KEGG ORTHOLOGY: K04130

ORTHOLOGY: K04130

Entry

K04130                      KO

Symbol

CHRM2

Name

muscarinic acetylcholine receptor M2

Pathway

map04020

Calcium signaling pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04151

PI3K-Akt signaling pathway

map04725

Cholinergic synapse

map04810

Regulation of actin cytoskeleton

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
   04024 cAMP signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
   04151 PI3K-Akt signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04130  CHRM2; muscarinic acetylcholine receptor M2
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04130  CHRM2; muscarinic acetylcholine receptor M2
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K04130  CHRM2; muscarinic acetylcholine receptor M2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04130  CHRM2; muscarinic acetylcholine receptor M2
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    K04130  CHRM2; muscarinic acetylcholine receptor M2

Other DBs

GO:

0016907

Genes

HSA:	1129(CHRM2)

PTR:	463758(CHRM2)

PPS:	103782638(CHRM2)

GGO:	101124976(CHRM2)

PON:	100450243(CHRM2)

NLE:	100593190(CHRM2)

HMH:	116814401(CHRM2)

MCC:	714780(CHRM2)

MCF:	102141940(CHRM2)

MTHB:

126949684

MNI:	105471325(CHRM2)

CSAB:

103226965(CHRM2)

CATY:

105589633(CHRM2)

PANU:

101001613(CHRM2)

TGE:	112620879(CHRM2)

MLEU:

105550540(CHRM2)

RRO:	104668941(CHRM2)

RBB:	108532444(CHRM2)

TFN:	117072748(CHRM2)

PTEH:

111524771(CHRM2)

CANG:

105511157(CHRM2)

CJC:	100411083(CHRM2)

SBQ:	104649836(CHRM2)

CIMI:

108286458(CHRM2)

CSYR:

103257129(CHRM2)

MMUR:

105860184(CHRM2)

LCAT:

123646880(CHRM2)

PCOQ:

105809011(CHRM2)

OGA:	100952938(CHRM2)

MMU:	243764(Chrm2)

MCAL:

110296617(Chrm2)

MPAH:

110316713(Chrm2)

RNO:	81645(Chrm2)

MCOC:

116098726(Chrm2)

ANU:	117720320(Chrm2)

MUN:	110557978(Chrm2)

CGE:	100770997(Chrm2)

MAUA:

101844151(Chrm2)

PROB:

127214320(Chrm2)

PLEU:

114691013(Chrm2)

MORG:

121463333(Chrm2)

MFOT:

126505258

AAMP:

119808071(Chrm2)

NGI:	103726078(Chrm2)

HGL:	101714286(Chrm2)

CPOC:

100715343(Chrm2)

CCAN:

109677776(Chrm2)

DORD:

105989551(Chrm2)

DSP:	122105971(Chrm2)

PLOP:

125345881(Chrm2)

NCAR:

124991906

MMMA:

107149189(Chrm2)

OCU:

100342878

OPI:	101532237(CHRM2)

TUP:	102470522(CHRM2)

GVR:	103606149(CHRM2)

CFA:	403858(CHRM2)

CLUD:

112670443(CHRM2)

VVP:	112908890(CHRM2)

VLG:	121489309(CHRM2)

NPO:	129515649(CHRM2)

AML:	100483729(CHRM2)

UMR:	103669054(CHRM2)

UAH:	113266585(CHRM2)

UAR:	123788910(CHRM2)

ELK:

111152067

LLV:

125081169

MPUF:

101689541(CHRM2)

MNP:	132014913(CHRM2)

MLK:	131829812(CHRM2)

NVS:	122905107(CHRM2)

ORO:	101386108(CHRM2)

EJU:	114211755(CHRM2)

ZCA:	113911755(CHRM2)

MLX:	118021391(CHRM2)

NSU:	110582928(CHRM2)

LWW:	102738226(CHRM2)

FCA:	101099790(CHRM2)

PYU:	121028280(CHRM2)

PCOO:

112866732(CHRM2)

PBG:	122488359(CHRM2)

PVIV:

125160698(CHRM2)

LRUF:

124525022

PTG:	102950279(CHRM2)

PPAD:

109269060(CHRM2)

PUC:

125930180

AJU:

106975696

HHV:	120224207(CHRM2)

BTA:	522170(CHRM2)

BOM:	102288004(CHRM2)

BIU:	109557673(CHRM2)

BBUB:

102412001(CHRM2)

BBIS:

104982278(CHRM2)

CHX:	102169456(CHRM2)

OAS:	101102897(CHRM2)

BTAX:

128046777(CHRM2)

ODA:	120877623(CHRM2)

CCAD:

122438688(CHRM2)

MBEZ:

129552682(CHRM2)

SSC:	397498(CHRM2)

CFR:	102509282(CHRM2)

CBAI:

105063049(CHRM2)

CDK:	105091619(CHRM2)

VPC:	102543989(CHRM2)

BACU:

103000729(CHRM2)

BMUS:

118900409(CHRM2)

LVE:	103070593(CHRM2)

OOR:	101284832(CHRM2)

DLE:	111182727(CHRM2)

PCAD:

102984774(CHRM2)

PSIU:

116759002(CHRM2)

NASI:

112397450(CHRM2)

ECB:	100064906(CHRM2)

EPZ:	103561369(CHRM2)

EAI:	106829990(CHRM2)

MYB:	102244198(CHRM2)

MYD:	102774659(CHRM2)

MMYO:

118666361(CHRM2)

MLF:	102431567(CHRM2)

PKL:	118713414(CHRM2)

EFUS:

103294109(CHRM2)

MNA:	107544520(CHRM2)

DRO:	112299910(CHRM2)

SHON:

118989109(CHRM2)

AJM:	119052925(CHRM2)

PDIC:

114507875(CHRM2)

PHAS:

123829775(CHRM2)

MMF:	118620177(CHRM2)

PPAM:

129062841(CHRM2)

HAI:	109388540(CHRM2)

RFQ:	117018247(CHRM2)

PALE:

102883382(CHRM2)

PGIG:

120600967(CHRM2)

PVP:	105291625(CHRM2)

RAY:	107499062(CHRM2)

MJV:	108391646(CHRM2) 118969906

TOD:	119247518(CHRM2)

SARA:

101554737(CHRM2)

SETR:

126011169(CHRM2)

LAV:	100666496(CHRM2)

TMU:

101349646

ETF:	101644587(CHRM2)

DNM:	101439024(CHRM2)

MDO:	100017080(CHRM2)

GAS:	123249515(CHRM2)

SHR:	100925629(CHRM2)

AFZ:

127537791

PCW:	110216282(CHRM2)

OAA:	100075952(CHRM2)

GGA:	418126(CHRM2)

PCOC:

116226774(CHRM2)

MGP:	100538353(CHRM2)

CJO:	107315784(CHRM2)

TPAI:

128073119(CHRM2)

LMUT:

125690697(CHRM2)

NMEL:

110394649(CHRM2)

APLA:

101792126(CHRM2)

ACYG:

106030984(CHRM2)

CATA:

118259206(CHRM2)

AFUL:

116501786(CHRM2)

TGU:	100220676(CHRM2)

LSR:	110482597(CHRM2)

SCAN:

103819622(CHRM2)

PMOA:

120501679(CHRM2)

OTC:	121332827(CHRM2)

PRUF:

121364343(CHRM2)

GFR:	102032522(CHRM2)

FAB:	101811127(CHRM2)

OMA:	130248544(CHRM2)

PHI:	102103691(CHRM2)

PMAJ:

107205035(CHRM2)

CCAE:

111936668(CHRM2)

CCW:	104696199(CHRM2)

CBRC:

103619564(CHRM2)

ETL:	114064295(CHRM2)

ZAB:	102070632(CHRM2)

ACHL:

103799504(CHRM2)

SVG:	106856335(CHRM2)

MMEA:

130585981(CHRM2)

HRT:	120751470(CHRM2)

FPG:	101919158(CHRM2)

FCH:	102054742(CHRM2)

CLV:	102098670(CHRM2)

EGZ:	104126091(CHRM2)

NNI:	104012391(CHRM2)

PCRI:

104030495(CHRM2)

PLET:

104623978(CHRM2)

EHS:	104515306(CHRM2)

PCAO:

104043821(CHRM2)

ACUN:

113491545(CHRM2)

TALA:

104364606(CHRM2)

PADL:

103924397(CHRM2)

AFOR:

103906436(CHRM2)

ACHC:

115352771(CHRM2)

HALD:

104315154(CHRM2)

HLE:	104830964(CHRM2)

AGEN:

126047899

GCL:

127026250

CCRI:

104162624(CHRM2)

CSTI:

104551746(CHRM2)

CMAC:

104473432(CHRM2)

MUI:	104546553(CHRM2)

BREG:

104643354(CHRM2)

FGA:	104073838(CHRM2)

GSTE:

104256323(CHRM2)

LDI:	104354445(CHRM2)

MNB:	103773997(CHRM2)

OHA:	104327993(CHRM2)

NNT:	104413158(CHRM2)

SHAB:

115605392(CHRM2)

DPUB:

104302499(CHRM2)

PGUU:

104469918(CHRM2)

ACAR:

104520644(CHRM2)

CPEA:

104398151(CHRM2)

AVIT:

104275300(CHRM2)

CVF:	104288285(CHRM2)

RTD:	128918811(CHRM2)

CUCA:

104058951(CHRM2)

TEO:	104376968(CHRM2)

BRHI:

104490548(CHRM2)

AAM:	106488476(CHRM2)

AROW:

112974693(CHRM2)

NPD:	112945638(CHRM2)

TGT:	104575430(CHRM2)

DNE:	112995018(CHRM2)

SCAM:

104147312(CHRM2)

ASN:	102382805(CHRM2)

AMJ:	102575025(CHRM2)

CPOO:

109316512(CHRM2)

GGN:	109296179(CHRM2)

PSS:	102445606(CHRM2)

CMY:	102940353(CHRM2)

CCAY:

125626850(CHRM2)

DCC:	119850050(CHRM2)

CPIC:

101940030(CHRM2)

TST:	117881928(CHRM2)

CABI:

116826457(CHRM2)

MRV:	120370417(CHRM2)

ACS:	100560735(chrm2)

ASAO:

132775814(CHRM2)

PVT:	110078260(CHRM2)

SUND:

121930292(CHRM2)

PBI:	103050753(CHRM2)

PMUR:

107294180(CHRM2)

CTIG:

120314374(CHRM2)

TSR:	106542367(CHRM2)

PGUT:

117655904(CHRM2)

APRI:

131202206(CHRM2)

PTEX:

113434751(CHRM2)

NSS:	113431078(CHRM2)

VKO:	123021485 123025382(CHRM2) 123032042

PMUA:

114605279(CHRM2)

PRAF:

128422206(CHRM2)

ZVI:	118091097(CHRM2)

HCG:	128327085(CHRM2)

GJA:	107119224(CHRM2)

STOW:

125434974(CHRM2)

EMC:	129336059(CHRM2)

XLA:	108704358(chrm2.L) 108712545(chrm2.S)

XTR:	100485603(chrm2)

NPR:	108788723(CHRM2)

RTEM:

120932878(CHRM2)

BBUF:

121005631(CHRM2)

BGAR:

122928423(CHRM2)

MUO:	115479174(CHRM2)

GSH:	117367021(CHRM2)

DRE:	352938(chrm2a) 555516(chrm2b)

SRX:	107707091 107707993 107716631 107753582

SANH:

107658987 107662193 107696228

SGH:	107554938 107561244 107568718 107575955

CCAR:

109061840 109064465 109077255 109079175

CAUA:

113047899 113064970 113066917 113071342 113088974

CGIB:

127946675 127956691 127979413 128014490

PTET:

122330476(chrm2b) 122333257(chrm2a)

LROH:

127157024(chrm2b) 127164446(chrm2a)

OMC:	131534576(chrm2b) 131538695(chrm2a)

PPRM:

120469084(chrm2b) 120471031(chrm2a)

RKG:	130080081(chrm2a) 130104500(chrm2b)

MAMB:

125244698(chrm2a) 125247461(chrm2b)

CIDE:

127507682 127510744

MASI:

127435198 127436026 127436974 127437336

TROS:

130547595(chrm2a) 130552291(chrm2b)

TDW:	130414670(chrm2b) 130420592(chrm2a)

MANU:

129432058(chrm2a) 129433823(chrm2b)

IPU:	108268785(chrm2b) 108274455(chrm2a)

IFU:	128611844(chrm2b) 128618185(chrm2a)

PHYP:

113528685 113529780(chrm2)

SMEO:

124385674(chrm2b) 124392504(chrm2a)

TFD:	113635571(chrm2b) 113654072(chrm2a)

TVC:	132855627(chrm2b) 132857461(chrm2a)

AMEX:

103021745 103039136(chrm2)

CMAO:

118806754(chrm2b) 118811992(chrm2a)

EEE:	113573657(chrm2) 113579735

CHAR:

105895599(chrm2b) 105896724(chrm2a)

TRU:	101064044(chrm2) 101067250

TFS:	130519128(chrm2a) 130536740

TNG:	GSTEN00021520G001 GSTEN00022775G001

LCO:	104935830(chrm2) 104940443

NCC:	104941984 104963385

TBEN:

117485036(chrm2a) 117491345

CGOB:

115009820 115028109

PGEO:

117448591 117468321(chrm2a)

GACU:

117545774 117552491(chrm2a)

EMAC:

134879330(chrm2a) 134882456

ELY:	117249107(chrm2a) 117262028

EFO:	125882897(chrm2a) 125887449

PLEP:

121950518 121961529(chrm2a)

SLUC:

116060031(chrm2a) 116062643

ECRA:

117938612(chrm2a) 117949570

ESP:	116673037(chrm2) 116694648

PFLV:

114550376(chrm2) 114560599

GAT:	120809871 120812186 120818375(chrm2a)

PPUG:

119196742 119210355(chrm2a)

AFB:	129108695 129112658(chrm2a)

CLUM:

117726256(chrm2a) 117732396

PSWI:

130195472 130200275(chrm2a)

MSAM:

119893052 119918229(chrm2a)

SCHU:

122871280(chrm2a) 122874706

CUD:	121505723(chrm2a) 121515461

ALAT:

119025071 119032827(chrm2a)

MZE:	101463912 101469188

ONL:	100534441(chrm2a) 100534567

OAU:	116318347 116318498(chrm2a)

OLA:	101157989(chrm2) 101163735

OML:	112152589 112154577(chrm2a)

CSAI:

133424496(chrm2a) 133444364

XMA:	102222978 102225705

XCO:	114151799 114160763

XHE:	116729334 116736405

PRET:

103459119(chrm2) 103466077

PFOR:

103133706 103140231

PLAI:

106945207 106956603

PMEI:

106926352 106927335

GAF:	122826634(chrm2a) 122835799

PPRL:

129351484(chrm2a) 129363872

CVG:	107085326(chrm2) 107103804

CTUL:

119780987(chrm2a) 119793003

GMU:	124878710 124883327(chrm2a)

NFU:	107386482 107388934

KMR:	108233278(chrm2a) 108239971

ALIM:

106520277 106527427

NWH:	119415646 119428259(chrm2a)

AOCE:

111565671(chrm2) 111585437

MCEP:

125000372(chrm2a) 125015408

CSEM:

103380168 103382732

POV:	109624680 109632850(chrm2)

SSEN:

122767307(chrm2a) 122776242

HHIP:

117757278(chrm2a) 117763542

HSP:	118101957(chrm2a) 118109253

SMAU:

118289690(chrm2a) 118315894

LCF:	108875222 108886191(chrm2a)

SDU:	111224678(chrm2) 111228487

SLAL:

111660037(chrm2) 111671210

XGL:	120793374 120801940(chrm2a)

HCQ:	109523706(chrm2) 109526789

SSCV:

125970869 125992149

SBIA:

133493560(chrm2a) 133502645

PEE:	133397342(chrm2a)

PTAO:

133471755(chrm2a)

BPEC:

110161877(chrm2) 110166866

MALB:

109967329 109969684

BSPL:

114857944 114863009(chrm2a)

SJO:	128353265(chrm2a) 128358298

SASA:

106573323 106576423 106609497

STRU:

115152155 115180074 115199012

OTW:	112217277(chrm2a) 112245281 121839374

OMY:	110490488 110499977 110520525

OGO:	123994433 124014212

ONE:	115107106 115108958 115132984

OKI:	109879464 109887850 109888883

OKE:	118365991 118370758 118400748

SALP:

111952341 111982232

SNH:	120031953 120049385 120053497

CCLU:

121549094 121557856 121577358

ELS:	105018412 105023422(chrm2)

SFM:	108920765(chrm2)

PKI:	111843396 111846991

AANG:

118218827 118218828 118232257

LOC:	102697102(chrm2)

PSPA:

121317896 121320266

ARUT:

117416119 117419667

PSEX:

120539637(chrm2a)

LCM:	102351552(CHRM2)

CMK:

103185606

RTP:	109910699 109910701 109910706 109919425 109921959 109925515 109934867 109934879 109938945 125486937

CPLA:

122541162 122541224 122541229 122541230 122541231 122541232 122541233 122541236 122541238 122541321 122545444 122547804 122559633

LERI:

129694283 129706534(chrm2a)

BFO:

118427742

BBEL:

109463722

CIN:	100176265 101243522

SPU:	105436766 105447576 115927947 586181 591158 591738

LPIC:

129259432 129264765 129273502 129274164 129277174 129282681

APLC:

110976217

DYA:	Dyak_GE16229

DSR:

110180416

DMN:

108164553

GAE:	121375374 121389325

PMAX:

117336817

RPHI:

132725145 132734897 132741539

DPOL:

ATEN:

HSY:

Reference

PMID:2825184

Authors

Gocayne J, Robinson DA, FitzGerald MG, Chung FZ, Kerlavage AR, Lentes KU, Lai J, Wang CD, Fraser CM, Venter JC

Title

Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

Journal

Proc Natl Acad Sci U S A 84:8296-300 (1987)
DOI:10.1073/pnas.84.23.8296

Sequence

[rno:81645]

LinkDB

DBGET integrated database retrieval system