KEGG   ORTHOLOGY: K01442
Entry
K01442                      KO                                     
Symbol
cbh, bsh
Name
choloylglycine hydrolase [EC:3.5.1.24]
Pathway
map00120  Primary bile acid biosynthesis
map00121  Secondary bile acid biosynthesis
map01100  Metabolic pathways
Reaction
R02797  taurocholate amidohydrolase
R03975  glycochenodeoxycholate amidohydrolase
R03977  chenodeoxycholoyltaurine amidohydrolase
R04486  glycodeoxycholate amidohydrolase
R04487  taurodeoxycholate amidohydrolase
R05835  glycocholate amidohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K01442  cbh, bsh; choloylglycine hydrolase
   00121 Secondary bile acid biosynthesis
    K01442  cbh, bsh; choloylglycine hydrolase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01442  cbh, bsh; choloylglycine hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.24  choloylglycine hydrolase
     K01442  cbh, bsh; choloylglycine hydrolase
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C59
   K01442  cbh, bsh; choloylglycine hydrolase
Other DBs
COG: COG3049
GO: 0045302
Genes
EUN: UMNK88_pK8826
ECY: ECSE_P3-0046
END: A4308_12525
ADP: NCTC12871_00060(cbh)
LYA: RDV84_21905
VHA: VIBHAR_02193
VCA: M892_02375
VHR: AL538_01075
VOW: A9237_00885
VRO: BSZ04_16345
VSC: VSVS12_01375
VSH: BSZ05_14500
VAF: D1115_07550
VFI: VF_A0241
VFM: VFMJ11_A0276
PDS: CAY62_18360
PPIL: ACJZU6_07785
ACOI: NQU59_15035
ACOT: QLH32_00745
SHL: Shal_0591
SWD: Swoo_2365
SKH: STH12_02744
SSPA: K0I31_16580
SHNS: K0J45_16390
SRHS: K0I63_16515
THAP: FNC98_05995
PSRR: ELR70_16715
HJA: BST95_01440
LOK: Loa_02519
LIB: E4T55_08905
LSS: NCTC12082_00361(yxeI)
LADL: NCTC12735_00521(yxeI)
HTR: EPV75_08300
HMAR: HVMH_1071
THIO: AYJ59_05605
TSY: THSYN_15570
HCS: FF32_04300
HAG: BB497_10035
HBP: HPTD01_1484
HALK: CUU95_07905
NBA: CUN60_05670
BUR: Bcep18194_B0916
BAEN: L3V59_24300
PEW: KZJ38_25220
PTRP: DCO17_08270
PANI: DCO16_10975
PPAL: AOC06_07615
PYT: PKF023_07140
PIU: AOC20_07735
POLK: PKF022_07060
POLT: TUM22923_17940(pacB)
AAQU: D3M96_12145
PHN: PAEH1_09890
BOZ: DBV39_15650
ODH: DHf2319_01470
PUD: G9Q38_03850
CKE: B5M06_12040
KMN: HW532_10045
KAI: K32_37770 K32_46880
BME: BMEI0543
BMEL: DK63_882
BMI: BMEA_A1518
BMZ: BM28_A1479
BMG: BM590_A1467
BMW: BMNI_I1418
BMEE: DK62_2064
BMF: BAB1_1488
BMB: BruAb1_1463
BMC: BAbS19_I13900
BAA: BAA13334_I01625
BABO: DK55_1449
BABR: DO74_441
BABT: DK49_1206
BABB: DK48_671
BABU: DK53_1432
BABS: DK51_27
BABC: DO78_1353
BMS: BR1468
BSI: BS1330_I1462
BSF: BSS2_I1426
BSUI: BSSP1_I1486
BSUP: BSPT1_I1500
BSUV: BSPT2_I1483
BSUC: BSSP2_I1489
BMT: BSUIS_A1521
BSZ: DK67_843
BSV: BSVBI22_A1462
BSW: IY71_07215
BSG: IY72_06965
BOV: BOV_1422
BCS: BCAN_A1503
BSK: BCA52141_I2834
BOL: BCOUA_I1468
BCAR: DK60_1494
BCAS: DA85_07030
BMR: BMI_I1480
BCET: V910_100537
BVL: BF3285c1_0073
BIO: BR141012304_11248
BPP: BPI_I1520
BPV: DK65_2014
BRU: BFS01_07065
BRJ: BKD03_14560
OIN: IAR37_14585
OAN: Oant_1703
OAH: DR92_1186
OPS: A8A54_06885 A8A54_20325
BPSN: NIK97_15790
BRUC: LJ361_17790
BRUB: GRI33_06955
OCR: HGK82_07795
OCL: GTN27_08150
OCC: KMS41_07280
OCH: CES85_1617
PSCQ: KHQ08_06870
PSXF: LDL70_04895
BRAI: FJV43_04825
STAR: G3545_07605
ANC: GBB76_05275
APRA: G3A50_02730 G3A50_18980
AQI: J5J86_09575
MSL: Msil_3557
MTUN: MTUNDRAET4_3160
MLG: CWB41_15845
MEDK: QEV83_09915
MPOL: RZS28_07385
BBAI: CU048_10220
HYPH: HNF_1130
MCG: GL4_0503
METG: HT051_01810 HT051_01815 HT051_02635
BLAG: BLTE_23450(cbaH)
MHEY: H2LOC_004005
MECQ: MSC49_06630
MSPR: MSP5_002702
MYSS: Ms3S1_32950
MEY: TM49_03610 TM49_20510
MAAD: AZF01_03040 AZF01_05250 AZF01_16710
MMED: Mame_02037(cbh_1) Mame_02196(cbh_2)
MLUT: JET14_06540 JET14_18915
PSIN: CAK95_26095
NOH: G5V57_14685
PSF: PSE_3526
SIW: GH266_09320
ACUT: MRB58_00230
MANH: LA6_002328(cbh)
HCL: NCTC13205_00078(cbh)
SPAL: FM071_02045
SMAX: FJR03_00115
NSA: Nitsa_1273
SUN: SUN_1118 SUN_2455
DMA: DMR_42620
DCB: C3Y92_01835
SOLI: ACP59X_01420 ACP59X_09525
DMS: E8L03_12800
PSEL: GM415_09795
PNW: SYK_15490
DSX: GD604_14285
DSD: GD606_11185
PBIZ: LWC08_15255
DPS: DP1182
DBK: DGMP_22020(cbaH)
DWD: DSCW_29670
DBR: Deba_2031
DMP: FAK_04230 FAK_26970
MVH: ACN6A1_09755
SNG: SNE_A17210
RUFI: K0V07_01085
RHOI: PSR62_14605
RML: FF011L_31620
ROL: CA51_28730(cbh)
RUV: EC9_31470(cbh)
GMR: GmarT_23860
GFM: Enr17x_25030(cbh)
ULI: ETAA1_63420
PCOR: KS4_01870(cbh)
SCOR: J3U87_31995
BFS: BF9343_1433(cbh)
BFB: VU15_14395 VU15_18620
BXY: BXY_10230
BOA: Bovatus_02350(cbh_2)
BCAE: A4V03_14545
BIS: DXK01_017585
BUN: Bun01g_25460
BEG: INE88_03395(cbh_1)
BSAL: K6V25_15150
BDS: ACNOGP_15990
BZA: ACNOHN_17940
BVU: BVU_2699
BSA: Bacsa_1560
BDO: EL88_06530
BDH: GV66_14440
PCOP: I6J50_16520
DYS: G7050_12935
DYH: G7051_13290
PDI: BDI_1550
PARC: CI960_12015
PGOL: K6V26_16620
PABC: NEE14_013455
BVS: BARVI_00680
COPR: Cop2CBH44_13780
CFAS: Cfast33896_08420
BVIR: I6J59_00230
BFH: F1611_13995
PCLR: PC1C4_14630
AFD: Alfi_1795
ACOU: A5CBH24_17950
ADA: A5CPEGH6_23320
AIT: AI2BBH_10610 AI2BBH_19080
ASEN: NQ519_13215
AIU: NQ491_10245
HXY: K5X82_18515
COY: HF329_17165
FLM: MY04_4579
FYA: KMW28_05260 KMW28_06095
WIN: WPG_3359
PRS: B9H02_11275
PROW: OO006_09110 OO006_09520 OO006_11220
PROI: OO005_08760 OO005_10275
PRD: F7984_02150
LMO: lmo2067
LMN: LM5578_2268
LMY: LM5923_2219
LMT: LMRG_01217
LMOC: LMOSLCC5850_2128(bsh)
LMOD: LMON_2137
LMOW: AX10_04575
LMOQ: LM6179_02838(bsh)
LMR: LMR479A_2178(cbh)
LMOM: IJ09_14875
LMF: LMOf2365_2098(cbH)
LMC: Lm4b_02088
LMOG: BN389_20960(cbh)
LMP: MUO_10605
LMOL: LMOL312_2080(bsh)
LMOJ: LM220_01025
LMOZ: LM1816_13317
LMOX: AX24_08170
LMH: LMHCC_0491
LMQ: LMM7_2157(bsh)
LML: lmo4a_2118(bsh)
LMG: LMKG_00256
LMS: LMLG_0361
LMJ: LMOG_01160
LMW: LMOSLCC2755_2129(bsh)
LMX: LMOSLCC2372_2133(bsh)
LMZ: LMOSLCC2482_2125(bsh)
LMON: LMOSLCC2376_2021(bsh)
LMOS: LMOSLCC7179_2038(bsh)
LMOO: LMOSLCC2378_2091(bsh)
LMOY: LMOSLCC2479_2130(bsh)
LMOT: LMOSLCC2540_2160(bsh)
LMOA: LMOATCC19117_2087(bsh)
LMOK: CQ02_10710
LMV: Y193_05195
LSG: lse_2056(bsh)
LIV: LIV_2050(bsh)
LII: JL52_10765
LIW: AX25_10935
LMAR: LAX80_010100(bsh)
EAUR: NMQ00_13810(bsh)
EMEX: ACNOIU_13475(bsh)
PKU: AUO94_08995
PFAE: AJGP001_08295
SPAT: A0O21_03545
SCHJ: DDV21_007255
SRUM: GPZ88_07805
SACY: O6R09_03380(bsh) O6R09_05445(bsh)
LJO: LJ_0056 LJ_1147 LJ_1412
LJF: FI9785_1052 FI9785_118(cbsHbeta) FI9785_854
LJH: LJP_0064c LJP_0828 LJP_1011c
LJN: T285_00330 T285_05035
LAC: LBA0892(bshA) LBA1078(bshB)
LAD: LA14_0914 LA14_1092
LAF: SD55_0913(bshA) SD55_1090(bshB)
LGA: LGAS_0054 LGAS_0959
LHL: LBHH_1220(cbh)
LHH: LBH_0786(cbh)
LCR: LCRIS_00906(cbh)
LAM: LA2_04690 LA2_06130
LAI: LAC30SC_04505 LAC30SC_05780
LAY: LAB52_04465 LAB52_05565
LPW: LpgJCM5343_00530 LpgJCM5343_07940 LpgJCM5343_09970
LTA: H1A07_00295
LUU: H4B44_06670
LIQ: KBW87_03680(bsh) KBW87_06820(bsh) KBW87_09595(bsh)
LPL: lp_3536(bsh1)
LPJ: JDM1_2822(bsh1)
LPT: zj316_0150(cbh)
LPS: LPST_C2886(bsh1)
LPR: LBP_cg2864
LPZ: Lp16_2762
LPB: SH83_14665
LARG: LPA65_15095
LRE: Lreu_0730
LRF: LAR_0701
LRT: LRI_1179
LRR: N134_04300
LMU: LBLM1_10135
LVA: LV515_03785
LFN: LF145_03730
LPAS: KZE55_04905(bsh)
LPOR: PRK60_04960(bsh) PRK60_07155(bsh)
LALO: ABC765_00780(bsh)
LSL: LSL_1801
LSI: HN6_01574
LSJ: LSJ_0788 LSJ_2111
LAGL: BEN83_06190
LANI: FAX13_01030
LMUR: CPS94_09990
LFD: QFX10_02840(bsh)
EFA: EF0521
EFL: EF62_0879(cbh)
EFD: EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFS: EFS1_0461
EFN: DENG_00539
EFC: EFAU004_01892(bsh)
EFAU: EFAU085_01787 EFAU085_01918
EFU: HMPREF0351_11722(cbh2) HMPREF0351_11857(cbh3)
EFM: M7W_1078 M7W_1119 M7W_1156
EFT: M395_05290
EHR: EHR_09940 EHR_11510
ECAS: ECBG_02025
EMU: EMQU_1455
EDU: LIU_08430
EGA: AL523_11285
ETH: CK496_06880
EAV: EH197_01690 EH197_17560
ELAC: I4Q40_04945
ECEC: NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
EIE: ENLAB_30050
ENI: CXM95_06650
ENQ: RBL01_004705(bsh)
VLC: G314FT_16730(cbh)
ALOY: CJ190_008655(bsh)
CML: BN424_2909(cbH)
CPE: CPE0709
CPF: CPF_0705(cbh)
CBB: CLD_2374
CBF: CLI_2250
CBM: CBF_2236
CBJ: H04402_02216
CLT: CM240_1766(cbh)
CLD: CLSPO_c22400
CNN: CNEO_1150(cbh)
CLOL: ONV75_09860(bsh)
RUC: LCN94_02585(bsh)
OHI: H8790_07320
PFAA: MM59RIKEN_19130
VFA: MM35RIKEN_11690
SVJ: NQ490_05350(bsh)
OKO: Ruko_11020(bsh)
RUK: A4V00_06830
AMUR: ADH66_02135
FWA: DCMF_14235
ELM: ELI_1322 ELI_1856
EMT: CPZ25_011475
ELIM: B2M23_16225
EVN: NQ558_04955(bsh)
BPEN: NQ488_02665(bsh)
BCRO: NQ527_08770(bsh)
RRK: H8S51_002210(bsh) H8S51_005350(bsh)
RFC: ACIRUI_15945(bsh)
BWX: NQ550_01420(bsh)
BMAS: LK422_16425(bsh)
BLUI: Blut17040_02510(bsh_1) Blut17040_34050(bsh_2)
RLR: NQ541_03745(bsh)
SCAG: ACI3DM_04520(bsh)
SCAZ: ACI3DN_05350(bsh)
WCP: H9Q76_10825
SSUN: H9Q77_06840
MFOR: NQ534_05100(bsh)
LBP: V1224_11045(bsh)
CLE: Clole_2713
CEW: EKH84_16375
EMJ: V1225_00610(bsh)
PBIF: KXZ80_01940 KXZ80_16485(bsh)
ROC: HF520_07105
RIL: CRIB_857
PHX: KGNDJEFE_01093(cbh)
IBR: NQ514_03985(bsh)
CMIU: B1H56_09150
MPEC: B9O19_00665(cbh)
PGK: M9426_09060(bsh)
AARG: Aargi30884_20240
ABSI: A9CBEGH2_18120
AMUO: KWG62_00310(bsh) KWG62_12690(bsh)
ALLO: KWG61_09625
TUR: AT726_06045 AT726_08870
TSG: HLK68_04930 HLK68_07680 HLK68_08040
TBB: J0J69_09040(bsh) J0J69_11500(bsh) J0J69_12075(bsh)
TFC: T23_03840(cbaH) T23_04480 T23_13610(cbh)
TUK: VXM77_04850 VXM77_09420(bsh) VXM77_09910(bsh)
CMIT: NQ499_05325(bsh)
MMOA: V5E84_01675(bsh)
PCAT: Pcatena_14070(yxeI)
LCAL: ATTO_06000
CAER: CSV91_00430
SHI: Shel_12270
AEQ: AEQU_1348
AHAT: ADCFC_09100 ADCFC_10310
DDT: AAY81_03275
CCHO: CCHOA_10235(cbh)
NAD: NCTC11293_00282(yxeI)
RHQ: IM25_02745
RRT: 4535765_04107(cbh)
RCR: NCTC10994_01103(cbh)
RGOR: NMQ04_17760(bsh)
RHOY: QNA09_18620(bsh)
RHPD: U9J23_19965(bsh)
RHSQ: E7742_04220
RHDM: HFP48_21720
RHRD: RDE2_40540
DIZ: CT688_16215
DPC: A6048_10685
DID: GJR88_05130
MIP: AXH82_07600
MPAL: BO218_13760
MWA: E4K62_09545
MOY: CVS54_00163(cbh)
MSF: IT882_10130
MCAW: F6J84_01105
MLZ: F6J85_09165
MICS: C1N74_13405
MPAO: IZR02_00865(bsh)
MARK: QUC20_13390(bsh)
MSUF: KV394_06010
MJI: QNO14_07130(bsh)
MWN: QNO26_07855(bsh)
MINX: MICNX66_0139(cbh)
MYL: C3E77_00485
SALD: FVA74_05805
MANT: BHD05_03695
SUBT: KPL76_07170(bsh)
AOG: LH407_09190(bsh)
AJG: KKR91_01570(bsh)
ASUN: KG104_07885(bsh)
ACAO: NF551_11050(bsh)
AZH: MUK71_06960(bsh)
AGEG: MUG94_01225(bsh)
AKO: N9A08_06495(bsh)
AZX: N2K95_14855(bsh)
AJR: N2K98_15855(bsh)
ARTA: OL239_16910(bsh)
ARTL: ArtHe_13485(bsh)
CET: B8281_01565
CCEU: CBR64_10410
CELZ: E5225_15685
CIRA: LFM56_02855(bsh)
CELC: K5O09_15170(bsh)
CDON: KKR89_01625(bsh)
CWAN: KG103_01665(bsh)
CFEN: KG102_16480(bsh)
CWN: NP075_01740(bsh)
CCHE: NP064_15205(bsh)
CXIE: NP048_01685(bsh)
CELE: P9841_15075(bsh)
OEK: FFI11_007435
GEZ: FE251_07070
PAUS: NCTC13651_02612(cbh)
NOI: FCL41_09945
NMAR: HPC71_13480
NFC: KG111_07030(bsh)
AEZ: C3E78_15230
AEF: GEV26_07670
ASEZ: H9L21_03880
ADB: NP095_03810(bsh)
AWN: NQV15_08045(bsh)
MUZ: H4N58_00060
MQR: AB3M34_11180(bsh)
ACTZ: CWT12_05480
ALIL: D5R93_00815
BLO: BL0796
BLJ: BLD_0536(cbaH)
BLN: Blon_1453
BLON: BLIJ_1499
BLF: BLIF_0937
BLL: BLJ_0948
BLB: BBMN68_536(cbaH)
BLM: BLLJ_0817
BLK: BLNIAS_01547
BLG: BIL_10200
BLZ: BLGT_05070
BLX: GS08_04925
BAD: BAD_0856
BADL: BADO_0911
BADO: BBMN23_0992
BFJ: B19861_09420(bsh)
BLA: BLA_1379
BLC: Balac_0863(bsh)
BLT: Balat_0863(bsh)
BBB: BIF_00207
BBC: BLC1_0823
BNM: BALAC2494_00268
BLV: BalV_0829(bsh)
BLW: W7Y_0865
BLS: W91_0886
BANI: BL12_04315(bsh)
BANL: BLAC_04390
BNI: BANAN_04270
BANM: EN10_04380
BDE: BDP_1106(cbh)
BDN: BBDE_1060
BBP: BBPR_0850(cbh)
BBI: BBIF_0879(cbh)
BBF: BBB_0854(cbh)
BBV: HMPREF9228_0895
BBRU: Bbr_0971(cbh)
BBRE: B12L_0890(bsh)
BBRV: B689b_0983
BBRJ: B7017_1020
BBRC: B7019_1045
BBRN: B2258_0935
BBRS: BS27_0970(cbh)
BBRD: BBBR_0919
BTP: D805_0402
BKA: AH68_05530
BKS: BBKW_0991
BCAT: BBCT_0907
BPSP: AH67_04680
BANG: BBAG_0770
BPSC: BBPC_0908
BCHO: BcFMB_07045
BFCA: BCSY61_00360(bsh)
SYNC: CB0101_03470
SYNL: KJJ24_03605
SYNO: LY254_01075
SYNU: SynWH8101_1668
FVA: FV113G1_28320 FV113G1_29080
FUL: C4N20_09600
FMO: C4N19_07925
FHO: H9Q81_02010
CSOM: MKD34_01085
MEIS: PXD04_06835(bsh)
METV: K4897_06545(bsh)
MFC: BRM9_1563
MFI: DSM1535_2252(cbh)
MCUB: MCBB_0969(cbh)
MSUB: BK009_01470
METN: BK008_09455
METO: CIT02_03540
MEUZ: KRP56_01830
 » show all
Reference
PMID:6016335
  Authors
Nair PP, Gordon M, Reback J
  Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
  Journal
J Biol Chem 242:7-11 (1967)
Reference
PMID:1476424
  Authors
Christiaens H, Leer RJ, Pouwels PH, Verstraete W
  Title
Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay.
  Journal
Appl Environ Microbiol 58:3792-8 (1992)
DOI:10.1128/AEM.58.12.3792-3798.1992
  Sequence
[lpl:lp_3536]
Reference
PMID:38326609
  Authors
Rimal B, Collins SL, Tanes CE, Rocha ER, Granda MA, Solanki S, Hoque NJ, Gentry EC, Koo I, Reilly ER, Hao F, Paudel D, Singh V, Yan T, Kim MS, Bittinger K, Zackular JP, Krausz KW, Desai D, Amin S, Coleman JP, Shah YM, Bisanz JE, Gonzalez FJ, Vanden Heuvel JP, Wu GD, Zemel BS, Dorrestein PC, Weinert EE, Patterson AD.
  Title
Bile salt hydrolase catalyses formation of amine-conjugated bile acids.
  Journal
Nature 626:859-863 (2024)
DOI:10.1038/s41586-023-06990-w
  Sequence
[blo:BL0796]
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