KEGG   DRUG: ClopidogrelHelp
Entry
D07729                      Drug                                   

Name
Clopidogrel (USP/INN);
Clopidogrel (TN);
Plavix (TN)
Formula
C16H16ClNO2S
Exact mass
321.059
Mol weight
321.8217
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
 DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A substrate
Remark
ATC code: 
Chemical group: 
Efficacy
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist
Comment
Thienopyridine derivative
CYP2C19 poor metabolizer status is associated with diminished response to Clopidogrel.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2B6 [HSA:1555]
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC04 Clopidogrel
      D07729  Clopidogrel (USP/INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2Y12 receptor
     Clopidogrel
      D07729  Clopidogrel (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2B6
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
  CYP2C19
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
 CYP substrates
  CYP1A2
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
  CYP2B6
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
  CYP2C19
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
  CYP3A4
   Clopidogrel
    D07729  Clopidogrel (USP/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07729
BRITE hierarchy
Other DBs
CAS: 
113665-84-2
PubChem: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        21
            1   N1y N    24.2900  -17.5700
            2   C1c C    23.1000  -18.2700
            3   C1x C    25.4800  -18.2700
            4   C1x C    24.2900  -16.1700
            5   C8y C    21.9100  -17.5700
            6   C7a C    23.1000  -19.6700
            7   C8y C    26.7400  -17.5700
            8   C1x C    25.4800  -15.4700
            9   C8y C    21.9100  -16.1700
            10  C8x C    20.6500  -18.2700
            11  O7a O    21.9100  -20.3700
            12  O6a O    24.2900  -20.3700
            13  C8y C    26.7400  -16.1700
            14  C8x C    28.0700  -17.9900
            15  C8x C    20.6500  -15.4700
            16  X   Cl   23.1000  -15.4700
            17  C8x C    19.4600  -17.5700
            18  C1a C    20.6500  -19.6700
            19  S2x S    28.0700  -15.7500
            20  C8x C    28.9100  -16.8700
            21  C8x C    19.4600  -16.1700
BOND        23
            1     2   5 1
            2     2   6 1 #Down
            3     3   7 1
            4     4   8 1
            5     5   9 1
            6     5  10 2
            7     6  11 1
            8     6  12 2
            9     7  13 2
            10    7  14 1
            11    9  15 2
            12    9  16 1
            13   10  17 1
            14   11  18 1
            15   13  19 1
            16   14  20 2
            17   15  21 1
            18    8  13 1
            19   17  21 2
            20   19  20 1
            21    1   2 1
            22    1   3 1
            23    1   4 1

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