KEGG ORTHOLOGY: K04466

ORTHOLOGY: K04466

Entry

K04466                      KO

Symbol

MAP3K14, NIK

Name

mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]

Pathway

map04010

MAPK signaling pathway

map04064

NF-kappa B signaling pathway

map04210

Apoptosis

map04380

Osteoclast differentiation

map04625

C-type lectin receptor signaling pathway

map04660

T cell receptor signaling pathway

map04668

TNF signaling pathway

map04672

Intestinal immune network for IgA production

map04936

Alcoholic liver disease

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05208

Chemical carcinogenesis - reactive oxygen species

Disease

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04064 NF-kappa B signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04668 TNF signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04660 T cell receptor signaling pathway
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   04672 Intestinal immune network for IgA production
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
   05169 Epstein-Barr virus infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14
Protein kinases [BR:ko01001]
Serine/threonine kinases: STE group
  Other
   K04466  MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14

Other DBs

GO:

0004709

Genes

HSA:	9020(MAP3K14)

PTR:	454750(MAP3K14)

PPS:	100984930(MAP3K14)

GGO:	101147819(MAP3K14)

PON:	100436201(MAP3K14)

NLE:	100600394(MAP3K14)

HMH:	116474979(MAP3K14)

MCC:	716258(MAP3K14)

MCF:	102145584(MAP3K14)

MTHB:

126938709

MNI:	105468661(MAP3K14)

CSAB:

103243289(MAP3K14)

CATY:

105585587(MAP3K14)

PANU:

101024657(MAP3K14)

TGE:	112609983(MAP3K14)

MLEU:

105543832(MAP3K14)

RRO:	104678377(MAP3K14)

RBB:	108532216(MAP3K14)

TFN:	117066854(MAP3K14)

PTEH:

111525786(MAP3K14)

CANG:

105510391(MAP3K14)

CJC:	100401112(MAP3K14)

SBQ:	101044826(MAP3K14)

CIMI:

108318325(MAP3K14)

CSYR:

103262848(MAP3K14)

MMUR:

105883589(MAP3K14)

LCAT:

123621038(MAP3K14)

PCOQ:

105824147(MAP3K14)

OGA:	100957606(MAP3K14)

MMU:	53859(Map3k14)

MCAL:

110304892(Map3k14)

MPAH:

110332218(Map3k14)

RNO:	360640(Map3k14)

MCOC:

116079161(Map3k14)

ANU:	117711275(Map3k14)

MUN:	110545661(Map3k14)

CGE:	100766459(Map3k14)

MAUA:

101825130(Map3k14)

PROB:

127216792(Map3k14)

PLEU:

114702264(Map3k14)

MORG:

121436161(Map3k14)

MFOT:

126510438

AAMP:

119813599(Map3k14)

NGI:	103738320(Map3k14)

HGL:	101703313(Map3k14)

CPOC:

100719582(Map3k14)

CCAN:

109691665(Map3k14)

DORD:

105997576(Map3k14)

DSP:	122103419(Map3k14)

PLOP:

125365518(Map3k14)

NCAR:

124980247

MMMA:

107150497(Map3k14)

OCU:

100351032

OPI:	101516061(MAP3K14)

TUP:	102500729(MAP3K14)

GVR:	103595998(MAP3K14)

CFA:	490926(MAP3K14)

CLUD:

112655568(MAP3K14)

VVP:	112910639(MAP3K14)

VLG:	121473037(MAP3K14)

NPO:	129512996(MAP3K14)

AML:	100472260(MAP3K14)

UMR:	103665883(MAP3K14)

UAH:	113265323(MAP3K14)

UAR:	123802960(MAP3K14)

ELK:

111158123

LLV:

125086838

MPUF:

101688261(MAP3K14)

MNP:	132004586(MAP3K14)

MLK:	131817097(MAP3K14)

NVS:	122906116(MAP3K14)

ORO:	101363246(MAP3K14)

EJU:	114200618(MAP3K14)

ZCA:	113939264(MAP3K14)

MLX:	118024997(MAP3K14)

NSU:	110573171(MAP3K14)

LWW:	102734276(MAP3K14)

FCA:	101083468(MAP3K14)

PYU:	121045129(MAP3K14)

PCOO:

112854134(MAP3K14)

PBG:	122485712(MAP3K14)

PVIV:

125158420(MAP3K14)

LRUF:

124522088

PTG:	102964388(MAP3K14)

PPAD:

109258173(MAP3K14)

PUC:

125926656

AJU:

106988147

HHV:	120222278(MAP3K14)

BTA:	508367(MAP3K14)

BOM:	102268339(MAP3K14)

BIU:	109574056(MAP3K14)

BBUB:

102397755(MAP3K14)

BBIS:

104982962(MAP3K14)

CHX:	102189617(MAP3K14)

OAS:	101118799(MAP3K14)

BTAX:

128065013(MAP3K14)

ODA:	120866995(MAP3K14)

CCAD:

122440265(MAP3K14)

MBEZ:

129544511(MAP3K14)

SSC:	100520402(MAP3K14)

CFR:	102504523(MAP3K14)

CBAI:

105072525(MAP3K14)

CDK:	105094405(MAP3K14)

VPC:	102526769(MAP3K14)

BACU:

103015859(MAP3K14)

BMUS:

118887081(MAP3K14)

LVE:	103082490(MAP3K14)

OOR:	101270119(MAP3K14)

DLE:	111170190(MAP3K14)

PCAD:

102991269(MAP3K14)

PSIU:

116745052(MAP3K14)

NASI:

112410215(MAP3K14)

ECB:	100050140(MAP3K14)

EPZ:	103554685(MAP3K14)

EAI:	106836478(MAP3K14)

MYB:	102262247(MAP3K14)

MYD:	102762988(MAP3K14)

MMYO:

118671685(MAP3K14)

MLF:	102432497(MAP3K14)

PKL:	118726383(MAP3K14)

EFUS:

103293009(MAP3K14)

MNA:	107528876(MAP3K14)

DRO:	112298609(MAP3K14)

SHON:

119001650(MAP3K14)

AJM:	119061562(MAP3K14)

PDIC:

114502860(MAP3K14)

PHAS:

123817083(MAP3K14)

MMF:	118634183(MAP3K14)

PPAM:

129086451(MAP3K14)

HAI:	109395015(MAP3K14)

RFQ:	117013869(MAP3K14)

PALE:

102897751(MAP3K14)

PGIG:

120589252(MAP3K14)

PVP:	105303461(MAP3K14)

RAY:	107508165(MAP3K14)

MJV:	108386996(MAP3K14)

TOD:	119230450(MAP3K14)

SARA:

101549152(MAP3K14)

SETR:

126016597(MAP3K14)

LAV:	100661927(MAP3K14)

TMU:

101343418

ETF:	101650553(MAP3K14)

DNM:	101428001(MAP3K14)

MDO:	100020668(MAP3K14)

GAS:	123243674(MAP3K14)

SHR:	100918124(MAP3K14)

AFZ:

127560369

PCW:	110215732(MAP3K14)

OAA:	100085554(MAP3K14)

GGA:	419964(MAP3K14)

PCOC:

116233854(MAP3K14)

MGP:	100538760(MAP3K14)

CJO:	107325016(MAP3K14)

TPAI:

128088788(MAP3K14)

LMUT:

125684686(MAP3K14)

NMEL:

110388448(MAP3K14)

APLA:

101791236(MAP3K14)

ACYG:

106046936(MAP3K14)

CATA:

118258242(MAP3K14)

AFUL:

116498521(MAP3K14)

TGU:	100217837(MAP3K14)

LSR:	110475629(MAP3K14)

SCAN:

103821648(MAP3K14)

PMOA:

120498305(MAP3K14)

OTC:	121332978(MAP3K14)

PRUF:

121350568(MAP3K14)

GFR:	102038763(MAP3K14)

FAB:	101813386(MAP3K14)

OMA:	130264129(MAP3K14)

PHI:	102113463(MAP3K14)

PMAJ:

107215307(MAP3K14)

CCAE:

111940095(MAP3K14)

CCW:	104698524(MAP3K14)

CBRC:

103622666(MAP3K14)

ETL:	114068663(MAP3K14)

ZAB:	102071857(MAP3K14)

ACHL:

103811582(MAP3K14)

SVG:	106858264(MAP3K14)

MMEA:

130583662(MAP3K14)

HRT:	120763856(MAP3K14)

FPG:	101919762(MAP3K14)

FCH:	102048630(MAP3K14)

CLV:	102088332(MAP3K14)

EGZ:	104132232(MAP3K14)

NNI:	104018900(MAP3K14)

PCRI:

104028095(MAP3K14)

PLET:

104623346(MAP3K14)

EHS:	104513073(MAP3K14)

PCAO:

104044905(MAP3K14)

ACUN:

113489146(MAP3K14)

TALA:

104367810(MAP3K14)

PADL:

103921921(MAP3K14)

AFOR:

103906041(MAP3K14)

ACHC:

115344910(MAP3K14)

HALD:

104310773(MAP3K14)

HLE:	104827955(MAP3K14)

AGEN:

126038780

GCL:

127026455

CCRI:

104159125(MAP3K14)

CSTI:

104554972(MAP3K14)

CMAC:

104478148(MAP3K14)

MUI:	104544021(MAP3K14)

BREG:

104639373(MAP3K14)

FGA:	104078879(MAP3K14)

GSTE:

104263875(MAP3K14)

LDI:	104349714(MAP3K14)

MNB:	103774719(MAP3K14)

OHA:	104333148(MAP3K14)

NNT:	104402159(MAP3K14)

SHAB:

115617822(MAP3K14)

DPUB:

104300039(MAP3K14)

PGUU:

104468872(MAP3K14)

ACAR:

104532303(MAP3K14)

CPEA:

104387011(MAP3K14)

CVF:	104285288(MAP3K14)

RTD:	128919265(MAP3K14)

CUCA:

104064883(MAP3K14)

TEO:	104382672(MAP3K14)

BRHI:

104495954(MAP3K14)

AAM:	106495649(MAP3K14)

AROW:

112971103(MAP3K14)

NPD:	112951091(MAP3K14)

TGT:	104578577(MAP3K14)

DNE:	112987825(MAP3K14)

SCAM:

104150857(MAP3K14)

ASN:	102388858(MAP3K14)

AMJ:	102575720(MAP3K14)

CPOO:

109323075(MAP3K14)

GGN:	109302060(MAP3K14)

PSS:	102464024(MAP3K14)

CMY:	102939834(MAP3K14)

CCAY:

125626604(MAP3K14)

DCC:	119849083(MAP3K14)

CPIC:

101932285(MAP3K14)

TST:	117869188(MAP3K14)

CABI:

116834675(MAP3K14)

MRV:	120385126(MAP3K14)

ACS:	100560190(map3k14)

ASAO:

132778327(MAP3K14)

PVT:	110081369(MAP3K14)

SUND:

121935260(MAP3K14)

PBI:	103066049(MAP3K14)

PMUR:

107303029(MAP3K14)

CTIG:

120302625(MAP3K14)

TSR:	106542520(MAP3K14)

PGUT:

117664727(MAP3K14)

APRI:

131197759(MAP3K14)

PTEX:

113447838(MAP3K14)

NSS:	113422085(MAP3K14)

VKO:	123031703(MAP3K14)

PMUA:

114581835(MAP3K14)

PRAF:

128399671(MAP3K14)

ZVI:	118094799(MAP3K14)

HCG:	128331536(MAP3K14)

GJA:	107125527(MAP3K14)

STOW:

125444265

EMC:	129338210(MAP3K14)

XLA:	108700848(map3k14.L) 108702551(map3k14.S)

XTR:	100489201(map3k14)

NPR:	108785983(MAP3K14)

RTEM:

120919584(MAP3K14)

BBUF:

121004595(MAP3K14)

BGAR:

122940347(MAP3K14)

MUO:	115481625(MAP3K14)

GSH:	117347767(MAP3K14)

DRE:	100004261(map3k14a) 795766

SRX:	107718093 107720017 107721479 107732105

SANH:

107654524 107667195 107674595 107677195

SGH:	107554607 107590367 107599747 107601304

CCAR:

109060827 109063225 109075409 109077428

CAUA:

113047004 113092744 113097181

CGIB:

127945919 127951501 127952266

PTET:

122329739 122341627(map3k14a)

LROH:

127155908 127162681(map3k14a)

OMC:	131532978 131536187(map3k14a)

PPRM:

120488026 120489596(map3k14a)

RKG:	130076070(map3k14a) 130084161

MAMB:

125258494 125272060(map3k14a)

CIDE:

127505789 127509022

MASI:

127434543 127450812 127451830

TROS:

130547116 130562096(map3k14a)

TDW:	130412833 130426820 130426833

MANU:

129426480 129433353(map3k14a)

IPU:	108259239(map3k14a) 108263809

IFU:	128602490(map3k14a) 128615878

PHYP:

113528261 113533797

SMEO:

124384893 124397147(map3k14a)

TFD:	113648526 113652180(map3k14a)

TVC:	132846352 132860710(map3k14a)

AMEX:

103043321 103047161

CMAO:

118821145(map3k14a) 118822540

EEE:	113583770 113589915

CHAR:

105898527(map3k14a)

TRU:	101067596 101068369

TFS:	130514970(map3k14a) 130524869

TNG:	GSTEN00021996G001 GSTEN00022300G001

LCO:	104923921 104938682

NCC:	104944878 104964716

TBEN:

117473515 117493041(map3k14a)

CGOB:

115012791 115024164

PGEO:

117451148(map3k14a) 117464499

GACU:

117548791(map3k14a) 117553501

EMAC:

134870938 134878203(map3k14a)

ELY:	117246698 117268475(map3k14a)

EFO:	125879172(map3k14a) 125880629

PLEP:

121956795(map3k14a) 121959145

SLUC:

116059283(map3k14a) 116061531

ECRA:

117937009 117958471(map3k14a)

ESP:	116703189(map3k14)

PFLV:

114547852 114570367

GAT:	120818953 120827961(map3k14a)

PPUG:

119212464 119220116(map3k14a)

AFB:	129099022(map3k14a)

CLUM:

117734462(map3k14a) 117749129

PSWI:

130189187(map3k14a) 130204111

MSAM:

119891999(map3k14a) 119916377

SCHU:

122867963 122868362(map3k14a)

CUD:	121503832(map3k14a) 121528505

ALAT:

119009268 119014377(map3k14a)

MZE:	101468753 101468797

ONL:	100695488 100707432

OAU:	116312492(map3k14a) 120441419

OLA:	101166422 101174595

OML:	112145949(map3k14a) 112154182

CSAI:

133419520 133421363(map3k14a)

XMA:	102224137 102235269

XCO:	114151841 114160257

XHE:	116726678 116735806

PRET:

103468661 103481612

PFOR:

103142240 103151039

PLAI:

106938787(map3k14) 106953890

PMEI:

106917289 106925139

GAF:	122822000(map3k14a) 122822864

PPRL:

129352553(map3k14a) 129368276

CVG:	107084720 107093973

CTUL:

119776029 119778852(map3k14a)

GMU:	124862201 124863966 124874891

NFU:	107378477 107387294

KMR:	108246150(map3k14a)

ALIM:

106522002(map3k14) 106528348

NWH:	119421922(map3k14a) 119423565

AOCE:

111570768 111581683

MCEP:

124997473(map3k14a) 125021920

CSEM:

103381634 103392614

POV:	109633940 109645298

SSEN:

122760915 122780434 122785133 122785170

HHIP:

117752515 117766955(map3k14a)

HSP:	118100220 118123057(map3k14a)

SMAU:

118286948 118288517(map3k14a)

LCF:	108892063 108900811(map3k14a)

SDU:	111217746 111219576

SLAL:

111660531 111664391

XGL:	120788413(map3k14a) 120794657

HCQ:	109518541 109519328

SSCV:

125983768

SBIA:

133496070 133514098(map3k14a)

PEE:	133414492(map3k14a) 133418292

PTAO:

133465930(map3k14a) 133469725

BPEC:

110168889

MALB:

109962735 109964259

BSPL:

114845633 114860603(map3k14a)

SJO:	128379174(map3k14a) 128381093

SASA:

100380862(m3k14) 106579033 106607326

STRU:

115158237 115171147 115198333

OTW:	112223536 112226021 112246048(map3k14a)

OMY:	110486292 110491468 110538227

OGO:	123999636 124015247 124047575

ONE:	115104159 115106439 115110305

OKI:	109865966 109893340 109893356

OKE:	118367281 118375729 118384507(map3k14a)

SALP:

111978338 111980803 112072746

SNH:	120034417 120036304

CCLU:

121549348 121550601 121569549

ELS:	105007974 105013210

SFM:	108928263 108941583

PKI:	111832882 111855960

AANG:

118216771 118221513

LOC:	102690698 107078787

PSPA:

121301894(map3k14a)

ARUT:

117427187 117433487(map3k14a)

PSEX:

120520062

LCM:	102351315(MAP3K14)

RTP:	109910938(map3k14a)

CPLA:

122540009(map3k14a)

HOC:	132830903(map3k14a)

LERI:

129710205(map3k14a)

BBEL:

CIN:

ATEN:

SPIS:

Reference

PMID:9020361

Authors

Malinin NL, Boldin MP, Kovalenko AV, Wallach D

Title

MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

Journal

Nature 385:540-4 (1997)
DOI:10.1038/385540a0

Sequence

[hsa:9020]

Reference

PMID:15084608

Authors

Liao G, Zhang M, Harhaj EW, Sun SC

Title

Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.

Journal

J Biol Chem 279:26243-50 (2004)
DOI:10.1074/jbc.M403286200

Sequence

[hsa:9020]

LinkDB

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