KEGG   DRUG: Rabeprazole sodiumHelp
Entry
D00724                      Drug                                   

Name
Rabeprazole sodium (JP17/USAN);
Aciphex (TN);
Pariet (TN)
Product
  Generic
RABEPRAZOLE SODIUM (Amneal Pharmaceuticals of New York), RABEPRAZOLE SODIUM (Golden State Medical Supply), RABEPRAZOLE SODIUM (Mylan Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Unit Dose Services), RABEPRAZOLE SODIUM (AvKARE), RABEPRAZOLE SODIUM (AvKARE), RABEPRAZOLE SODIUM (Breckenridge Pharmaceutical), RABEPRAZOLE SODIUM (Kremers Urban Pharmaceuticals), RABEPRAZOLE SODIUM (Lupin Pharmaceuticals), RABEPRAZOLE SODIUM (Major Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (Teva Pharmaceuticals USA), RABEPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), RABEPRAZOLE SODIUM (Unit Dose Services)
Formula
C18H20N3O3S. Na
Exact mass
381.1123
Mol weight
381.4245
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01646  Proton pump inhibitor (PPI)
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
Comment
Benzimidazole derivative
Target
ATP4A [HSA:495] [KO:K01542];
ATP4B [HSA:496] [KO:K01543]
  Pathway
Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D00724  Rabeprazole sodium (JP17/USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D00724  Rabeprazole sodium (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00724  Rabeprazole sodium (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Rabeprazole
     D00724  Rabeprazole sodium (JP17/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Rabeprazole
    D00724  Rabeprazole sodium (JP17/USAN)
 CYP substrates
  CYP2C19
   Rabeprazole
    D00724  Rabeprazole sodium (JP17/USAN)
  CYP3A4
   Rabeprazole
    D00724  Rabeprazole sodium (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00724  Rabeprazole sodium
Gastrointestinal agents [br08371.html]
 Antiulcer agent
  D00724
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00724
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00724
BRITE hierarchy
Other DBs
CAS: 
117976-90-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        26
            1   Z   Na   14.9181  -21.7880 #+
            2   C8x C    11.7600  -23.5900
            3   C8x C    11.7600  -24.9900
            4   C8x C    12.9724  -25.6900
            5   C8y C    14.1849  -24.9900
            6   C8y C    14.1849  -23.5900
            7   C8x C    12.9724  -22.8900
            8   N5x N    15.5164  -25.4226
            9   C8y C    16.3393  -24.2900
            10  N4x N    15.5164  -23.1574 #-
            11  S4a S    17.7100  -24.2900
            12  C1b C    18.4100  -25.5024
            13  O3c O    18.4100  -23.0776
            14  C8y C    19.8098  -25.5024
            15  C8y C    20.5003  -26.6980
            16  C8y C    21.9003  -26.6978
            17  C8x C    22.6001  -25.4853
            18  C8x C    21.9097  -24.2898
            19  N5x N    20.5097  -24.2899
            20  C1a C    19.8149  -27.8852
            21  O2a O    22.5910  -27.8932
            22  C1b C    24.0096  -27.8932
            23  C1b C    24.6956  -29.0806
            24  C1b C    26.1097  -29.0806
            25  O2a O    26.7968  -30.2700
            26  C1a C    28.2097  -30.2699
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   15  20 1
            22   16  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1

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