KEGG   DRUG: D00088Help
Entry
D00088                      Drug                                   

Name
Hydrocortisone (JP17/USP/INN);
HC;
Acticort (TN);
Anusol HC (TN);
Colocort (TN);
Cortef (TN);
Hytone (TN);
Plenadren (TN)
Product
  Generic
HYDROCORTISONE (A-S Medication Solutions LLC), HYDROCORTISONE (A-S Medication Solutions LLC), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (ANIP Acquisition Company), HYDROCORTISONE (Actavis Mid Atlantic LLC), HYDROCORTISONE (Actavis Mid Atlantic LLC), HYDROCORTISONE (Aidarex Pharmaceuticals LLC), PROCTOCREAM (Alaven Pharmaceutical LLC), HYDROCORTISONE (American Health Packaging), HYDROCORTISONE (American Health Packaging), PEDIADERM HC (Arbor Pharmaceuticals), HYDROCORTISONE (Avera McKennan Hospital), HYDROCORTISONE (Carilion Materials Management), HYDROCORTISONE (Carilion Materials Management), HYDROCORTISONE (Carolina Medical Products Company), HYDROCORTISONE (Crown Laboratories), ALACORT (Crown Laboratories), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (E. FOUGERA & CO. A division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E.FOUGERA & COMPANY A division of Fougera Pharmaceuticals), HYDROCORTISONE (Golden State Medical Supply), HYDROCORTISONE (Greenstone LLC), HYDROCORTISONE (KAISER FOUNDATION HOSPITALS), HYDROCORTISONE (KAISER FOUNDATION HOSPITALS), HYDROCORTISONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROCORTISONE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCORTISONE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCORTISONE (Lineage Therapeutics), HYDROCORTISONE (Lyne Laboratories), HYDROCORTISONE (Major Pharmaceuticals), TEXACORT (Mission Pharmacal Company), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), COLOCORT (Paddock Laboratories), HYDROCORTISONE (Perrigo New York), HYDROCORTISONE (Perrigo New York), HYDROCORTISONE (Physicians Total Care), HYDROCORTISONE (Physicians Total Care), HYDROCORTISONE (Physicians Total Care), HYDROCORTISONE (Physicians Total Care), PROCTOZONE (Physicians Total Care), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), PROCTOZONE (Preferred Pharmaceuticals), PROCTOSOL-HC (Preferred Pharmaceuticals), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (Qualitest Pharmaceuticals), HYDROCORTISONE (Qualitest Pharmaceuticals), HYDROCORTISONE (Qualitest Pharmaceuticals), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), PROCTOSOL-HC (Ranbaxy Laboratories), HYDROCORTISONE (Rebel Distributors Corp), HYDROCORTISONE (Rebel Distributors Corp), HYDROCORTISONE (Rebel Distributors Corp), PROCTO-PAK (Rising Pharmaceuticals), PROCTOZONE (Rising Pharmaceuticals), HYDROCORTISONE (STAT RX USA LLC), HYDROCORTISONE (STAT Rx USA LLC), HYDROCORTISONE (STAT Rx USA LLC), ANUSOL (Salix Pharmaceuticals), PROCTOCORT (Salix Pharmaceuticals), HYDROCORTISONE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE (Unit Dose Services), HYDROCORTISONE (West-Ward Pharmaceuticals Corp), PROCTOZONE (Rising Pharmaceuticals)
Formula
C21H30O5
Exact mass
362.2093
Mol weight
362.4599
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glucocorticoid
Remark
Target
glucocorticoid receptor agonist [HSA:2908] [KO:K05771]
  Pathway
Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00088  Hydrocortisone (JP16/USP/INN)
  Hydrocortisone
   D00088  Hydrocortisone (JP16/USP/INN)
  Hydrocortisone
   D00088  Hydrocortisone (JP16/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00088  Hydrocortisone (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00088  Hydrocortisone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00088  Hydrocortisone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    glucocorticoid receptor
     Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
  CYP3A5
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
  CYP3A7
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00088  Hydrocortisone
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00088
Topical steroids [br08317.html]
 Classification in the USA
  D00088
Rx-to-OTC switch list in the USA [br08315.html]
 D00088
BRITE hierarchy
Other DBs
CAS: 
50-23-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        26
            1   C1y C    25.3915  -16.8055
            2   C1y C    24.2081  -17.4875
            3   C1z C    25.3915  -15.4414
            4   C1x C    27.7583  -16.8055
            5   C1y C    23.0247  -16.8055
            6   C1x C    24.1965  -18.8575
            7   C1z C    26.5809  -14.7535
            8   C1x C    24.2081  -14.7535
            9   C1a C    25.3858  -14.0713
            10  C1x C    27.7583  -15.4414
            11  C1z C    21.8356  -17.4875
            12  C1y C    23.0247  -15.4414
            13  C1x C    23.0247  -19.5395
            14  C5a C    26.5866  -13.3893
            15  C2y C    21.8356  -18.8575
            16  C1x C    20.6579  -16.8055
            17  C1a C    21.8239  -16.1233
            18  O1a O    21.8356  -14.7535
            19  C1b C    27.7643  -12.7072
            20  O5a O    25.3975  -12.7072
            21  C2x C    20.6579  -19.5395
            22  C1x C    19.4687  -17.4875
            23  O1a O    28.9534  -13.3951
            24  C5x C    19.4687  -18.8575
            25  O5x O    18.2853  -19.5395
            26  O1a O    27.9332  -14.3911
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down

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