KEGG ORTHOLOGY: K04422

ORTHOLOGY: K04422

Entry

K04422                      KO

Symbol

MAP3K13, LZK

Name

mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04361

Axon regeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13
09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13
Protein kinases [BR:ko01001]
Serine/threonine kinases: TKL group
  MLK family
   K04422  MAP3K13, LZK; mitogen-activated protein kinase kinase kinase 13

Other DBs

GO:

0004709

Genes

HSA:	9175(MAP3K13)

PTR:	737524(MAP3K13)

PPS:	100985472(MAP3K13)

GGO:	101128207(MAP3K13)

PON:	100172983(MAP3K13)

NLE:	100587341(MAP3K13)

HMH:	116479925(MAP3K13)

MCC:	701085(MAP3K13)

MCF:	102119428(MAP3K13)

MTHB:

126948442

MNI:	105480146(MAP3K13)

CSAB:

103221113(MAP3K13)

CATY:

105573954(MAP3K13)

PANU:

101025803(MAP3K13)

TGE:	112618518(MAP3K13)

MLEU:

105541038(MAP3K13)

RRO:	104672741(MAP3K13)

RBB:	108525357(MAP3K13)

TFN:	117083841(MAP3K13)

PTEH:

111523200(MAP3K13)

CANG:

105519848

CJC:	100395753(MAP3K13)

SBQ:	101049991(MAP3K13)

CIMI:

108311095(MAP3K13)

CSYR:

103268752(MAP3K13)

MMUR:

105863058(MAP3K13)

LCAT:

123630347(MAP3K13)

PCOQ:

105808678(MAP3K13)

OGA:	100964785(MAP3K13)

MMU:	71751(Map3k13)

MCAL:

110311270(Map3k13)

MPAH:

110329718(Map3k13)

RNO:	303823(Map3k13)

MCOC:

116085741(Map3k13)

ANU:	117717508(Map3k13)

MUN:	110561590(Map3k13)

CGE:	100754991(Map3k13)

MAUA:

101828272(Map3k13)

PROB:

127226987(Map3k13)

PLEU:

114684252(Map3k13)

MORG:

121465079(Map3k13)

MFOT:

126504182

AAMP:

119825626(Map3k13)

NGI:	103732670(Map3k13)

HGL:	101700680(Map3k13)

CPOC:

100727150(Map3k13)

CCAN:

109699287(Map3k13)

DORD:

105999678(Map3k13)

DSP:	122098790(Map3k13)

PLOP:

125351910(Map3k13)

NCAR:

124992671

MMMA:

107154342(Map3k13)

OCU:

100345602

OPI:	101529583(MAP3K13)

TUP:	102478254(MAP3K13)

GVR:	103591456(MAP3K13)

CFA:	100685499(MAP3K13)

CLUD:

112662626(MAP3K13)

VVP:	112926277(MAP3K13)

VLG:	121477477(MAP3K13)

NPO:	129498401(MAP3K13)

AML:	100467807(MAP3K13)

UMR:	103676070(MAP3K13)

UAH:	113254044(MAP3K13)

UAR:	123778945(MAP3K13)

ELK:

111150584

LLV:

125101721

MPUF:

101687195(MAP3K13)

MNP:	132011969(MAP3K13)

MLK:	131824772(MAP3K13)

NVS:	122908771(MAP3K13)

ORO:	101370047(MAP3K13)

EJU:	114207028(MAP3K13)

ZCA:	113916907(MAP3K13)

MLX:	118006912(MAP3K13)

NSU:	110582357(MAP3K13)

LWW:	102728519(MAP3K13)

FCA:	101093205(MAP3K13)

PYU:	121034102(MAP3K13)

PCOO:

112849671(MAP3K13)

PBG:	122491644(MAP3K13)

PVIV:

125174639(MAP3K13)

LRUF:

124526779

PTG:	102965107(MAP3K13)

PPAD:

109275247(MAP3K13)

PUC:

125921101

AJU:

106967988

HHV:	120238093(MAP3K13)

BTA:	505369(MAP3K13)

BOM:	102285655(MAP3K13)

BIU:	109557274(MAP3K13)

BBUB:

102404576(MAP3K13)

BBIS:

104998610(MAP3K13)

CHX:	102178859(MAP3K13)

OAS:	101117036(MAP3K13)

BTAX:

128050640(MAP3K13) 128070371

ODA:	120872231(MAP3K13)

CCAD:

122444838(MAP3K13)

MBEZ:

129544903(MAP3K13)

SSC:	100515448(MAP3K13)

CFR:	102506410(MAP3K13)

CBAI:

105072315(MAP3K13)

CDK:	105085862(MAP3K13)

VPC:	102534966(MAP3K13)

BACU:

103020592(MAP3K13)

BMUS:

118894236(MAP3K13)

LVE:	103073201(MAP3K13)

OOR:	101278099(MAP3K13)

DLE:	111173071(MAP3K13)

PCAD:

102989494(MAP3K13)

PSIU:

116753452(MAP3K13)

NASI:

112415491(MAP3K13)

ECB:	100059237(MAP3K13)

EPZ:	103564958(MAP3K13)

EAI:	106834499(MAP3K13)

MYB:	102239254(MAP3K13)

MYD:	102753720(MAP3K13)

MMYO:

118676633(MAP3K13)

MLF:	102437763(MAP3K13)

PKL:	118723608(MAP3K13)

EFUS:

103300680(MAP3K13)

MNA:	107527317(MAP3K13)

DRO:	112308163(MAP3K13)

SHON:

118974257(MAP3K13)

AJM:	119038751(MAP3K13)

PDIC:

114490458(MAP3K13)

PHAS:

123826833(MAP3K13)

MMF:	118617309(MAP3K13)

PPAM:

129079846(MAP3K13)

HAI:	109371277(MAP3K13)

RFQ:	117033961(MAP3K13)

PALE:

102880315(MAP3K13)

PGIG:

120592996(MAP3K13)

PVP:	105307825(MAP3K13)

RAY:	107518243(MAP3K13)

MJV:	108410204(MAP3K13)

TOD:	119257361(MAP3K13)

SARA:

101543875(MAP3K13)

SETR:

126012038(MAP3K13)

LAV:	100677466(MAP3K13)

TMU:

101352644

ETF:	101653397(MAP3K13)

DNM:	101422096(MAP3K13)

MDO:	100014282(MAP3K13)

GAS:	123246862(MAP3K13)

SHR:	100913796(MAP3K13)

AFZ:

127563516

PCW:	110221295(MAP3K13)

OAA:	100076986(MAP3K13)

GGA:	424876(MAP3K13)

PCOC:

116231027(MAP3K13)

MGP:	100547994(MAP3K13)

CJO:	107317933(MAP3K13)

TPAI:

128082766(MAP3K13)

LMUT:

125697492(MAP3K13)

NMEL:

110399087(MAP3K13)

APLA:

101792050(MAP3K13)

ACYG:

106039243(MAP3K13)

CATA:

118247087(MAP3K13)

AFUL:

116492442(MAP3K13)

TGU:	100225400(MAP3K13)

LSR:	110474076(MAP3K13)

SCAN:

103815669(MAP3K13)

PMOA:

120496444(MAP3K13)

OTC:	121342107(MAP3K13)

PRUF:

121364073(MAP3K13)

GFR:	102040792(MAP3K13)

FAB:	101812912(MAP3K13)

OMA:	130256663(MAP3K13)

PHI:	102112025(MAP3K13)

PMAJ:

107208746(MAP3K13)

CCAE:

111933696(MAP3K13)

CCW:	104696697(MAP3K13)

CBRC:

103612409(MAP3K13)

ETL:	114054812(MAP3K13)

ZAB:	102075302(MAP3K13)

ACHL:

103811889

SVG:	106849691(MAP3K13)

MMEA:

130581482(MAP3K13)

HRT:	120757016(MAP3K13)

FPG:	101916440(MAP3K13)

FCH:	102050412(MAP3K13)

CLV:	102091011(MAP3K13)

EGZ:	104131267(MAP3K13)

NNI:	104010621(MAP3K13)

PCRI:

104033630(MAP3K13)

PLET:

104621004(MAP3K13)

EHS:	104513305(MAP3K13)

PCAO:

104039774(MAP3K13)

ACUN:

113483720(MAP3K13)

TALA:

104360515(MAP3K13)

PADL:

103916918(MAP3K13)

AFOR:

103903703(MAP3K13)

ACHC:

115347721(MAP3K13)

HALD:

104319394(MAP3K13)

HLE:	104827865(MAP3K13)

AGEN:

126039473

GCL:

127020068

CCRI:

104161133(MAP3K13)

CMAC:

104477127(MAP3K13)

MUI:	104546815(MAP3K13)

BREG:

104638429

FGA:	104070279(MAP3K13)

GSTE:

104254486(MAP3K13)

LDI:	104346260(MAP3K13)

MNB:	103769935(MAP3K13)

OHA:	104335080(MAP3K13)

NNT:	104411019(MAP3K13)

SHAB:

115611349(MAP3K13)

DPUB:

104305531(MAP3K13)

PGUU:

104458403(MAP3K13)

ACAR:

104530731(MAP3K13)

CPEA:

104385090(MAP3K13)

AVIT:

104276006

CVF:	104288540(MAP3K13)

RTD:	128911219(MAP3K13)

CUCA:

104067429(MAP3K13)

TEO:	104378130(MAP3K13)

BRHI:

104501065(MAP3K13)

AAM:	106493178(MAP3K13)

AROW:

112970782(MAP3K13)

NPD:	112946786(MAP3K13)

TGT:	104573790(MAP3K13)

DNE:	112983450(MAP3K13)

SCAM:

104154207(MAP3K13)

ASN:	102381053(MAP3K13)

AMJ:	102566049(MAP3K13)

CPOO:

109315317(MAP3K13)

GGN:	109288280(MAP3K13)

PSS:	102453748(MAP3K13)

CMY:	102939329(MAP3K13)

CCAY:

125642407(MAP3K13)

DCC:	119861384(MAP3K13)

CPIC:

101939982(MAP3K13)

TST:	117882518(MAP3K13)

CABI:

116815339(MAP3K13)

MRV:	120372134(MAP3K13)

ACS:	100558270(map3k13)

ASAO:

132770768(MAP3K13)

PVT:	110075834(MAP3K13)

SUND:

121927036(MAP3K13)

PBI:	103053098(MAP3K13)

PMUR:

107285893(MAP3K13)

CTIG:

120313908(MAP3K13)

TSR:	106544597(MAP3K13)

PGUT:

117678498(MAP3K13)

APRI:

131200454(MAP3K13)

PTEX:

113436766(MAP3K13)

NSS:	113426125(MAP3K13)

VKO:	123025691(MAP3K13)

PMUA:

114597691(MAP3K13)

PRAF:

128414453(MAP3K13)

ZVI:	118093425(MAP3K13)

HCG:	128351911(MAP3K13)

GJA:	107123584(MAP3K13)

STOW:

125437773(MAP3K13)

EMC:	129332150(MAP3K13)

XLA:	100337577(map3k13.S) 100337578(map3k13.L)

XTR:	100493878(map3k13)

NPR:	108795599(MAP3K13)

RTEM:

120943838(MAP3K13)

BBUF:

121007961(MAP3K13)

BGAR:

122945103(MAP3K13)

MUO:	115474253(MAP3K13)

GSH:	117361425(MAP3K13)

DRE:	568412(si:ch211-45c16.2)

SRX:	107722698 107742817

SANH:

107663946 107675121

SGH:	107558389 107567712

CCAR:

109100262 109100263

CAUA:

113052923 113108228

CGIB:

127965402 128011163 128020262

PTET:

122333098(si:ch211-45c16.2)

LROH:

127170973(si:ch211-45c16.2)

OMC:	131547098(si:ch211-45c16.2)

PPRM:

120487227(si:ch211-45c16.2)

RKG:	130105389(si:ch211-45c16.2)

MAMB:

125270788(si:ch211-45c16.2)

CIDE:

127518616(si:ch211-45c16.2)

MASI:

127446918 127448228(si:ch211-45c16.2)

TROS:

130555560(si:ch211-45c16.2)

TDW:	130427684(si:ch211-45c16.2)

MANU:

129451798(si:ch211-45c16.2)

IPU:	108266772(si:ch211-45c16.2)

IFU:	128609063(si:ch211-45c16.2)

PHYP:

113525928

SMEO:

124382883(si:ch211-45c16.2)

TFD:	113645378(si:ch211-45c16.2)

TVC:	132850363(si:ch211-45c16.2)

AMEX:

103032151(map3k13)

CMAO:

118807602(si:ch211-45c16.2)

EEE:	113577953(map3k13)

CHAR:

105912646(si:ch211-45c16.2)

TRU:	101063413(map3k13)

TFS:	130522869(si:ch211-45c16.2)

TNG:	GSTEN00030516G001

LCO:	104928841(map3k13)

NCC:	104961137(map3k13)

TBEN:

117485831(si:ch211-45c16.2)

CGOB:

115026620(map3k13)

PGEO:

117467000(si:ch211-45c16.2)

GACU:

117538363(si:ch211-45c16.2)

EMAC:

134867327(si:ch211-45c16.2)

ELY:	117251448(si:ch211-45c16.2)

EFO:	125899842(si:ch211-45c16.2)

PLEP:

121949050(si:ch211-45c16.2)

SLUC:

116049637(si:ch211-45c16.2)

ECRA:

117953234(si:ch211-45c16.2)

ESP:	116697676(map3k13)

PFLV:

114563712(map3k13)

GAT:	120834003(si:ch211-45c16.2)

PPUG:

119228670(si:ch211-45c16.2)

AFB:	129104645(si:ch211-45c16.2)

CLUM:

117750797(si:ch211-45c16.2)

PSWI:

130204531(si:ch211-45c16.2)

MSAM:

119904001(si:ch211-45c16.2)

SCHU:

122885640(si:ch211-45c16.2)

CUD:	121522792(si:ch211-45c16.2)

ALAT:

119026114(si:ch211-45c16.2)

MZE:	101463743(map3k13)

ONL:	100711574(map3k13)

OAU:	116335381(si:ch211-45c16.2)

OLA:	101170310(map3k13)

OML:	112155112(si:ch211-45c16.2)

CSAI:

133446009(si:ch211-45c16.2)

XMA:	102220942(map3k13)

XCO:	114148301(map3k13)

XHE:	116723202(map3k13)

PRET:

103461651(map3k13)

PFOR:

103155765(map3k13)

PLAI:

106948033(map3k13)

PMEI:

106927889(map3k13)

GAF:	122839945(si:ch211-45c16.2)

PPRL:

129361205(si:ch211-45c16.2)

CVG:	107091898(map3k13)

CTUL:

119771912(si:ch211-45c16.2)

GMU:	124871422(si:ch211-45c16.2)

NFU:

107390127

KMR:	108240785(si:ch211-45c16.2)

ALIM:

106535790(map3k13)

NWH:	119419575(si:ch211-45c16.2)

AOCE:

111575582(map3k13)

MCEP:

125017583

CSEM:

103392054(map3k13)

POV:	109631386(map3k13)

SSEN:

122761379(si:ch211-45c16.2)

HHIP:

117755438(si:ch211-45c16.2)

HSP:	118120283(si:ch211-45c16.2)

SMAU:

118282488(si:ch211-45c16.2)

LCF:	108880463(si:ch211-45c16.2)

SDU:	111218550(map3k13)

SLAL:

111671514(map3k13)

XGL:	120801442(si:ch211-45c16.2)

HCQ:	109523279(map3k13)

SSCV:

125973284(si:ch211-45c16.2)

SBIA:

133511957(si:ch211-45c16.2)

PEE:	133410451(si:ch211-45c16.2)

PTAO:

133486639(si:ch211-45c16.2)

BPEC:

110159957(map3k13)

MALB:

109957145(map3k13)

BSPL:

114847185(si:ch211-45c16.2)

SJO:	128367837(si:ch211-45c16.2)

SASA:

106582565(map3k13) 106582576

STRU:

115155384(map3k13)

OTW:	112224902(si:ch211-45c16.2)

OMY:	110502204(si:ch211-45c16.2)

OGO:	124036308(si:ch211-45c16.2)

ONE:

115125532

OKI:	109884299(map3k13)

OKE:	118375196(si:ch211-45c16.2)

SALP:

112072696

SNH:	120036444(si:ch211-45c16.2)

CCLU:

121554873

ELS:	105006267(map3k13)

SFM:	108918254(map3k13)

PKI:	111858314(map3k13)

AANG:

118213699 118223872

LOC:	102684665(map3k13)

PSPA:

121322227 121323244(si:ch211-45c16.2)

ARUT:

117404502 117426139

PSEX:

120531140(si:ch211-45c16.2)

LCM:	102367402(MAP3K13)

CMK:	103190572(si:ch211-45c16.2)

CPLA:

122551456(si:ch211-45c16.2)

HOC:

132817670

LERI:

129698871

PMRN:

116938820 116949302

LRJ:	133345258 133345849

BFO:

BBEL:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG8789(wnd)

DER:

6545525

DSE:

6619382

DSI:	Dsimw501_GD12264(Dsim_GD12264)

DYA:	Dyak_GE22480

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13508

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203927

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

NLU:	111054242 120351831

PHU:	Phum_PHUM582410

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_52374

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

TCF:

PPOI:

RSAN:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

LPOL:

CEL:	CELE_F33E2.2(dlk-1)

CBR:	CBG_08707(Cbr-dlk-1)

CRQ:	GCK72_001535

LOA:	LOAG_17863

HRO:	HELRODRAFT_74446 HELRODRAFT_76766

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ADF:

AMIL:

XEN:

AQU:

TVS:	TRAVEDRAFT_165009

DSQ:	DICSQDRAFT_98246

PCO:	PHACADRAFT_255498

» show all

Reference

PMID:18855897

Authors

Craig EA, Stevens MV, Vaillancourt RR, Camenisch TD

Title

MAP3Ks as central regulators of cell fate during development.

Journal

Dev Dyn 237:3102-14 (2008)
DOI:10.1002/dvdy.21750

Reference

PMID:9353328

Authors

Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T

Title

Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.

Journal

J Biol Chem 272:28622-9 (1997)
DOI:10.1074/jbc.272.45.28622

Sequence

[hsa:9175]

LinkDB

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