KEGG ORTHOLOGY: K05036

ORTHOLOGY: K05036

Entry

K05036                      KO

Symbol

SLC6A3, DAT

Name

solute carrier family 6 (neurotransmitter transporter, dopamine) member 3

Pathway

map04721

Synaptic vesicle cycle

map04728

Dopaminergic synapse

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

map05030

Cocaine addiction

map05031

Amphetamine addiction

map05034

Alcoholism

Disease

H02676

Infantile-onset parkinsonism-dystonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
   04721 Synaptic vesicle cycle
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
   05022 Pathways of neurodegeneration - multiple diseases
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
  09165 Substance dependence
   05030 Cocaine addiction
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
   05031 Amphetamine addiction
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
   05034 Alcoholism
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   K05036  SLC6A3, DAT; solute carrier family 6 (neurotransmitter transporter, dopamine) member 3

Other DBs

GO:

0005330

TC:	2.A.22.1.3

Genes

HSA:	6531(SLC6A3)

PTR:	750842(SLC6A3)

PPS:	100991516(SLC6A3)

PON:	100435121(SLC6A3)

NLE:	100596846(SLC6A3)

HMH:	116456672(SLC6A3)

MCC:	574143(SLC6A3)

MCF:	102142756(SLC6A3)

MTHB:

126957406

MNI:	105464564(SLC6A3)

CSAB:

103214932(SLC6A3)

CATY:

105600707(SLC6A3)

PANU:

101022805(SLC6A3)

TGE:	112625992(SLC6A3)

MLEU:

105528127(SLC6A3)

RRO:	104668699(SLC6A3)

RBB:	108513703(SLC6A3)

TFN:	117064705(SLC6A3)

PTEH:

111528338(SLC6A3)

CANG:

105519692(SLC6A3)

CJC:	100393968(SLC6A3)

SBQ:	101032424(SLC6A3)

CIMI:

108294173(SLC6A3)

CSYR:

103271220(SLC6A3)

MMUR:

105876449(SLC6A3)

LCAT:

123648018(SLC6A3)

PCOQ:

105825819(SLC6A3)

OGA:	100965905(SLC6A3)

MMU:	13162(Slc6a3)

MCAL:

110307893(Slc6a3)

MPAH:

110328936(Slc6a3)

RNO:	24898(Slc6a3)

MCOC:

116083177(Slc6a3)

ANU:	117723935(Slc6a3)

MUN:	110545376(Slc6a3)

CGE:

100774258

MAUA:

110343686(Slc6a3)

PROB:

127220860(Slc6a3)

PLEU:

114696105(Slc6a3)

MORG:

121433667(Slc6a3)

MFOT:

126503802

AAMP:

119810258(Slc6a3)

NGI:	103749676(Slc6a3)

HGL:	101709245(Slc6a3)

CPOC:

100714898(Slc6a3)

CCAN:

109698262(Slc6a3)

DORD:

105983816(Slc6a3)

DSP:	122120948(Slc6a3)

PLOP:

125367624(Slc6a3)

NCAR:

124987217

MMMA:

107146304(Slc6a3)

OPI:	101536711(SLC6A3)

TUP:	102500212(SLC6A3)

GVR:	103606824(SLC6A3)

CFA:	609304(SLC6A3)

CLUD:

112662644(SLC6A3)

VVP:	112935444(SLC6A3)

VLG:	121477472(SLC6A3)

NPO:	129498894(SLC6A3)

AML:	100478402(SLC6A3)

UMR:	103679238(SLC6A3)

UAH:	113260791(SLC6A3)

UAR:	123799122(SLC6A3)

ELK:

111153448

LLV:

125100023

MPUF:

101689277(SLC6A3)

MNP:	132027708(SLC6A3)

MLK:	131831543(SLC6A3)

NVS:	122902425(SLC6A3)

ORO:	101362179(SLC6A3)

EJU:	114198569(SLC6A3)

ZCA:	113929486(SLC6A3)

MLX:	118006229(SLC6A3)

NSU:	110577687(SLC6A3)

LWW:	102748609(SLC6A3)

FCA:	101101618(SLC6A3)

PBG:	122480191(SLC6A3)

PVIV:

125159802(SLC6A3)

LRUF:

124510500

PTG:	102971363(SLC6A3)

PPAD:

109267683(SLC6A3)

PUC:

125934743

AJU:

106985115

HHV:	120235641(SLC6A3)

BTA:	788410(SLC6A3)

BOM:	102268138(SLC6A3)

BIU:	109574743(SLC6A3)

BBUB:

102401631(SLC6A3)

BBIS:

105001019(SLC6A3)

CHX:	102187167(SLC6A3)

OAS:	101111908(SLC6A3)

BTAX:

128066092(SLC6A3)

ODA:	120879278(SLC6A3)

CCAD:

122454559(SLC6A3)

MBEZ:

129553081(SLC6A3)

SSC:	100521346(SLC6A3)

CFR:	102510470(SLC6A3)

CBAI:

105081248(SLC6A3)

CDK:	105102174(SLC6A3)

VPC:	102539205(SLC6A3)

BACU:

103002528(SLC6A3)

BMUS:

118892910(SLC6A3)

LVE:	103087626(SLC6A3)

OOR:	101289168(SLC6A3)

DLE:	111178539(SLC6A3)

PCAD:

102981726(SLC6A3)

PSIU:

116752055(SLC6A3)

NASI:

112390883(SLC6A3)

ECB:	100054747(SLC6A3)

EPZ:	103567498(SLC6A3)

EAI:	106835898(SLC6A3)

MYB:	102244563(SLC6A3)

MYD:	102770667(SLC6A3)

MMYO:

118657033(SLC6A3)

MLF:	102424965(SLC6A3)

PKL:	118703499(SLC6A3)

EFUS:

103305117(SLC6A3)

MNA:	107536458(SLC6A3)

DRO:	112320941(SLC6A3)

SHON:

118998658(SLC6A3)

AJM:	119043343(SLC6A3)

PDIC:

114505082(SLC6A3)

PHAS:

123824758(SLC6A3)

MMF:	118641782(SLC6A3)

PPAM:

129074725(SLC6A3)

HAI:	109371679(SLC6A3)

RFQ:	117024975(SLC6A3)

PALE:

102895017(SLC6A3)

PGIG:

120586141(SLC6A3)

PVP:	105301307(SLC6A3)

RAY:	107499955(SLC6A3)

MJV:	108400617(SLC6A3)

TOD:	119260671(SLC6A3)

SARA:

101548982(SLC6A3)

SETR:

126000782(SLC6A3)

LAV:	100675742(SLC6A3)

TMU:

101341243

ETF:	101660195(SLC6A3)

MDO:	100015498(SLC6A3)

GAS:	123231574(SLC6A3)

SHR:	100914957(SLC6A3)

AFZ:

127543592

PCW:	110201221(SLC6A3)

OAA:	100074809(SLC6A3)

XLA:	108720038(slc6a3.S)

XTR:	100488824(slc6a3)

NPR:	108802238(SLC6A3)

RTEM:

120940580(SLC6A3)

BBUF:

121002523(SLC6A3)

BGAR:

122939416(SLC6A3)

DRE:	80787(slc6a3)

SRX:

107758825

SANH:

107701804(slc6a3)

SGH:	107558633 107564665

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127177824(slc6a3)

OMC:	131521266(slc6a3)

PPRM:

120465478(slc6a3)

RKG:	130090404(slc6a3)

MAMB:

125243975(slc6a3)

CIDE:

127497960

MASI:

127452625 127454385

TROS:

130558610(slc6a3)

TDW:	130432689(slc6a3)

MANU:

129449102(slc6a3)

IPU:	108272311(slc6a3)

IFU:	128621879(slc6a3)

PHYP:

113533694(slc6a3)

SMEO:

124385325(slc6a3)

TFD:	113648304(slc6a3)

TVC:	132846342(slc6a3)

AMEX:

103026128(slc6a3)

CMAO:

118813836(slc6a3)

EEE:

113592231

CHAR:

105905497(slc6a3)

TRU:	101072244(slc6a3)

TFS:	130533084(slc6a3)

TNG:	GSTEN00013866G001

LCO:	104940426(slc6a3)

NCC:	104943319(slc6a3)

TBEN:

117480670(slc6a3)

CGOB:

115021666(slc6a3)

PGEO:

117461063(slc6a3)

GACU:

117541450(slc6a3)

EMAC:

134862351(slc6a3)

ELY:	117265547(slc6a3)

EFO:	125893853(slc6a3)

PLEP:

121945820(slc6a3)

SLUC:

116049211(slc6a3)

ECRA:

117946100(slc6a3)

ESP:	116690847(slc6a3)

PFLV:

114557281(slc6a3)

GAT:	120810599(slc6a3)

PPUG:

119198149(slc6a3)

AFB:	129109450(slc6a3)

CLUM:

117745771(slc6a3)

PSWI:

130213270(slc6a3)

MSAM:

119897882(slc6a3)

SCHU:

122881557(slc6a3)

CUD:	121513842(slc6a3)

ALAT:

119005645(slc6a3)

MZE:	101475398(slc6a3)

ONL:	100706735(slc6a3)

OAU:	116329393(slc6a3)

OLA:	101158881(slc6a3)

OML:	112144056(slc6a3)

CSAI:

133440933(slc6a3)

XMA:	102218251(slc6a3)

XCO:	114141853(slc6a3)

XHE:	116717885(slc6a3)

PRET:

103478700(slc6a3)

PFOR:

103143599(slc6a3)

PLAI:

106945236(slc6a3)

PMEI:

106907849(slc6a3)

GAF:	122831123(slc6a3)

PPRL:

129367678(slc6a3)

CVG:	107102765(slc6a3)

CTUL:

119791322(slc6a3)

GMU:	124864227(slc6a3)

NFU:	107378744(slc6a3)

KMR:	108232182(slc6a3)

ALIM:

106521609

NWH:	119410352(slc6a3)

AOCE:

111566236(slc6a3)

MCEP:

125016506(slc6a3)

CSEM:

103388332(slc6a3)

POV:	109632076(slc6a3)

SSEN:

122775206(slc6a3)

HHIP:

117777284(slc6a3)

HSP:	118113106(slc6a3)

SMAU:

118292922(slc6a3)

LCF:

108889083

SDU:	111227736(slc6a3)

SLAL:

111673067(slc6a3)

XGL:	120784168(slc6a3)

HCQ:	109521906(slc6a3)

SSCV:

125975124

SBIA:

133501098(slc6a3)

PEE:	133401809(slc6a3)

PTAO:

133479378(slc6a3)

BPEC:

110171536(slc6a3)

MALB:

109958350(slc6a3)

BSPL:

114842584(slc6a3)

SJO:	128365915(slc6a3)

STRU:

115190613 115191073(slc6a3)

OMY:	110511094(slc6a3)

OGO:

124025757

OKI:	109885449 116359300

OKE:	127928230(slc6a3)

CCLU:

121542316 121559425

ELS:	105016608(slc6a3)

SFM:	108940585(slc6a3)

PKI:	111843531(slc6a3)

AANG:

118219797(slc6a3)

LOC:	102685205(slc6a3)

PSPA:

121308264 121314774

ARUT:

117394811 117400504

PSEX:

120515953(slc6a3)

LCM:	102364171(SLC6A3)

CMK:

103184821

CPLA:

122549736

HOC:	132815949(slc6a3)

LERI:

129705860

PMRN:

116957015

SPU:	115926893 584179

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG8380(DAT)

DER:

6548430

DSE:

6609460

DSI:	Dsimw501_GD25533(Dsim_GD25533)

DYA:	Dyak_GE14056

DAN:

DSR:

DPO:

DPE:

DMN:	108159069 117191542

DWI:

6640614

DGR:

6571527

DMO:	Dmoj_GI19005

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108361169 108366618

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ010746

CPII:

120422641

CNS:

116352262

BCOO:

119080698

AME:	412285(Dat)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

MDL:

CGLO:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:	124406193 124413674

NPT:	124213730 124222346

NFB:

124178536

NLO:	107226905 107227060

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111425481 111425995

BMOR:

101744281

BMAN:

114248855

MSEX:

115443108 115447274

DPL:	KGM_212172

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:	106126168 106127228

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103506499 103515758

CLEC:

106661545

HHAL:

106678308

NLU:

111053418

HVI:	124367521 124368017

MQU:	128990791 128993991

PHU:	Phum_PHUM097380

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110850919 110852168

DPX:	DAPPUDRAFT_60804

DMK:

116922827

DPZ:

124321010

PVM:

113806330

PJA:	122248067 122255136

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128684359 128684361 128685051

PTRU:

123513149

ESN:	126999270 127010420

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_T23G5.5(dat-1)

CBR:	CBG_10151(Cbr-dat-1)

CRQ:	GCK72_009388

BMY:	BM_BM5960(Bma-dat-1)

LOA:	LOAG_07270

TSP:

Tsp_00144

HRO:	HELRODRAFT_74696

LGI:	LOTGIDRAFT_103896

PVUL:

126824022

PCAN:

112553260 112561268

BGT:

106074484

GAE:	121368532 121389464

HRF:	124124869 124131020 124131023 124131024 124138925 124142096 124148020

HRJ:	124253536 124255180 124259036 124259039 124262729 124264939 124270287 124280952 124290245

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_156320

OVI:	T265_12790

» show all

Reference

PMID:14531049

Authors

Uhl GR

Title

Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism.

Journal

Mov Disord 18 Suppl 7:S71-80 (2003)
DOI:10.1002/mds.10578

Reference

PMID:1406597

Authors

Giros B, el Mestikawy S, Godinot N, Zheng K, Han H, Yang-Feng T, Caron MG

Title

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

Journal

Mol Pharmacol 42:383-90 (1992)

Sequence

[hsa:6531]

LinkDB

DBGET integrated database retrieval system