| Entry |
|
|---|
| Name |
Losartan (INN);
Losartic (TN) |
|---|
| Formula |
C22H23ClN6O
|
|---|
| Exact mass |
422.1622
|
|---|
| Mol weight |
422.91
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
|---|
| Remark |
| Product (DG00348): | D00357<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin II receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07229 | Angiotensin receptor and endothelin receptor antagonists |
|
|---|
| Other map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
C09CA Angiotensin II receptor blockers (ARBs), plain
C09CA01 Losartan
D08146 Losartan (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
D08146 Losartan
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
D08146 Losartan
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00348 Losartan
D08146 Losartan
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
AGTR1
D08146 Losartan (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08146
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
DG03231 Antihypertensive
DG01495 Angiotensin II receptor antagonist
DG00348 Losartan
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00348 Losartan
|
|---|
| Other DBs |
|
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| LinkDB |
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|---|
| KCF data |
ATOM 30
1 N4y N 28.8231 -16.7197
2 C8y C 29.2429 -18.0488
3 C8y C 29.9424 -15.8802
4 C1b C 27.5639 -16.0201
5 N5x N 30.6420 -18.0488
6 C1b C 28.4034 -19.1681
7 C8y C 31.0617 -16.7197
8 C1b C 29.9424 -14.4811
9 C8y C 26.3747 -16.7896
10 C1b C 28.9630 -20.4273
11 X Cl 32.3909 -16.2999
12 O1a O 31.1317 -13.7815
13 C8x C 26.3747 -18.1887
14 C8x C 25.1854 -16.0901
15 C1b C 28.1935 -21.5466
16 C8x C 25.1854 -18.8883
17 C8x C 23.9962 -16.8596
18 C1a C 28.7532 -22.8758
19 C8y C 23.9962 -18.1887
20 C8y C 22.7369 -18.8883
21 C8y C 21.5477 -18.2587
22 C8x C 22.7370 -20.2874
23 C8y C 21.5477 -16.8596
24 C8x C 20.3585 -18.9583
25 C8x C 21.6177 -20.9870
26 N4x N 20.4284 -16.0201
27 N5x N 22.7370 -16.0201
28 C8x C 20.3585 -20.3573
29 N5x N 20.8482 -14.6910
30 N5x N 22.2473 -14.6910
BOND 33
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 9 13 2
13 9 14 1
14 10 15 1
15 13 16 1
16 14 17 2
17 15 18 1
18 16 19 2
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 1
23 21 24 2
24 22 25 1
25 23 26 1
26 23 27 2
27 24 28 1
28 26 29 1
29 27 30 1
30 5 7 1
31 17 19 1
32 25 28 2
33 29 30 2
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