KEGG   DRUG: D00593Help
Entry
D00593                      Drug                                   

Name
Glimepiride (JP17/USP/INN);
Amaryl (TN)
Product
  Generic
GLIMEPIRIDE (A-S Medication Solutions), GLIMEPIRIDE (A-S Medication Solutions), GLIMEPIRIDE (Accord Healthcare), GLIMEPIRIDE (Aidarex Pharmaceuticals LLC), GLIMEPIRIDE (Aidarex Pharmaceuticals LLC), GLIMEPIRIDE (American Health Packaging), GLIMEPIRIDE (Aurobindo Pharma Limited), GLIMEPIRIDE (Avera McKennan Hospital), GLIMEPIRIDE (Bionpharma), GLIMEPIRIDE (Blenheim Pharmacal), GLIMEPIRIDE (BluePoint Laboratories), GLIMEPIRIDE (Bryant Ranch Prepack), GLIMEPIRIDE (Bryant Ranch Prepack), GLIMEPIRIDE (Cardinal Health), GLIMEPIRIDE (Cardinal Health), GLIMEPIRIDE (Carlsbad Technology), GLIMEPIRIDE (Citron Pharma LLC), GLIMEPIRIDE (Clinical Solutions Wholesale), GLIMEPIRIDE (DIRECT RX), GLIMEPIRIDE (DirectRX), GLIMEPIRIDE (DirectRX), GLIMEPIRIDE (Dr. Reddy's Laboratories Limited), GLIMEPIRIDE (International Laboratories), GLIMEPIRIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIMEPIRIDE (MedVantx), GLIMEPIRIDE (Micro Labs Limited), GLIMEPIRIDE (Mylan Institutional), GLIMEPIRIDE (Mylan Pharmaceuticals), GLIMEPIRIDE (NCS HealthCare of KY), GLIMEPIRIDE (Northwind Pharmaceuticals), GLIMEPIRIDE (Northwind Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Physicians Total Care), GLIMEPIRIDE (Proficient Rx LP), GLIMEPIRIDE (Proficient Rx LP), GLIMEPIRIDE (Proficient Rx LP), GLIMEPIRIDE (Qualitest Pharmaceuticals), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (Rebel Distributors Corp), GLIMEPIRIDE (STAT Rx USA LLC), GLIMEPIRIDE (STAT Rx USA LLC), GLIMEPIRIDE (St Marys Medical Park Pharmacy), GLIMEPIRIDE (St Marys Medical Park Pharmacy), GLIMEPIRIDE (Teva Pharmaceuticals USA), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Virtus Pharmaceuticals), GLIMEPIRIDE (Virtus Pharmaceuticals LLC)
Formula
C24H34N4O5S
Exact mass
490.225
Mol weight
490.6156
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypoglycemic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
sulfonylurea receptor 1 agonist [HSA:6833] [KO:K05032]
  Pathway
ABC transporters
Insulin secretion
Type II diabetes mellitus
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB12 Glimepiride
      D00593  Glimepiride (JP17/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glimepiride
    D00593  Glimepiride (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00593  Glimepiride (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glimepiride
      D00593  Glimepiride (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Glimepiride
    D00593  Glimepiride (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00593  Glimepiride
  D00593  Glimepiride tablets
Antidiabetics [br08361.html]
 D00593
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00593
BRITE hierarchy
Other DBs
CAS: 
93479-97-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        34
            1   N1y N    11.7600  -17.3600
            2   C5x C    10.5700  -16.5900
            3   C1x C    11.3400  -18.7600
            4   C5a C    12.9500  -16.6600
            5   C2y C     9.4500  -17.4300
            6   O5x O    10.5700  -15.2600
            7   C2y C     9.8700  -18.7600
            8   N1b N    14.2100  -17.4300
            9   O5a O    12.9500  -15.2600
            10  C1b C     8.3300  -16.8000
            11  C1a C     9.1000  -19.8800
            12  C1b C    15.4000  -16.7300
            13  C1a C     7.2800  -17.4300
            14  C1b C    16.5900  -17.4300
            15  C8y C    17.8500  -16.7300
            16  C8x C    17.8500  -15.2600
            17  C8x C    19.0400  -17.4300
            18  C8x C    19.0400  -14.5600
            19  C8x C    20.3000  -16.7300
            20  C8y C    20.3000  -15.2600
            21  S4a S    21.4900  -14.5600
            22  N1b N    22.7500  -15.2600
            23  C5a C    23.9400  -14.5600
            24  N1b N    25.1300  -15.2600
            25  O5a O    23.9400  -13.1600
            26  C1y C    26.3900  -14.5600
            27  C1x C    26.3900  -13.1600
            28  C1x C    27.5800  -15.2600
            29  C1x C    27.5800  -12.4600
            30  C1x C    28.8400  -14.5600
            31  C1y C    28.8400  -13.1600
            32  C1a C    30.0300  -12.4600
            33  O3c O    22.1900  -13.3476
            34  O3c O    20.7900  -13.3476
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   23  25 2
            25   24  26 1
            26   26  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31   31  32 1
            32    5   7 2
            33   19  20 1
            34   30  31 1
            35   21  33 2
            36   21  34 2

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