]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-tyrosyl-L-arginine [CPD:C02993]

History

EC 6.3.2.24 created 1992

Reference

1 [PMID:3597366]

Authors

Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H.

Title

Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes.

Journal

J Biol Chem 262:8165-73 (1987)

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:	116036-78-3

LinkDB

DBGET integrated database retrieval system