Entry
Symbol
cobL-cbiET
Name
Pathway
Module
M00924 Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
M00925 Cobalamin biosynthesis, aerobic, uroporphyrinogen III => precorrin 2 => cobyrinate a,c-diamide
Reaction
R05149 S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)
R07774 S-adenosyl-L-methionine:cobalt-precorrin-6B C15-methyltransferase (C12-decarboxylating)
R07775 S-adenosyl-L-methionine:cobalt-precorrin-7 C5-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
K00595 cobL-cbiET; precorrin-6B C5,15-methyltransferase / cobalt-precorrin-6B C5,C15-methyltransferase
Enzymes [BR:ko01000 ]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)
K00595 cobL-cbiET; precorrin-6B C5,15-methyltransferase / cobalt-precorrin-6B C5,C15-methyltransferase
2.1.1.196 cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
K00595 cobL-cbiET; precorrin-6B C5,15-methyltransferase / cobalt-precorrin-6B C5,C15-methyltransferase
2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase
K00595 cobL-cbiET; precorrin-6B C5,15-methyltransferase / cobalt-precorrin-6B C5,C15-methyltransferase
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Reference
Authors
Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J
Title
Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product.
Journal
Sequence
Reference
Authors
Raux E, Lanois A, Warren MJ, Rambach A, Thermes C
Title
Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon.
Journal
Sequence
LinkDB
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