KEGG ORTHOLOGY: K04239

ORTHOLOGY: K04239

Entry

K04239                      KO

Symbol

HCRTR2

Name

hypocretin (orexin) receptor 2

Pathway

map04080

Neuroactive ligand-receptor interaction

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04239  HCRTR2; hypocretin (orexin) receptor 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04239  HCRTR2; hypocretin (orexin) receptor 2
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Peptide
   Orexin
    K04239  HCRTR2; hypocretin (orexin) receptor 2

Other DBs

GO:

0016499

Genes

HSA:	3062(HCRTR2)

PTR:	462786(HCRTR2)

PPS:	100991356(HCRTR2)

GGO:	101134230(HCRTR2)

PON:	100457334(HCRTR2)

NLE:	100603910(HCRTR2)

HMH:	116460020(HCRTR2)

MCC:	711662(HCRTR2)

MCF:	102127749(HCRTR2)

MTHB:

126953391

MNI:	105479550(HCRTR2)

CSAB:

103243991(HCRTR2)

CATY:

105590090(HCRTR2)

PANU:

101013423(HCRTR2)

TGE:	112623288(HCRTR2)

MLEU:

105540586(HCRTR2)

RRO:	104671619(HCRTR2)

RBB:

108526337

TFN:	117087383(HCRTR2)

PTEH:

111549807(HCRTR2)

CANG:

105524799(HCRTR2)

CJC:	100392404(HCRTR2)

SBQ:	101044593(HCRTR2)

CIMI:

108314157(HCRTR2)

CSYR:

103268734(HCRTR2)

MMUR:

105880028(HCRTR2)

LCAT:

123632107(HCRTR2)

PCOQ:

105813901(HCRTR2)

OGA:	100960676(HCRTR2)

MMU:	387285(Hcrtr2)

MCAL:

110302003(Hcrtr2)

MPAH:

110328098(Hcrtr2)

RNO:	25605(Hcrtr2)

MCOC:

116073105(Hcrtr2)

ANU:	117712926(Hcrtr2)

MUN:	110566077(Hcrtr2)

CGE:	100762569(Hcrtr2)

MAUA:

101823735(Hcrtr2)

PROB:

127231991(Hcrtr2)

PLEU:

114690259(Hcrtr2)

MORG:

121466147(Hcrtr2)

MFOT:

126491624

AAMP:

119810591(Hcrtr2)

NGI:	103744374(Hcrtr2)

HGL:	101723112(Hcrtr2)

CPOC:

100733363(Hcrtr2)

CCAN:

109677096(Hcrtr2)

DORD:

105987703(Hcrtr2)

DSP:	122101526(Hcrtr2)

PLOP:

125352164(Hcrtr2)

NCAR:

124989097

MMMA:

107144099(Hcrtr2)

OCU:

100344413

OPI:	101526789(HCRTR2)

TUP:	102469282(HCRTR2)

GVR:	103597144(HCRTR2)

CFA:	399545(HCRTR2)

CLUD:

112641780(HCRTR2)

VVP:	112914247(HCRTR2)

VLG:	121471289(HCRTR2)

NPO:	129513121(HCRTR2)

AML:	100480101(HCRTR2)

UMR:	103663986(HCRTR2)

UAH:	113261170(HCRTR2)

UAR:	123797390(HCRTR2)

ELK:

111152380

LLV:

125102480

MPUF:

101673834(HCRTR2)

MNP:	132017243(HCRTR2)

MLK:	131834118(HCRTR2)

NVS:	122899737(HCRTR2)

ORO:	101367732(HCRTR2)

EJU:	114204572(HCRTR2)

ZCA:	113927424(HCRTR2)

MLX:	118000706(HCRTR2)

NSU:	110582138(HCRTR2)

LWW:	102751173(HCRTR2)

FCA:	101088488(HCRTR2)

PYU:	121029604(HCRTR2)

PCOO:

112862303(HCRTR2)

PBG:	122489643(HCRTR2)

PVIV:

125166216(HCRTR2)

LRUF:

124529341

PTG:	102964971(HCRTR2)

PPAD:

109271777(HCRTR2)

PUC:

125938597

AJU:

106973057

HHV:	120239813(HCRTR2)

BTA:	529603(HCRTR2)

BOM:	102270411(HCRTR2)

BIU:	109576846(HCRTR2)

BBUB:

102412216(HCRTR2)

BBIS:

104994868(HCRTR2)

CHX:	102183738(HCRTR2)

OAS:	443181(HCRTR2)

BTAX:

128056602(HCRTR2)

ODA:	120869879(HCRTR2)

CCAD:

122429630(HCRTR2)

MBEZ:

129543567(HCRTR2)

SSC:	397428(HCRTR2)

CFR:	102520909(HCRTR2)

CBAI:

105083934(HCRTR2)

CDK:	105102121(HCRTR2)

VPC:	102525813(HCRTR2)

BACU:

103016538(HCRTR2)

BMUS:

118903940(HCRTR2)

LVE:	103068336(HCRTR2)

OOR:	101271344(HCRTR2)

DLE:	111178598(HCRTR2)

PCAD:

102977714(HCRTR2)

PSIU:

116762334(HCRTR2)

NASI:

112406049(HCRTR2)

ECB:	100056772(HCRTR2)

EPZ:	103567422(HCRTR2)

EAI:	106837957(HCRTR2)

MYB:	102253967(HCRTR2)

MYD:	102766997(HCRTR2)

MMYO:

118660256(HCRTR2)

MLF:	102441836(HCRTR2)

PKL:	118705957(HCRTR2)

EFUS:

103294821(HCRTR2)

MNA:	107525827(HCRTR2)

DRO:	112302298(HCRTR2)

SHON:

118993724(HCRTR2)

AJM:	119054236(HCRTR2)

PDIC:

114494758(HCRTR2)

PHAS:

123822064(HCRTR2)

MMF:	118621598(HCRTR2)

PPAM:

129067097(HCRTR2)

HAI:	109374633(HCRTR2)

RFQ:	117020281(HCRTR2)

PALE:

102894217(HCRTR2)

PGIG:

120594905(HCRTR2)

PVP:	105302078(HCRTR2)

RAY:

107511360

MJV:	108385705(HCRTR2)

TOD:	119252576(HCRTR2)

SARA:

101542427(HCRTR2)

SETR:

126013818(HCRTR2)

LAV:	100667267(HCRTR2)

TMU:

101351711

ETF:	101638828(HCRTR2)

DNM:	101430897(HCRTR2)

MDO:	100619955(HCRTR2)

GAS:	123244884(HCRTR2)

SHR:	100931148(HCRTR2)

PCW:	110217912(HCRTR2)

OAA:	100086450(HCRTR2)

GGA:	428644(HCRTR2)

PCOC:

116240717(HCRTR2)

MGP:

100539649

CJO:	107312092(HCRTR2)

TPAI:

128077603(HCRTR2)

LMUT:

125689247(HCRTR2)

NMEL:

110397204(HCRTR2)

APLA:

101794034(HCRTR2)

ACYG:

106030426(HCRTR2)

CATA:

118246184(HCRTR2)

AFUL:

116488037(HCRTR2)

TGU:	100229747(HCRTR2)

LSR:	110482154(HCRTR2)

SCAN:

103819937(HCRTR2)

PMOA:

120511475(HCRTR2)

OTC:	121339138(HCRTR2)

PRUF:

121358924(HCRTR2)

GFR:	102036832(HCRTR2)

FAB:	101813409(HCRTR2)

OMA:	130251180(HCRTR2)

PHI:	102105602(HCRTR2)

PMAJ:

107201115(HCRTR2)

CCAE:

111925870(HCRTR2)

CCW:	104693445(HCRTR2)

CBRC:

103619146(HCRTR2)

ETL:	114064900(HCRTR2)

ZAB:	102063719(HCRTR2)

ACHL:

103797661

SVG:	106849079(HCRTR2)

MMEA:

130577082(HCRTR2)

HRT:	120750722(HCRTR2)

FPG:	101924105(HCRTR2)

FCH:	102048152(HCRTR2)

CLV:	102089313(HCRTR2)

EGZ:	104126232(HCRTR2)

NNI:	104020900(HCRTR2)

PCRI:

104025668(HCRTR1)

PLET:

104614690

EHS:

104503901

PCAO:

104039992

ACUN:

113477624(HCRTR2)

TALA:

104368704(HCRTR2)

PADL:

103924620(HCRTR2)

AFOR:

103899293(HCRTR2)

ACHC:

115351328(HCRTR2)

HALD:

104316450

HLE:	104831051(HCRTR2)

AGEN:

126046677

GCL:

127014712

CCRI:

104164697

CSTI:

104549450(HCRTR2)

CMAC:

104486151(HCRTR2)

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:	104336495(HCRTR2)

NNT:

104400096

SHAB:

115609896(HCRTR2)

DPUB:

104310238(HCRTR2)

PGUU:

104458910

ACAR:

104532454

CPEA:

104390099(HCRTR2)

AVIT:

104267098

CVF:	104281784(HCRTR2)

RTD:	128907454(HCRTR2)

CUCA:

104065320(HCRTR2)

BRHI:

104490485

AAM:

106493250

AROW:

112970167(HCRTR2)

NPD:	112943164(HCRTR2)

TGT:	104575090(HCRTR2)

DNE:	112984874(HCRTR2)

SCAM:

104151950(HCRTR2)

ASN:	102371511(HCRTR2)

AMJ:	102576749(HCRTR2)

CPOO:

109311740(HCRTR2)

GGN:	109299994(HCRTR2)

PSS:	102444325(HCRTR2)

CMY:	102935131(HCRTR2)

CCAY:

125634467(HCRTR2)

DCC:	119853384(HCRTR2)

CPIC:

101932355(HCRTR2)

TST:	117875652(HCRTR2)

CABI:

116819417(HCRTR2)

MRV:	120401333(HCRTR2)

ACS:	100554062(hcrtr2)

ASAO:

132762028(HCRTR2)

PVT:	110073005(HCRTR2)

SUND:

121919164(HCRTR2)

PBI:	103055542(HCRTR2)

PMUR:

107297196(HCRTR2)

CTIG:

120297566(HCRTR2)

TSR:	106538287(HCRTR2)

PGUT:

117676897(HCRTR2)

APRI:

131195104(HCRTR2)

PTEX:

113455283(HCRTR2)

NSS:	113410531(HCRTR2)

VKO:	123019082(HCRTR2)

PMUA:

114593831(HCRTR2)

PRAF:

128410210(HCRTR2)

ZVI:	118082772(HCRTR2)

HCG:	128340782(HCRTR2)

GJA:	107121118(HCRTR2)

STOW:

125442589(HCRTR2)

EMC:	129338557(HCRTR2)

XLA:	100628313(hcrtr2.S) 108716913(hcrtr2.L)

XTR:	100495420(hcrtr2)

NPR:	108788956(HCRTR2)

RTEM:

120936988(HCRTR2)

BBUF:

120996922(HCRTR2)

BGAR:

122936305(HCRTR2)

MUO:	115465213 115465214

GSH:	117357628(HCRTR2)

DRE:	561260(hcrtr2)

SRX:	107751512(hcrtr2)

SANH:

107681024(hcrtr2) 107699124

SGH:	107597729(hcrtr2)

CCAR:

109065540 109099860

CAUA:

113057365(hcrtr2) 113113132

CGIB:

127969650 128026729

LROH:

127174747(hcrtr2)

OMC:	131552325(hcrtr2)

PPRM:

120492249(hcrtr2)

RKG:	130092328(hcrtr2)

MAMB:

125277499(hcrtr2)

CIDE:

127524871

MASI:

127411746 127413621

TROS:

130559004(hcrtr2)

TDW:	130432013(hcrtr2)

MANU:

129415835(hcrtr2)

IPU:

108262846

IFU:	128605292(hcrtr2)

PHYP:

113542140(hcrtr2)

SMEO:

124395355(hcrtr2)

TFD:	113655273(hcrtr2)

TVC:	132846643(hcrtr2)

AMEX:

103037678(hcrtr2)

CMAO:

118809881(hcrtr2)

EEE:	113585989(hcrtr2)

CHAR:

105911532(hcrtr2)

TRU:	101071650(hcrtr2)

TFS:	130533697(hcrtr2)

LCO:	104940179(hcrtr2)

NCC:	104947220(hcrtr2)

TBEN:

117499506(hcrtr2)

CGOB:

115020330(hcrtr2)

PGEO:

117460165(hcrtr2)

GACU:

117536855(hcrtr2)

EMAC:

134858492(hcrtr2)

ELY:	117248759(hcrtr2)

EFO:	125903584(hcrtr2)

PLEP:

121954503(hcrtr2)

SLUC:

116050910(hcrtr2)

ECRA:

117960233(hcrtr2)

ESP:	116705523(hcrtr2)

PFLV:

114572529

GAT:	120820292(hcrtr2)

PPUG:

119214084(hcrtr2)

AFB:	129091958(hcrtr2)

CLUM:

117744247(hcrtr2)

PSWI:

130207375(hcrtr2)

MSAM:

119900138 119917584(hcrtr2)

SCHU:

122884880(hcrtr2)

CUD:	121510786(hcrtr2)

ALAT:

119033061(hcrtr2)

MZE:	101474594(hcrtr2)

ONL:	100696863(hcrtr2)

OAU:	116322797(hcrtr2)

OLA:	101170456(hcrtr2)

OML:	112162172(hcrtr2)

CSAI:

133463795(hcrtr2)

XMA:	102223503(hcrtr2)

XCO:	114138481(hcrtr2)

XHE:	116712568(hcrtr2)

PRET:

103477003(hcrtr2)

PFOR:

103134179(hcrtr2)

PLAI:

106964711(hcrtr2)

PMEI:

106914809(hcrtr2)

GAF:	122842342(hcrtr2)

PPRL:

129360073(hcrtr2)

CVG:	107084590(hcrtr2)

CTUL:

119790667(hcrtr2)

GMU:	124858802(hcrtr2)

NFU:	107375780(ffar4)

KMR:	108234050(hcrtr2)

ALIM:

106523724(hcrtr2)

NWH:	119418198(hcrtr2)

AOCE:

111562688(hcrtr2)

MCEP:

125019260(hcrtr2)

CSEM:

103387444(hcrtr2)

POV:	109631964(hcrtr2)

SSEN:

122781571(hcrtr2)

HHIP:

117775972

HSP:	118118768(hcrtr2)

SMAU:

118284283(hcrtr2)

LCF:

108892395

SDU:	111235140(hcrtr2)

SLAL:

111656669(hcrtr2)

XGL:	120796072(hcrtr2)

HCQ:	109516104(hcrtr2)

SSCV:

125979052

SBIA:

133510078(hcrtr2)

PEE:	133409896(hcrtr2)

PTAO:

133486184(hcrtr2)

BPEC:

110156878(hcrtr2)

MALB:

109961917(hcrtr2)

BSPL:

114841759(hcrtr2)

SJO:	128372993(hcrtr2)

SASA:

106589791(hcrtr2)

STRU:

115201602(hcrtr2)

OTW:	112224631(hcrtr2)

OMY:	110499373(hcrtr2)

OGO:	124039359(hcrtr2)

ONE:	115144401(hcrtr2)

OKI:	109870206(hcrtr2)

OKE:	118402769(hcrtr2)

SALP:

111968098(hcrtr2)

SNH:	120029391(hcrtr2)

CCLU:

121548089

ELS:	105021361(hcrtr2)

SFM:	108932742(hcrtr2)

PKI:	111852827(hcrtr2)

AANG:

118217812(hcrtr2)

LOC:	102682232 102686897(hcrtr2)

PSPA:

121303450 121315266 121316846

ARUT:

117403187 117411270(hcrtr2) 117413432 117413596

PSEX:

120516577(hcrtr2) 120518106

LCM:	102349219(HCRTR2) 102361429(HCRTR1)

CMK:	103179029(hcrtr2)

RTP:	109915824(hcrtr2)

CPLA:

122548631(hcrtr2) 122563551

HOC:	132830033 132834751 132835905(hcrtr2)

LERI:

129697031(hcrtr2)

BFO:	118410086 118431558

BBEL:

109466282 109466289

CIN:

100180967

SPU:	100890665 584658

LPIC:

129261756 129261862 129267349 129272649 129272656 129279845 129279997

APLC:

110978711 110988356

AJC:

117113273

SKO:	100313694 100378064

ECOE:

CLON:

ACOZ:

AARA:

ASTE:

AFUN:

AMOU:

AAG:

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:	105194591 105197452

MPHA:

105830948

AEC:	105143113 105148806

ACEP:

105623261

PBAR:

105428770

VEM:	105561150 105564222

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:	103574833 103577555

CGLO:

123262672 123266752

FAS:	105269083 105270464

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:	124407227 124409366

NPT:	124213989 124214561 124216641

NFB:	124177532 124178579 124179944

NLO:	107221652 107223577 107226471

NVG:	124300178 124300836 124303055

AROA:

105684691

TCA:

662555

SOY:	115882289 115883421

AGRG:

126733612 126742994

ATD:	109594204 109604489

CSET:

123307357 123307904

AGB:

108910944

LDC:	111506419 111512836

NVL:	108565713 108567943

APLN:

108739844 108742812

PPYR:

116170609 116174081

OTU:	111421130 111425108 111425112

BMOR:

100174926(NGR-A16) 100187564(NGR-A5)

BMAN:

114242478 114242526

MSEX:

115443194 115449958 119190721

DPL:	KGM_209869 KGM_213408

BANY:

112045299 112054783

MJU:	123865217 123865678

NIQ:

126777186

VCD:	124540201 124540319

PMAC:

106708716 106708787

PPOT:

106108222 106108303

PXU:	106122825 106124352

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

126967635 126967651 126972986

AAGE:

121726502 121730417

HAW:	110376614 110376619

HZE:

124641292

TNL:	113494073 113494084

SLIU:

111361539 111361541

OFU:

114352001

PXY:	105388735 105392195

PGW:	126376584 126376855

CCRN:

123300376 123301530

API:	100568898 100570431

DNX:

107162988

AGS:	114124322 114130933

RMD:	113557155 113561242

ACOO:

126833221 126842813

DVT:	126895272 126907629

BTAB:

DCI:

CLEC:

NLU:

HVI:	124365332 124370590

MQU:	128990440 128994714 128994878 128995497 128995510 129004853 129005469

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:	124155248 124156070

FCD:

110844810

DPX:	DAPPUDRAFT_234062

DMK:	116917505 116932823 116932826 116936683

DPZ:

124327115

PJA:	122248821 122255251 122259968 122267314

HAME:

121858410 121864066 121876414

PCLA:

123763456 123765854

CQD:	128689104 128692422

PTRU:

123518121

MNZ:	135217399 135224607

HAZT:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

111613423 111622057 111622072 111633563 111636819 111639573 111641970

PTEP:

107440975 107441417 107442448 107450501 107453545

ABRU:

129963254 129963959 129981960

UDV:	129222998 129224355 129225272 129234209 129235205

SDM:	118184495 118187800 118203138

LPOL:

106461969 106467491 106469416 106471741 106471775 106478012 111089136

PMEO:

129582013 129590624

LGI:	LOTGIDRAFT_120990 LOTGIDRAFT_126576 LOTGIDRAFT_127723 LOTGIDRAFT_152502 LOTGIDRAFT_156802 LOTGIDRAFT_162500 LOTGIDRAFT_162575 LOTGIDRAFT_162749 LOTGIDRAFT_171228 LOTGIDRAFT_171849 LOTGIDRAFT_231336 LOTGIDRAFT_52425

PVUL:

126812013 126812550 126815669 126817353 126817544 126818445 126818936 126818937 126819105 126819108 126819517 126819518 126822139 126827049 126827256 126827648 126828163 126829471

PCAN:

112562908 112568413 112569463 112573859 112574215 112574478 112576949

BGT:	106060387 106062279 106063479 106069031 106070357 106070374 106073647 106075197

CRG:	105319314 105319837 105326469 105327592 105329130 105334467 105340587 105340591 105344805 105344806 105348812 109617956

CVN:	111099668 111099669 111100075 111101231 111101321 111102655 111117723 111117724 111118445 111118709 111119424 111130789 111132102 111137419

CANU:

128159383 128163615 128164483 128166744 128166777 128167734 128168185 128172913 128184518 128184916 128185002 128185292 128185838 128187006 128190705

OED:	125647014 125647039 125648139 125663914 125668070 125669038 125669641 125670317 125671207 125671210 125672734 125675123 125675603

MYI:	110442602 110443393 110445204 110450603 110454814 110455748 110456177 110456290

PMAX:

117316096 117316489 117323030 117323228 117324200 117324239 117324946 117325010 117325901 117325902 117326378 117329987 117330021 117330401 117330402 117334178 117337639

MCAF:

127732352 127732404

MMER:

123525173 123525190 123525333 123525805 123528559 123538764 123539805 123540845 123541216 123546970 123547805 123554088 123554091 123555351 128558318

DPOL:

127831544 127832031 127858704 127866180 127867552 127873914 127873954 127873964 127874531 127877486 127878305 127878306 127880369 127880580 127882303

OBI:	106867949 106870482 106870526 106870912 106874907

OSN:	115210954 115213029 115215151 115218025 115219935 118766189

LAK:	106155213 106171969

NVE:	5509276 5520596

EPA:	110233643 110236799 110238993 110241554 110247743 110250618 110251224 110253276

ATEN:

116287017 116288583 116292242 116297093 116297213 116299119 116300002 116301319 116301937 116302173 116305025 116306698 116307477 116307607 116308502

ADF:	107339644 107339646 107339649 107354001 107357310

AMIL:

114953299 114957629 114966041

PDAM:

113665993 113668864 113669656 113673842 113682075

SPIS:

111321091 111322162 111338767

DGT:	114521761 114527859

XEN:	124445210 124453321

» show all

Reference

PMID:9491897

Authors

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M

Title

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Journal

Cell 92:573-85 (1998)
DOI:10.1016/S0092-8674(00)80949-6

Sequence

[hsa:3062]

Reference

PMID:15070969

Authors

Karteris E, Chen J, Randeva HS

Title

Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system.

Journal

J Clin Endocrinol Metab 89:1957-62 (2004)
DOI:10.1210/jc.2003-031778

LinkDB

DBGET integrated database retrieval system