KEGG   DRUG: Rabeprazole sodiumHelp
Entry
D00724                      Drug                                   

Name
Rabeprazole sodium (JP17/USAN);
Aciphex (TN);
Pariet (TN)
Product
  Generic
RABEPRAZOLE SODIUM (Amneal Pharmaceuticals LLC), RABEPRAZOLE SODIUM (Golden State Medical Supply), RABEPRAZOLE SODIUM (Mylan Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Unit Dose Services), RABEPRAZOLE SODIUM (Aurobindo Pharma Limited), RABEPRAZOLE SODIUM (AvKARE), RABEPRAZOLE SODIUM (AvKARE), RABEPRAZOLE SODIUM (Breckenridge Pharmaceutical), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Kremers Urban Pharmaceuticals), RABEPRAZOLE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), RABEPRAZOLE SODIUM (Lupin Pharmaceuticals), RABEPRAZOLE SODIUM (Major Pharmaceuticals), RABEPRAZOLE SODIUM (NuCare Pharmaceuticals), RABEPRAZOLE SODIUM (NuCare Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (Teva Pharmaceuticals USA), RABEPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), RABEPRAZOLE SODIUM (Unit Dose Services), RABEPRAZOLE SODIUM (Unit Dose Services), RABERPRAZOLE SODIUM D/R (DIRECT RX)
Formula
C18H20N3O3S. Na
Exact mass
381.1123
Mol weight
381.4245
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Gastrointestinal agent
 DG01646  Proton pump inhibitor (PPI)
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
Remark
Same as: C07865
Therapeutic category: 2329
ATC code: A02BC04
Chemical structure group: DG00022
Product (DG00022): D00724<JP/US>
Product (mixture): D10519<JP> D10520<JP>
Efficacy
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor
  Disease
Erosive or ulcerative GERD [DS:H01602]
Duodenal ulcer [DS:H01634]
Helicobacter pylori eradication [DS:H00320]
Zollinger-Ellison syndrome [DS:H01522]
Comment
Benzimidazole derivative
Target
ATP4 [HSA:495 496] [KO:K01542 K01543]
  Pathway
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07038  Antiulcer drugs
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D00724  Rabeprazole sodium (JP17/USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D00724  Rabeprazole sodium (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00724  Rabeprazole sodium (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Rabeprazole
     D00724  Rabeprazole sodium (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00724  Rabeprazole sodium
Drug classes of therapeutic agents [br08360.html]
 Gastrointestinal agents
  D00724
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00724
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00724
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00724
BRITE hierarchy
Other DBs
CAS: 117976-90-6
PubChem: 7847789
ChEBI: 8769
ChEMBL: CHEMBL1200930
DrugBank: DB01129
LigandBox: D00724
NIKKAJI: J561.822C
LinkDB All DBs
KCF data Show

ATOM        26
            1   Z   Na   14.9181  -21.7880 #+
            2   C8x C    11.7600  -23.5900
            3   C8x C    11.7600  -24.9900
            4   C8x C    12.9724  -25.6900
            5   C8y C    14.1849  -24.9900
            6   C8y C    14.1849  -23.5900
            7   C8x C    12.9724  -22.8900
            8   N5x N    15.5164  -25.4226
            9   C8y C    16.3393  -24.2900
            10  N4x N    15.5164  -23.1574 #-
            11  S4a S    17.7100  -24.2900
            12  C1b C    18.4100  -25.5024
            13  O3c O    18.4100  -23.0776
            14  C8y C    19.8098  -25.5024
            15  C8y C    20.5003  -26.6980
            16  C8y C    21.9003  -26.6978
            17  C8x C    22.6001  -25.4853
            18  C8x C    21.9097  -24.2898
            19  N5x N    20.5097  -24.2899
            20  C1a C    19.8149  -27.8852
            21  O2a O    22.5910  -27.8932
            22  C1b C    24.0096  -27.8932
            23  C1b C    24.6956  -29.0806
            24  C1b C    26.1097  -29.0806
            25  O2a O    26.7968  -30.2700
            26  C1a C    28.2097  -30.2699
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   15  20 1
            22   16  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1

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