KEGG ORTHOLOGY: K05696

ORTHOLOGY: K05696

Entry

K05696                      KO

Symbol

PTPN1, PTP1B

Name

tyrosine-protein phosphatase non-receptor type 1 [EC:3.1.3.48]

Pathway

map04520

Adherens junction

map04910

Insulin signaling pathway

map04931

Insulin resistance

map05208

Chemical carcinogenesis - reactive oxygen species

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K05696  PTPN1, PTP1B; tyrosine-protein phosphatase non-receptor type 1

Other DBs

GO:

0004725

Genes

HSA:	5770(PTPN1)

PTR:	469970(PTPN1)

PPS:	100975196(PTPN1)

GGO:	101127138(PTPN1)

PON:	100172151(PTPN1)

NLE:	100603341(PTPN1)

HMH:	116461451(PTPN1)

MCC:	702016(PTPN1)

MCF:	101865216(PTPN1)

MTHB:

126964386

MNI:	105470681(PTPN1)

CSAB:

103244412(PTPN1)

CATY:

105585387(PTPN1)

PANU:

101008050(PTPN1)

TGE:	112632769(PTPN1)

MLEU:

105548953(PTPN1)

RRO:	104678520(PTPN1)

RBB:	108539452(PTPN1)

TFN:	117068920(PTPN1)

PTEH:

111521026(PTPN1)

CANG:

105502371(PTPN1)

CJC:	100387823(PTPN1) 103790335

SBQ:	101045896(PTPN1)

CIMI:

108281329(PTPN1) 108285145

CSYR:

103262955(PTPN1)

MMUR:

105872274(PTPN1)

LCAT:

123622720(PTPN1)

PCOQ:

105824844(PTPN1)

OGA:	100952815(PTPN1)

MMU:	19246(Ptpn1)

MCAL:

110285654(Ptpn1)

MPAH:

110317689(Ptpn1)

RNO:	24697(Ptpn1)

MCOC:

116091435(Ptpn1)

ANU:	117703085(Ptpn1)

MUN:	110548929(Ptpn1)

CGE:	100761071(Ptpn1)

MAUA:

101844125(Ptpn1)

PROB:

127223333(Ptpn1)

PLEU:

114692671(Ptpn1)

MORG:

121460249(Ptpn1)

MFOT:

126487393

AAMP:

119814862(Ptpn1)

NGI:	103735772(Ptpn1)

HGL:	101696680(Ptpn1)

CPOC:

100730699(Ptpn1)

CCAN:

109696597(Ptpn1)

DORD:

105991691(Ptpn1)

DSP:	122124603(Ptpn1)

PLOP:

125353885(Ptpn1)

NCAR:

124978253

MMMA:

107136710 107137187(Ptpn1)

OCU:

100354834

OPI:	101518547(PTPN1)

TUP:	102484232(PTPN1)

GVR:	103585051(PTPN1)

CFA:	477263(PTPN1)

CLUD:

112674115(PTPN1)

VVP:	112931859(PTPN1)

VLG:	121478162(PTPN1)

NPO:	129498663(PTPN1)

AML:	100481720(PTPN1)

UMR:	103669667(PTPN1)

UAH:	113258718(PTPN1)

UAR:	123775918(PTPN1)

ELK:

111141368

LLV:

125109707

MPUF:

101677842(PTPN1)

MNP:	132022023(PTPN1)

MLK:	131807454(PTPN1)

NVS:	122915978(PTPN1)

ORO:	101378977(PTPN1)

EJU:	114225510(PTPN1)

ZCA:	113937243(PTPN1)

MLX:	118023969(PTPN1)

NSU:	110576693(PTPN1)

LWW:	102726478(PTPN1)

FCA:	101099626(PTPN1)

PYU:	121019865(PTPN1)

PCOO:

112868889(PTPN1)

PBG:	122467275(PTPN1)

PVIV:

125162152(PTPN1)

LRUF:

124504380

PTG:	102965168(PTPN1)

PPAD:

109272277(PTPN1)

PUC:

125936051

AJU:

106980390

HHV:	120230421(PTPN1)

BTA:	508658(PTPN1)

BOM:	102273630(PTPN1)

BIU:	109567547(PTPN1)

BBUB:

102393312(PTPN1)

BBIS:

104985082(PTPN1)

CHX:	102191814(PTPN1)

OAS:	101118209(PTPN1)

BTAX:

128058441(PTPN1)

ODA:	120869085(PTPN1)

CCAD:

122447833(PTPN1)

MBEZ:

129535016(PTPN1)

SSC:	396667(PTPN1)

CFR:	102516397(PTPN1)

CBAI:

105071851(PTPN1)

CDK:	105087880(PTPN1)

VPC:	102534755(PTPN1)

BACU:

103020806(PTPN1)

BMUS:

118880814(PTPN1)

LVE:	103086578(PTPN1)

OOR:	101288096(PTPN1)

DLE:	111186782(PTPN1)

PCAD:

102975154(PTPN1)

PSIU:

116739720(PTPN1)

NASI:

112403107(PTPN1)

ECB:	100052066(PTPN1)

EPZ:	103560571(PTPN1)

EAI:	106825676(PTPN1)

MYB:	102261669(PTPN1)

MYD:	102764615(PTPN1)

MMYO:

118662717(PTPN1)

MLF:	102417949(PTPN1)

PKL:	118708336(PTPN1)

EFUS:

103285744(PTPN1)

MNA:	107538233(PTPN1)

DRO:	112304225(PTPN1)

SHON:

118996495(PTPN1)

AJM:	119065325(PTPN1)

PDIC:

114506981(PTPN1)

PHAS:

123814833(PTPN1)

MMF:	118618192(PTPN1)

PPAM:

129070618(PTPN1)

HAI:	109381866(PTPN1)

RFQ:	117015848(PTPN1)

PALE:

102896636(PTPN1)

PGIG:

120603810(PTPN1)

PVP:	105296070(PTPN1)

RAY:	107510340(PTPN1)

MJV:	108391994(PTPN1) 118969580

TOD:	119236459(PTPN1)

SARA:

101553726(PTPN1)

SETR:

126019145(PTPN1)

LAV:	100671219(PTPN1)

TMU:

101358370

ETF:	101664386(PTPN1)

DNM:	101411619(PTPN1)

MDO:	100028717(PTPN1)

GAS:	123237136(PTPN1)

SHR:	116421513(PTPN1)

AFZ:

127548913

PCW:	110206657(PTPN1)

OAA:	100077166(PTPN1)

GGA:	395688(PTPN1)

PCOC:

116243738(PTPN1)

MGP:	100543385(PTPN1)

CJO:	107323063(PTPN1)

TPAI:

128080986(PTPN1)

LMUT:

125701408(PTPN1)

NMEL:

110408156(PTPN1)

APLA:

101801370(PTPN1)

ACYG:

106041511(PTPN1)

CATA:

118248786(PTPN1)

AFUL:

116495887(PTPN1)

TGU:	100227679(PTPN1)

LSR:	110481747(PTPN1)

SCAN:

103818769(PTPN1)

PMOA:

120507103(PTPN1)

OTC:	121343027(PTPN1)

PRUF:

121359491(PTPN1)

GFR:	102037829(PTPN1)

FAB:	101808942(PTPN1)

OMA:	130261408(PTPN1)

PHI:	102110267(PTPN1)

PMAJ:

107213436(PTPN1)

CCAE:

111938426(PTPN1)

CCW:	104687591(PTPN1)

CBRC:

103616882(PTPN1)

ETL:	114067269(PTPN1)

ZAB:	102064196(PTPN1)

ACHL:

103811813(PTPN1)

SVG:	106853050(PTPN1)

MMEA:

130581387(PTPN1)

HRT:	120760195(PTPN1)

FPG:	101923225(PTPN1)

FCH:	102055390(PTPN1)

CLV:	102084760(PTPN1)

EGZ:	104132199(PTPN1)

NNI:	104013067(PTPN1)

PCRI:

104032335(PTPN1)

PLET:

104624989(PTPN1)

EHS:	104508224(PTPN1)

PCAO:

104053436(PTPN1)

ACUN:

113487420(PTPN1)

TALA:

104368210(PTPN1)

PADL:

103919268(PTPN1)

AFOR:

103894647(PTPN1)

ACHC:

115338784(PTPN1)

HALD:

104318471(PTPN1)

HLE:	104833098(PTPN1)

AGEN:

126045382

GCL:

127023234

CCRI:

104159301(PTPN1)

CSTI:

104550906(PTPN1)

CMAC:

104480485(PTPN1)

MUI:	104536306(PTPN1)

BREG:

104638755(PTPN1)

FGA:	104070820(PTPN1)

GSTE:

104255614(PTPN1)

LDI:	104351437(PTPN1)

MNB:	103773313(PTPN1)

OHA:	104328776(PTPN1)

NNT:	104408507(PTPN1)

SHAB:

115615121(PTPN1)

DPUB:

104302668(PTPN1)

PGUU:

104471935(PTPN1)

ACAR:

104527751(PTPN1)

CPEA:

104389639(PTPN1)

AVIT:

104272658(PTPN1)

CVF:	104293823(PTPN1)

RTD:	128916521(PTPN1)

CUCA:

104057384(PTPN1)

TEO:	104376024(PTPN1)

BRHI:

104489817(PTPN1)

AAM:	106486459(PTPN1)

AROW:

112961790(PTPN1)

NPD:	112949777(PTPN1)

TGT:	104566316(PTPN1)

DNE:	112982885(PTPN1)

SCAM:

104150044(PTPN1)

ASN:	102371275(PTPN1)

AMJ:	102564666(PTPN1)

CPOO:

109318746(PTPN1)

GGN:	109292682(PTPN1)

PSS:	102445513(PTPN1)

CMY:	102946999(PTPN1)

CCAY:

125622571(PTPN1)

DCC:	119841549(PTPN1)

CPIC:

101932653(PTPN1)

TST:	117885723(PTPN1)

CABI:

116838671(PTPN1)

MRV:	120380950(PTPN1)

ACS:	100556985(ptpn1)

ASAO:

132773138(PTPN1)

PVT:	110071802(PTPN1)

SUND:

121928163(PTPN1)

PBI:	103067846(PTPN1)

PMUR:

107289379(PTPN1)

CTIG:

120308782(PTPN1)

TSR:	106543829(PTPN1)

PGUT:

117663558(PTPN1)

APRI:

131194260(PTPN1)

PTEX:

113434360(PTPN1)

NSS:	113410416(PTPN1)

VKO:	123028476(PTPN1)

PMUA:

114599637(PTPN1)

PRAF:

128416458(PTPN1)

ZVI:	118088760(PTPN1)

HCG:	128323810(PTPN1)

GJA:	107111128(PTPN1)

STOW:

125432957(PTPN1)

EMC:	129330251(PTPN1)

XLA:	108702596(ptpn1.S) 444514(ptpn1.L)

XTR:	549875(ptpn1)

NPR:	108795181(PTPN1)

RTEM:

120919351(PTPN1)

BBUF:

121004033(PTPN1)

BGAR:

122941207(PTPN1)

MUO:	115476976(PTPN1)

GSH:	117369231(PTPN1)

DRE:	30081(ptpn1)

SRX:	107711854 107751444

SANH:

107669644 107679845

SGH:	107556311 107594510

CCAR:

109083343 109092414 109095104

CAUA:

113072096 113107529 113107547

CGIB:

127963402 128018560

PTET:

122350563(ptpn1)

LROH:

127169773(ptpn1)

OMC:	131546250(ptpn1)

PPRM:

120484216(ptpn1)

RKG:	130071758(ptpn1)

MAMB:

125279725(ptpn1)

CIDE:

127517931

MASI:

127414928 127424255

TROS:

130568305(ptpn1)

TDW:	130407048(ptpn1)

MANU:

129414321(ptpn1)

IPU:	108265420(ptpn1)

IFU:	128608022(ptpn1)

PHYP:

113531502

SMEO:

124399978(ptpn1)

TFD:	113655762(ptpn1)

TVC:	132854204(ptpn1)

AMEX:

103032056(ptpn1)

CMAO:

118813417(ptpn1)

EEE:

113572078

CHAR:

105894250(ptpn1)

TRU:	101062679(ptpn1)

TFS:

130530731

TNG:	GSTEN00023470G001

LCO:	104919931(ptpn1)

NCC:

104963453

TBEN:

117499354

PGEO:

117440728(ptpn1)

GACU:

117535024

EMAC:

134862219(ptpn1)

ELY:

117258263

EFO:	125891908(ptpn1)

PLEP:

121947281(ptpn1)

SLUC:

116043599

ECRA:

117947024(ptpn1)

ESP:

116692074

PFLV:

114558637(ptpn1)

GAT:	120829153(ptpn1)

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:	121517725(ptpn1)

ALAT:

119022216

MZE:	101485042(ptpn1)

ONL:

100694996

OAU:

116317175

OLA:	101171745(ptpn1)

OML:

112158996

CSAI:

133456736(ptpn1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

129370167(ptpn1)

CVG:

107090730

CTUL:

119799432

GMU:	124858472(ptpn1)

NFU:	107391300(ptpn1)

KMR:	108249567(ptpn1)

ALIM:

106522952

NWH:	119417488(ptpn1)

AOCE:

111572074

MCEP:

125004374(ptpn1)

CSEM:

103385605

POV:	109640627(ptpn1)

SSEN:

122777380(ptpn1)

HHIP:

117764706

HSP:	118111558(ptpn1)

SMAU:

118317481

LCF:	108890482(ptpn1)

SDU:	111235072(ptpn1)

SLAL:

111661874(ptpn1)

XGL:	120804136(ptpn1)

HCQ:

109526882

SSCV:

125989088

SBIA:

133514886(ptpn1)

PEE:	133401688(ptpn1)

PTAO:

133477749(ptpn1)

BPEC:

110164566(ptpn1)

MALB:

109970329

BSPL:

114858652(ptpn1)

SJO:

128357385

SASA:

106567201 106572479

STRU:

115165688 115168033

OTW:	112216224 112221867(ptpn1)

OMY:	110492134 110532529

OGO:	124032140 124045950

ONE:	115102401 115132372

OKI:	109869120 109908189

OKE:	118359926 118360799

SALP:

111966691 111976473

SNH:	120031560 120059244 120061131

CCLU:

121538053 121545699

ELS:

105022331

SFM:	108936323 108939346

PKI:	111835885(ptpn1) 111855814

AANG:

118208475(ptpn1) 118210864

LOC:	102693115(ptpn1)

PSPA:

121297909(ptpn1) 121319189

ARUT:

117405737 117432607

PSEX:

120514295(ptpn1)

LCM:	102351595(PTPN1)

CMK:	103190931(ptpn1)

RTP:

CPLA:

HOC:

LERI:

PMRN:

116954154(PTPN2) 116956061 116957066

LRJ:	133355899(PTPN2) 133357920 133363007

BFO:

118417213

CIN:

100178520

SPU:

582421

DME:	Dmel_CG9181(Ptp61F)

DER:

6545690

DSE:

6610309

DSI:	Dsimw501_GD13480(Dsim_GD13480)

DYA:	Dyak_GE20964

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12440

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ011976

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100579140(Bmptp-Z)

BMAN:

114247390

MSEX:

115440547

DPL:	KGM_203965

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110377579(Ptp61f)

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

NLU:

PHU:	Phum_PHUM581330

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DPX:	DAPPUDRAFT_207917

DMK:

DPZ:

EAF:

LSM:

TCF:

VDE:	111247302 111247386

VJA:	111258919 111262499

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

LOA:	LOAG_06149

LGI:	LOTGIDRAFT_218669

PVUL:

BGT:

HRF:

HRJ:

CRG:

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_139930 Smp_156870

NVE:

EPA:

AMIL:

PDAM:

SPIS:

HMG:

TAD:	TRIADDRAFT_52495

» show all

Reference

PMID:18819921

Authors

Sangwan V, Paliouras GN, Abella JV, Dube N, Monast A, Tremblay ML, Park M

Title

Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.

Journal

J Biol Chem 283:34374-83 (2008)
DOI:10.1074/jbc.M805916200

Sequence

[hsa:5770]

Reference

PMID:2157211

Authors

Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG

Title

Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

Journal

Proc Natl Acad Sci U S A 87:2735-9 (1990)
DOI:10.1073/pnas.87.7.2735

Sequence

[hsa:5770]

LinkDB

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