KEGG   DRUG: Buprenorphine
Entry
D07132                      Drug                                   
Name
Buprenorphine (JAN/INN);
Temgesic (TN)
Product
BRIXADI (Braeburn), BUTRANS (Purdue Pharma LP), SUBLOCADE (Indivior)
  Generic
BUPRENORPHINE (Amneal Pharmaceuticals NY LLC), BUPRENORPHINE (INGENUS PHARMACEUTICALS), BUPRENORPHINE (Rhodes Pharmaceuticals L.P.), BUPRENORPHINE (Teva Pharmaceuticals USA), BUPRENORPHINE TRANSDERMAL SYSTEM (Alvogen)
Formula
C29H41NO4
Exact mass
467.3036
Mol weight
467.6401
Structure
Simcomp
Class
Analgesic
 DG01984  Opioid analgesics
 DG01586  Opioid receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C08007
Therapeutic category: 1149
ATC code: N02AE01 N07BC01
Chemical structure group: DG00820
Product (DG00820): D07132<JP/US> D00836<JP/US>
Product (mixture): D10250<US>
Efficacy
Analgesic, Opioid receptor agonist/antagonist
Comment
Morphinan derivative, Oripavine derivative
Target
OPRK1 [HSA:4986] [KO:K04214]
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07039  Opioid analgesics
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AE Oripavine derivatives
     N02AE01 Buprenorphine
      D07132  Buprenorphine (JAN/INN) <JP/US>
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC01 Buprenorphine
      D07132  Buprenorphine (JAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Buprenorphine
    D07132  Buprenorphine (JAN/INN)
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence
   Buprenorphine
    D07132  Buprenorphine (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D07132  Buprenorphine (JAN/INN)
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
    D07132  Buprenorphine
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
    D07132  Buprenorphine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
     D07132  Buprenorphine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D07132  Buprenorphine (JAN/INN) <JP/US>
    OPRK1
     D07132  Buprenorphine (JAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07132
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07132
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07132
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07132
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D07132
Drug groups [BR:br08330]
 Analgesic
  DG01984  Opioid analgesics
   DG00820  Buprenorphine
  DG01586  Opioid receptor antagonist
   DG00820  Buprenorphine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00820  Buprenorphine
Other DBs
CAS: 52485-79-7
PubChem: 51091471
ChEBI: 3216
LigandBox: D07132
NIKKAJI: J291.229E
LinkDB
KCF data

ATOM        34
            1   C1z C    16.5998  -15.1247
            2   C1z C    17.7863  -15.8227
            3   C1y C    15.4132  -15.8227
            4   C8y C    16.5998  -13.7986
            5   C1x C    17.7863  -14.4267
            6   C1y C    18.9729  -15.1247
            7   C1x C    17.7863  -17.2186
            8   C1x C    17.2280  -16.8697
            9   C1z C    15.4132  -17.1488
            10  O2x O    14.7851  -14.2872
            11  C8y C    15.4830  -13.1006
            12  C8y C    17.8561  -13.1006
            13  C1x C    20.1595  -14.4267
            14  N1y N    20.1595  -15.8227
            15  C1x C    18.9727  -13.7986
            16  C1y C    16.5998  -17.8468
            17  C1x C    16.0414  -16.1717
            18  C8y C    15.4830  -11.7047
            19  C8x C    17.8561  -11.7047
            20  C1b C    21.3460  -15.1945
            21  C8x C    16.6696  -11.0067
            22  O1a O    14.2965  -11.0067
            23  C1y C    22.5326  -15.8925
            24  C1x C    23.2305  -17.0790
            25  C1x C    23.9285  -15.8925
            26  O2a O    14.0173  -17.1488
            27  C1a C    13.3193  -15.9400
            28  C1d C    17.2978  -19.0557
            29  C1a C    18.6935  -19.0557
            30  C1d C    16.6094  -20.2477
            31  O1a O    17.9861  -20.2478
            32  C1a C    15.2041  -20.2478
            33  C1a C    17.2930  -21.4316
            34  C1a C    15.7619  -21.4443
BOND        40
            1     1   5 1 #Up
            2     2   6 1
            3     2   7 1
            4     2   8 1 #Down
            5     3   9 1
            6     3  10 1 #Down
            7     4  11 1
            8     4  12 2
            9     5  13 1
            10    6  14 1 #Up
            11    6  15 1
            12    7  16 1
            13    8  17 1
            14   11  18 2
            15   12  19 1
            16   14  20 1
            17   18  21 1
            18   18  22 1
            19    9  16 1
            20    9  17 1 #Down
            21   10  11 1
            22   12  15 1
            23   14  13 1 #Up
            24   19  21 2
            25    1   2 1
            26   20  23 1
            27    1   3 1
            28    1   4 1
            29   23  24 1
            30   23  25 1
            31   25  24 1
            32    9  26 1
            33   26  27 1
            34   16  28 1
            35   28  29 1 #Up
            36   28  30 1
            37   28  31 1 #Down
            38   30  32 1
            39   30  33 1
            40   30  34 1

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