KEGG   DRUG: D00593Help
Entry
D00593                      Drug                                   

Name
Glimepiride (JP16/USP/INN);
Amaryl (TN)
Product
  Generic
GLIMEPIRIDE (Accord Healthcare), GLIMEPIRIDE (Aidarex Pharmaceuticals LLC), GLIMEPIRIDE (Aidarex Pharmaceuticals LLC), GLIMEPIRIDE (American Health Packaging), GLIMEPIRIDE (Aurobindo Pharma Limited), GLIMEPIRIDE (Blenheim Pharmacal), GLIMEPIRIDE (BluePoint Laboratories), GLIMEPIRIDE (Bryant Ranch Prepack), GLIMEPIRIDE (Bryant Ranch Prepack), GLIMEPIRIDE (Cardinal Health), GLIMEPIRIDE (Cardinal Health), GLIMEPIRIDE (Carlsbad Technology), GLIMEPIRIDE (Clinical Solutions Wholesale), GLIMEPIRIDE (Dr. Reddy's Laboratories Limited), GLIMEPIRIDE (International Labs), GLIMEPIRIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIMEPIRIDE (MedVantx), GLIMEPIRIDE (Micro Labs Limited), GLIMEPIRIDE (Mylan Pharmaceuticals), GLIMEPIRIDE (NCS HealthCare of KY), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (PD-Rx Pharmaceuticals), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Perrigo New York), GLIMEPIRIDE (Physicians Total Care), GLIMEPIRIDE (Qualitest Pharmaceuticals), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (REMEDYREPACK), GLIMEPIRIDE (Rebel Distributors Corp), GLIMEPIRIDE (STAT Rx USA LLC), GLIMEPIRIDE (STAT Rx USA LLC), GLIMEPIRIDE (St Marys Medical Park Pharmacy), GLIMEPIRIDE (St Marys Medical Park Pharmacy), GLIMEPIRIDE (Teva Pharmaceuticals USA), GLIMEPIRIDE (UDL Laboratories), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Unit Dose Services), GLIMEPIRIDE (Virtus Pharmaceuticals LLC)
Formula
C24H34N4O5S
Exact mass
490.225
Mol weight
490.6156
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Hypoglycemic [DS:H00409]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
sulfonylurea receptor 1 agonist [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonamides, urea derivatives
     A10BB12 Glimepiride
      D00593  Glimepiride (JP16/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glimepiride
    D00593  Glimepiride (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00593  Glimepiride (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glimepiride
      D00593  Glimepiride (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Glimepiride
    D00593  Glimepiride (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00593  Glimepiride
  D00593  Glimepiride tablets
BRITE hierarchy
Other DBs
CAS: 
93479-97-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        34
            1   N1y N    28.5146  -13.6871
            2   C5x C    29.6588  -14.5054
            3   C1x C    28.9428  -12.3382
            4   C5a C    27.2872  -14.3903
            5   C2y C    30.7967  -13.6743
            6   O5x O    29.6781  -15.8478
            7   C2y C    30.3557  -12.3319
            8   N1b N    26.0662  -13.6806
            9   O5a O    27.2872  -15.7966
            10  C1b C    31.8899  -14.2879
            11  C1a C    31.1738  -11.1876
            12  C1b C    24.8516  -14.3840
            13  C1a C    32.9638  -13.6424
            14  C1b C    23.6306  -13.6806
            15  C8y C    22.4097  -14.3840
            16  C8x C    22.4032  -15.7966
            17  C8x C    21.1822  -13.6806
            18  C8x C    21.1822  -16.4998
            19  C8x C    19.9676  -14.3840
            20  C8y C    19.9741  -15.7966
            21  S4a S    18.7529  -16.4998
            22  N1b N    17.5257  -15.7903
            23  O3c O    18.7466  -17.9063
            24  O3c O    18.7722  -15.0616
            25  C5a C    16.3047  -16.4935
            26  N1b N    15.0901  -15.7903
            27  O5a O    16.3047  -17.9063
            28  C1y C    13.8691  -16.4935
            29  C1x C    13.8691  -17.9063
            30  C1x C    12.6480  -15.7903
            31  C1x C    12.6480  -18.6095
            32  C1x C    11.4207  -16.4935
            33  C1y C    11.4207  -17.9063
            34  C1a C    10.2061  -18.6095
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   18  20 2
            20   20  21 1
            21   21  22 1
            22   21  23 2
            23   21  24 2
            24   22  25 1
            25   25  26 1
            26   25  27 2
            27   26  28 1
            28   28  29 1
            29   28  30 1
            30   29  31 1
            31   30  32 1
            32   31  33 1
            33   33  34 1
            34    5   7 2
            35   19  20 1
            36   32  33 1

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