KEGG   ORTHOLOGY: K05083
Entry
K05083                      KO                                     
Symbol
ERBB2, HER2, CD340
Name
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05206  MicroRNAs in cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05219  Bladder cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05226  Gastric cancer
map05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00019  Pancreatic cancer
H00022  Bladder cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00042  Glioma
H00046  Cholangiocarcinoma
H01508  Salivary gland cancer
H01554  Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04151 PI3K-Akt signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04530 Tight junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05230 Central carbon metabolism in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05226 Gastric cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05224 Breast cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01524 Platinum drug resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01522 Endocrine resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04090 CD molecules
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
CD molecules [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
Genes
HSA: 2064(ERBB2)
PTR: 454636(ERBB2)
PPS: 100977227(ERBB2)
GGO: 101140885(ERBB2)
PON: 100450307(ERBB2)
NLE: 100601700(ERBB2)
HMH: 116474757(ERBB2)
MCC: 697573(ERBB2)
MCF: 102146608(ERBB2)
MTHB: 126938415
MNI: 105472243(ERBB2)
CSAB: 103243533(ERBB2)
CATY: 105579553(ERBB2)
PANU: 101007278(ERBB2)
TGE: 112608971(ERBB2)
MLEU: 105553066(ERBB2)
RRO: 104674848(ERBB2)
RBB: 108527784(ERBB2)
TFN: 117067088(ERBB2)
PTEH: 111537465(ERBB2)
CANG: 105503119(ERBB2)
CJC: 100391332(ERBB2)
SBQ: 101043415(ERBB2)
CIMI: 108281617(ERBB2)
CSYR: 103251030(ERBB2)
MMUR: 105872099(ERBB2)
LCAT: 123620839(ERBB2)
PCOQ: 105824348(ERBB2)
OGA: 100953964(ERBB2)
MMU: 13866(Erbb2)
MCAL: 110304771(Erbb2)
MPAH: 110331339(Erbb2)
RNO: 24337(Erbb2)
MCOC: 116077605(Erbb2)
ANU: 117710649(Erbb2)
MUN: 110562952(Erbb2)
CGE: 100759983(Erbb2)
MAUA: 101822760(Erbb2)
PROB: 127215359(Erbb2)
PLEU: 114706940(Erbb2)
MORG: 121442379 121456320
MFOT: 126510532
AAMP: 119811725(Erbb2)
NGI: 103743825(Erbb2)
HGL: 101705227(Erbb2)
CPOC: 100727657(Erbb2)
CCAN: 109693877(Erbb2)
DORD: 106003227(Erbb2)
DSP: 122103204(Erbb2)
PLOP: 125365164(Erbb2)
NCAR: 124979806
MMMA: 107160020(Erbb2)
OCU: 100009554
OPI: 101527578(ERBB2)
TUP: 102487164(ERBB2)
GVR: 103605206(ERBB2)
CFA: 403883(ERBB2)
CLUD: 112655065(ERBB2)
VVP: 112917778(ERBB2)
VLG: 121473120(ERBB2)
NPO: 129505762(ERBB2)
AML: 100480029(ERBB2)
UMR: 103661560(ERBB2)
UAH: 113265512(ERBB2)
UAR: 123779529(ERBB2)
ELK: 111151268
LLV: 125087205
MPUF: 101693248(ERBB2)
MNP: 132003912(ERBB2)
MLK: 131815770(ERBB2)
NVS: 122906299(ERBB2)
ORO: 101364161(ERBB2)
EJU: 114198487(ERBB2)
ZCA: 113939823(ERBB2)
MLX: 118024846(ERBB2)
NSU: 110593180(ERBB2)
FCA: 751824(ERBB2)
PYU: 121044914(ERBB2)
PCOO: 112854095(ERBB2)
PBG: 122485481(ERBB2)
PVIV: 125158497(ERBB2)
LRUF: 124513327
PTG: 102961961(ERBB2)
PPAD: 109247423(ERBB2)
PUC: 125926482
AJU: 106980462
HHV: 120229105(ERBB2)
BTA: 505709(ERBB2)
BOM: 102267975(ERBB2)
BIU: 109573971(ERBB2)
BBUB: 102398312(ERBB2)
BBIS: 104990532(ERBB2)
CHX: 102181989(ERBB2)
OAS: 780519(ERBB2)
BTAX: 128064538(ERBB2)
ODA: 120867212(ERBB2)
MBEZ: 129544356(ERBB2)
SSC: 100516641(ERBB2)
CFR: 102519604(ERBB2)
CBAI: 105073259(ERBB2)
CDK: 105099069(ERBB2)
VPC: 102539783(ERBB2)
BACU: 103002640(ERBB2)
BMUS: 118886253(ERBB2)
LVE: 103075672(ERBB2)
OOR: 101283619(ERBB2)
DLE: 111166300(ERBB2)
PCAD: 102990192(ERBB2)
PSIU: 116745518(ERBB2)
NASI: 112398419(ERBB2)
ECB: 100054739(ERBB2)
EPZ: 103550160(ERBB2)
EAI: 106826341(ERBB2)
MYB: 102243033(ERBB2)
MYD: 102771013(ERBB2)
MMYO: 118671218(ERBB2)
MLF: 102427788(ERBB2)
PKL: 118702172(ERBB2)
EFUS: 103297187(ERBB2)
MNA: 107529006(ERBB2)
DRO: 112316215(ERBB2)
SHON: 118978214(ERBB2)
PDIC: 114502459(ERBB2)
PHAS: 123816974(ERBB2)
MMF: 118633888(ERBB2)
PPAM: 129087036(ERBB2)
HAI: 109380800(ERBB2)
RFQ: 117013264(ERBB2)
PALE: 102885300(ERBB2)
PGIG: 120611190(ERBB2)
PVP: 105307498(ERBB2)
RAY: 107520699(ERBB2)
MJV: 108390012(ERBB2)
TOD: 119230565(ERBB2)
SARA: 101540816(ERBB2)
SETR: 126016368(ERBB2)
LAV: 100662583(ERBB2)
TMU: 101354844
ETF: 101647544(ERBB2)
DNM: 101425577(ERBB2)
MDO: 100017172(ERBB2)
GAS: 123245551(ERBB2)
SHR: 100914727(ERBB2)
AFZ: 127560210
PCW: 110215729(ERBB2)
OAA: 100091139(ERBB2)
GGA: 426130(ERBB2)
PCOC: 116233633(ERBB2)
MGP: 100550880(ERBB2)
CJO: 107325215(ERBB2)
TPAI: 128089037(ERBB2)
LMUT: 125684537(ERBB2)
NMEL: 110388649(ERBB2)
AFUL: 116498599(ERBB2)
TGU: 101233610
LSR: 110471930(ERBB2)
SCAN: 103821628(ERBB2)
PMOA: 120496682(ERBB2)
OTC: 121347628(ERBB2)
PRUF: 121351120(ERBB2)
FAB: 101818019(ERBB2)
OMA: 130264066(ERBB2)
PHI: 102108835(ERBB2)
PMAJ: 107215327(ERBB2)
CCAE: 111944944
CCW: 104697788(ERBB2)
ETL: 114070427 114073581
ZAB: 102064221(ERBB2)
SVG: 106858712(ERBB2)
MMEA: 130585971(ERBB2)
FPG: 101914383(ERBB2)
FCH: 102057575(ERBB2)
CLV: 102094013(ERBB2)
NNI: 104013874(ERBB2)
TALA: 116960148(ERBB2)
ACHC: 115344932(ERBB2)
HLE: 104843013(ERBB2)
AGEN: 126038617
SHAB: 115617626(ERBB2)
CPEA: 104385087(ERBB2)
RTD: 128919329(ERBB2)
CUCA: 104067826(ERBB2)
AAM: 106486153(ERBB2)
AROW: 112969537(ERBB2)
NPD: 112949026(ERBB2)
DNE: 112993877(ERBB2)
ASN: 102369818(ERBB2)
AMJ: 102561352(ERBB2)
CPOO: 109320284(ERBB2)
GGN: 109290561(ERBB2)
PSS: 102457099(ERBB2)
CMY: 102946701(ERBB2)
CCAY: 125626753(ERBB2)
DCC: 119849062(ERBB2)
CPIC: 101931763(ERBB2)
TST: 117869182(ERBB2)
CABI: 116831381(ERBB2)
MRV: 120392163(ERBB2)
ACS: 100565910(erbb2)
ASAO: 132778279(ERBB2)
PVT: 110082059(ERBB2)
SUND: 121933598(ERBB2)
PMUR: 107303070(ERBB2)
CTIG: 120315180(ERBB2)
TSR: 106538863(ERBB2)
PGUT: 117664667(ERBB2)
APRI: 131198329(ERBB2)
PTEX: 113447396(ERBB2)
NSS: 113420001(ERBB2)
VKO: 123031797(ERBB2)
PMUA: 114581630 114581735
PRAF: 128400677(ERBB2)
ZVI: 118094199(ERBB2)
HCG: 128330528(ERBB2)
GJA: 107114744(ERBB2)
STOW: 125444708(ERBB2)
EMC: 129340441(ERBB2)
XLA: 108700774(erbb2.L) 108702492
XTR: 100492078(erbb2)
NPR: 108792756(ERBB2)
RTEM: 120918450(ERBB2)
BBUF: 121003142(ERBB2)
BGAR: 122940045(ERBB2)
MUO: 115482293(ERBB2)
GSH: 117347323(ERBB2)
DRE: 386966(erbb2)
SRX: 107751707 107753308
SANH: 107684762 107694064
SGH: 107560555 107573419
CCAR: 109066314 109102100
CAUA: 113056299 113111896
CGIB: 127969164 128024945
PTET: 122355427(erbb2)
LROH: 127173720(erbb2)
OMC: 131550671(erbb2)
PPRM: 120467144(erbb2)
RKG: 130080463(erbb2)
MAMB: 125255361(erbb2)
CIDE: 127523623
MASI: 127422905 127427097
TROS: 130568880(erbb2)
TDW: 130438708(erbb2)
MANU: 129420704(erbb2)
IPU: 108273851(erbb2)
IFU: 128617463(erbb2)
PHYP: 113547490(erbb2)
SMEO: 124389245(erbb2)
TFD: 113650671(erbb2)
TVC: 132841305(erbb2)
AMEX: 103042851(erbb2)
CMAO: 118809704(erbb2)
EEE: 113576854(erbb2)
CHAR: 105902239 122128993(erbb2)
TRU: 101074842 115246515
TFS: 130531780(erbb2)
TNG: GSTEN00035042G001
LCO: 104926899(erbb2)
NCC: 104946774(erbb2)
TBEN: 117473547(erbb2)
CGOB: 115024277
PGEO: 117464942(erbb2)
GACU: 117544977(erbb2)
EMAC: 134870530(erbb2)
ELY: 117247291(erbb2)
EFO: 125880367(erbb2)
SLUC: 116061112(erbb2)
ECRA: 117937271(erbb2)
ESP: 116671269(erbb2)
PFLV: 114547884(erbb2)
GAT: 120819148(erbb2)
PPUG: 119212576(erbb2)
AFB: 129090945(erbb2)
CLUM: 117749018(erbb2)
PSWI: 130203325(erbb2)
MSAM: 119915537(erbb2)
SCHU: 122867228(erbb2)
CUD: 121528226(erbb2)
ALAT: 119009342(erbb2)
MZE: 101482712(erbb2)
ONL: 100690421
OAU: 116335111(erbb2)
OLA: 101174230
OML: 112154010(erbb2)
CSAI: 133419771(erbb2)
XMA: 102234046(erbb2)
XCO: 114152068(erbb2)
XHE: 116726742(erbb2)
PRET: 103481805
PFOR: 103152369(erbb2)
PLAI: 106956127(erbb2)
PMEI: 106925971(erbb2)
GAF: 122823551(erbb2)
PPRL: 129377813(erbb2)
CVG: 107085581(erbb2)
CTUL: 119792246(erbb2)
GMU: 124875242(erbb2)
NFU: 107387934
KMR: 108248942(erbb2)
ALIM: 106521372(erbb2)
NWH: 119423986(erbb2)
AOCE: 111577732
MCEP: 125022253(erbb2)
CSEM: 103381605(erbb2)
POV: 109641267(erbb2)
SSEN: 122762905(erbb2)
HHIP: 117752732(erbb2)
HSP: 118100226(erbb2)
SMAU: 118287647(erbb2)
LCF: 108890417
SDU: 111219739(erbb2)
SLAL: 111652260(erbb2)
XGL: 120794240(erbb2)
HCQ: 109523903(erbb2)
SSCV: 125991021
SBIA: 133495273(erbb2)
PEE: 133417636(erbb2)
PTAO: 133468974(erbb2)
BPEC: 110171045(erbb2)
MALB: 109973611(erbb2)
BSPL: 114846056(erbb2)
SJO: 128380955(erbb2)
SASA: 106579080(erbb2)
STRU: 115162108(erbb2)
OTW: 112223875(erbb2)
OMY: 110491754(erbb2)
OGO: 124048486(erbb2)
ONE: 115106706(erbb2)
OKI: 109865589(erbb2)
OKE: 118364277(erbb2)
SALP: 111977625(erbb2)
SNH: 120046383(erbb2)
CCLU: 121572082(erbb2)
ELS: 105030222(erbb2)
SFM: 108919192(erbb2) 108922533
PKI: 111837750 111854099(erbb2)
AANG: 118220322(erbb2)
LOC: 102686895(erbb2)
PSPA: 121301839 121324586
ARUT: 117433463 117434964 117971274
PSEX: 120518186(erbb2)
LCM: 102348821(ERBB2)
CMK: 103183785(erbb2)
CPLA: 122539698
HOC: 132830882
LERI: 129710062(erbb2)
CIN: 778955(egfr1)
 » show all
Reference
PMID:3003577
  Authors
Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K
  Title
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
  Journal
Nature 319:230-4 (1986)
DOI:10.1038/319230a0
  Sequence
[hsa:2064]
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