| Entry |
|
|---|
| Name |
Safinamide (USAN/INN) |
|---|
| Formula |
C17H19FN2O2
|
|---|
| Exact mass |
302.1431
|
|---|
| Mol weight |
302.3434
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
| Product (DG01260): | D10191<JP/US> |
|
|---|
| Efficacy |
Antiparkinsonian, Monoamine oxidase B (MAO-B) inhibitor |
|---|
| Comment |
Treatment of Parkinson's disease
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: MAOA [HSA: 4128]; CYP3A4 [HSA: 1576]
|
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BD Monoamine oxidase B inhibitors
N04BD03 Safinamide
D10158 Safinamide (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG01260 Safinamide
D10158 Safinamide
DG01967 Antiparkinson agent
DG01260 Safinamide
D10158 Safinamide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01260 Safinamide
D10158 Safinamide
DG02917 MAO substrate
DG03178 MAOA substrate
DG01260 Safinamide
D10158 Safinamide
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Amine oxidases
MAOB
D10158 Safinamide (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10158
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG01260 Safinamide
DG01967 Antiparkinson agent
DG01260 Safinamide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01260 Safinamide
DG02917 MAO substrate
DG03178 MAOA substrate
DG01260 Safinamide
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8x C 10.2200 -23.5200
2 C8x C 10.2200 -22.1200
3 C8x C 11.4100 -21.4200
4 C8y C 12.6700 -22.1200
5 C8x C 12.6700 -23.5200
6 C8y C 11.4100 -24.2200
7 C1b C 13.8600 -21.4200
8 O2a O 15.0500 -22.1200
9 C8y C 16.2400 -21.4200
10 C8x C 16.2400 -20.0200
11 C8x C 17.5000 -19.3200
12 C8y C 18.6900 -20.0200
13 C8x C 18.6900 -21.4200
14 C8x C 17.5000 -22.1200
15 C1b C 19.8800 -19.3200
16 N1b N 21.0700 -20.0200
17 C1c C 22.2600 -19.3200
18 C5a C 23.4500 -20.0200
19 N1a N 24.6400 -19.3200
20 O5a O 23.4500 -21.4200
21 C1a C 22.2600 -17.9200
22 X F 11.3928 -25.6199
BOND 23
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 13 14 2
15 9 14 1
16 12 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 18 20 2
22 17 21 1 #Up
23 6 22 1
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