KEGG ORTHOLOGY: K04417

ORTHOLOGY: K04417

Entry

K04417                      KO

Symbol

MAP3K9, MLK1

Name

mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04361

Axon regeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9
   04013 MAPK signaling pathway - fly
    K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9
09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K04417  MAP3K9, MLK1; mitogen-activated protein kinase kinase kinase 9

Other DBs

GO:

0004709

Genes

HSA:	4293(MAP3K9)

PTR:	467498(MAP3K9)

PPS:	100990426(MAP3K9)

GGO:	101135149(MAP3K9)

PON:	100433831(MAP3K9)

NLE:	100589608(MAP3K9)

HMH:	116484762(MAP3K9)

MCC:	693835(MAP3K9)

MCF:	102123979(MAP3K9)

MTHB:

126958762

MNI:	105494312(MAP3K9)

CSAB:

103229274(MAP3K9)

CATY:

105599537(MAP3K9)

PANU:

101019871(MAP3K9)

TGE:	112628781(MAP3K9)

MLEU:

105541870(MAP3K9)

RRO:	104660313(MAP3K9)

RBB:	108536203(MAP3K9)

PTEH:

111520286(MAP3K9)

CANG:

105517204(MAP3K9)

CJC:	100385131(MAP3K9)

SBQ:	101051154(MAP3K9)

CIMI:

108304520(MAP3K9)

CSYR:

103260103(MAP3K9)

MMUR:

105866663(MAP3K9)

LCAT:

123647333(MAP3K9)

PCOQ:

105819941(MAP3K9)

OGA:	100941407(MAP3K9)

MMU:	338372(Map3k9)

MCAL:

110306985(Map3k9)

MPAH:

110324226(Map3k9)

RNO:	500690(Map3k9)

MCOC:

116079640(Map3k9)

ANU:	117696947(Map3k9)

MUN:	110558804(Map3k9)

CGE:	100762934(Map3k9)

MAUA:

101822573(Map3k9)

PROB:

127230939(Map3k9)

PLEU:

114698668(Map3k9)

MORG:

121452574(Map3k9)

MFOT:

126515181

AAMP:

119819048(Map3k9)

NGI:	103725874(Map3k9)

HGL:	101696673(Map3k9)

CPOC:

100715894(Map3k9)

CCAN:

109700426(Map3k9)

DORD:

105986666(Map3k9)

DSP:	122118824(Map3k9)

PLOP:

125363264(Map3k9)

NCAR:

124977280

MMMA:

107148751(Map3k9)

OCU:

100341731

OPI:	101536245(MAP3K9)

TUP:	102470721(MAP3K9)

GVR:	103588927(MAP3K9)

CFA:	490765(MAP3K9)

CLUD:

112657061(MAP3K9)

VVP:	112927232(MAP3K9)

VLG:	121493506(MAP3K9)

NPO:	129496105(MAP3K9)

AML:	100472044(MAP3K9)

UMR:	103671518(MAP3K9)

UAH:	113270380(MAP3K9)

UAR:	123799026(MAP3K9)

ELK:

111148486

LLV:

125104197

MPUF:

101686850(MAP3K9)

MNP:	132000206(MAP3K9)

MLK:	131836919(MAP3K9)

NVS:	122894342(MAP3K9)

ORO:	101379119(MAP3K9)

EJU:	114206961(MAP3K9)

ZCA:	113909391(MAP3K9)

MLX:	118002008(MAP3K9)

NSU:	110571621(MAP3K9)

LWW:	102730950(MAP3K9)

FCA:	101084717(MAP3K9)

PYU:	121031994(MAP3K9)

PCOO:

112855300(MAP3K9)

PBG:	122469274(MAP3K9)

PVIV:

125167866(MAP3K9)

LRUF:

124512066

PTG:	102948678(MAP3K9)

PPAD:

109268227(MAP3K9)

PUC:

125909380

AJU:

106974370

HHV:	120245000(MAP3K9)

BTA:	538340(MAP3K9)

BOM:	102271481(MAP3K9)

BIU:	109565306(MAP3K9)

BBUB:

102398758(MAP3K9)

BBIS:

104993427(MAP3K9)

CHX:	102180599(MAP3K9)

OAS:	101103160(MAP3K9)

BTAX:

128053937(MAP3K9)

ODA:	120852752(MAP3K9)

CCAD:

122443814(MAP3K9)

MBEZ:

129562798(MAP3K9)

SSC:	100155753(MAP3K9)

CFR:	102513589(MAP3K9)

CBAI:

105074721(MAP3K9)

CDK:	105086141(MAP3K9)

VPC:	102535753(MAP3K9)

BACU:

103019037(MAP3K9)

BMUS:

118890375(MAP3K9)

LVE:	103083922(MAP3K9)

OOR:	101270573(MAP3K9)

DLE:	111173006(MAP3K9)

PCAD:

102991211(MAP3K9)

PSIU:

116749666(MAP3K9)

NASI:

112396102(MAP3K9)

ECB:	100054289(MAP3K9)

EPZ:

103567590

EAI:	106824083(MAP3K9)

MYB:	102243445(MAP3K9)

MYD:	102756379(MAP3K9)

MMYO:

118657478(MAP3K9)

MLF:	102441121(MAP3K9)

PKL:	118716011(MAP3K9)

EFUS:

103283614(MAP3K9)

MNA:	107536244(MAP3K9)

DRO:	112311900(MAP3K9)

SHON:

118976655(MAP3K9)

AJM:	119035863(MAP3K9)

PDIC:

114493139(MAP3K9)

PHAS:

123808150(MAP3K9)

MMF:	118633491(MAP3K9)

PPAM:

129065743(MAP3K9)

HAI:	109376677(MAP3K9)

RFQ:	117023507(MAP3K9)

PALE:

102880725(MAP3K9)

PGIG:

120619461(MAP3K9)

PVP:	105308820(MAP3K9)

RAY:	107508239(MAP3K9)

MJV:	108383459(MAP3K9)

TOD:	119239245(MAP3K9)

SARA:

101545233(MAP3K9)

SETR:

126004128(MAP3K9)

LAV:	100665212(MAP3K9)

TMU:

101343482

ETF:	101658423(MAP3K9)

DNM:	101435256(MAP3K9)

MDO:	100020082(MAP3K9)

GAS:	123234003(MAP3K9)

SHR:	100916246(MAP3K9)

AFZ:

127549542

PCW:	110208372(MAP3K9)

OAA:	100086943(MAP3K9)

GGA:	425792(MAP3K9)

PCOC:

116229257(MAP3K9)

MGP:	100550901(MAP3K9)

CJO:	107314878(MAP3K9)

TPAI:

128085789(MAP3K9)

LMUT:

125694841(MAP3K9)

NMEL:

110400952(MAP3K9)

APLA:

101796310(MAP3K9)

ACYG:

106042342(MAP3K9)

CATA:

118244627(MAP3K9)

AFUL:

116489929(MAP3K9)

TGU:	100229586(MAP3K9)

LSR:	110476074(MAP3K9)

SCAN:

103826623(MAP3K9)

PMOA:

120500262(MAP3K9)

OTC:	121333237(MAP3K9)

PRUF:

121349481(MAP3K9)

GFR:	102034934(MAP3K9)

FAB:	101812702(MAP3K9)

OMA:	130254274(MAP3K9)

PHI:	102111999(MAP3K9)

PMAJ:

107206205(MAP3K9)

CCAE:

111930888(MAP3K9)

CCW:	104683461(MAP3K9)

CBRC:

103620793(MAP3K9)

ETL:	114055484(MAP3K9)

ZAB:	102075220(MAP3K9)

ACHL:

103803769

SVG:	106849023(MAP3K9)

MMEA:

130573960(MAP3K9)

HRT:	120754071(MAP3K9)

FPG:	101918542(MAP3K9)

FCH:	102057922(MAP3K9)

CLV:	102086335(MAP3K9)

EGZ:	104129655(MAP3K9)

NNI:	104020321(MAP3K9)

PLET:

104620696(MAP3K9)

EHS:

104516784

PCAO:

104053315(MAP3K9)

ACUN:

113480320(MAP3K9)

TALA:

104359777(MAP3K9)

PADL:

103912780(MAP3K9)

AFOR:

103898897(MAP3K9)

ACHC:

115353765(MAP3K9)

HALD:

104324664

HLE:	104835899(MAP3K9)

AGEN:

126049366

GCL:

127016522

CCRI:

104159782

CSTI:

104550002(MAP3K9)

CMAC:

104483201(MAP3K9)

MUI:	104542790(MAP3K9)

BREG:

104633447(MAP3K9)

FGA:	104083395(MAP3K9)

GSTE:

104251502(MAP3K9)

LDI:	104351345(MAP3K9)

MNB:

103773052

OHA:	104334257(MAP3K9)

NNT:	104400662(MAP3K9)

SHAB:

115607167(MAP3K9)

DPUB:

104300341(MAP3K9)

PGUU:

104468698(MAP3K9)

ACAR:

104528174(MAP3K9)

CPEA:

104397667(MAP3K9)

CVF:	104283940(MAP3K9)

RTD:	128909202(MAP3K9)

CUCA:

104061712(MAP3K9)

TEO:	104370149(MAP3K9)

BRHI:

104501139(MAP3K9)

AAM:	106498093(MAP3K9)

AROW:

112972356(MAP3K9)

NPD:	112946696(MAP3K9)

TGT:	104571953(MAP3K9)

DNE:	112980643(MAP3K9)

SCAM:

104153821(MAP3K9)

ASN:	102382735(MAP3K9)

AMJ:	106736664(MAP3K9)

CPOO:

109320781(MAP3K9)

GGN:	109299356(MAP3K9)

PSS:	102459971(MAP3K9)

CMY:	102940369(MAP3K9)

CCAY:

125637670(MAP3K9)

DCC:	119857575(MAP3K9)

CPIC:

101932636(MAP3K9)

TST:	117877194(MAP3K9)

CABI:

116826192(MAP3K9)

MRV:	120403502(MAP3K9)

ACS:	100556486(map3k9)

ASAO:

132767087(MAP3K9)

PVT:	110076402(MAP3K9)

SUND:

121919537(MAP3K9)

PBI:	103067160(MAP3K9)

PMUR:

107294300(MAP3K9)

CTIG:

120304087(MAP3K9)

TSR:

106550204

PGUT:

117665602(MAP3K9)

APRI:

131187548(MAP3K9)

PTEX:

113438496(MAP3K9)

NSS:	113414379(MAP3K9)

VKO:	123026781(MAP3K9)

PRAF:

128411943(MAP3K9)

ZVI:	118083971(MAP3K9)

HCG:	128332987(MAP3K9)

GJA:	107122639(MAP3K9)

STOW:

125427368(MAP3K9)

EMC:	129324371(MAP3K9)

XLA:	100381159(map3k9.L) 108699730(map3k9.S)

XTR:	100488949(map3k9)

RTEM:

120920861(MAP3K9)

BBUF:

120982216(MAP3K9)

BGAR:

122921788(MAP3K9)

MUO:	115478106(MAP3K9)

GSH:	117364373(MAP3K9)

DRE:	560639(map3k9)

SRX:

107705427

SANH:

107654958

SGH:	107553203 107602953

CAUA:

113056779 113112491

CGIB:

127969750 128026034

PTET:

122356867(map3k9)

LROH:

127175690(map3k9)

OMC:	131552403(map3k9)

PPRM:

120467702(map3k9)

RKG:	130088268(map3k9)

MAMB:

125277287(map3k9)

CIDE:

127524701

MASI:

127411636 127413883

TROS:

130559105(map3k9)

TDW:	130431405(map3k9)

MANU:

129416682(map3k9)

AMEX:

103030442(map3k9)

CMAO:

118810015(map3k9)

EEE:	113574678(map3k9)

CHAR:

105908153(map3k9)

TRU:	101062891(map3k9)

TFS:	130539859(map3k9)

TNG:	GSTEN00035806G001

LCO:	104929782(map3k9)

TBEN:

117481427(map3k9)

CGOB:

115027785(map3k9)

PGEO:

117467282(map3k9)

GACU:

117533864(map3k9)

EMAC:

134881325(map3k9)

ELY:	117266625(map3k9)

EFO:	125900476(map3k9)

PLEP:

121953170(map3k9)

SLUC:

116057403(map3k9)

ECRA:

117935405(map3k9)

ESP:	116669704(map3k9)

PFLV:

114547164(map3k9)

GAT:	120832472(map3k9)

PPUG:

119227507(map3k9)

AFB:	129103160(map3k9)

CLUM:

117725120(map3k9)

PSWI:

130201234(map3k9)

MSAM:

119887743(map3k9)

SCHU:

122862146(map3k9)

CUD:	121525741(map3k9)

ALAT:

119004787(map3k9)

MZE:	101472971(map3k9)

ONL:	100708160(map3k9)

OAU:	116315187(map3k9)

OLA:	101169326(map3k9)

OML:	112148179(map3k9)

CSAI:

133462391(map3k9)

XMA:	102233228(map3k9)

XCO:	114134112(map3k9)

XHE:	116709334(map3k9)

PRET:

103458299(map3k9)

PFOR:

103144750(map3k9)

PLAI:

106937765(map3k9)

PMEI:

106906283

GAF:	122845823(map3k9)

PPRL:

129365469(map3k9)

CVG:	107095004(map3k9)

CTUL:

119776493(map3k9)

GMU:	124855259(map3k9)

NFU:	107391734(map3k9)

KMR:	108237522(map3k9)

ALIM:

106530138 106534763(map3k9)

NWH:	119427078(map3k9)

AOCE:

111579383(map3k9)

MCEP:

125023453(map3k9)

CSEM:

103381093(map3k9)

POV:	109636300(map3k9)

SSEN:

122783081(map3k9)

HHIP:

117756660(map3k9)

HSP:	118116148(map3k9)

SMAU:

118286665(map3k9)

LCF:

108886688

SDU:

111225561

SLAL:

111654335

XGL:	120795624(map3k9)

HCQ:	109517251(map3k9)

SSCV:

125980964

SBIA:

133513546(map3k9)

PEE:	133412991(map3k9)

PTAO:

133487796(map3k9)

BPEC:

110171100(map3k9)

MALB:

109973381(map3k9)

BSPL:

114848375(map3k9)

SJO:	128375213(map3k9)

SASA:

106600704(map3k9)

STRU:

115172999(map3k9)

OTW:	112262249(map3k9)

OMY:	110498588(map3k9)

OGO:	124002275(map3k9)

ONE:

115123351

OKI:	109893836(map3k9)

OKE:	118362010(map3k9)

SNH:	120059721(map3k9)

CCLU:

121539081(map3k9)

ELS:	105015920(map3k9)

SFM:	108919475(map3k9)

PKI:	111856245(map3k9)

AANG:

118209118(map3k9)

LOC:	102692821(map3k9)

PSPA:

121324836(map3k9)

ARUT:

117422669 117424577

PSEX:

120518843(map3k9)

LCM:	102356869(MAP3K9)

CMK:	103178584(map3k9)

RTP:	109921628(map3k9)

CPLA:

122553798(map3k9)

HOC:	132818166(map3k9)

LERI:

129700386(map3k9)

PMRN:

116939753 116943327

LRJ:	133342264 133347063 133347067

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG2272(slpr)

DER:

6550523

DSE:

6620185

DSI:	Dsimw501_GD27793(Dsim_GD27793)

DSR:

DPO:

DPE:

DMN:

DGR:

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ002878

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

NVL:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105384634 105396019

PGW:

API:

DNX:

AGS:

RMD:

DVT:

BTAB:

CLEC:

NLU:

PHU:	Phum_PHUM230730

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_322731

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:

LSM:	121128175 121130485

TCF:

TUT:

CSCU:

PTEP:

ABRU:

UDV:	129226005 129229759

SDM:	118187243 118202383

LPOL:

106464683 106470334

CEL:	CELE_K11D12.10(mlk-1)

CBR:	CBG_08663(Cbr-mlk-1)

CRQ:	GCK72_018477

NAI:	NECAME_00333

BMY:	BM_BM9342(Bm9342)

LOA:	LOAG_11337

TSP:

Tsp_07016

HRO:	HELRODRAFT_111211 HELRODRAFT_81107

PCAN:

BGT:

OED:

MYI:

PMAX:

MMER:

LAK:	106160655 106164541

SMM:	Smp_176580

OVI:	T265_06687

EGL:

ATEN:

DGT:

HMG:

HSY:

TAD:	TRIADDRAFT_26486

AQU:

100632684

SRE:	PTSG_01588

» show all

Reference

PMID:15610029

Authors

Durkin JT, Holskin BP, Kopec KK, Reed MS, Spais CM, Steffy BM, Gessner G, Angeles TS, Pohl J, Ator MA, Meyer SL

Title

Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.

Journal

Biochemistry 43:16348-55 (2004)
DOI:10.1021/bi049866y

Sequence

[hsa:4293]

LinkDB

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