KEGG ORTHOLOGY: K03878

ORTHOLOGY: K03878

Entry

K03878                      KO

Symbol

ND1

Name

NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04714

Thermogenesis

map04723

Retrograde endocannabinoid signaling

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00142

NADH:ubiquinone oxidoreductase, mitochondria

Reaction

R11945

NADH:ubiquinone oxidoreductase

Disease

H00068

Leber hereditary optic atrophy

H00473

Mitochondrial complex I deficiency

H01347

MELAS syndrome

H01365

Leber hereditary optic neuropathy and dystonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
   05012 Parkinson disease
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
   05014 Amyotrophic lateral sclerosis
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
   05016 Huntington disease
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
   05020 Prion disease
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
   05022 Pathways of neurodegeneration - multiple diseases
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
Enzymes [BR:ko01000]
7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.2  NADH:ubiquinone reductase (H+-translocating)
     K03878  ND1; NADH-ubiquinone oxidoreductase chain 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Mitochondrial respiratory chain complex I
    K03878  ND1; NADH-ubiquinone oxidoreductase chain 1

Other DBs

GO:

0008137

TC:

3.D.1.6

Genes

HSA:

4535(ND1)

PTR:	807867(ND1)

PPS:	807884(ND1)

GGO:	6742683(ND1)

PON:	808473(ND1)

NLE:	16545241(ND1)

MCC:	2846627(ND1)

MCF:	7857751(ND1)

CSAB:

4097488(ND1)

CATY:

26408639(ND1)

PANU:

14444642(ND1)

TGE:	14216794(ND1)

RRO:	4171534(ND1)

RBB:	10549380(ND1)

TFN:	18985085(ND1)

CJC:	22203913(ND1)

SBQ:	13228911(ND1)

CSYR:

7944474(ND1)

MMUR:

26823996(ND1)

LCAT:

68929174(ND1)

PCOQ:

6458118(ND1)

MMU:	17716(ND1)

MCAL:

20832255(ND1)

MPAH:

36165356(ND1)

RNO:	26193(ND1)

MCOC:

34682989(ND1)

MUN:	18129817(ND1)

CGE:	3979183(ND1)

MAUA:

8457936(ND1)

PROB:

30213863(BOP69_gp13)

PLEU:

36275544(ND1)

NGI:	15088436(ND1)

HGL:	10201222(ND1)

CPOC:

808631(ND1)

CCAN:

31082893(ND1)

OCU:	808226(ND1)

OPI:	2717280(ND1)

GVR:	804978(ND1)

CFA:	804476(ND1)

VVP:	4355757(ND1)

VLG:	23629759(ND1)

NPO:	8690253(ND1)

AML:	5179729(ND1)

UMR:	804861(ND1)

UAR:	804833(ND1)

LLV:	71922402(ND1)

MNP:	20466151(ND1)

NVS:	14841852(ND1)

EJU:	805015(ND1)

ZCA:	4355794(ND1)

MLX:	4355870(ND1)

LWW:	4355832(ND1)

FCA:	807939(ND1)

PYU:	26129864(ND1)

PCOO:

11473378(ND1)

PBG:	26129484(ND1)

PVIV:

26129636(ND1)

PPAD:

6262379(ND1)

PUC:	6262408(ND1)

AJU:	2654018(ND1)

HHV:	14842168(ND1)

BTA:	3283877(ND1)

BOM:	22161779(ND1)

BIU:	2885975(ND1)

BBUB:

56055846(ND1)

CHX:	1485856(ND1)

OAS:	808249(ND1)

BTAX:

8250974(ND1)

ODA:	11452038(ND1)

CCAD:

59433129(ND1)

MBEZ:

7872555(ND1)

SSC:	808501(ND1)

CFR:	5326219(ND1)

CBAI:

5309946(ND1)

CDK:	5618953(ND1)

VPC:	809425(ND1)

BMUS:

807743(ND1)

LVE:	3802087(ND1)

OOR:	72909410(ND1)

DLE:	31412977(ND1)

PCAD:

809418(ND1)

ECB:	807846(ND1)

EPZ:	19019447(ND1)

EAI:	808061(ND1)

MYB:	20964692(ND1)

MYD:	22203923(ND1)

MMYO:

26889517(ND1)

MLF:	27214809(ND1)

DRO:	17046640(ND1)

AJM:	808336(ND1)

HAI:	13539878(ND1)

PALE:

17963481(ND1)

RAY:	3666157(ND1)

MJV:	24019682(ND1)

TOD:	38289010(D9W85_mgp13)

LAV:	808794(ND1)

ETF:	802330(ND1)

DNM:	808126(ND1)

MDO:	3074661(ND1)

GAS:	63652827(ND1)

SHR:	13826446(ND1)

AFZ:	65342071(ND1)

PCW:	4108302(ND1)

OAA:	808708(ND1)

GGA:	39116926(ND1)

PCOC:

10609909(ND1)

MGP:	5848011(ND1)

CJO:	804668(ND1)

LMUT:

31079457(ND1)

NMEL:

32282781(ND1)

APLA:

5405817(ND1)

CATA:

7996697(ND1)

AFUL:

19909408(ND1)

TGU:	3950790(ND1)

SCAN:

37275780(ND1)

PMOA:

20355709(ND1)

OTC:	22548471(ND1)

PRUF:

17674390(ND1)

FAB:	16027862(ND1)

PHI:	9481005(ND1)

PMAJ:

39089575(ND1)

CCW:	71712370(ND1)

MMEA:

130587653 20357145(ND1)

FPG:	808589(ND1)

FCH:	23808611(ND1)

CLV:	8890008(ND1)

EGZ:	18985247(ND1)

NNI:	4108698(ND1)

PADL:

26737698(ND1)

AGEN:

7256443(ND1)

GSTE:

3416060(ND1)

RTD:	84348643(ND1)

AROW:

62676585(ND1)

NPD:	62676474(ND1)

DNE:	803255(ND1)

ASN:	806142(ND1)

AMJ:	808237(ND1)

CPOO:

4108090(ND1)

GGN:	4178388(ND1)

PSS:	2943117(ND1)

CMY:	808642(ND1)

CCAY:

11747776(ND1)

CPIC:

18983007(ND1)

CABI:

60253682(ND1)

ACS:	6385981(ND1)

PVT:	3338357(ND1)

PBI:	YP_008083599

PMUR:

15822643(ND1)

PMUA:

7056473(ND1)

ZVI:	24146092(YC27_gp13)

GJA:	26044419(ND1)

EMC:	30861809(ND1)

XLA:	2642086(ND1)

XTR:	3283492(ND1)

NPR:	24020224(ND1)

BGAR:

4356060(ND1)

MUO:	18490108(ND1)

GSH:	14469882(ND1)

DRE:	140531(ND1)

SRX:	24419169(ND1)

SANH:

24419957(ND1)

SGH:	8382175(ND1)

CCAR:

807764(ND1)

CGIB:

9222077(ND1)

PTET:

5787383(ND1)

LROH:

12079590(ND1)

OMC:	18668130(ND1)

PPRM:

26048334(ND1)

MAMB:

5912302(ND1)

CIDE:

5857715(ND1)

MASI:

3131142(ND1)

TROS:

14048448(ND1)

TDW:	36952182(ND1)

MANU:

6879722(ND1)

IPU:	804880(ND1)

IFU:	26118477(ND1)

PHYP:

16216580(ND1)

SMEO:

10079910(ND1)

TVC:	10079799(ND1) 132858793

CHAR:

5228442(ND1)

TRU:	805222(ND1)

TFS:	19524531(ND1)

TNG:	BAE79217(ND1)

LCO:	7095394(ND1)

NCC:	10752035(ND1)

PGEO:

67284283(ND1)

EMAC:

30862027(ND1)

ELY:	7095516(ND1)

EFO:	14412340(ND1)

PLEP:

4363295(ND1)

SLUC:

23629815(ND1)

ESP:	40141426(ND1)

PFLV:

14048206(ND1)

PPUG:

119199125 7042826(ND1)

AFB:	13230441(ND1)

PSWI:

72130153(ND1)

MSAM:

4100035(ND1)

SCHU:

10965121(ND1)

CUD:	8774884(ND1)

MZE:	26037634(APK84_gp13)

ONL:	8677324(ND1)

OAU:	8745952(ND1)

OLA:	805441(ND1)

OML:	13540120(ND1)

CSAI:

804095(ND1)

XMA:	6986203(ND1)

XCO:	26048182(ND1)

XHE:	8302520(ND1)

PRET:

19590702(ND1)

GAF:	805456(ND1)

CVG:	26048372(ND1)

CTUL:

26129142(ND1)

NFU:	7256390(ND1)

KMR:	804473(ND1)

AOCE:

4850676(ND1)

CSEM:

7996493(ND1)

POV:	808850(ND1)

SSEN:

4266845(ND1)

HHIP:

5405703(ND1)

HSP:	5405777(ND1)

SMAU:

8382072(ND1)

LCF:	3703587(ND1)

SDU:	11669686(ND1)

XGL:	7871594(ND1)

HCQ:	14658023(ND1)

SSCV:

125966268

SBIA:

35996578(ND1)

PTAO:

74193740(ND1)

BPEC:

YP_004935131.1

MALB:

803935(ND1)

BSPL:

23631943(ND1)

SJO:	8703813(ND1)

SASA:

808311(ND1)

STRU:

19099188(ND1)

OTW:	KEF73_p13(ND1)

OMY:	807982(ND1)

OGO:	6383214(ND1)

ONE:	4555718(ND1)

OKI:	4955078(ND1)

OKE:	12486859(ND1)

SALP:

808544(ND1)

SNH:	35115211(ND1)

CCLU:

14842644(ND1)

ELS:	806647(ND1)

SFM:	3416104(ND1)

AANG:

3190265(ND1)

LOC:	807198(ND1)

PSPA:

805407(ND1)

ARUT:

17097831(ND1)

LCM:	808083(ND1)

CMK:	9385357(ND1)

RTP:	18267189(ND1)

CPLA:

7768754(ND1)

LERI:

11452178(ND1)

PMRN:

807812(ND1)

LRJ:	9385087(ND1)

BFO:	808737(ND1)

BBEL:

806242(ND1)

SCLV:

36165640(ND1)

SPU:	2652716(ND1)

APLC:

3907679(ND1)

SKO:	3703613(ND1)

DME:	Dmel_CG34092(ND1)

DER:

113564595

DSE:	2760947(ND1)

DSI:

ND1

DYA:

ND1

DAN:	116655729 26515294

DGR:

116806146

CCAT:

808526(ND1)

BOD:	2717263(ND1)

BDR:	4657581(ND1)

AOQ:	79023100(ND1)

TDA:

119665298

MDE:	20358598(ND1)

LSQ:	5469270(ND1)

ECOE:

35199162(ND1)

HIS:	33350942(ND1)

ACOZ:

26121334(ND1)

AARA:

26121220(ND1)

AMER:

26121524(ND1)

AFUN:

76054184(ND1)

AMOU:

73620868(ND1)

AAG:	33307571(ND1)

AALB:

3260128(ND1)

CQU:

ND1

CPII:

10200339(ND1)

BCOO:

119082522

ACER:

9385649(ND1)

ALAB:

34829171(ND1)

AFLR:

15822494(ND1)

BAFF:

126928013 126928669

SOC:	9977800(ND1)

VEM:	27912165(ND1)

CFO:

109610427

LHU:	42265456(ND1)

PGC:

109862627

TPRE:

111693311

LBD:

127290340

AGIF:

63649842(ND1)

CCIN:

107274032 7872303(ND1)

AROA:

112694907

TCA:	803824(ND1)

SOY:	28481415(ND1)

ATD:	34926375(ND1)

AGB:	4171595(ND1)

APLN:

28479658(ND1)

OTU:

111425784

BMOR:

809263(ND1)

BMAN:

804653(ND1)

MSEX:

5848758(ND1)

DPL:	AGL76310(ND1)

BANY:

128199783

PMAC:

106711773 13080339(ND1)

PPOT:

106103434 106106472 106110406 20159557(ND1)

PXU:	106116406 26836895(ND1)

PRAP:

11030472(ND1)

PNAP:

60241357(ND1)

LSIN:

126969268

HAW:	9977723(ND1)

HZE:	124645586 124645589 71203150(ND1)

TNL:	44149132(ND1)

SLIU:

17427405(ND1)

PXY:	20834457(ND1)

PGW:	73956692(ND1)

API:	7055886(ND1)

DNX:	17428420(ND1)

AGS:	19909111(ND1)

BTAB:

109035889 109040671 3077225(ND1)

DCI:	113467916 27914382(ND1)

CLEC:

27787568(ND1)

HHAL:

106685853 8457893(ND1)

NLU:	16216537(ND1)

HVI:	3332274(ND1)

MQU:	32891633(ND1)

FOC:	YP_006576363

TPAL:

38092123(ND1)

ZNE:	20004821(ND1)

SGRE:

73491817(ND1)

DPX:	AAD33242(ND1)

DMK:	24147219(ND1)

DPZ:

124311800

PVM:	113820286 5333210(ND1)

PJA:	3416046(ND1)

PCHN:

5333406(ND1)

PMOO:

808981(ND1)

HAME:

10743682(ND1) 121861319 121871283

PCLA:

11763616(ND1)

CQD:	17728541(ND1)

PTRU:

1482828(ND1)

ESN:	126986713 3355539(ND1)

MNZ:

135223734

HAZT:

38169087(ND1)

EAF:	54124853(ND1)

TCF:	4788311(ND1)

DSV:	23630423(ND1)

RSAN:

808372(ND1)

RMP:	18250941(ND1)

VDE:	806163(ND1)

VJA:

111273417

TUT:	6164207(ND1)

DPTE:

7564650(ND1)

LPOL:

106462800 803780(ND1)

CEL:	KEF34_p10(ND1)

CBR:

ND1

NAI:	804826(ND1)

BMY:	KEF88_p05(ND1)

LOA:

ND1

TSP:

ND1

HRO:	HELRODRAFT_92831

PCAN:

19909181(ND1)

BGT:	2746312(ND1)

HRF:	35985161(ND1)

HRJ:	2846696(ND1)

CRG:	808836(ND1)

CANU:

7865916(ND1)

MYI:	4910437(ND1)

PMAX:

117319647 117319648

MMER:

55289766(ND1)

RPHI:

29141325(ND1)

OBI:	27205972(ND1)

OSN:	62676641(ND1)

LAK:	C2G87_mgp06(ND1)

SMM:

ND1

SHX:	4097440(ND1)

EGL:	41697853(nad1)

ATEN:

41854778(ND1)

ADF:	17674599(ND1)

PDAM:

5580403(ND1)

SPIS:

6798792(ND1)

DGT:	8656266(ND1)

HMG:	6904241(ND1)

HSY:	130628201 130628250

TAD:	TradoM_p19(ND1)

AQU:	4794361(ND1)

ATH:	AT2G07785 DA397_mgp34(nad1)

CRB:	40490704(nad1)

BRP:	56141010(nad1)

BNA:	4237888(nad1)

RSZ:	13630174(nad1)

THJ:

104820711

CPAP:

7441422(nad1)

CIT:	36487065(nad1)

GRA:	27429634(nad1)

GAB:	33134351(nad1)

EGR:	38466560(nad1)

GMX:	15308632(nad1)

VUN:	114171284 114171347 114172406

CCAJ:

109793693

APRC:

113851155

MTR:	26974318(nad1)

TPRA:

55290723(nad1)

CAM:

101490819

PSAT:

127133940

AIP:

107647095

AHF:	112754623 114926186 114926190 114927343

MDM:	13630238(nad1)

MSYL:

73938927(nad1)

ZJU:	27215287(nad1)

CSAV:

115702082 27215501(nad1)

CSV:	11123890(nad1)

BHJ:	120079171 120087066

RCU:	10221448(nad1)

MESC:

42317495(nad1)

PALZ:

39331216(nad1)

QSU:

112003814

QLO:

115990447

VVI:	7498511(nad1)

SLY:	101256862 112941454

SPEN:

34925974(nad1) 34926038(nad1)

CANN:

19989177(nad1)

NTA:	3205188(nad1)

NSY:	27214892(nad1)

NAU:	109207198 109239076 109244851 35198935(nad1)

INI:	29082032(nad1)

SMIL:

18126425(nad1)

LSV:	40498716(nad1)

DCR:	12598559(nad1)

CSIN:

40867580(nad1)

RVL:

131300219

BVG:	809450(nad1)

NNU:	28482718(nad1)

MING:

122071019 122089809

TSS:

122640180

PSOM:

113294875

OSA:	107276733 6450162(nad1)

TDC:	119270059 119272928 119279052 119279551 119280945 119283422 119284113 119308987 119310187 119315692 119325602 119333638 119354776

TAES:

123081765 123149586 34688809(nad1)

TUA:

125546263

SBI:	4306037(nad1)

PVIR:

120693847 120694100

PHAI:

112893409

PDA:	11542581(nad1)

MUS:

103973022

DCT:

114578845

PEQ:

110019532

NCOL:

36487343(nad1)

PPP:	3989054(nad1)

CRE:	ChrepMp07(nad1)

CSL:	CospCoM_p05(nad1)

CVR:	OJ20_p09(nad1)

APRO:

ChprMp009(nad1)

OTA:	OstapMp29(nad1)

BPG:	BathyMg00020(nad1)

MIS:	MicpuN_mit12(nad1_1) MicpuN_mit40(nad1_2)

GSL:	JL72_p12(nad1)

CCP:	ChcroMp14(nad1)

DHA:

ND1

CAL:	CaalfMp03(NAD1)

YLI:	YalifMp02(nd1)

CLUS:

16792601(nad1)

NCR:

NCU16018

SMP:	SMAC_12678(nad1)

PAN:	PoanfMp49(nad1)

CTHR:

CTHT_m000470

SSCK:

SPSK_11053

FGR:	GizefMp11(nad1)

PTKZ:

MRV25_mgp07(nad1)

VAL:	VDBG_17004 VDBG_17017

CLUP:

AYB75_mgp14(nad1)

SSL:	SS1G_20036

ANI:	ANID_20007

ANG:	Asnifp02(nad1)

ALUC:

EJ508_mgp16(nad1)

PNO:	SNOGp08(nad1)

TML:	GSTUM_00002043001

ABP:	AGABI1DRAFT47778(AGABI1DRAFT_47778)

MRT:	D9L16_mgp10(nad1)

PSTR:

EFH26_mgp13(nad1)

DDI:	DidioMp14(nad1)

DFA:	Difao_mp13(nad1)

TET:	TepyoMp40(nad1_a)

PSOJ:

PhsooMp30(nad1)

» show all

Reference

PMID:6260957

Authors

Sanger F, Coulson AR, Barrell BG, Smith AJ, Roe BA

Title

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

Journal

J Mol Biol 143:161-78 (1980)
DOI:10.1016/0022-2836(80)90196-5

Sequence

[hsa:4535]

LinkDB

DBGET integrated database retrieval system