KEGG ORTHOLOGY: K05113

ORTHOLOGY: K05113

Entry

K05113                      KO

Symbol

EPHB4, HTK

Name

Eph receptor B4 [EC:2.7.10.1]

Pathway

map04360

Axon guidance

Disease

H00535

Lymphatic malformation

H02043

Capillary malformation-arteriovenous malformation

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K05113  EPHB4, HTK; Eph receptor B4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05113  EPHB4, HTK; Eph receptor B4
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05113  EPHB4, HTK; Eph receptor B4
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
  EPH family [OT]
   K05113  EPHB4, HTK; Eph receptor B4

Other DBs

GO:

0005003

Genes

HSA:	2050(EPHB4)

PTR:	463610(EPHB4)

PPS:	100979334(EPHB4)

GGO:	101142406(EPHB4)

PON:	100461743(EPHB4)

NLE:	100582943 100591047(EPHB4)

HMH:	116463844 116463872 116811750

MCC:	719320(EPHB4)

MCF:	101866702(EPHB4)

MTHB:

126950332

MNI:	105496992(EPHB4)

CSAB:

103246716(EPHB4)

CATY:

105584447(EPHB4)

PANU:

101013895(EPHB4)

TGE:	112620025(EPHB4)

MLEU:

105543666(EPHB4)

RRO:	104673630(EPHB4)

RBB:	108538207(EPHB4)

TFN:	117072308(EPHB4)

PTEH:

111530187(EPHB4)

CANG:

105513104(EPHB4)

CJC:	100393954(EPHB4)

SBQ:	101049187(EPHB4)

CIMI:

108307965(EPHB4)

CSYR:

103255363(EPHB4)

MMUR:

105868364(EPHB4)

LCAT:

123631643(EPHB4)

PCOQ:

105806047(EPHB4)

OGA:	100966510(EPHB4)

MMU:	13846(Ephb4)

MCAL:

110294435(Ephb4)

MPAH:

110313170(Ephb4)

RNO:	686310(Ephb4)

MCOC:

116068594(Ephb4)

ANU:	117698232(Ephb4)

MUN:	110540911(Ephb4)

CGE:	100769535(Ephb4)

MAUA:

101831963(Ephb4)

PROB:

127237310(Ephb4)

PLEU:

114686780(Ephb4)

MORG:

121445997(Ephb4)

MFOT:

126493992

AAMP:

119824923(Ephb4)

NGI:	103733504(Ephb4)

HGL:	101709678(Ephb4)

CPOC:

100735745(Ephb4)

CCAN:

109698102(Ephb4)

DORD:

105997320(Ephb4)

DSP:	122113750(Ephb4)

PLOP:

125367725(Ephb4)

NCAR:

124970370

MMMA:

107147078(Ephb4)

OCU:

100359286

OPI:	101530779(EPHB4)

TUP:	102480872(EPHB4)

GVR:	103608861(EPHB4)

CFA:	489830(EPHB4)

CLUD:

112646222(EPHB4)

VVP:	112935759(EPHB4)

VLG:	121487885(EPHB4)

NPO:	129520064(EPHB4)

AML:	100483535(EPHB4)

UMR:	103670121(EPHB4)

UAH:	113267846(EPHB4)

UAR:	123777335(EPHB4)

ELK:

111145619

LLV:

125090903

MPUF:

101679598(EPHB4)

MNP:	132026566(EPHB4)

MLK:	131819532(EPHB4)

NVS:	122895256(EPHB4)

ORO:	101379798(EPHB4)

EJU:	114214415(EPHB4)

ZCA:	113933345(EPHB4)

MLX:	117999430(EPHB4)

NSU:	110571962(EPHB4)

LWW:	102739487(EPHB4)

FCA:	101094226(EPHB4)

PYU:	121017647(EPHB4)

PCOO:

112859918(EPHB4)

PBG:	122471303(EPHB4)

PVIV:

125154574(EPHB4)

LRUF:

124519179

PTG:	102954410(EPHB4)

PPAD:

109251305(EPHB4)

PUC:

125928222

AJU:

106974600

HHV:	120223660(EPHB4)

BTA:	515756(EPHB4)

BOM:	102280099(EPHB4)

BIU:	109578608(EPHB4)

BBUB:

102397457(EPHB4)

BBIS:

104987136(EPHB4)

CHX:	102187644(EPHB4)

OAS:	101120886(EPHB4)

BTAX:

128043572(EPHB4)

ODA:	120879094(EPHB4)

CCAD:

122433506(EPHB4)

MBEZ:

129545673(EPHB4)

SSC:	100517028(EPHB4)

CFR:	102507927(EPHB4)

CBAI:

105067760(EPHB4)

CDK:	105088565(EPHB4)

VPC:	102535893(EPHB4)

BACU:

102998552(EPHB4)

BMUS:

118881465(EPHB4)

LVE:	103070981(EPHB4)

OOR:	101276506(EPHB4)

DLE:	111181982(EPHB4)

PCAD:

102974408(EPHB4)

PSIU:

116740540(EPHB4)

NASI:

112399985(EPHB4)

ECB:	100069098(EPHB4)

EPZ:	103555656(EPHB4)

EAI:	106839308(EPHB4)

MYB:	102259061(EPHB4)

MYD:	102757526(EPHB4)

MMYO:

118656419(EPHB4)

MLF:	102419021(EPHB4)

PKL:	118703275(EPHB4)

EFUS:

103285997(EPHB4)

MNA:	107540913(EPHB4)

DRO:	112314967(EPHB4)

SHON:

118992857(EPHB4)

AJM:	119041593(EPHB4)

PDIC:

114493902(EPHB4)

PHAS:

123806366(EPHB4)

MMF:	118641629(EPHB4)

PPAM:

129083809(EPHB4)

HAI:	109374941(EPHB4)

RFQ:	117024709(EPHB4)

PALE:

102882917(EPHB4)

PGIG:

120591478(EPHB4)

PVP:	105299733(EPHB4)

RAY:	107500028(EPHB4)

MJV:	108409373(EPHB4)

TOD:	119241574(EPHB4)

SARA:

101555932(EPHB4)

SETR:

126029556(EPHB4)

LAV:	100675998(EPHB4)

TMU:

101346339

ETF:	101664331(EPHB4)

DNM:	101423420(EPHB4)

MDO:	100017247(EPHB4)

GAS:	123244824(EPHB4)

SHR:	100916652(EPHB4)

AFZ:

127560967

PCW:	110202813(EPHB4)

OAA:	100093589(EPHB4)

PCOC:

116241739

PHI:	102100274(EPHB4)

AGEN:

126034605

SHAB:

115603017(EPHB4)

RTD:

128901784

ASN:	102375072(EPHB4)

AMJ:	102559234(EPHB4)

PSS:	102445923(EPHB4)

CCAY:

125628559(EPHB4)

DCC:	119849285(EPHB4)

CPIC:

101932231

MRV:	120381791(EPHB4)

ACS:	100563254(ephb4)

ASAO:

132777505(EPHB4)

PVT:	110082317(EPHB4)

SUND:

121935164(EPHB4)

PBI:	103055427(EPHB4)

PMUR:

107297486(EPHB4)

CTIG:

120305664(EPHB4)

TSR:	106556424(EPHB4)

PGUT:

117658688

APRI:

131197635(EPHB4)

VKO:	123016671(EPHB4)

PMUA:

114581573(EPHB4)

PRAF:

128400149(EPHB4)

ZVI:	118095768(EPHB4)

HCG:	128332100(EPHB4)

GJA:	107118077(EPHB4)

STOW:

125444509

EMC:	129340356(EPHB4)

XLA:	100191023(ephb4.L) 121401677 398362(ephb4.S)

XTR:	100497297(ephb4)

NPR:

108803607

RTEM:

120933698(EPHB4)

BBUF:

120986679(EPHB4)

BGAR:

122923302(EPHB4)

MUO:	115456940(EPHB4)

GSH:	117350632(EPHB4)

DRE:	30688(ephb4a) 30691(ephb4b)

SRX:	107739999 107752256 107757165

SANH:

107662063 107677667 107679372 107702956

SGH:	107556053(ephb4) 107560321 107573198 107573942

CCAR:

109079821

CAUA:

113041374 113065401 113085130 113085601 113094298

CGIB:

127944834 127958320 127990744 128011618

PTET:

122325026(ephb4a) 122334601(ephb4b)

LROH:

127162257(ephb4b) 127165515(ephb4a)

OMC:	131531799(ephb4b) 131540783(ephb4a)

PPRM:

120463296(ephb4b) 120472317(ephb4a)

RKG:	130078632(ephb4b) 130082540(ephb4a)

MAMB:

125259869(ephb4b) 125267807(ephb4a)

CIDE:

127504514 127512987

MASI:

127419552 127419820 127425961 127437155

TROS:

130545577(ephb4b) 130567280(ephb4a)

TDW:	130408955(ephb4b) 130418987(ephb4a)

MANU:

129431536(ephb4b) 129441071(ephb4a)

IPU:	108260128 108276001(ephb4b)

IFU:	128619125(ephb4b)

PHYP:

113525390

SMEO:

124378833(ephb4a) 124398923(ephb4b)

TVC:	132841361 132861921

AMEX:

103037101 103046640

CMAO:

118814894 118822484(ephb4b)

EEE:	113567492(ephb4) 113592187

CHAR:

105904571 105906592(ephb4a)

TRU:	101074460 101079080(ephb4)

TFS:	130523046(ephb4b) 130537662(ephb4a)

TNG:	GSTEN00008002G001 GSTEN00019060G001 GSTEN00019061G001

LCO:	104938059 104938675

NCC:

104941839

TBEN:

117490360(ephb4a)

CGOB:

115004604 115018613

PGEO:

117458205(ephb4a)

GACU:

117535908(ephb4a) 117550541

EMAC:

134872125 134875799

ELY:	117245795(ephb4b) 117268258(ephb4a)

EFO:	125883439 125898263(ephb4a)

PLEP:

121952138(ephb4a)

SLUC:

116059948(ephb4b) 116064815(ephb4a)

ECRA:

117955054(ephb4a)

ESP:	116700327(ephb4)

PFLV:

114566475(ephb4) 114574040

GAT:	120821412 120822468

PPUG:

119215525 119223270

AFB:	129093682(ephb4b) 129113072(ephb4a)

CLUM:

117742978(ephb4a) 117747478(ephb4b)

PSWI:

130212041 130213025(ephb4a)

MSAM:

119895259(ephb4a) 119912599

SCHU:

122870093(ephb4b) 122888500(ephb4a)

CUD:	121504387(ephb4b) 121518507(ephb4a)

ALAT:

119026686(ephb4b) 119031223(ephb4a)

MZE:	101467581 101487975

ONL:	100693438(ephb4) 100696307

OAU:	116334472(ephb4b) 116336186(ephb4a)

OLA:	101162466(ephb4)

OML:	112141486(ephb4b) 112142685(ephb4a)

CSAI:

133420764 133459579

XMA:	102220425(ephb4) 102230691

XCO:	114140525 114153159(ephb4)

XHE:	116728641(ephb4) 116732015

PRET:

103460830 103475844(ephb4)

PFOR:

103132802 103141741(ephb4)

PLAI:

106941572 106960931(ephb4)

PMEI:

106923482(ephb4) 106933610

GAF:	122820900 122845073(ephb4a)

PPRL:

129368888(ephb4a)

CVG:	107093502 107104658

CTUL:

119777846 119778450

GMU:	124876451(ephb4a) 124880672

NFU:	107373869 107373973 107386433(ephb4)

KMR:	108248809(ephb4a) 108250472(ephb4b)

ALIM:

106511683 106526142(ephb4) 106533132

NWH:	119416118 119420693(ephb4a)

AOCE:

111584156 111587177(ephb4)

MCEP:

125008515 125021064(ephb4a)

CSEM:

103389888 103395574(ephb4)

POV:	109628616(ephb4)

SSEN:

122766797 122779597

HHIP:

117774916(ephb4a) 117779229

HSP:	118102479(ephb4b) 118122165(ephb4a)

SMAU:

118283691(ephb4b) 118300885(ephb4a)

LCF:	108874232 108893770(ephb4a)

SDU:	111234278(ephb4) 111239147

SLAL:

111666209(ephb4) 111671490

XGL:	120797229(ephb4b) 120802284(ephb4a)

HCQ:	109517828(ephb4)

SSCV:

125981939

SBIA:

133491690(ephb4a)

PEE:	133415837(ephb4a)

PTAO:

133467271(ephb4a)

BPEC:

110155978 110158375

MALB:

109952430 109959512(ephb4)

BSPL:

114846765(ephb4b) 114869012(ephb4a)

SJO:	128354765 128371640(ephb4a)

SASA:

106578236 106603099

STRU:

115154736 115185813

OTW:	112228866 112230657(ephb4a) 112241359

OMY:	110509419(ephb4a) 110518852 110534033

OGO:	124006768 124007136 124008456

ONE:	115119932 115135587

OKI:	109872767 109873880 109887546

OKE:	118381812 118389716 127927437

SALP:

111950960 111963713

SNH:	120021391(ephb4a) 120057267

CCLU:

121541889 121559682 121579528 123484807

ELS:	105009281 105010828(ephb4)

SFM:	108920338 108922885

PKI:	111836333 111839533

AANG:

118223572 118236172

LOC:	102694592(ephb4)

PSPA:

121305560 121306533(ephb4a)

ARUT:

PSEX:

LCM:

Reference

PMID:8188704

Authors

Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT

Title

Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.

Journal

J Biol Chem 269:14211-8 (1994)

Sequence

[hsa:2050]

Reference

PMID:21078817

Authors

Pitulescu ME, Adams RH

Title

Eph/ephrin molecules--a hub for signaling and endocytosis.

Journal

Genes Dev 24:2480-92 (2010)
DOI:10.1101/gad.1973910

LinkDB

DBGET integrated database retrieval system