KEGG   DRUG: D00094Help
Entry
D00094                      Drug                                   

Name
Tretinoin (JAN/USP/INN);
Avita (TN);
Renova (TN);
Retin A (TN);
Tretinoin (TN);
Vesanoid (TN)
Product
  Generic
TRETINOIN (Actavis Mid Atlantic LLC), TRETINOIN (American Health Packaging), TRETINOIN (Barr Laboratories), TRETINOIN (Clinical Solutions Wholesale), REFISSA (Coria Laboratories), TRETINOIN (Dispensing Solutions), TRETINOIN (OMP), TRETINOIN (OMP), REFISSA (Obagi Medical Products), TRETINOIN (Oceanside Pharmaceuticals), TRETINOIN (Oceanside Pharmaceuticals), TRETIN.X (Onset Dermatologics LLC), TRETINX (Onset Dermatologics), TRETINOIN (Par Pharmaceutical), TRETINOIN (Perrigo New York), TRETINOIN (Physicians Total Care), TRETINOIN (Preferred Pharmaceuticals), TRETINOIN (Preferred Pharmaceuticals), TRETINOIN (Rebel Distributors Corp), TRETINOIN (Rebel Distributors Corp), TRETINOIN (Rebel Distributors Corp), TRETINOIN (Rouses Point Pharm), TRETINOIN (Spear Dermatology Products), TRETINOIN GEL MICROSPHERE (Spear Dermatology Products), TRETINOIN (Spear Dermatology Products), REFISSA (Suneva Medical), REFISSA (Suneva Medical), TRETIN-X (Triax Pharmaceuticals), TRETIN-X (Triax Pharmaceuticals), OBAGI (YS PLUS CORPORATION), TRETINOIN CREAM (YS PLUS CORPORATION), OBAGI (YS PLUS CORPORATION)
Formula
C20H28O2
Exact mass
300.2089
Mol weight
300.4351
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Keratolytic, Treatment of acute promyelocytic leukemia
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Retinoic acid
Target
retinoic acid receptor (RAR) agonist [HSA:5914 5915 5916] [KO:K08527 K08528 K08529]
Interaction
Genomic biomarker: PML-RARA [HSA:5371 5914]
Drug interaction
Structure map
Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AD Retinoids for topical use in acne
     D10AD01 Tretinoin
      D00094  Tretinoin (JAN/USP/INN)
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX14 Tretinoin
      D00094  Tretinoin (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Retinoids
   Tretinoin
    D00094  Tretinoin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00094  Tretinoin (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Retinoic acid receptor (RAR)
    retinoic acid receptor
     Tretinoin
      D00094  Tretinoin (JAN/USP/INN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Retinoic acid receptor expression modification
   Tretinoin
    D00094  Tretinoin (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
302-79-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1x C    14.4200  -19.8100
            2   C1x C    14.4200  -21.2100
            3   C1x C    15.6324  -21.9100
            4   C2y C    16.8449  -21.2100
            5   C2y C    16.8449  -19.8100
            6   C1z C    15.6324  -19.1100
            7   C1a C    16.4540  -17.9930
            8   C1a C    14.6889  -18.0557
            9   C1a C    18.0760  -21.9210
            10  C2b C    18.0760  -19.0990
            11  C2b C    19.2812  -19.7947
            12  C2c C    20.4635  -19.1119
            13  C2b C    21.6575  -19.8012
            14  C1a C    20.4635  -17.7102
            15  C2b C    22.8454  -19.1152
            16  C2b C    24.0365  -19.8029
            17  C2c C    25.2259  -19.1161
            18  C2b C    26.4162  -19.8034
            19  C6a C    27.6061  -19.1163
            20  O6a O    28.7962  -19.8035
            21  C1a C    25.2260  -17.7102
            22  O6a O    27.6061  -17.7102
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     6   7 1
            8     6   8 1
            9     4   9 1
            10    5  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   12  14 1
            15   13  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 1
            21   17  21 1
            22   19  22 2

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