KEGG ORTHOLOGY: K02157

ORTHOLOGY: K02157

Entry

K02157                      KO

Symbol

AXIN1

Name

axin 1

Pathway

map04310

Wnt signaling pathway

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04934

Cushing syndrome

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

map05165

Human papillomavirus infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05213

Endometrial cancer

map05217

Basal cell carcinoma

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Disease

H00048

Hepatocellular carcinoma

H00934

Caudal duplication anomaly

H01667

Medulloblastoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02157  AXIN1; axin 1
   04390 Hippo signaling pathway
    K02157  AXIN1; axin 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02157  AXIN1; axin 1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02157  AXIN1; axin 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02157  AXIN1; axin 1
   05225 Hepatocellular carcinoma
    K02157  AXIN1; axin 1
   05226 Gastric cancer
    K02157  AXIN1; axin 1
   05217 Basal cell carcinoma
    K02157  AXIN1; axin 1
   05213 Endometrial cancer
    K02157  AXIN1; axin 1
   05224 Breast cancer
    K02157  AXIN1; axin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K02157  AXIN1; axin 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02157  AXIN1; axin 1
   05022 Pathways of neurodegeneration - multiple diseases
    K02157  AXIN1; axin 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02157  AXIN1; axin 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02157  AXIN1; axin 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02157  AXIN1; axin 1

Genes

HSA:	8312(AXIN1)

PTR:	453789(AXIN1)

PPS:	100986279(AXIN1)

GGO:	101150555(AXIN1)

PON:	100434225(AXIN1)

NLE:	101179424(AXIN1)

HMH:	116462417(AXIN1)

MCC:	100424087(AXIN1)

MCF:	102142970(AXIN1)

MTHB:

126944825

MNI:	105485918(AXIN1)

CSAB:

103225216(AXIN1)

CATY:

105574573(AXIN1)

TGE:	112613775(AXIN1)

MLEU:

105529686(AXIN1)

RRO:	104676962(AXIN1)

RBB:	108521119(AXIN1)

TFN:	117097916(AXIN1)

PTEH:

111524116(AXIN1)

CANG:

105524707(AXIN1)

CJC:	100392475(AXIN1)

SBQ:	101035780(AXIN1)

CIMI:

108290841(AXIN1)

CSYR:

103270394(AXIN1)

MMUR:

105856263(AXIN1)

LCAT:

123631377(AXIN1)

PCOQ:

105822607(AXIN1)

OGA:	100964150(AXIN1)

MMU:	12005(Axin1)

MCAL:

110284040(Axin1)

MPAH:

110338127(Axin1)

RNO:	79257(Axin1)

MCOC:

116076684(Axin1)

ANU:	117710223(Axin1)

MUN:	110548696(Axin1)

CGE:	100758169(Axin1)

MAUA:

101838080(Axin1)

PROB:

127219478(Axin1)

PLEU:

114709466(Axin1)

MORG:

121463835(Axin1)

MFOT:

126496629

AAMP:

119813237(Axin1)

NGI:	103748223(Axin1)

HGL:	101700795(Axin1)

CPOC:

100718536(Axin1)

CCAN:

109694685(Axin1)

DORD:

105982203(Axin1)

DSP:	122098148(Axin1)

PLOP:

125341178(Axin1)

NCAR:

124970513

MMMA:

107146791(Axin1)

OCU:

100348127

OPI:	101533051(AXIN1)

TUP:	102469399(AXIN1)

GVR:	103604797(AXIN1)

CFA:	490099(AXIN1)

CLUD:

112640639(AXIN1)

VVP:	112909128(AXIN1)

VLG:	121486746(AXIN1)

NPO:	129519365(AXIN1)

AML:	100473018(AXIN1)

UMR:	103668450(AXIN1)

UAH:	113245367(AXIN1)

UAR:	123783241(AXIN1)

ELK:

111156118

LLV:

125090605

MPUF:

101671201(AXIN1)

MNP:	132027097(AXIN1)

MLK:	131820017(AXIN1)

NVS:	122896100(AXIN1)

ORO:	101375084(AXIN1)

EJU:	114215556(AXIN1)

ZCA:	113932986(AXIN1)

MLX:	118021650(AXIN1)

NSU:	110587966(AXIN1)

LWW:	102732857(AXIN1)

FCA:	101088804(AXIN1)

PYU:	121019790(AXIN1)

PCOO:

112860062(AXIN1)

PBG:	122471934(AXIN1)

PVIV:

125154035(AXIN1)

LRUF:

124525491

PTG:	102951323(AXIN1)

PPAD:

109259643(AXIN1)

PUC:

125928387

AJU:

106977359

HHV:	120225169(AXIN1)

BTA:	504357(AXIN1)

BOM:	102267637(AXIN1)

BIU:	109578518(AXIN1)

BBUB:

102394098(AXIN1)

BBIS:

104989351(AXIN1)

CHX:	102170375(AXIN1)

OAS:	101122656(AXIN1)

BTAX:

128061865(AXIN1)

ODA:	120854912(AXIN1)

CCAD:

122433487(AXIN1)

MBEZ:

129545182(AXIN1)

SSC:	100523725(AXIN1)

CFR:	102508916(AXIN1)

CBAI:

105065738(AXIN1)

CDK:	105098424(AXIN1)

VPC:	102533258(AXIN1)

BACU:

103006014(AXIN1)

BMUS:

118881169(AXIN1)

LVE:	103085333(AXIN1)

OOR:	101272348(AXIN1)

DLE:	111185093(AXIN1)

PCAD:

102986270(AXIN1)

PSIU:

116739932(AXIN1)

NASI:

112409352(AXIN1)

ECB:	100065116(AXIN1)

EPZ:	103564115(AXIN1)

EAI:	106836161(AXIN1)

MYB:	102248340(AXIN1)

MYD:	102759594(AXIN1)

MMYO:

118652848(AXIN1) 118654322

MLF:	102421524(AXIN1)

PKL:	118731609(AXIN1)

EFUS:

103300773(AXIN1)

MNA:	107539654(AXIN1)

DRO:	112298256(AXIN1)

SHON:

118978824(AXIN1)

AJM:	119058201(AXIN1)

PDIC:

114496332(AXIN1)

PHAS:

123825603(AXIN1)

MMF:	118641544(AXIN1)

PPAM:

129081256(AXIN1)

HAI:	109385980(AXIN1)

RFQ:	117019614(AXIN1)

PALE:

102878657(AXIN1)

PGIG:

120620161(AXIN1)

PVP:	105303252(AXIN1)

RAY:	107506131(AXIN1)

MJV:	108408106(AXIN1)

TOD:	119242068(AXIN1)

SARA:

101552077(AXIN1)

SETR:

126000852(AXIN1)

LAV:	100655765(AXIN1)

TMU:

101346985

ETF:	101647742(AXIN1)

DNM:	101411463(AXIN1)

MDO:	100016298(AXIN1)

GAS:	123231357(AXIN1)

SHR:	100923576(AXIN1)

AFZ:

127542931

PCW:	110221974(AXIN1)

OAA:	100093450(AXIN1)

GGA:	395786(AXIN1)

PCOC:

116230227(AXIN1)

MGP:	100539162(AXIN1)

CJO:	107320950(AXIN1)

TPAI:

128079319(AXIN1)

LMUT:

125700696(AXIN1)

NMEL:

110405669(AXIN1)

APLA:

101800899(AXIN1)

ACYG:

106033419(AXIN1)

CATA:

118249207(AXIN1)

AFUL:

116495477(AXIN1)

TGU:	100226467(AXIN1)

LSR:	110480560(AXIN1)

SCAN:

103817752(AXIN1)

PMOA:

120513037(AXIN1)

OTC:	121334495(AXIN1)

PRUF:

121350800(AXIN1)

GFR:	102034015(AXIN1)

FAB:	101812314(AXIN1)

OMA:	130259001(AXIN1)

PHI:	102108019(AXIN1)

PMAJ:

107211202(AXIN1)

CCAE:

111935875(AXIN1)

CCW:	104684681(AXIN1)

CBRC:

103620477(AXIN1)

ETL:	114057037(AXIN1)

ZAB:	102063258(AXIN1)

ACHL:

103798351

SVG:	106862122(AXIN1)

MMEA:

130577195(AXIN1)

HRT:	120759494(AXIN1)

FPG:	101924311(AXIN1)

FCH:	102054847(AXIN1)

CLV:	102091034(AXIN1)

EGZ:	104135741(AXIN1)

NNI:	104023427(AXIN1)

PCRI:

104033951(AXIN1)

PLET:

104627631

PCAO:

104050220(AXIN1)

ACUN:

113485942(AXIN1)

TALA:

104359668(AXIN1)

PADL:

103917539(AXIN1)

AFOR:

103897631(AXIN1)

ACHC:

115335763(AXIN1)

HALD:

104314355

HLE:	104838585(AXIN1)

AGEN:

126034012

GCL:

127022370

CCRI:

104165989(AXIN1)

CMAC:

104482387

MUI:

104536562

FGA:	104077355(AXIN1)

GSTE:

104265102

LDI:	104342410(AXIN1)

MNB:

103778308

OHA:	104330977(AXIN1)

NNT:	104404030(AXIN1)

SHAB:

115606478(AXIN1)

DPUB:

104306909(AXIN1)

PGUU:

104463659(AXIN1)

ACAR:

104520951(AXIN1)

CPEA:

104386820(AXIN1)

AVIT:

104276134

CVF:	104283711(AXIN1)

RTD:	128913579(AXIN1)

CUCA:

104066414(AXIN1)

TEO:	104376288(AXIN1)

BRHI:

104502151

AAM:	106482339(AXIN1)

AROW:

112973112(AXIN1)

NPD:	112955711(AXIN1)

TGT:	104578614(AXIN1)

DNE:	112987725(AXIN1)

SCAM:

104143899(AXIN1)

ASN:	102383198(AXIN1)

AMJ:	102566966(AXIN1)

CPOO:

109313475(AXIN1)

GGN:	109290681(AXIN1)

PSS:	102453080(AXIN1)

CMY:	102945350(AXIN1)

CCAY:

125643407(AXIN1)

DCC:	119862222(AXIN1)

CPIC:

101932057(AXIN1)

TST:	117883604(AXIN1)

CABI:

116825505(AXIN1)

MRV:	120373560(AXIN1)

ACS:	100561864(axin1)

ASAO:

132782041(AXIN1)

PVT:

110089118

SUND:

121914485(AXIN1)

PBI:	103053070(AXIN1)

PMUR:

107283957

CTIG:

120315608(AXIN1)

TSR:	106551582(AXIN1)

PGUT:

117679434(AXIN1)

APRI:

131185141(AXIN1)

PTEX:

113438913(AXIN1)

NSS:	113422418(AXIN1)

VKO:	123025077(AXIN1)

PMUA:

114583932(AXIN1)

PRAF:

128401420(AXIN1)

ZVI:	118093005(AXIN1)

HCG:	128336705(AXIN1)

GJA:	107109315(AXIN1)

STOW:

125431598(AXIN1)

EMC:	129338811(AXIN1)

XLA:	398097(axin1.L) 734298(axin1.S)

XTR:	100498631(axin1)

NPR:	108796271(AXIN1)

RTEM:

120943196(AXIN1)

BBUF:

121008143(AXIN1)

BGAR:

122945177(AXIN1)

MUO:	115476252(AXIN1)

GSH:	117345582(AXIN1)

DRE:	57931(axin1)

SRX:	107727128 107745589 107758382

SANH:

107662718 107674664 107703383

SGH:	107564695 107568923 107575039

CCAR:

109047174 109096359 109110185

CAUA:

113039572 113049900(axin1) 113071533 113092146

CGIB:

127952236 127952387

PTET:

122341605(axin1)

LROH:

127162714(axin1)

OMC:	131536425(axin1)

PPRM:

120489386(axin1)

RKG:	130071028(axin1)

MAMB:

125269928(axin1)

CIDE:

127509733

MASI:

127450669 127451857

TROS:

130561377(axin1)

TDW:	130426130(axin1)

MANU:

129432060(axin1)

IPU:

108257243

IFU:	128600388(axin1) 128601849

PHYP:

113536021(axin1)

SMEO:

124375951(axin1) 124377848

TFD:	113658465 113660389(axin1) 125139376

TVC:	132837648(axin1) 132839693

AMEX:

103030717 103045152(axin1)

CMAO:

118798353 118805746(axin1)

EEE:	113570287(axin1) 113591421

CHAR:

105890806(axin1) 105893690

TRU:	101065196(axin1) 101075840

TFS:	130514972(axin1) 130526812

TNG:	GSTEN00015703G001 GSTEN00034436G001

LCO:	104918719(axin1) 104921153

NCC:

104952093

TBEN:

117481688 117492071(axin1)

CGOB:

115012822(axin1) 115025778

PGEO:

117449728 117451442(axin1)

GACU:

117533835 117548757(axin1)

EMAC:

134864080 134878552(axin1)

ELY:	117255476 117269001(axin1)

EFO:	125879444(axin1) 125885675

PLEP:

121941928 121956692(axin1)

SLUC:

116042628 116059510(axin1)

ECRA:

117956464 117958153(axin1)

ESP:	116697227 116702973(axin1)

PFLV:

114562602 114569895(axin1)

GAT:	120825280 120827628(axin1)

PPUG:

119217885 119220694(axin1)

AFB:	129095484 129098717(axin1)

CLUM:

117735078(axin1) 117737146

PSWI:

130188474(axin1) 130190359

MSAM:

119891839(axin1) 119898684

SCHU:

122868913(axin1) 122873422

CUD:	121503385(axin1) 121508151

ALAT:

119014393(axin1) 119017075

MZE:	101472703 101487168(axin1)

ONL:	100695880 100697931

OAU:	116318411(axin1) 116329980

OLA:	101155494 101155852(axin1)

OML:	112137206 112146794(axin1)

CSAI:

133422686(axin1) 133442184

XMA:	102228925 102232266(axin1)

XCO:	114144827 114160292(axin1)

XHE:	116720637 116735811(axin1)

PRET:

103456513 103468679(axin1)

PFOR:

103136433 103143797(axin1)

PLAI:

106959222 106962176(axin1)

PMEI:

106928869 106933568(axin1)

GAF:	122821495(axin1) 122830364

PPRL:

129352559(axin1) 129376858

CVG:	107092806(axin1) 107097051

CTUL:

119778836(axin1) 119784694

GMU:	124862968 124864934 124868576

NFU:	107378411(axin1) 107395828

KMR:	108241749 108243734(axin1)

ALIM:

106522717 106528550(axin1)

NWH:

119422433

AOCE:

111576703(axin1) 111587652

MCEP:

124998384(axin1) 125004408

CSEM:

103383461 103392632(axin1)

POV:	109634337(axin1) 109639592

SSEN:

122770864 122785330(axin1)

HHIP:

117766555(axin1) 117770259

HSP:	118121858 118123910(axin1)

SMAU:

118289216(axin1) 118312550

LCF:	108901170 108903015

SDU:	111216635 111217642(axin1)

SLAL:

111651284 111660637(axin1)

XGL:	120788410(axin1) 120800151

HCQ:	109511398 109513801(axin1)

SSCV:

125968987 125984017

SBIA:

133505984 133514825(axin1)

PEE:	133404379 133414991(axin1)

PTAO:

133466539(axin1) 133476750

BPEC:

110157754 110168848

MALB:

109965916(axin1) 109973291

BSPL:

114856124 114860052(axin1)

SJO:	128374653 128379590(axin1)

SASA:

106593205 106595544 106601114 106607340

STRU:

115171165 115178127 115184100 115198550

OTW:	112226036 112246035 121845001

OMY:	110485340 110486310 110512102 110538248

OGO:	123999048 124015509 124018420

ONE:	115104176 115110322

OKI:	109885463 109893373 109898453

OKE:	118365307(axin1) 118365311

SALP:

111980490 111980587

SNH:	120033907 120036447 120037216 120040475

CCLU:

121550638 121550725 121581030

ELS:	105013228(axin1) 105030252

SFM:	108927488 108929577

PKI:	111836909 111845554

AANG:

118220949(axin1)

LOC:	102695606(axin1)

PSPA:

121300589 121330874

ARUT:

117418194 117962440

PSEX:

120543368(axin1)

LCM:	102351869(AXIN1)

CMK:	103188268(axin1)

CPLA:

122560823(axin1)

HOC:	132825356(axin1)

LERI:

129706996(axin1)

PMRN:

116946113 116949690(AXIN1) 116952891 116955145

LRJ:	133345529 133353465 133358667 133358672

BFO:

118429299

BBEL:

109481533

CIN:	778548(axin)

SCLV:

SPU:

LPIC:

APLC:

SKO:	100303567(axin1)

DME:	Dmel_CG7926(Axn)

DER:

6554369

DSE:

6612800

DSI:	Dsimw501_GD21494(Dsim_Axn)

DYA:	Dyak_GE10849

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24204

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ001221

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105557855 105563303 105567083

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	655873(Axn)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210820

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	129000789 129005001

PHU:	Phum_PHUM327400

FOC:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_301655

DMK:	116931944 123467045

DPZ:

124349462

PVM:	113802786 113809792

PJA:

PCHN:

EAF:

LSM:

PPOI:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106461765 106463132 106475618

CEL:	CELE_C37A5.9(pry-1)

CBR:	CBG_18802(Cbr-pry-1)

CRQ:	GCK72_001754

NAI:	NECAME_03426

BMY:	BM_BM2642(Bma-pry-1) BM_BM4751(Bma-axl-1)

LOA:	LOAG_02197 LOAG_09731

TSP:

PVUL:

PCAN:

GAE:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_166200 Smp_171750

OVI:	T265_07915 T265_14407

EGL:	EGR_02768 EGR_07621

NVE:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_53011

» show all

Reference

PMID:9230313

Authors

Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F

Title

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

Journal

Cell 90:181-92 (1997)
DOI:10.1016/S0092-8674(00)80324-4

Sequence

[hsa:8312]

Reference

PMID:15067197

Authors

Luo W, Lin SC

Title

Axin: a master scaffold for multiple signaling pathways.

Journal

Neurosignals 13:99-113 (2004)
DOI:10.1159/000076563

Reference

PMID:10457025

Authors

Willert K, Logan CY, Arora A, Fish M, Nusse R

Title

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.

Journal

Development 126:4165-73 (1999)

Sequence

[dme:Dmel_CG7926]

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