KEGG ORTHOLOGY: K00207

ORTHOLOGY: K00207

Entry

K00207                      KO

Symbol

DPYD

Name

dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]

Pathway

map00240

Pyrimidine metabolism

map00410

beta-Alanine metabolism

map00770

Pantothenate and CoA biosynthesis

map00983

Drug metabolism - other enzymes

map01100

Metabolic pathways

Module

M00046

Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate

Reaction

R00978

5,6-dihydrouracil:NADP+ oxidoreductase

R01415

5,6-dihydrothymine:NADP+ oxidoreductase

R08226

5,6-dihydro-5-fluorouracil:NADP+ 5-oxidoreductase

Disease

H00193

Dihydropyrimidine dehydrogenase deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     K00207  DPYD; dihydropyrimidine dehydrogenase (NADP+)

Other DBs

GO:

0017113

Genes

HSA:	1806(DPYD)

PTR:	457047(DPYD)

PPS:	100967375(DPYD)

GGO:	101144752(DPYD)

PON:	100173131(DPYD)

NLE:	100604410(DPYD)

MCC:	715672(DPYD)

MCF:	102116182(DPYD)

MTHB:

126964310

MNI:	105485445(DPYD)

CSAB:

103224388(DPYD)

CATY:

105590162(DPYD)

PANU:

100997971(DPYD)

TGE:	112636894(DPYD)

MLEU:

105531412(DPYD)

RRO:	104656399(DPYD)

RBB:	108514391(DPYD)

TFN:	117076084(DPYD)

PTEH:

111555134(DPYD)

CANG:

105524218(DPYD)

CJC:	100399327(DPYD)

SBQ:	101050776(DPYD)

CIMI:

108286187(DPYD)

CSYR:

103263796

MMUR:

105885769(DPYD)

LCAT:

123635366(DPYD)

OGA:	100940469(DPYD)

MMU:	99586(Dpyd)

MCAL:

110291713(Dpyd)

MPAH:

110320876(Dpyd)

RNO:	81656(Dpyd)

MCOC:

116093698(Dpyd)

ANU:	117707855(Dpyd)

MUN:	110561851(Dpyd)

CGE:	100765169(Dpyd)

MAUA:

101842442(Dpyd)

PROB:

127223090(Dpyd)

PLEU:

114700463(Dpyd)

MORG:

121445675(Dpyd)

MFOT:

126512098

AAMP:

119801309(Dpyd)

NGI:	103734644(Dpyd)

HGL:	101704452(Dpyd) 106007540

CPOC:

100727906(Dpyd)

CCAN:

109684940(Dpyd)

DORD:

106000801(Dpyd)

DSP:	122106473(Dpyd)

PLOP:

125355579(Dpyd)

NCAR:

124983056

MMMA:

107155044(Dpyd)

OCU:

100356889

OPI:	101517804(DPYD)

TUP:	102480430(DPYD)

CFA:	479935(DPYD)

CLUD:

112640799(DPYD)

VVP:	112918343(DPYD)

VLG:	121487181(DPYD)

NPO:	129519484(DPYD)

AML:	100466550(DPYD)

UMR:	103669348(DPYD)

UAH:	113254371(DPYD)

UAR:	123795180(DPYD)

ELK:

111142998

LLV:

125098417

MPUF:

101693928(DPYD)

MNP:	132001171(DPYD)

MLK:	131810470(DPYD)

NVS:	122900225(DPYD)

ORO:	101365435(DPYD)

EJU:	114207889(DPYD)

ZCA:	113935827(DPYD)

MLX:	118019104(DPYD)

NSU:	110580563(DPYD)

LWW:	102728785(DPYD)

FCA:	101084380(DPYD)

PYU:	121027529(DPYD)

PCOO:

112872134(DPYD)

PBG:	122480812(DPYD)

PVIV:

125173055(DPYD)

LRUF:

124515401

PPAD:

109271896(DPYD)

PUC:

125913348

AJU:

106968124

HHV:	120229445(DPYD)

BTA:	281124(DPYD)

BOM:	102267734(DPYD)

BIU:	109556033(DPYD)

BBUB:

102407735(DPYD)

CHX:	102181553(DPYD)

OAS:	101109311(DPYD)

BTAX:

128044934(DPYD)

ODA:	120856824(DPYD)

CCAD:

122436655(DPYD)

MBEZ:

129540747(DPYD)

SSC:	397109(DPYD)

CFR:	102504040(DPYD)

CBAI:

105065339(DPYD)

CDK:	105085122(DPYD)

VPC:	102524977(DPYD)

BACU:

103009948(DPYD)

BMUS:

118881008(DPYD)

LVE:	103085271(DPYD)

OOR:	101279013(DPYD)

DLE:	111164012(DPYD)

PCAD:

102986090(DPYD)

PSIU:

116753023(DPYD)

NASI:

112403639(DPYD)

ECB:	100057177(DPYD)

EPZ:	103540156(DPYD)

EAI:	106828119(DPYD)

MYB:

102257347

MYD:	102754526(DPYD)

MMYO:

118673617(DPYD)

MLF:

102434586

PKL:	118727125(DPYD)

EFUS:

103291302(DPYD)

MNA:	107530660(DPYD)

DRO:	112313689(DPYD)

SHON:

118990649(DPYD)

AJM:	119054992(DPYD)

PDIC:

114489423(DPYD)

PHAS:

123804405(DPYD)

MMF:	118637328(DPYD)

PPAM:

129063744(DPYD)

HAI:	109386016(DPYD)

RFQ:	117014653(DPYD)

PALE:

102878429(DPYD)

PGIG:

120607821(DPYD)

PVP:	105305987(DPYD)

RAY:

107517295

MJV:	108383468(DPYD)

TOD:	119235158(DPYD)

SARA:

101541274(DPYD)

SETR:

125997237(DPYD)

LAV:	100676827(DPYD)

TMU:

101360586

ETF:	101648630(DPYD)

DNM:	101444218(DPYD)

MDO:	100032923(DPYD)

GAS:	123243930(DPYD)

SHR:	100930277(DPYD)

AFZ:

127559473

PCW:	110217286(DPYD)

OAA:	100077139(DPYD)

GGA:	429083(DPYD)

PCOC:

116243498(DPYD)

MGP:

100538897

CJO:	107317539(DPYD)

TPAI:

128072550(DPYD)

LMUT:

125692837(DPYD)

NMEL:

110402541(DPYD)

APLA:

101793833(DPYD)

ACYG:

106039427(DPYD)

CATA:

118243800(DPYD)

AFUL:

116491841(DPYD)

TGU:	100222559(DPYD)

LSR:	110467965(DPYD)

SCAN:

103815131(DPYD)

PMOA:

120506502(DPYD)

OTC:	121345174(DPYD)

PRUF:

121362166(DPYD)

GFR:	102041285(DPYD)

FAB:	101814169(DPYD)

OMA:	130256006(DPYD)

PHI:	102101448(DPYD)

PMAJ:

107208013(DPYD)

CCAE:

111932636(DPYD)

CCW:	104695364(DPYD)

CBRC:

103612770(DPYD)

ETL:	114055644(DPYD)

ZAB:	102066238(DPYD)

ACHL:

103810492(DPYD)

SVG:	106858246(DPYD)

MMEA:

130577781(DPYD)

HRT:	120756718(DPYD)

FPG:	101911279(DPYD)

FCH:	102050877(DPYD)

CLV:	102092031(DPYD)

EGZ:	104134025(DPYD)

NNI:	104015600(DPYD)

ACUN:

113482868(DPYD)

TALA:

104359316(DPYD)

PADL:

103925182(DPYD)

AFOR:

103908151(DPYD)

ACHC:

115349370(DPYD)

HALD:

104324167(DPYD)

HLE:	104841242(DPYD)

AGEN:

126041986

GCL:

127019091

CCRI:

104159053(DPYD)

CSTI:

104560643(DPYD)

LDI:	104345914(DPYD)

MNB:	103772264(DPYD)

OHA:	104332593(DPYD)

NNT:	104408106(DPYD)

SHAB:

115611387(DPYD)

DPUB:

104309713

ACAR:

104520410(DPYD)

CPEA:

104396872(DPYD)

AVIT:

104270603(DPYD)

CVF:	104286331(DPYD)

RTD:	128913859(DPYD)

CUCA:

104061582(DPYD)

AAM:	106499764(DPYD)

AROW:

112961947(DPYD)

NPD:	112946230(DPYD)

TGT:	104573512 104577998(DPYD)

DNE:	112979780(DPYD)

SCAM:

104151256(DPYD)

ASN:	102371859(DPYD)

AMJ:	102574438(DPYD)

CPOO:

109307260(DPYD)

GGN:	109286864(DPYD)

PSS:	102451891(DPYD)

CMY:	102931992(DPYD)

CCAY:

125640767(DPYD)

DCC:	119860746(DPYD)

CPIC:

101944618

TST:	117881664(DPYD)

CABI:

116826931

MRV:	120370087(DPYD)

ACS:	100566998(dpyd)

ASAO:

132774141(DPYD)

PVT:	110083089(DPYD)

PBI:

103065336

PMUR:

107284500(DPYD)

CTIG:

120306487(DPYD)

TSR:	106550261(DPYD)

PGUT:

117677212(DPYD)

APRI:

131194716(DPYD)

NSS:	113416340(DPYD)

VKO:	123024534(DPYD)

PMUA:

114598746(DPYD)

PRAF:

128415475(DPYD)

ZVI:	118089265(DPYD)

HCG:	128322091(DPYD)

GJA:

107121000

STOW:

125433140(DPYD)

EMC:	129330104(DPYD)

XLA:	447312(dpyd.L)

XTR:	734021(dpyd)

NPR:	108795821(DPYD)

RTEM:

120945656(DPYD)

BBUF:

120978613(DPYD)

BGAR:

122944045(DPYD)

MUO:	115471601(DPYD)

GSH:	117346354(DPYD)

DRE:	405829(dpydb)

SRX:	107710600(dpyd) 107712781 107718148 107739013

SANH:

107677268 107677757 107700576(dpyd)

SGH:	107570487 107589900 107590279 107594652(dpyd)

CCAR:

109078535

CAUA:

113045497 113045498 113093832 113115806

CGIB:

127946544 127951434 128027277

PTET:

122330059(dpyda.1) 122360317(dpydb)

LROH:

127156007(dpyda.1) 127175303(dpydb)

OMC:	131532634(dpydb) 131533613(dpyda.1)

PPRM:

120478773(dpyda.1) 120483195(dpydb)

RKG:	130084063(dpyda.1) 130089583(dpydb)

MAMB:

125250007(dpydb) 125258450(dpyda.1)

CIDE:

127495656 127505764 127524791

MASI:

127440388 127442398

TROS:

130546673(dpyda.1) 130554329(dpydb)

TDW:	130412839(dpyda.1) 130417895(dpydb)

MANU:

129442391(dpydb)

IPU:	108268608(dpyda.1)

IFU:	128611099(dpyda.1)

PHYP:

113533990(dpyd)

SMEO:

124383889(dpyda.1)

TFD:	113644504(dpyda.1)

TVC:	132845840(dpyda.1)

AMEX:

103045749(dpyd)

CMAO:

118818422(dpyda.1)

EEE:	113581184(dpyd)

CHAR:

105889391(dpyda.1) 105910742(dpydb)

TRU:	101067586(dpyd)

TFS:

130538462

TNG:	GSTEN00010070G001

LCO:	104933920(dpyd)

NCC:

104943349

TBEN:

117473766(dpydb)

CGOB:

115022154

PGEO:

117462777(dpydb)

GACU:

117545494

EMAC:

134866102(dpydb)

ELY:	117272060(dpydb)

EFO:	125902709(dpydb)

PLEP:

121951329(dpydb)

SLUC:

116057757(dpydb)

ECRA:

117954432(dpydb)

ESP:	116699029(dpyd)

PFLV:

114565059(dpyd)

GAT:	120816280(dpydb)

PPUG:

119209265(dpydb)

AFB:	129094237(dpydb)

CLUM:

117746356(dpydb)

PSWI:

130198170(dpydb)

MSAM:

119902592(dpydb)

SCHU:

122887097(dpydb)

ALAT:

119010710(dpydb)

MZE:	101482026(dpyd)

ONL:	100689784(dpyd)

OAU:	116316784(dpydb)

OLA:	101175598(dpyd)

OML:	112147590(dpydb)

CSAI:

133452582(dpydb)

XMA:	102231146(dpyd)

XCO:	114146947(dpyd)

XHE:	116722177(dpyd)

PRET:

103479304(dpyd)

PFOR:

103146989(dpyd)

PLAI:

106951348(dpyd)

PMEI:

106917803(dpyd)

GAF:	122841104(dpydb)

PPRL:

129361619(dpydb)

CVG:	107088605(dpyd)

CTUL:

119774143(dpydb)

GMU:	124869881(dpydb)

NFU:	107384175(dpyd)

KMR:	108239550(dpydb)

ALIM:

106524919(dpyd)

NWH:	119414399(dpydb)

AOCE:

111582266(dpyd)

MCEP:

125010506(dpydb)

CSEM:

103396555(dpyd)

POV:	109645501(dpyd)

SSEN:

122777477(dpydb)

HHIP:

117777907(dpydb)

HSP:	118117321(dpydb)

SMAU:

118311172(dpydb)

LCF:	108884496(dpydb)

SDU:	111239137(dpyd)

SLAL:

111650603(dpyd)

XGL:	120799301(dpydb)

HCQ:	109515477(dpyd)

SSCV:

125984655

SBIA:

133510892(dpydb)

PEE:	133411646(dpydb)

PTAO:

133488554(dpydb)

BPEC:

110170438(dpyd)

MALB:

109974739(dpyd)

BSPL:

114844095(dpydb)

SJO:	128368849(dpydb)

SASA:

106568897 106578501 106598776(dpyd)

STRU:

115153181 115156802

OTW:	112215544 112260360(dpydb)

OMY:	110530943 110535495

OGO:	123991186 124009398

ONE:	115105060 115114290

OKI:	109875091 109909978(dpyd)

OKE:	118361160 118402232(dpydb)

SALP:

111956525 111973028

SNH:	120028105 120055832(dpydb)

CCLU:

121535103 121549908

ELS:	105022585(dpyd)

SFM:	108935471(dpyd)

PKI:	111840098(dpyd)

AANG:

118225829(dpyda.1)

LOC:	102688311(dpyd)

PSPA:

ARUT:

PSEX:

LCM:

CMK:

CPLA:

HOC:

LERI:

PMRN:

116944958(DPYD)

LRJ:	133346378 133346384

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG2194(su(r))

DER:

6549848

DSE:

6619786

DSI:	Dsimw501_GD16077(Dsim_GD16077)

DYA:	Dyak_GE17405

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:	6644270 6648584

DGR:

6569257

DMO:	Dmoj_GI15089

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106615762 106615819

BDR:	105224908 105224909

RZE:	108375880 108378517

AOQ:

129238464

TDA:	119670250 119670251

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005573

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114871645 114871653

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210796

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110372024(Su(r))

HZE:

TNL:

SLIU:

OFU:

PXY:	105384082 105396948

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM424200

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_202177

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111704528 111704529

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C25F6.3(dpyd-1)

CBR:	CBG_14689(Cbr-dpyd-1)

CRQ:	GCK72_024429

NAI:	NECAME_11849

HRO:	HELRODRAFT_69873

LGI:	LOTGIDRAFT_233044

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106175633 106175638 106178467

OVI:	T265_12739

EGL:

NVE:

EPA:

ATEN:

ADF:	107328165 107354002

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

AQU:

ATH:	AT3G17810(PYD1)

ALY:

9321297

CRB:

17893581

CSAT:

104746129 104765626 104782634

EUS:	EUTSA_v10020777mg

BRP:	103839011 103869649

BNA:	106347415 106427199 106429281 106435966 106452022

BOE:	106293455 106343135

RSZ:	108812448 108835351 108856752 108858907 130494369

THJ:

104820334

CPAP:

110823211

CIT:

102610369

CIC:	CICLE_v10020301mg

PVY:

MINC:

TCC:

GRA:

GHI:	107890863 121206239

GAB:

108457198

HSYR:

120192070 120209384

DZI:	111282270 111311393

EGR:

104425851

GMX:	100804632 100818990

GSJ:	114368747 114418704

PVU:	PHAVU_004G148000g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj2g3v0658080.1(Lj2g3v0658080.1) Lj2g3v0658080.2(Lj2g3v0658080.2)

ADU:

107490600

AIP:

107644107

AHF:	112750889 112802382

LANG:

109343061

PCIN:

129285129

QSA:	O6P43_005228 O6P43_008460

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103438108 114820973

MSYL:

126599834 126626756

PXB:	103946911 103950551

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:	18105605 7486698

PEU:	105110421 105142036

PALZ:

118057291

JRE:	108983065 108993229

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:	543719(PYD1A)

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107809767 107809801

NSY:

104250053

NTO:

104118980

NAU:

109231263

INI:	109147604 109157123

ITR:

SIND:

OEU:

EGT:

SSPL:

121760203 121763093 121763637 121787038

SMIL:

131020214

SHIS:

125200982 125214107

APAN:

127243615

HAN:	110912634 110918786

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110699514 110706070

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os02t0736400-01(Os02g0736400)

OBR:

OGL:

BDI:

ATS:

TDC:	119317803 119322547

TAES:

123128329 123138178 123145434

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:	103706801 103723740 120106106

EGU:	105042108 105053171

MUS:

103995258

ZOF:	122052057 122056573

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_80950 SELMODRAFT_88846

PPP:	112272917 112275905

CRE:	CHLRE_13g578750v5

VCN:	VOLCADRAFT_80405

MNG:

MNEG_4561

CSL:	COCSUDRAFT_18241

CVR:	CHLNCDRAFT_31559 CHLNCDRAFT_55724

APRO:

F751_5402

MIS:	MICPUN_109450

DDI:	DDB_G0267966(pyd1)

DPP:	DICPUDRAFT_94040

DFA:	DFA_11424(pyd1)

EHI:	EHI_012980(14.t00017)

EDI:	EDI_044620

EIV:	EIN_151150

ACAN:

ACA1_192070

TET:	TTHERM_01250100

PTM:	GSPATT00007208001

NGR:	NAEGRDRAFT_78714

TVA:	TVAG_2v0073560

MBD:	MEBOL_006458

CFUS:

CYFUS_005391

AAGG:

ETAA8_48610(preA)

LPAV:

PLANPX_2064

AMUC:

Pan181_21750(preA)

PND:	Pla175_14190(preA)

CACI:

CLOAM1631

» show all

Reference

PMID:8083224

Authors

Yokota H, Fernandez-Salguero P, Furuya H, Lin K, McBride OW, Podschun B, Schnackerz KD, Gonzalez FJ

Title

cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

Journal

J Biol Chem 269:23192-6 (1994)

Sequence

[hsa:1806] [ssc:397109]

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