KEGG   ORTHOLOGY: K04604
Entry
K04604                      KO                                     
Symbol
GRM5
Name
metabotropic glutamate receptor 5
Pathway
map04020  Calcium signaling pathway
map04072  Phospholipase D signaling pathway
map04080  Neuroactive ligand-receptor interaction
map04540  Gap junction
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map05010  Alzheimer disease
map05016  Huntington disease
map05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
   04072 Phospholipase D signaling pathway
    K04604  GRM5; metabotropic glutamate receptor 5
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04604  GRM5; metabotropic glutamate receptor 5
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04604  GRM5; metabotropic glutamate receptor 5
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04604  GRM5; metabotropic glutamate receptor 5
   04720 Long-term potentiation
    K04604  GRM5; metabotropic glutamate receptor 5
   04723 Retrograde endocannabinoid signaling
    K04604  GRM5; metabotropic glutamate receptor 5
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04604  GRM5; metabotropic glutamate receptor 5
   05016 Huntington disease
    K04604  GRM5; metabotropic glutamate receptor 5
   05022 Pathways of neurodegeneration - multiple diseases
    K04604  GRM5; metabotropic glutamate receptor 5
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04604  GRM5; metabotropic glutamate receptor 5
G protein-coupled receptors [BR:ko04030]
 Metabotropic glutamate receptor family
  Glutamate (metabotropic)
   K04604  GRM5; metabotropic glutamate receptor 5
Other DBs
GO: 0001639
Genes
HSA: 2915(GRM5)
PTR: 451472(GRM5)
PPS: 100988134(GRM5)
GGO: 101148125(GRM5)
PON: 100452002(GRM5)
NLE: 100595085(GRM5)
HMH: 116476794(GRM5)
MCC: 705445(GRM5)
MCF: 101926080(GRM5)
MTHB: 126934742
MNI: 105468894(GRM5)
CSAB: 103248193(GRM5)
CATY: 105592965(GRM5)
PANU: 101020156(GRM5)
TGE: 112606361(GRM5)
MLEU: 105543126(GRM5)
RRO: 104657433(GRM5)
RBB: 108539155(GRM5)
TFN: 117080117(GRM5)
PTEH: 111540751(GRM5)
CANG: 105509299(GRM5)
CJC: 100400074(GRM5)
SBQ: 101043023(GRM5)
CIMI: 108293823(GRM5)
CSYR: 103268803(GRM5)
MMUR: 105860421(GRM5)
LCAT: 123642238(GRM5)
PCOQ: 105808222(GRM5)
OGA: 100959574(GRM5)
MMU: 108071(Grm5)
MCAL: 110298141(Grm5)
MPAH: 110318463(Grm5)
RNO: 24418(Grm5)
MCOC: 116102534(Grm5)
ANU: 117694519(Grm5)
MUN: 110539846(Grm5)
CGE: 100763614
MAUA: 101840496(Grm5)
PROB: 127227874(Grm5)
PLEU: 114682737(Grm5)
MORG: 121457717(Grm5)
MFOT: 126491505
AAMP: 119802846(Grm5)
NGI: 103742957(Grm5)
HGL: 101696979(Grm5)
CPOC: 100714109
CCAN: 109674757
DORD: 105983955(Grm5)
DSP: 122115429(Grm5)
PLOP: 125361415(Grm5)
NCAR: 124958602
MMMA: 107135439(Grm5)
OCU: 100340633
OPI: 101517326(GRM5)
TUP: 102486954(GRM5)
GVR: 103600566(GRM5)
CFA: 485146(GRM5)
CLUD: 112642041(GRM5)
VVP: 112932312(GRM5)
VLG: 121475906(GRM5)
NPO: 129506787(GRM5)
AML: 100466868(GRM5)
UMR: 103675379(GRM5)
UAH: 113269419(GRM5)
UAR: 123792340(GRM5)
ELK: 111154498
LLV: 125078918
MPUF: 101683208(GRM5)
MNP: 132012077(GRM5)
MLK: 131839461(GRM5)
NVS: 122912504(GRM5)
ORO: 101372426
EJU: 114199712(GRM5)
ZCA: 113915273(GRM5)
MLX: 118013460(GRM5)
NSU: 110571020(GRM5)
LWW: 102743020(GRM5)
FCA: 101091895(GRM5)
PYU: 121039179(GRM5)
PCOO: 112865771(GRM5)
PBG: 122483229(GRM5)
PVIV: 125177287(GRM5)
LRUF: 124506270
PPAD: 109267326(GRM5)
PUC: 125938187
AJU: 106967780
HHV: 120246249(GRM5)
BTA: 100336861(GRM5)
BBUB: 102399934(GRM5)
BBIS: 104993807(GRM5)
CHX: 102182568(GRM5)
OAS: 443069(GRM5)
BTAX: 128068942(GRM5)
ODA: 120874853(GRM5)
CCAD: 122430926(GRM5)
MBEZ: 129549079(GRM5)
SSC: 102161751(GRM5)
CBAI: 105083519(GRM5)
CDK: 105098361(GRM5)
VPC: 102543854(GRM5)
BACU: 103017209(GRM5)
BMUS: 118899393(GRM5)
LVE: 103089884(GRM5)
OOR: 101280226(GRM5)
DLE: 111184956(GRM5)
PCAD: 102993906(GRM5)
PSIU: 116757903(GRM5)
NASI: 112410930(GRM5)
ECB: 100060364(GRM5)
EPZ: 103547854(GRM5)
EAI: 106848216(GRM5)
MYD: 102763091(GRM5)
MMYO: 118664538(GRM5)
MLF: 102418574(GRM5)
PKL: 118712915(GRM5)
EFUS: 103296993(GRM5)
MNA: 107532400(GRM5)
DRO: 112316028(GRM5)
SHON: 118984757(GRM5)
AJM: 119043577(GRM5)
PDIC: 114499828(GRM5)
PHAS: 123805619(GRM5)
MMF: 118628445(GRM5)
PPAM: 129072823(GRM5)
HAI: 109375479(GRM5)
RFQ: 117030808(GRM5)
PALE: 102894122(GRM5)
PGIG: 120590530(GRM5)
PVP: 105294211(GRM5)
RAY: 107514938(GRM5)
MJV: 108386876(GRM5)
TOD: 119254713(GRM5)
SARA: 101558999(GRM5)
SETR: 126019119(GRM5)
LAV: 100676641(GRM5)
TMU: 101340926
ETF: 101659445(GRM5)
DNM: 101445594(GRM5)
MDO: 100009917(GRM5)
GAS: 123241237(GRM5)
SHR: 100913241(GRM5)
AFZ: 127555165
PCW: 110213450(GRM5)
OAA: 100080549(GRM5)
GGA: 373933(GRM5)
PCOC: 116241944(GRM5)
MGP: 104909422
CJO: 107308455(GRM5)
TPAI: 128073999(GRM5)
LMUT: 125690973(GRM5)
APLA: 101805339(GRM5)
ACYG: 106034184(GRM5)
CATA: 118245920(GRM5)
AFUL: 116502289(GRM5)
TGU: 752008(GRM5)
LSR: 110478417(GRM5)
SCAN: 103827248(GRM5)
PMOA: 120506647(GRM5)
OTC: 121340981(GRM5)
PRUF: 121362282(GRM5)
GFR: 102035609(GRM5)
FAB: 101814322(GRM5)
OMA: 130257819(GRM5)
PHI: 102104616(GRM5)
PMAJ: 107207537(GRM5)
CCAE: 111924947(GRM5)
CCW: 104690322(GRM5)
CBRC: 103616714(GRM5)
ETL: 114063510(GRM5)
ZAB: 102073872(GRM5)
ACHL: 103803177(GRM5)
SVG: 106853953(GRM5)
MMEA: 130577941(GRM5)
HRT: 120749105(GRM5)
FPG: 101915830(GRM5)
FCH: 102054087
CLV: 102093525(GRM5)
EGZ: 104128833(GRM5)
NNI: 104017356(GRM5)
ACUN: 113477161(GRM5)
TALA: 104369353(GRM5)
AFOR: 103904765(GRM5)
ACHC: 115353418(GRM5)
HLE: 104838489(GRM5)
AGEN: 126048428
GCL: 127018121
CCRI: 104164153(GRM5)
CSTI: 104558761(GRM5)
CMAC: 104475012(GRM5)
FGA: 104083784(GRM5)
GSTE: 104255402(GRM5)
LDI: 104354717(GRM5)
MNB: 103775561(GRM5)
OHA: 104327636(GRM5)
NNT: 104401698(GRM5)
SHAB: 115603930(GRM5)
DPUB: 104301161(GRM5)
PGUU: 104467414(GRM5)
ACAR: 104525011(GRM5)
CPEA: 104394782
AVIT: 104276285(GRM5)
CVF: 104283045(GRM5)
RTD: 128904186(GRM5)
CUCA: 104064101(GRM5)
BRHI: 104495603(GRM5)
AAM: 106482085(GRM5)
AROW: 112976183(GRM5)
NPD: 112951479(GRM5)
TGT: 104580979(GRM5)
DNE: 112988578(GRM5)
SCAM: 104153273(GRM5)
ASN: 102385450(GRM5)
AMJ: 102576482(GRM5)
CPOO: 109306794(GRM5)
GGN: 109303234(GRM5)
PSS: 102454127(GRM5)
CMY: 102935827(GRM5)
CCAY: 125632925(GRM5)
DCC: 119845698(GRM5)
CPIC: 101935299(GRM5)
TST: 117871231
CABI: 116818083(GRM5)
MRV: 120383806(GRM5)
ACS: 100563209(grm5)
ASAO: 132772244(GRM5)
PVT: 110088579(GRM5)
SUND: 121926706(GRM5)
PBI: 103056145(GRM5)
PMUR: 107289538 107294160(GRM5)
CTIG: 120307810(GRM5)
TSR: 106554628(GRM5)
PGUT: 117659847(GRM5)
APRI: 131199393(GRM5)
PTEX: 113440505(GRM5)
NSS: 113420141(GRM5)
VKO: 123029270(GRM5)
PMUA: 114595611(GRM5)
PRAF: 128412527(GRM5)
ZVI: 118085495(GRM5)
HCG: 128349623(GRM5)
GJA: 107113358(GRM5)
STOW: 125431556(GRM5)
EMC: 129325758(GRM5)
XLA: 108707585 108710022
XTR: 100485273(grm5)
NPR: 108794764(GRM5)
RTEM: 120928964(GRM5)
BBUF: 120994198(GRM5)
BGAR: 122931933(GRM5)
MUO: 115468443(GRM5)
GSH: 117362542(GRM5)
DRE: 100332913(grm5b) 568406(grm5a)
SRX: 107718729 107720647 107731813 107737424
SANH: 107669866 107670133 107693909 107701127
SGH: 107555132 107558819 107570104
CCAR: 109063968 109077074(grm5)
CAUA: 113058768 113071626 113109861 113114713
CGIB: 127965895 127972938 128021194 128029064
PTET: 122353071(grm5a) 122358801(grm5b)
LROH: 127172077(grm5a) 127177560(grm5b)
OMC: 131548474(grm5a) 131554174(grm5b)
PPRM: 120470716(grm5b) 120476443(grm5a)
RKG: 130073180(grm5b) 130082823(grm5a)
MAMB: 125248563(grm5b) 125258730(grm5a)
CIDE: 127496093 127520943
MASI: 127422185 127429873 127432950 127433844
TROS: 130546147(grm5a) 130549339
TDW: 130411869(grm5a) 130428406(grm5b)
MANU: 129438657(grm5b) 129446969(grm5a)
IPU: 108277301(grm5a) 108277953(grm5b)
IFU: 128620036(grm5a) 128621339(grm5b)
PHYP: 113543677(grm5) 113544619
SMEO: 124393889(grm5a) 124394670(grm5b)
TFD: 113637960 113659177(grm5a)
TVC: 132858496(grm5b) 132863018(grm5a)
AMEX: 103040533 103045948
CMAO: 118800552(grm5b) 118825233(grm5a)
EEE: 113578739 113581659
CHAR: 105890452(grm5a) 116221777
TRU: 101064551(grm5) 101079916
TFS: 130535555(grm5b) 130537312(grm5a)
TNG: GSTEN00018905G001
LCO: 104920135(grm5) 104923830
NCC: 104959637 104963006(grm5)
TBEN: 117470533(grm5b) 117490799(grm5a)
CGOB: 115017453(grm5) 115018921
PGEO: 117457805(grm5b) 117458960(grm5a)
GACU: 117536124(grm5a) 117552214
EMAC: 134871963(grm5a) 134880265(grm5b)
ELY: 117259111(grm5b) 117270178(grm5a)
EFO: 125889366(grm5b) 125898723(grm5a)
PLEP: 121943054(grm5b) 121952099(grm5a)
SLUC: 116037088(grm5a) 116048237(grm5b)
ECRA: 117941929(grm5b) 117954990(grm5a)
ESP: 116679383(grm5) 116700241
PFLV: 114551675 114567045
GAT: 120815686(grm5b) 120822131(grm5a)
PPUG: 119194615(grm5b) 119215362(grm5a)
AFB: 129108672(grm5b) 129113160(grm5a)
CLUM: 117741347(grm5b) 117742654(grm5a)
PSWI: 130189816(grm5a) 130211083(grm5b)
MSAM: 119883508(grm5b) 119895754(grm5a) 119916758
SCHU: 122879440(grm5b) 122888176(grm5a)
CUD: 121519285(grm5a) 121522399(grm5b)
ALAT: 119006147(grm5b) 119031317(grm5a)
MZE: 101480374
ONL: 100700102 106097981(grm5)
OAU: 116322873(grm5b) 116331460(grm5a)
OLA: 101164491(grm5) 101173805
OML: 112142635(grm5a) 112149106(grm5b)
CSAI: 133441685(grm5b) 133459397(grm5a)
XMA: 102230735 102230987(grm5)
XCO: 114152916 114161838(grm5)
XHE: 116707754(grm5) 116728119
PRET: 103474487(grm5) 103475526
PFOR: 103140495 103146264(grm5)
PLAI: 106950589 106958861(grm5)
PMEI: 106914103 106918011(grm5)
GAF: 122832630(grm5b) 122844986(grm5a)
PPRL: 129358993(grm5b) 129368632(grm5a)
CVG: 107087909
CTUL: 119771746(grm5b) 119783447(grm5a)
GMU: 124876316(grm5a) 124884085(grm5b)
NFU: 107380453(grm5) 107386961
KMR: 108236979(grm5a) 108244640(grm5b)
ALIM: 106514124 106517252(grm5)
NWH: 119410491(grm5b) 119420007(grm5a)
AOCE: 111572653(grm5)
MCEP: 125012977(grm5b) 125021749(grm5a)
CSEM: 103378562(grm5) 103395387
POV: 109635914
SSEN: 122765056 122779547(grm5a)
HHIP: 117773203(grm5b) 117773989(grm5a)
HSP: 118106627(grm5b) 118122667(grm5a)
SMAU: 118299691(grm5b) 118301461(grm5a)
LCF: 108886623(grm5b) 108893271(grm5a)
SDU: 111217123 111224046(grm5)
SLAL: 111651617 111655286(grm5)
XGL: 120791809(grm5b) 120802552(grm5a)
HCQ: 109509731 109525514(grm5)
SSCV: 125972194 125982278
SBIA: 133492011(grm5a) 133504589(grm5b)
PEE: 133404824(grm5b) 133416507(grm5a)
PTAO: 133467399(grm5a) 133482443(grm5b)
BPEC: 110158381 110174304(grm5)
MALB: 109959199 109971622(grm5)
BSPL: 114867491(grm5b) 114869296(grm5a)
SJO: 128360909(grm5b) 128370915(grm5a)
SASA: 106581415
STRU: 115191138 115202675
OTW: 112241035 112267482(grm5b)
OMY: 110503210 110507213 110516146(grm5a)
OGO: 123993915 124005922
ONE: 115142226
OKI: 109881645 109882914 109909495
OKE: 118379387(grm5b) 118381834
SNH: 120018950 120035953
CCLU: 121541374 121566811 121567809
ELS: 105024084(grm5) 105026648
SFM: 108932228(grm5)
PKI: 111833937(grm5)
AANG: 118208818(grm5b) 118236719(grm5a)
LOC: 102695448(grm5)
PSPA: 121302602 121321206
ARUT: 117405888 117972761
PSEX: 120523150(grm5b)
CMK: 103184347(grm5b)
CPLA: 122550590(grm5b)
HOC: 132816709(grm5b)
LERI: 129698246(grm5b)
PMRN: 116955616
LPIC: 129259627
RZE: 108375215
TCA: 657397
SOY: 115880860
AGRG: 126736682
APLN: 108741204
OTU: 111416080
CCRN: 123300298
MQU: 128992858
IEL: 124165654
DPZ: 124313868
PJA: 122260224
PCHN: 125029528
PCLA: 123763970
CQD: 128701648
PTRU: 123502556
HAZT: 108680921 108682189 108682190
DSV: 119461420
RSAN: 119396207
RMP: 119173808 119174401
VDE: 111246314 111247409
VJA: 111260807 111265512
DFR: 124491099
UDV: 129232180
SDM: 118181916
PMEO: 129587719
CEL: CELE_F45H11.4(mgl-2)
CBR: CBG_02196(Cbr-mgl-2)
CRQ: GCK72_002359
LOA: LOAG_07544
PVUL: 126810918
BGT: 106077013
GAE: 121371777
HRJ: 124290634
CRG: 105326827
CVN: 111103192 111104100 111104676
CANU: 128184778
OED: 125673064
PMAX: 117327854
MMER: 123548775
ATEN: 116297877
 » show all
Reference
PMID:23165119
  Authors
Xiao XL, Ma DL, Wu J, Tang FR
  Title
Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.
  Journal
Brain Res 1493:1-12 (2013)
DOI:10.1016/j.brainres.2012.11.015
Reference
PMID:7908515
  Authors
Minakami R, Katsuki F, Yamamoto T, Nakamura K, Sugiyama H
  Title
Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.
  Journal
Biochem Biophys Res Commun 199:1136-43 (1994)
DOI:10.1006/bbrc.1994.1349
  Sequence
[hsa:2915]
LinkDB

DBGET integrated database retrieval system