KEGG   DRUG: Infigratinib phosphate
Entry
D11611                      Drug                                   
Name
Infigratinib phosphate (USAN);
Truseltiq (TN)
Formula
C26H31Cl2N7O3. H3PO4
Exact mass
657.1634
Mol weight
658.4706
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03208  FGFR inhibitor
Remark
ATC code: L01EN03
Chemical structure group: DG03062
Efficacy
Antineoplastic, Angiogenesis inhibitor
  Disease
Cholangiocarcinoma (FGFR2 fusion or other rearrangement) [DS:H00046]
Target
FGFR2* (CD332) [HSA_VAR:2263v2 2263v1] [HSA:2263] [KO:K05093]
FGFR1 (CD331) [HSA:2260] [KO:K04362]
FGFR3 (CD333) [HSA:2261] [KO:K05094]
  Pathway
hsa04010  MAPK signaling pathway
hsa05205  Proteoglycans in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EN Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors
     L01EN03 Infigratinib
      D11611  Infigratinib phosphate (USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Infigratinib
    D11611  Infigratinib phosphate (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03062  Infigratinib
      D11611  Infigratinib phosphate
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR1 (CD331)
     D11611  Infigratinib phosphate (USAN)
    FGFR2* (CD332) [HSA_VAR:2263v2 2263v1]
     D11611  Infigratinib phosphate (USAN)
    FGFR3 (CD333)
     D11611  Infigratinib phosphate (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11611
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11611
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11611
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03208  FGFR inhibitor
     DG03062  Infigratinib
Other DBs
CAS: 1310746-10-1
PubChem: 405226478
LinkDB
KCF data

ATOM        43
            1   N1y N     9.6102  -13.7182
            2   C1x C     9.6102  -15.1806
            3   C1x C    10.8636  -15.8769
            4   N1y N    12.0474  -15.1806
            5   C1x C    12.0474  -13.7182
            6   C1x C    10.8636  -13.0219
            7   C1b C     8.4264  -13.0219
            8   C1a C     7.2427  -13.7182
            9   C8y C    13.2312  -15.8769
            10  C8x C    13.2312  -17.2696
            11  C8x C    14.4846  -17.9659
            12  C8y C    15.6684  -17.2696
            13  C8x C    15.6684  -15.8769
            14  C8x C    14.4846  -15.1806
            15  N1b N    16.9218  -17.9659
            16  C8y C    18.1055  -17.2696
            17  C8x C    19.2893  -17.9659
            18  C8y C    20.4731  -17.2696
            19  N5x N    20.4731  -15.8073
            20  C8x C    19.2893  -15.1806
            21  N5x N    18.1055  -15.8769
            22  N1c N    21.7265  -17.9659
            23  C5a C    22.9103  -17.2696
            24  C1a C    21.7265  -19.3586
            25  N1b N    24.0941  -17.9659
            26  O5a O    22.9103  -15.8769
            27  C8y C    25.2778  -17.2696
            28  C8y C    26.4616  -17.9659
            29  C8y C    27.6454  -17.2696
            30  C8x C    27.6454  -15.8073
            31  C8y C    26.4616  -15.1806
            32  C8y C    25.2778  -15.8769
            33  X   Cl   26.4616  -19.3586
            34  O2a O    26.4616  -13.7182
            35  C1a C    27.7150  -13.0219
            36  O2a O    28.8988  -17.9659
            37  C1a C    30.0826  -17.2696
            38  X   Cl   24.0244  -15.1109
            39  P1b P    34.9300  -17.2200
            40  O1c O    34.9300  -15.8200
            41  O1c O    33.5300  -17.2200
            42  O1c O    36.3300  -17.2200
            43  O1c O    34.9300  -18.6200
BOND        45
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   18  22 1
            25   22  23 1
            26   22  24 1
            27   23  25 1
            28   23  26 2
            29   25  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   27  32 1
            36   28  33 1
            37   31  34 1
            38   34  35 1
            39   29  36 1
            40   36  37 1
            41   32  38 1
            42   39  40 2
            43   39  41 1
            44   39  42 1
            45   39  43 1

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