KEGG ORTHOLOGY: K05094

ORTHOLOGY: K05094

Entry

K05094                      KO

Symbol

FGFR3, CD333

Name

fibroblast growth factor receptor 3 [EC:2.7.10.1]

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04144

Endocytosis

map04151

PI3K-Akt signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04810

Regulation of actin cytoskeleton

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05219

Bladder cancer

map05230

Central carbon metabolism in cancer

Disease

H00010

Multiple myeloma

H00022

Bladder cancer

H00023

Testicular cancer

H00458

Syndromic craniosynostoses

H00505

FGFR3-related short limb skeletal dysplasia

H00642

Lacrimo-auriculo-dento-digital syndrome

H00997

CATSHL syndrome

H01749

Achondroplasia

H01750

Thanatophoric dysplasia

H01754

Crouzon syndrome

H01990

Muenke syndrome

H02068

Hypochondroplasia

H02069

SADDAN

H02627

Epidermal nevus

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04014 Ras signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04015 Rap1 signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04020 Calcium signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   04151 PI3K-Akt signaling pathway
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05206 MicroRNAs in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
   05230 Central carbon metabolism in cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09162 Cancer: specific types
   05219 Bladder cancer
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05094  FGFR3, CD333; fibroblast growth factor receptor 3
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  FGFR family [OT]
   K05094  FGFR3, CD333; fibroblast growth factor receptor 3
CD molecules [BR:ko04090]
Proteins
  K05094  CD333, FGFR3; fibroblast growth factor receptor 3

Other DBs

GO:

0005007

Genes

HSA:	2261(FGFR3)

PTR:	461067(FGFR3)

PPS:	100976551(FGFR3)

GGO:	101139997(FGFR3) 115932714 115932715

PON:	100433126(FGFR3)

NLE:	100591839(FGFR3)

HMH:	116456707(FGFR3)

MCC:	712829(FGFR3)

MCF:	102128947(FGFR3)

MTHB:

126955560

MNI:	105483839(FGFR3)

CSAB:

103246479(FGFR3)

CATY:

105585485(FGFR3)

PANU:

101014560(FGFR3)

TGE:	112625207(FGFR3)

MLEU:

105532657(FGFR3)

RRO:	104678934(FGFR3)

RBB:	108532286(FGFR3)

TFN:	117085041(FGFR3)

PTEH:

111539069(FGFR3)

CANG:

105508015(FGFR3)

CJC:	100409938(FGFR3)

SBQ:	101051421(FGFR3)

CIMI:

108311571(FGFR3)

CSYR:

103272218(FGFR3)

MMUR:

105856032(FGFR3)

LCAT:

123622909(FGFR3)

PCOQ:

105826215(FGFR3)

OGA:	100962219(FGFR3)

MMU:	14184(Fgfr3)

MCAL:

110293909(Fgfr3)

MPAH:

110330788(Fgfr3)

RNO:	84489(Fgfr3)

MCOC:

116069961(Fgfr3)

ANU:	117712554(Fgfr3)

MUN:	110557305(Fgfr3)

CGE:	100764560(Fgfr3)

MAUA:

101826351(Fgfr3)

PROB:

127233728(Fgfr3)

PLEU:

114694056(Fgfr3)

MORG:

121436445 121444101 121445397 121445442 121445462 121445490 121445507 121445523 121459483

MFOT:

126500888

AAMP:

119805744 119805838 119805841 119805848 119805908 119811014 119811259 119812129(Fgfr3)

NGI:	103741127(Fgfr3)

HGL:	101711651(Fgfr3)

CPOC:

100732948(Fgfr3)

CCAN:

109695016(Fgfr3)

DORD:

105991261(Fgfr3)

DSP:	122100692(Fgfr3)

PLOP:

125364429(Fgfr3)

NCAR:

124995087

MMMA:

107139080(Fgfr3)

OCU:

127485863

OPI:	101521291(FGFR3)

TUP:	102500041(FGFR3)

GVR:	103587648(FGFR3)

CFA:	488808(FGFR3)

CLUD:

112653432(FGFR3)

VVP:	112922612(FGFR3)

VLG:	121489705(FGFR3)

NPO:	129510326(FGFR3)

AML:	100481826(FGFR3)

UMR:	103676958(FGFR3)

UAH:	113245744(FGFR3)

UAR:	123777846(FGFR3)

ELK:

111149137

LLV:

125093458

MPUF:

101691659(FGFR3)

MNP:	132003670(FGFR3)

MLK:	131827098(FGFR3)

NVS:	122919116(FGFR3)

ORO:	101381434(FGFR3)

EJU:	114196996(FGFR3)

ZCA:	113925082(FGFR3)

MLX:	118010795(FGFR3)

NSU:	110569786(FGFR3)

LWW:	102747964(FGFR3)

FCA:	100141386(FGFR3)

PYU:	121039432(FGFR3)

PBG:	122479132(FGFR3)

PVIV:

125159206(FGFR3)

LRUF:

124522669

PPAD:

109269781(FGFR3)

AJU:

106978850

HHV:	120231844(FGFR3)

BTA:	281769(FGFR3)

BOM:	102264670(FGFR3)

BIU:	109560724(FGFR3)

BBUB:

102395462(FGFR3)

BBIS:

104983412(FGFR3)

OAS:	554324(FGFR3)

BTAX:

128049397(FGFR3)

ODA:	120861835(FGFR3)

CCAD:

122428025(FGFR3) 122442295

MBEZ:

129561939(FGFR3)

SSC:	100514115(FGFR3)

CFR:	102512878(FGFR3)

CBAI:

105072182(FGFR3)

CDK:	105100875(FGFR3)

VPC:	102531487(FGFR3)

BACU:

103002473(FGFR3)

BMUS:

118895440(FGFR3)

LVE:	103086424(FGFR3)

OOR:	101273169(FGFR3)

DLE:	111164861(FGFR3)

PCAD:

102982240(FGFR3)

PSIU:

116754486(FGFR3)

NASI:

112391392(FGFR3)

ECB:	100034114(FGFR3)

EPZ:	103556997(FGFR3)

EAI:	106830606(FGFR3)

MMYO:

118665364(FGFR3)

PKL:	118707163(FGFR3)

EFUS:

103294577(FGFR3)

MNA:	107524118(FGFR3)

SHON:

118987768(FGFR3)

AJM:	119035526(FGFR3)

PDIC:

114489924(FGFR3)

PHAS:

123815667(FGFR3)

MMF:	118633856(FGFR3)

PPAM:

129077479(FGFR3)

HAI:	109390958(FGFR3)

RFQ:	117022243(FGFR3)

PALE:

102878342(FGFR3)

PGIG:

120582906(FGFR3)

PVP:	105301871(FGFR3)

RAY:	107518024(FGFR3)

MJV:	108383914(FGFR3)

TOD:	119260900(FGFR3)

SARA:

101551516(FGFR3)

SETR:

126032236(FGFR3)

LAV:	100674054(FGFR3)

TMU:

101341002

ETF:	101644525(FGFR3)

DNM:	101428113(FGFR3)

MDO:	100023287(FGFR3)

GAS:	123252878(FGFR3)

SHR:	100913979(FGFR3)

AFZ:

127541109

PCW:	110212245(FGFR3)

OAA:	100084071(FGFR3)

GGA:	396515(FGFR3)

PCOC:

116225737(FGFR3)

MGP:	100543461(FGFR3)

CJO:	107313983(FGFR3)

TPAI:

128080206(FGFR3)

LMUT:

125692392(FGFR3)

NMEL:

110398027(FGFR3)

APLA:

101804995(FGFR3)

ACYG:

106034332(FGFR3)

CATA:

118248370(FGFR3)

AFUL:

116488690(FGFR3)

TGU:	100218924(FGFR3)

LSR:	110473290(FGFR3)

SCAN:

103826117(FGFR3)

PMOA:

120509387(FGFR3)

OTC:	121334977(FGFR3)

PRUF:

121348993(FGFR3)

GFR:	102044988(FGFR3)

FAB:	101812160(FGFR3)

OMA:	130252416(FGFR3)

PHI:	102114034(FGFR3)

PMAJ:

107203422(FGFR3)

CCAE:

111927721(FGFR3)

CCW:	104690922(FGFR3)

CBRC:

103611188(FGFR3)

ETL:	114061475(FGFR3)

ZAB:	102063305(FGFR3)

ACHL:

103800822(FGFR3)

SVG:	106865281(FGFR3)

MMEA:

130578156(FGFR3)

HRT:	120752756(FGFR3)

FPG:	101920747(FGFR3)

FCH:	102052231(FGFR3)

CLV:	102098275(FGFR3)

EGZ:	104130196(FGFR3)

NNI:	104018093(FGFR3)

PCRI:

104033657(FGFR3)

PLET:

104617923(FGFR3)

EHS:	104514694(FGFR3)

PCAO:

104043239(FGFR3)

TALA:

104357159(FGFR3)

PADL:

103920985(FGFR3)

AFOR:

103904083(FGFR3)

ACHC:

115343423(FGFR3)

HALD:

104321767(FGFR3)

HLE:	104838266(FGFR3)

AGEN:

126035046

GCL:

127015502

CCRI:

104158035(FGFR3)

CSTI:

104558825(FGFR3)

CMAC:

104487232(FGFR3)

MUI:	104543091(FGFR3)

BREG:

104641774(FGFR3)

FGA:	104075917(FGFR3)

GSTE:

104253812(FGFR3)

LDI:	104354170(FGFR3)

MNB:	103771881(FGFR3)

OHA:	104329660(FGFR3)

NNT:	104403452(FGFR3)

SHAB:

115610522(FGFR3)

DPUB:

104303599(FGFR3)

PGUU:

104464393(FGFR3)

ACAR:

104528429(FGFR3)

CPEA:

104391064(FGFR3)

AVIT:

104278693(FGFR3)

CVF:	104284264(FGFR3)

RTD:	128910311(FGFR3)

CUCA:

104054953(FGFR3)

TEO:	104378928(FGFR3)

BRHI:

104500002(FGFR3)

AAM:	106498761(FGFR3)

AROW:

112965516(FGFR3)

NPD:	112942995(FGFR3)

TGT:	104572917(FGFR3)

DNE:	112990762(FGFR3)

SCAM:

104151349(FGFR3)

ASN:	102371740(FGFR3)

AMJ:	106736800(FGFR3)

CPOO:

109322182(FGFR3)

GGN:	109303914(FGFR3)

PSS:	102444715(FGFR3)

CMY:	102939991(FGFR3)

CCAY:

125636247(FGFR3)

DCC:	119854594(FGFR3)

CPIC:

101933794(FGFR3)

TST:	117878458(FGFR3)

CABI:

116817612(FGFR3) 116826290

MRV:	120375536 120375538 120375622 120406018(FGFR3)

ASAO:

132771374

PVT:	110085587(FGFR3)

SUND:

121925139(FGFR3)

PBI:	103067086(FGFR3)

CTIG:

120309914(FGFR3)

TSR:

106555648

PGUT:

117664767(FGFR3)

APRI:

131200224(FGFR3)

PTEX:

113449380(FGFR3)

NSS:

113427454

VKO:	123032384(FGFR3)

PMUA:

114596954(FGFR3)

PRAF:

128413599(FGFR3)

ZVI:	118078263 118096480(FGFR3)

HCG:	128350194(FGFR3)

STOW:

125437836

EMC:	129331875(FGFR3)

XLA:	399347(fgfr3.S) 779370(fgfr3.L)

XTR:	100196923(fgfr3)

NPR:	108788840(FGFR3)

RTEM:

120924362(FGFR3)

BBUF:

120990414(FGFR3)

BGAR:

122939392(FGFR3)

MUO:	115461353(FGFR3)

GSH:	117363392(FGFR3)

DRE:	58129(fgfr3)

SRX:	107733743 107747578

SANH:

107666479 107695022

SGH:	107556915 107585263

CCAR:

109098492

CAUA:

113057063 113078253 113112845

CGIB:

128026358

PTET:

122356737(fgfr3)

LROH:

127175122(fgfr3)

OMC:	131552377(fgfr3)

PPRM:

120479581(fgfr3)

RKG:	130102901(fgfr3)

MAMB:

125276568(fgfr3)

CIDE:

127525140

MASI:

127411879 127414110

TROS:

130558844(fgfr3)

TDW:	130431290(fgfr3)

MANU:

129415896(fgfr3)

IPU:	108263592(fgfr3)

IFU:	128605481(fgfr3)

PHYP:

113539741(fgfr3)

SMEO:

124398345(fgfr3)

TFD:	113645004(fgfr3)

TVC:	132847187(fgfr3)

AMEX:

103045058(fgfr3)

CMAO:

118810287(fgfr3)

EEE:	113589671(fgfr3)

CHAR:

105909593(fgfr3)

TRU:	101063860(fgfr3)

TFS:	130539790(fgfr3)

TNG:	GSTEN00023332G001

LCO:	104926793(fgfr3)

NCC:

104955633

TBEN:

117487249(fgfr3)

CGOB:

115027139

PGEO:

117467594(fgfr3)

GACU:

117558903(fgfr3)

EMAC:

134881346(fgfr3)

ELY:	117267283(fgfr3)

EFO:	125900843(fgfr3)

PLEP:

121953470(fgfr3)

SLUC:

116036735(fgfr3)

ECRA:

117935936(fgfr3)

ESP:	116695713(fgfr3)

PFLV:

114546647

GAT:	120833006(fgfr3)

PPUG:

119227613(fgfr3)

AFB:	129103846(fgfr3)

CLUM:

117751575(fgfr3)

PSWI:

130201204(fgfr3)

MSAM:

119910102(fgfr3)

SCHU:

122861558(fgfr3)

CUD:	121526058(fgfr3)

ALAT:

119004435(fgfr3)

MZE:	101476450(fgfr3)

ONL:	100689850(fgfr3)

OAU:	116329031(fgfr3)

OLA:	100049424(fgfr3)

OML:	112139739(fgfr3)

CSAI:

133462938(fgfr3)

XMA:

102228238

XCO:	114134047(fgfr3)

XHE:	116708872(fgfr3)

PRET:

103458160

PFOR:

103149422(fgfr3)

PLAI:

106952470(fgfr3)

PMEI:

106922536(fgfr3)

GAF:	122846087(fgfr3)

PPRL:

129377229(fgfr3)

CVG:

107087110

CTUL:

119796224(fgfr3)

GMU:	124855142(fgfr3)

NFU:

107391665

KMR:	108249920(fgfr3)

ALIM:

106519945(fgfr3)

NWH:	119426968(fgfr3)

AOCE:

111580110(fgfr3)

MCEP:

125023542(fgfr3)

CSEM:

103383204(fgfr3)

SSEN:

122782744(fgfr3)

HHIP:

117755965(fgfr3)

HSP:	118116294(fgfr3)

SMAU:

118286161(fgfr3)

LCF:

108889150

SDU:	111226196(fgfr3)

SLAL:

111646819(fgfr3)

XGL:	120795599(fgfr3)

HCQ:	109520993(fgfr3)

SSCV:

125980639

SBIA:

133512977(fgfr3)

PEE:	133412419(fgfr3)

PTAO:

133488274(fgfr3)

BPEC:

110155643(fgfr3)

MALB:

109962419(fgfr3)

BSPL:

114848555(fgfr3)

SJO:	128375655(fgfr3)

STRU:

115161812(fgfr3) 115183113

OTW:	112241224(fgfr3)

OMY:	110519382(fgfr3)

OGO:	124046839(fgfr3)

OKI:	109880780(fgfr3)

OKE:	118369015(fgfr3)

CCLU:

121555326(fgfr3) 121556697

ELS:	105015916(fgfr3)

SFM:	108920925(fgfr3)

PKI:	111844207(fgfr3)

AANG:

118227480(fgfr3)

LOC:	102691474(fgfr3)

PSPA:

121325532 121330903

ARUT:

117409079 117421175 117968011

PSEX:

120527855(fgfr3)

LCM:	102364583(FGFR3)

CMK:	103181516(fgfr3)

CPLA:

HOC:

LERI:

PMRN:

LRJ:	133345528(FGFR2) 133361846 133361984 133361988 133362016 133362163 133362396 133362748 133362781 133362858

BFO:	118415178 118415531

SCLV:

120342709 120342893

LPIC:

129273246

DME:	Dmel_CG7223(htl)

DER:

6552001

DYA:	Dyak_GE25239

DGR:

ECOE:

CLON:

HIS:

ASTE:

AFUN:

AMOU:

CPII:

CNS:	116337088 116343908

BCOO:

FEX:

PFUC:

VPS:

TPRE:

LBD:

FAS:

DAM:

AGIF:

CINS:

SOY:	115875106 115883858

AGRG:

126748840

CSET:

123321607

AGB:	108906277 108910095

LDC:

APLN:

PPYR:

OTU:

MSEX:

PPOT:

PXU:

CCRN:

ACOO:

DVT:

HVI:

MQU:

PHU:	Phum_PHUM515380

FOC:

TPAL:

CSEC:

DMK:

DPZ:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

TCF:	131877905 131880455

PPOI:

119090471

UDV:	129216617 129224223

SDM:	118200307 118204686

LPOL:

106457385 106458212 106472806

PVUL:

BGT:

GAE:

HRF:

HRJ:	124272352 124274368

CRG:

105325059

CVN:	111123772 111125084

CANU:

128155495 128181356 128192465

OED:	125679668 125681667

PMAX:

117339943

MMER:

123541439 123546561

RPHI:

132731090

NVE:	116617489 5505429 5521468

ATEN:

116292117 116292127 116297901 116297912 116300811 116301850 116305188 116305549

XEN:	124443506 124444412 124444763 124444765 124444944 124453013 124453073

HMG:	100206525 100214111

HSY:	130644345 130647317 130648124 130654628

» show all

Reference

PMID:11703096

Authors

Terada M, Shimizu A, Sato N, Miyakaze SI, Katayama H, Kurokawa-Seo M

Title

Fibroblast growth factor receptor 3 lacking the Ig IIIb and transmembrane domains secreted from human squamous cell carcinoma DJM-1 binds to FGFs.

Journal

Mol Cell Biol Res Commun 4:365-73 (2001)
DOI:10.1006/mcbr.2001.0306

Sequence

[hsa:2261]

LinkDB

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