KEGG ORTHOLOGY: K04308

ORTHOLOGY: K04308

Entry

K04308                      KO

Symbol

LGR5, GPR49

Name

leucine-rich repeat-containing G protein-coupled receptor 5

Pathway

map04310

Wnt signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04308  LGR5, GPR49; leucine-rich repeat-containing G protein-coupled receptor 5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04308  LGR5, GPR49; leucine-rich repeat-containing G protein-coupled receptor 5
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Others
   R-spondin
    K04308  LGR5, GPR49; leucine-rich repeat-containing G protein-coupled receptor 5

Genes

HSA:	8549(LGR5)

PTR:	743138(LGR5)

PPS:	100979934(LGR5)

GGO:	101147660(LGR5)

PON:	100458220(LGR5)

NLE:	100585327(LGR5)

HMH:	116479013(LGR5)

MCC:	718661(LGR5)

MCF:	102120216(LGR5)

MTHB:

126931700

MNI:	105473374(LGR5)

CSAB:

103238723(LGR5)

CATY:

105581027(LGR5)

PANU:

101001924(LGR5)

TGE:	112635283(LGR5)

MLEU:

105538617(LGR5)

RRO:	104668088(LGR5)

RBB:	108526672(LGR5)

TFN:	117089742(LGR5)

PTEH:

111552352(LGR5)

CANG:

105502688(LGR5)

CJC:	100399702(LGR5)

SBQ:	101049062(LGR5)

CIMI:

108290283(LGR5)

CSYR:

103257545(LGR5)

MMUR:

105856891(LGR5)

LCAT:

123640527(LGR5)

PCOQ:

105808384(LGR5)

OGA:	100950967(LGR5)

MMU:	14160(Lgr5)

MCAL:

110302755(Lgr5)

MPAH:

110326108(Lgr5)

RNO:	299802(Lgr5)

MCOC:

116075974(Lgr5)

ANU:	117696128(Lgr5)

MUN:	110553075(Lgr5)

CGE:	100763381(Lgr5)

MAUA:

101840038(Lgr5)

PROB:

127215742(Lgr5)

PLEU:

114699039(Lgr5)

MORG:

121459363(Lgr5)

MFOT:

126497517

AAMP:

119803413(Lgr5)

NGI:	103735337(Lgr5)

HGL:	101717513(Lgr5)

CPOC:

100719443(Lgr5)

CCAN:

109696104(Lgr5)

DORD:

105987978(Lgr5)

DSP:	122124129(Lgr5)

PLOP:

125361201(Lgr5)

NCAR:

124982578

MMMA:

107140059(Lgr5)

OCU:

100343386

OPI:	101523353(LGR5)

TUP:	102476161(LGR5)

GVR:	103593163(LGR5)

CFA:	609478(LGR5)

CLUD:

112677851(LGR5)

VVP:	112922185(LGR5)

VLG:	121491422(LGR5)

NPO:	129511279(LGR5)

AML:	100473167(LGR5)

UMR:	103656976(LGR5)

UAH:	113256270(LGR5)

UAR:	123787126(LGR5)

ELK:

111142179

LLV:

125107584

MPUF:

101682190(LGR5)

MNP:	132019415(LGR5)

MLK:	131839163(LGR5)

NVS:	122891717(LGR5)

ORO:	101367769(LGR5)

EJU:	114215105(LGR5)

ZCA:	113922732(LGR5)

MLX:	118008565(LGR5)

NSU:	110570543(LGR5)

LWW:	102746906(LGR5)

FCA:	101080720(LGR5)

PYU:	121040744(LGR5)

PCOO:

112863281(LGR5)

PBG:	122474058(LGR5)

PVIV:

125170372(LGR5)

LRUF:

124502112

PTG:	102956763(LGR5)

PPAD:

109270514(LGR5)

PUC:

125919344

AJU:

106967379

HHV:	120223355(LGR5)

BTA:	520189(LGR5)

BOM:	102276475(LGR5)

BIU:	109558303(LGR5)

BBUB:

102392755(LGR5)

BBIS:

104989309(LGR5)

CHX:	102172413(LGR5)

OAS:	101121592(LGR5)

BTAX:

128048368(LGR5)

ODA:	120858133(LGR5)

CCAD:

122427593(LGR5)

MBEZ:

129537033(LGR5)

SSC:	100151994(LGR5)

CFR:	102516819(LGR5)

CBAI:

105072068(LGR5)

CDK:	105096009(LGR5)

VPC:	102537255(LGR5)

BACU:

103009302(LGR5)

BMUS:

118902580(LGR5)

LVE:	103089496(LGR5)

OOR:	101269261(LGR5)

DLE:	111173740(LGR5)

PCAD:

102979156(LGR5)

PSIU:

116760316(LGR5)

NASI:

112394381(LGR5)

ECB:	100064565(LGR5)

EPZ:

103564340

EAI:	106842187(LGR5)

MYB:	102257180(LGR5)

MYD:	102760335(LGR5)

MMYO:

118650397(LGR5)

MLF:	102435853(LGR5)

PKL:	118730427(LGR5)

EFUS:

103298786(LGR5)

MNA:	107526657(LGR5)

DRO:	112319065(LGR5)

SHON:

118989346(LGR5)

AJM:	119039425(LGR5)

PDIC:

114512777(LGR5)

PHAS:

123812581(LGR5)

MMF:	118623934(LGR5)

PPAM:

129075995(LGR5)

HAI:	109387675(LGR5)

RFQ:	117029441(LGR5)

PALE:

102889362(LGR5)

PGIG:

120605068(LGR5)

PVP:	105301570(LGR5)

RAY:	107512630(LGR5)

MJV:	108402381(LGR5)

TOD:	119247508(LGR5)

SARA:

101550300(LGR5)

SETR:

126022190(LGR5)

LAV:	100668785(LGR5)

TMU:

101354037

ETF:	101638042(LGR5)

DNM:	101412787(LGR5)

MDO:	100016120(LGR5)

GAS:	123250587(LGR5)

PCW:	110195942(LGR5)

OAA:	100081690(LGR5)

GGA:	427867(LGR5)

PCOC:

116226754(LGR5)

MGP:	100549342(LGR5)

CJO:	107310333(LGR5)

TPAI:

128073794(LGR5)

LMUT:

125691615(LGR5)

NMEL:

110392814(LGR5)

APLA:

101791864(LGR5)

ACYG:

106046773(LGR5)

CATA:

118246660(LGR5)

AFUL:

116501758(LGR5)

TGU:	100224745(LGR5)

LSR:	110469838(LGR5)

SCAN:

103813441(LGR5)

PMOA:

120499771(LGR5)

OTC:	121339477(LGR5)

PRUF:

121352600(LGR5)

GFR:	102040311(LGR5)

FAB:	101816491(LGR5)

OMA:	130267064(LGR5)

PHI:	102102928(LGR5)

PMAJ:

107205047(LGR5)

CCAE:

111937544(LGR5)

CCW:	104698389(LGR5)

CBRC:

103614823(LGR5)

ETL:	114059994(LGR5)

ZAB:	102066940(LGR5)

ACHL:

103798646(LGR5)

SVG:	106855124(LGR5)

MMEA:

130580344(LGR5)

HRT:	120751689(LGR5)

FPG:	101922267(LGR5)

FCH:	102050023(LGR5)

CLV:	102092142(LGR5)

EGZ:	104132922(LGR5)

NNI:	104010992(LGR5)

PCRI:

104031532(LGR5)

PLET:

104617456(LGR5)

EHS:	104509895(LGR5)

PCAO:

104047772(LGR5)

ACUN:

113491338(LGR5)

TALA:

104365874(LGR5)

PADL:

103919946(LGR5)

AFOR:

103893912(LGR5)

ACHC:

115336090(LGR5)

HALD:

104317370(LGR5)

HLE:	104828237(LGR5)

AGEN:

126034376

GCL:

127016611

CCRI:

104154489(LGR5)

CSTI:

104549210

CMAC:

104473627(LGR5)

MUI:	104548649(LGR5)

BREG:

104632749(LGR5)

FGA:	104073709(LGR5)

GSTE:

104250256(LGR5)

LDI:	104351955(LGR5)

MNB:	103778029(LGR5)

OHA:	104326754(LGR5)

NNT:	104403030(LGR5)

SHAB:

115605808(LGR5)

DPUB:

104304248(LGR5)

PGUU:

104463012(LGR5)

ACAR:

104520998(LGR5)

CPEA:

104388801(LGR5)

AVIT:

104280972(LGR5)

CVF:	104288908(LGR5)

RTD:	128904319(LGR5)

CUCA:

104063917(LGR5)

TEO:	104380550(LGR5)

BRHI:

104496119(LGR5)

AAM:	106488788(LGR5)

AROW:

112964093(LGR5)

NPD:	112947666(LGR5)

TGT:	104564631(LGR5)

DNE:	112983319(LGR5)

SCAM:

104140678(LGR5)

ASN:	102378062(LGR5)

AMJ:	106736699(LGR5)

CPOO:

109315973(LGR5)

GGN:	109296371(LGR5)

PSS:	102458277(LGR5)

CMY:	102930696(LGR5)

CCAY:

125630187(LGR5)

DCC:	119846148(LGR5)

CPIC:

101945872(LGR5)

TST:	117877869(LGR5)

CABI:

116838528(LGR5)

MRV:	120381905(LGR5)

ACS:	100567980(lgr5)

ASAO:

132776158(LGR5)

PVT:	110084939(LGR5)

SUND:

121930748(LGR5)

PBI:	103061569(LGR5)

PMUR:

107283821(LGR5)

CTIG:

120308428(LGR5)

TSR:	106549365(LGR5)

PGUT:

117655795(LGR5)

APRI:

131202190(LGR5)

PTEX:

113435586(LGR5)

VKO:	123033297(LGR5)

PMUA:

114605120(LGR5)

PRAF:

128422722(LGR5)

ZVI:	118091006(LGR5)

HCG:	128328485(LGR5)

GJA:	107105697(LGR5)

STOW:

125435004(LGR5)

EMC:	129335664(LGR5)

XLA:	100526795(lgr5.L) 108713148(lgr5.S)

XTR:	100486389(lgr5)

NPR:	108788313(LGR5)

RTEM:

120931972(LGR5)

BBUF:

120980674(LGR5)

BGAR:

122925791(LGR5)

MUO:	115477478(LGR5)

GSH:	117364086(LGR5)

IPU:

108280064

IFU:

128623091

PHYP:

113532419(lgr5)

SMEO:

124401591

TFD:

113645530

TVC:

132859330

EEE:	113575825(lgr5)

CHAR:

105910344

TRU:	101073258(lgr5)

TFS:

130519525

LCO:

104935806

TBEN:

117487125

CGOB:

115005992 115006003(lgr5)

GACU:

117553105

EMAC:

134879095

ELY:	117249353 117261972

EFO:	125882625 125887848

SLUC:

116040237 116051982

ECRA:

117949496

PFLV:

114550480(lgr5)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101478911(lgr5)

ONL:	100700915(lgr5)

OAU:

116319730

OLA:	101157030(lgr5)

OML:

112157951

XMA:	102237482(lgr5)

XCO:	114160612(lgr5)

XHE:	116736390(lgr5)

PRET:

103459341(lgr5)

PFOR:

103154272

PLAI:

106957156(lgr5)

PMEI:

106917301(lgr5)

GAF:

122826522

PPRL:

129352864

CVG:	107089076(lgr5)

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:	111224544(lgr5)

SLAL:

111664914(lgr5)

XGL:	120793097 120799836

BPEC:

110161519(lgr5)

MALB:

109967747(lgr5)

BSPL:

114862503

SJO:

128385186

SASA:

106561543(lgr5) 106609731

STRU:

115189731 115197534

OTW:	112218843 121845484

OMY:	110490687 110499401 118942829

OGO:

123995973

ONE:

115133978

OKI:	109867784 109877201 109886808

OKE:

SALP:

SNH:

CCLU:

ELS:	105018244 105023115(lgr5)

SFM:	108936582(lgr5) 108942205

PKI:	111851501(lgr5) 111858640

AANG:

118218661

LOC:	102694225(lgr5)

PSPA:

121318029 121320062

ARUT:

117414733 117419431

PSEX:

120534382

LCM:	102363702(LGR5)

CMK:

RTP:

CPLA:

HOC:

LERI:

CIN:

SCLV:

HRF:	124115460 124142315

MMER:

123528236

» show all

Reference

PMID:21693646

Authors

Carmon KS, Gong X, Lin Q, Thomas A, Liu Q

Title

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.

Journal

Proc Natl Acad Sci U S A 108:11452-7 (2011)
DOI:10.1073/pnas.1106083108

Sequence

[hsa:8549]

LinkDB

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