KEGG   DRUG: D00724Help
Entry
D00724                      Drug                                   

Name
Sodium rabeprazole (JP16);
Rabeprazole sodium (USAN);
Aciphex (TN);
Pariet (TN)
Product
  Generic
Formula
C18H20N3O3S. Na
Exact mass
381.1123
Mol weight
381.4245
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-ulcerative;
Gastric acid pump inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
proton pump inhibitor
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
hsa00190  Oxidative phosphorylation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Rabeprazole
     D00724  Rabeprazole sodium (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Rabeprazole
    D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
  CYP3A4
   Rabeprazole
    D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
 Inhbitors
  CYP2C19
   Rabeprazole
    D00724  Sodium rabeprazole (JP16); Rabeprazole sodium (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00724  Rabeprazole sodium
BRITE hierarchy
Other DBs
CAS: 
117976-90-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        26
            1   Z   Na   14.9181  -21.7880 #+
            2   C8x C    11.7600  -23.5900
            3   C8x C    11.7600  -24.9900
            4   C8x C    12.9724  -25.6900
            5   C8y C    14.1849  -24.9900
            6   C8y C    14.1849  -23.5900
            7   C8x C    12.9724  -22.8900
            8   N5x N    15.5164  -25.4226
            9   C8y C    16.3393  -24.2900
            10  N4x N    15.5164  -23.1574 #-
            11  S4a S    17.7100  -24.2900
            12  C1b C    18.4100  -25.5024
            13  O3c O    18.4100  -23.0776
            14  C8y C    19.8098  -25.5024
            15  C8y C    20.5003  -26.6980
            16  C8y C    21.9003  -26.6978
            17  C8x C    22.6001  -25.4853
            18  C8x C    21.9097  -24.2898
            19  N5x N    20.5097  -24.2899
            20  C1a C    19.8149  -27.8852
            21  O2a O    22.5910  -27.8932
            22  C1b C    24.0096  -27.8932
            23  C1b C    24.6956  -29.0806
            24  C1b C    26.1097  -29.0806
            25  O2a O    26.7968  -30.2700
            26  C1a C    28.2097  -30.2699
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   15  20 1
            22   16  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1

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