KEGG ORTHOLOGY: K08527

ORTHOLOGY: K08527

Entry

K08527                      KO

Symbol

RARA, NR1B1

Name

retinoic acid receptor alpha

Pathway

map04659

Th17 cell differentiation

map04915

Estrogen signaling pathway

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05221

Acute myeloid leukemia

Disease

H02542

Acute promyelocytic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K08527  RARA, NR1B1; retinoic acid receptor alpha
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
   05202 Transcriptional misregulation in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08527  RARA, NR1B1; retinoic acid receptor alpha
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   K08527  RARA, NR1B1; retinoic acid receptor alpha

Other DBs

GO:

0003708

Genes

HSA:	5914(RARA)

PTR:	454647(RARA)

PPS:	100967548(RARA)

GGO:	101149605(RARA)

PON:	100439672(RARA)

NLE:	100603497(RARA)

HMH:	116474780(RARA)

MCC:	700206(RARA)

MCF:	102132722(RARA)

MTHB:

126938478

MNI:	105472220(RARA)

CSAB:

103243515(RARA)

CATY:

105579577(RARA)

PANU:

101019389(RARA)

TGE:	112609757(RARA)

MLEU:

105553040(RARA)

RRO:	104655108(RARA)

RBB:	108534716(RARA)

TFN:	117067065(RARA)

PTEH:

111537451(RARA)

CANG:

105503096(RARA)

CJC:	100410811(RARA)

SBQ:	101036514(RARA)

CIMI:

108281518(RARA)

CSYR:

103269466(RARA)

MMUR:

105872083(RARA)

LCAT:

123620865(RARA)

PCOQ:

105824217(RARA)

OGA:	100948279(RARA)

MMU:	19401(Rara)

MCAL:

110304400(Rara)

MPAH:

110331544(Rara)

RNO:	24705(Rara)

MCOC:

116076864(Rara)

ANU:	117710620(Rara)

MUN:	110558507(Rara)

CGE:	100771910(Rara)

MAUA:

101825414(Rara)

PROB:

127215615(Rara)

PLEU:

114706921(Rara)

MORG:

121442430(Rara) 121456676

MFOT:

126510185

AAMP:

119812399(Rara)

NGI:	103731122(Rara)

HGL:	101722948(Rara)

CPOC:

100728220(Rara)

CCAN:

109694431(Rara)

DORD:

106003262(Rara)

DSP:	122103359(Rara)

PLOP:

125365475(Rara)

NCAR:

124979933

MMMA:

107150624(Rara)

OCU:

100009009

OPI:	101532790(RARA)

TUP:	102498662(RARA)

GVR:	103607734(RARA)

CFA:	480526(RARA)

CLUD:

112655020(RARA)

VVP:	112917766(RARA)

VLG:	121473248(RARA)

NPO:	129504221(RARA)

AML:	100463678(RARA)

UMR:	103662226(RARA)

UAH:	113265491(RARA)

UAR:	123781944(RARA)

ELK:

111151320

LLV:

125087842

MPUF:

101682641(RARA)

MNP:	132004211(RARA)

MLK:	131816638(RARA)

NVS:	122906282(RARA)

ORO:	101381332(RARA)

EJU:	114198489(RARA)

ZCA:	113939435(RARA)

MLX:	118024863(RARA)

NSU:	110592791(RARA)

LWW:	102733025(RARA)

FCA:	101083048(RARA)

PYU:	121044935(RARA)

PCOO:

112854085(RARA)

PBG:	122485502(RARA)

PVIV:

125158500(RARA)

LRUF:

124513342

PTG:	102969575(RARA)

PPAD:

109247445(RARA)

PUC:

125926500

AJU:

106980526

HHV:	120229003(RARA)

BTA:	534280(RARA)

BOM:	102274769(RARA)

BIU:	109574115(RARA)

BBUB:

102412210(RARA)

BBIS:

104990509(RARA)

CHX:	102188350(RARA)

OAS:	101107973(RARA)

BTAX:

128064403(RARA)

ODA:	120867195(RARA)

MBEZ:

129544375(RARA)

SSC:	396709(RARA)

CFR:	102503688(RARA)

CBAI:

105073239(RARA)

CDK:	105099020(RARA)

VPC:	102544822(RARA)

BACU:

103009412(RARA)

BMUS:

118886880(RARA)

LVE:	103082251(RARA)

OOR:	101269345(RARA)

DLE:	111166235(RARA)

PCAD:

102981217(RARA)

PSIU:

116744993(RARA)

NASI:

112397827(RARA)

ECB:	100054274(RARA)

EPZ:	103550195(RARA)

EAI:	106826262(RARA)

MYB:	102260476(RARA)

MYD:	102755605(RARA)

MMYO:

118671579(RARA)

MLF:	102429033(RARA)

PKL:	118732278(RARA)

EFUS:

103289024(RARA)

MNA:	107528992(RARA)

DRO:	112316405(RARA)

SHON:

118978038(RARA)

AJM:	119037490(RARA)

PDIC:

114502794(RARA)

PHAS:

123817049(RARA)

MMF:	118634433(RARA)

PPAM:

129087044(RARA)

HAI:	109380809(RARA)

RFQ:	117013301(RARA)

PALE:

102880130(RARA)

PGIG:

120611169(RARA)

PVP:	105307523(RARA)

RAY:	107520689(RARA)

MJV:	108392195(RARA)

TOD:	119232992(RARA)

SARA:

101542943(RARA)

SETR:

126017691(RARA)

LAV:	100666758(RARA)

TMU:

101340976

ETF:	101643941(RARA)

DNM:	101433218(RARA)

MDO:	100015353(RARA)

GAS:	123244150(RARA)

SHR:	100923612(RARA)

AFZ:

127560190

PCW:	110215735(RARA)

OAA:	100092826(RARA)

GGA:	395213(RARA)

PCOC:

116233659(RARA)

CJO:	107325261(RARA)

TPAI:

128089081(RARA)

LMUT:

125684436(RARA)

NMEL:

110388413

APLA:

101792081

CATA:

118261306

AFUL:

116498593(RARA)

TGU:	778445(RARA)

LSR:	110471901(RARA)

SCAN:

103821620(RARA)

PMOA:

120496676(RARA)

OTC:	121347649(RARA)

PRUF:

121351046(RARA)

GFR:	102041075(RARA)

FAB:	101814830(RARA)

OMA:	130263873(RARA)

PHI:	102111110(RARA)

PMAJ:

107215144(RARA)

CCAE:

111940005(RARA)

ETL:	114069278(RARA)

SVG:	106858717(RARA)

MMEA:

130584977(RARA)

HRT:	120763884(RARA)

FPG:	101912143(RARA)

FCH:	102055030(RARA)

CLV:	102092082(RARA)

TALA:

116964471(RARA)

AFOR:

103902068(RARA)

ACHC:

115344525(RARA)

HLE:	104842910(RARA)

AGEN:

126038961

GCL:

127026410

NNT:

104413511

SHAB:

115617659(RARA)

CPEA:

104385728(RARA)

RTD:	128919086(RARA)

CUCA:

104054429(RARA)

AAM:	106486419(RARA)

NPD:	112948997(RARA)

DNE:	112993031(RARA)

ASN:	102387253(RARA)

AMJ:	102560946(RARA)

CPOO:

109320309(RARA)

GGN:	109290376(RARA)

PSS:	102449811(RARA)

CMY:	102930278(RARA)

CCAY:

125626640(RARA)

DCC:	119849013(RARA)

TST:	117869276(RARA)

CABI:

116829873(RARA)

MRV:	120392236(RARA)

ACS:	100562365(rara)

ASAO:

132778258(RARA)

PVT:	110085568(RARA)

SUND:

121935227(RARA)

PBI:	103066803(RARA)

PMUR:

107295660 107303084(RARA)

CTIG:

120312787(RARA)

TSR:	106555178(RARA)

PGUT:

117664643(RARA)

APRI:

131196817(RARA)

PTEX:

113447413(RARA)

NSS:	113419987(RARA)

VKO:	123031838(RARA)

PMUA:

114582798(RARA)

PRAF:

128401033(RARA)

ZVI:	118094956(RARA)

HCG:	128329953(RARA)

GJA:	107108914(RARA)

STOW:

125444538(RARA)

EMC:	129338608(RARA)

XLA:	108702480(rara.S) 399081(rara.L)

XTR:	100038052(rara)

NPR:	108795221(RARA)

RTEM:

120918706(RARA)

BBUF:

121003034(RARA)

BGAR:

122941106(RARA)

MUO:	115481493(RARA)

GSH:	117347474(RARA)

DRE:	30680(raraa) 555364(rarab)

SRX:	107716487 107737746 107745620 107758480

SANH:

107660476 107678286 107689638 107695008

SGH:	107554136 107571738 107582978

CCAR:

109075887 109101281

CAUA:

113045332 113047292 113072486 113082385 113111880

CGIB:

127950414 127953949 127968896 128024932

PTET:

122341626(rarab) 122355733(raraa)

LROH:

127160550(rarab) 127174509(raraa)

OMC:	131536331(rarab) 131550623(raraa)

PPRM:

120484117 120484118 120489320(rarab)

RKG:	130070193(raraa) 130088419(rarab)

MAMB:

125255695(raraa) 125277889(rarab)

CIDE:

127508565 127523851

MASI:

127423478 127427123 127449736 127452287

TROS:

130561415(rarab) 130568920(raraa)

TDW:	130425535(rarab) 130439201(raraa)

MANU:

129420351(raraa) 129435799(rarab)

IPU:	108273576(raraa) 108276117(rarab)

IFU:	128603502(rarab) 128617484(raraa)

PHYP:

113528026 113547519

SMEO:

124388733(raraa) 124396634(rarab)

TFD:	113635916(rarab) 113662169(raraa)

TVC:	132841172 132860633(rarab)

AMEX:

103025523 103030376

CMAO:

118809677(raraa) 118820880(rarab)

EEE:

113582193

CHAR:

105907867(rarab) 105909127(raraa)

TRU:	101070619 445948(rara)

TFS:	130514378 130522073(raraa)

TNG:	GSTEN00021064G001 GSTEN00024106G001 GSTEN00033708G001

LCO:	104923246(rara) 104935789

NCC:

104949876

TBEN:

117470215 117473622(raraa)

CGOB:

115012337 115024878

PGEO:

117464386(raraa)

GACU:

117539406 117539407 117539411 117544833(raraa)

EMAC:

134870462(raraa) 134878368

ELY:	117247646(raraa) 117269005

EFO:	125879579 125880322(raraa)

PLEP:

121956359 121958514(raraa)

SLUC:

116044221(raraa) 116045009

ECRA:

117936654(raraa) 117958473

ESP:	116671158(rara) 116703640

PFLV:

114547985(rara) 114569992

GAT:	120819801(raraa) 120828004(rarab)

PPUG:

119212739(raraa) 119220272

AFB:	129091067(raraa) 129098134

CLUM:

117734508 117748549(raraa)

PSWI:

130188355 130204060(raraa)

MSAM:

119896427 119916061(raraa)

SCHU:

122868098(raraa) 122869255

CUD:	121528129(raraa) 121529586

ALAT:

119009810(raraa) 119013797(rarab)

MZE:	101473358(rara) 101481144 112432486

ONL:	100690706(rara) 100692530

OAU:	116320126(raraa) 116324940(rarab)

OLA:

100049282

OML:	112153888(raraa)

CSAI:

133419594(raraa) 133421832(rarab)

XMA:	102222808(rara)

XCO:	114150468(rara)

XHE:	116727099(rara)

PRET:

103481985(rara)

PFOR:

103143208(rara)

PLAI:

106958678(rara)

PMEI:

106923303

GAF:	122823734(raraa)

PPRL:

129377548(raraa)

CVG:	107091050(rara)

CTUL:

119790979(raraa)

GMU:	124875007(raraa)

NFU:	107388099(rara)

KMR:	108237228(raraa) 108248182

ALIM:

106517345(rara)

NWH:	119423935(raraa)

AOCE:

111579172 111584526

MCEP:

124998129(rarab) 125021988(raraa)

CSEM:

103393600

POV:	109640454 109643925

SSEN:

122759262(raraa) 122785570

HHIP:

117753478(raraa) 117766901(rarab)

HSP:	118100444(raraa) 118123384 124851072

SMAU:

118287255(raraa) 118288957(rarab)

LCF:	108875743(raraa) 108898567

SDU:	111219812(rara) 111223734

SLAL:

111650283(rara) 111662467

XGL:	120783984(rarab) 120793890(raraa)

HCQ:	109522485 109524750

SSCV:

125983051 125991168

SBIA:

133495178 133514783

PEE:	133414859 133417683(raraa)

PTAO:

133466090 133469008(raraa)

BPEC:

110162387

MALB:

109951096 109963578

BSPL:

114845354(raraa)

SJO:	128378757 128381060(raraa)

SASA:

100136372(rar-alpha) 106578316 106600859 106607468

STRU:

115159264 115170984 115196684 115200948

OTW:	112223652(raraa) 112224099 112225905 112259174(rarab)

OMY:	110486146 110491557(raraa) 110498837 110538070(rarab)

OGO:	123998824(rarab) 124016157 124018557 124039907 124048315(raraa)

ONE:	115104038 115106526 115143919

OKI:	109865451 109875680 109884064 109898305

OKE:	118357613 118365176 118366221(raraa) 118384139

SALP:

111961398 111977887 112071869

SNH:	120034296 120034730 120046233(raraa) 120060898

CCLU:

121547235 121550468 121567881(raraa) 121569690

ELS:	105013101 105024528

SFM:	108928193(rara)

PKI:

111848637

AANG:

118216695 118218199

LOC:	102698568(rara)

PSPA:

121301899 121324573

ARUT:

117433414 117434630(raraa)

PSEX:

120518183(raraa)

LCM:	102356597(RARA)

CMK:	103189277(raraa)

RTP:	109921635(raraa)

CPLA:

122539822(raraa)

HOC:	132830874(raraa)

LERI:

129710180(raraa)

BFO:

118405347

BBEL:

109479038

LPIC:

129258856

DPX:	DAPPUDRAFT_116674

EAF:

GAE:

OED:

LAK:

Reference

PMID:2825036

Authors

Giguere V, Ong ES, Segui P, Evans RM

Title

Identification of a receptor for the morphogen retinoic acid.

Journal

Nature 330:624-9 (1987)
DOI:10.1038/330624a0

Sequence

[hsa:5914]

Reference

PMID:12877645

Authors

Parmar S, Tallman MS

Title

Acute promyelocytic leukaemia:a review.

Journal

Expert Opin Pharmacother 4:1379-92 (2003)
DOI:10.1517/14656566.4.8.1379

Reference

PMID:11704847

Authors

Zelent A, Guidez F, Melnick A, Waxman S, Licht JD

Title

Translocations of the RARalpha gene in acute promyelocytic leukemia.

Journal

Oncogene 20:7186-203 (2001)
DOI:10.1038/sj.onc.1204766

LinkDB

DBGET integrated database retrieval system