KEGG ORTHOLOGY: K05701

ORTHOLOGY: K05701

Entry

K05701                      KO

Symbol

TJP1, ZO1

Name

tight junction protein 1

Pathway

map04520

Adherens junction

map04530

Tight junction

map04540

Gap junction

map05110

Vibrio cholerae infection

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05701  TJP1, ZO1; tight junction protein 1
   04530 Tight junction
    K05701  TJP1, ZO1; tight junction protein 1
   04540 Gap junction
    K05701  TJP1, ZO1; tight junction protein 1
09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05701  TJP1, ZO1; tight junction protein 1
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05701  TJP1, ZO1; tight junction protein 1
   05130 Pathogenic Escherichia coli infection
    K05701  TJP1, ZO1; tight junction protein 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05701  TJP1, ZO1; tight junction protein 1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Others
     K05701  TJP1, ZO1; tight junction protein 1

Genes

HSA:	7082(TJP1)

PTR:	453253(TJP1)

PPS:	100986510(TJP1)

GGO:	101150313(TJP1)

PON:	100446271(TJP1)

NLE:	100589256(TJP1)

HMH:	116482444(TJP1)

MCC:	720550(TJP1)

MCF:	102140934(TJP1)

MTHB:

126960109

MNI:	105497535(TJP1)

CSAB:

103245955(TJP1)

CATY:

105597533(TJP1)

PANU:

100999330(TJP1)

TGE:	112627572(TJP1)

MLEU:

105550764(TJP1)

RRO:	104678441(TJP1)

RBB:	108526799(TJP1)

TFN:	117070956(TJP1)

PTEH:

111523252(TJP1)

CANG:

105516908(TJP1)

CJC:	100395578(TJP1)

SBQ:	101045649(TJP1)

CIMI:

108296484(TJP1)

CSYR:

103258785(TJP1)

MMUR:

105871292(TJP1)

LCAT:

123645034(TJP1)

PCOQ:

105808954(TJP1)

OGA:	100952145(TJP1)

MMU:	21872(Tjp1)

MCAL:

110297425(Tjp1)

MPAH:

110313355(Tjp1)

RNO:	292994(Tjp1)

MCOC:

116102342(Tjp1)

ANU:	117703064(Tjp1)

MUN:	110546439(Tjp1)

CGE:	100773110(Tjp1)

MAUA:

101825009(Tjp1)

PROB:

127238010(Tjp1)

PLEU:

114695488(Tjp1)

MORG:

121449634(Tjp1)

MFOT:

126505895

AAMP:

119802555(Tjp1)

NGI:	103747201(Tjp1)

HGL:	101696637(Tjp1)

CPOC:

100718142(Tjp1)

CCAN:

109695793(Tjp1)

DORD:

105982324(Tjp1)

DSP:	122123949(Tjp1)

PLOP:

125367999(Tjp1)

NCAR:

124975977

MMMA:

107148479(Tjp1)

OCU:

100346390

OPI:	101519063(TJP1)

TUP:	102502102(TJP1)

GVR:	103589205(TJP1)

CFA:	403752(TJP1)

CLUD:

112653832(TJP1)

VVP:	112922382(TJP1)

VLG:	121489184(TJP1)

NPO:	129510301(TJP1)

AML:	100479188(TJP1)

UMR:	103659975(TJP1)

UAH:	113263619(TJP1)

UAR:	123790774(TJP1)

ELK:

111152592

LLV:

125103911

MPUF:

101692546(TJP1)

MNP:	131999107(TJP1)

MLK:	131835702(TJP1)

NVS:	122893355(TJP1)

ORO:	101378687(TJP1)

EJU:	114223839(TJP1)

ZCA:	113909046(TJP1)

MLX:	118022980(TJP1)

NSU:	110572361(TJP1)

LWW:	102730618(TJP1)

FCA:	101082238(TJP1)

PYU:	121042506(TJP1)

PCOO:

112856145(TJP1)

PBG:	122468317(TJP1)

PVIV:

125167767(TJP1)

LRUF:

124517383

PTG:	102971662(TJP1)

PPAD:

109273325(TJP1)

PUC:

125910229

AJU:

106983747

HHV:	120233677(TJP1)

BTA:	407102(TJP1)

BOM:	102277556(TJP1)

BIU:	109575369(TJP1)

BBUB:

102402627(TJP1)

BBIS:

104990931(TJP1)

CHX:	102178667(TJP1)

OAS:	443200(TJP1)

BTAX:

128066996(TJP1)

ODA:	120875526(TJP1)

CCAD:

122455215(TJP1)

MBEZ:

129550382(TJP1)

SSC:	100736682(TJP1)

CFR:	102504594(TJP1)

CBAI:

105075143(TJP1)

CDK:	105093462(TJP1)

VPC:	102531900(TJP1)

BACU:

103014304

BMUS:

118890460(TJP1)

LVE:

103090553

OOR:	101270894(TJP1)

DLE:	111164686(TJP1)

PCAD:

102979621(TJP1)

PSIU:

116748800(TJP1)

NASI:

112398291(TJP1)

ECB:	100050412(TJP1)

EPZ:	103559371(TJP1)

EAI:	106834042(TJP1)

MYB:	102240751(TJP1)

MYD:	102766760(TJP1)

MMYO:

118679201(TJP1)

MLF:	102423361(TJP1)

PKL:	118717020(TJP1)

EFUS:

103303128(TJP1)

MNA:	107527961(TJP1)

DRO:	112306071(TJP1)

SHON:

118992036(TJP1)

AJM:	119049780(TJP1)

PDIC:

114488548(TJP1)

PHAS:

123809588

MMF:	118640827(TJP1)

PPAM:

129061238(TJP1)

HAI:	109380376(TJP1)

RFQ:	117018741(TJP1)

PALE:

102891825(TJP1)

PGIG:

120595328(TJP1)

PVP:	105309151(TJP1)

RAY:	107515774(TJP1)

MJV:	108390850(TJP1)

TOD:	119244346(TJP1)

SARA:

101546054(TJP1)

SETR:

126021813(TJP1)

LAV:	100654164(TJP1)

TMU:

101350122

ETF:	101654621(TJP1)

DNM:	101412669(TJP1)

MDO:	100021326(TJP1)

GAS:	123238071(TJP1)

SHR:	100924427(TJP1)

AFZ:

127551324

PCW:	110192395(TJP1)

OAA:	100078517(TJP1)

GGA:	415388(TJP1)

PCOC:

116244634(TJP1)

MGP:	100542752(TJP1)

CJO:	107318600(TJP1)

TPAI:

128075481(TJP1)

LMUT:

125698268(TJP1)

NMEL:

110403631(TJP1)

APLA:

101791291(TJP1)

ACYG:

106033714(TJP1)

CATA:

118251586(TJP1)

AFUL:

116493451(TJP1)

TGU:	100231257(TJP1)

LSR:	110471403(TJP1)

SCAN:

103815972(TJP1)

PMOA:

120508835(TJP1)

OTC:	121343295(TJP1)

PRUF:

121354273(TJP1)

GFR:	102044956(TJP1)

FAB:	101816839(TJP1)

OMA:	130257232(TJP1)

PHI:	102108685(TJP1)

PMAJ:

107209334(TJP1)

CCAE:

111934185(TJP1)

CCW:	104683818(TJP1)

CBRC:

103618580(TJP1)

ETL:	114064909(TJP1)

ZAB:	102061658(TJP1)

ACHL:

103810610(TJP1)

SVG:	106851807(TJP1)

MMEA:

130576900(TJP1)

HRT:	120758914(TJP1)

FPG:	101912031(TJP1)

FCH:	102053227(TJP1)

CLV:	102083865(TJP1)

EGZ:	104130878(TJP1)

NNI:	104016764(TJP1)

PCRI:

104032832(TJP1)

PLET:

104627575(TJP1)

EHS:	104509907(TJP1)

PCAO:

104048465(TJP1)

ACUN:

113483880(TJP1)

TALA:

104365183(TJP1)

PADL:

103914850(TJP1)

AFOR:

103899804(TJP1)

ACHC:

115342270(TJP1)

HALD:

104324387(TJP1)

HLE:	104834447(TJP1)

AGEN:

126044067

GCL:

127020867

CCRI:

104166821(TJP1)

CSTI:

104553691(TJP1)

CMAC:

104486385(TJP1)

MUI:	104541444(TJP1)

BREG:

104637734(TJP1)

FGA:	104081301(TJP1)

GSTE:

104251021(TJP1)

LDI:	104352151(TJP1)

MNB:	103768182(TJP1)

OHA:	104330564(TJP1)

NNT:	104407533(TJP1)

SHAB:

115612992(TJP1)

DPUB:

104309879(TJP1)

PGUU:

104470160(TJP1)

ACAR:

104521756(TJP1)

CPEA:

104385891(TJP1)

AVIT:

104280024(TJP1)

CVF:	104287090(TJP1)

RTD:	128914758(TJP1)

CUCA:

104054351(TJP1)

TEO:	104375549(TJP1)

BRHI:

104493955(TJP1)

AAM:	106496461(TJP1)

AROW:

112975696(TJP1)

NPD:	112958897(TJP1)

TGT:	104580203(TJP1)

DNE:	112991107(TJP1)

SCAM:

104148322(TJP1)

ASN:	102377249(TJP1)

AMJ:	102571498(TJP1)

CPOO:

109308957(TJP1)

GGN:	109288666(TJP1)

PSS:	102444512(TJP1)

CMY:	102946392(TJP1)

CCAY:

125643530(TJP1)

DCC:	119862168(TJP1)

CPIC:

101931168(TJP1)

TST:	117884235(TJP1)

CABI:

116824426(TJP1)

MRV:

120373192

ACS:	100562712(tjp1)

ASAO:

132762618(TJP1)

PVT:	110074496(TJP1)

SUND:

121934696(TJP1)

PBI:	103065791(TJP1)

PMUR:

107293008(TJP1)

CTIG:

120306596(TJP1)

TSR:	106549310(TJP1)

PGUT:

117660989(TJP1)

APRI:

131184520(TJP1)

PTEX:

113453066 113453067

NSS:	113421615(TJP1)

VKO:	123027607(TJP1)

PMUA:

114584155(TJP1)

PRAF:

128401905(TJP1)

ZVI:	118093068(TJP1)

HCG:	128334764(TJP1)

GJA:	107117388(TJP1)

STOW:

125446163(TJP1)

EMC:	129345417(TJP1)

XLA:	108712948 496307(tjp1.S)

XTR:	100498413(tjp1)

NPR:	108790274(TJP1)

RTEM:

120931400(TJP1)

BBUF:

120985745(TJP1)

BGAR:

122927663(TJP1)

MUO:	115461652(TJP1)

GSH:	117348400(TJP1)

DRE:	378845(tjp1a) 565459(tjp1b)

SRX:	107712515 107739097 107750483 107755055

SANH:

107662450 107670746

SGH:	107557981 107586031 107589322 107595074

CCAR:

109073005 109113122

CAUA:

113043481 113051534 113067044 113105952

CGIB:

127943388 127946825 127962139 128013957 128016958

PTET:

122330606(tjp1b) 122348254(tjp1a)

LROH:

127157045(tjp1b) 127168564(tjp1a)

OMC:	131534569(tjp1b) 131544090(tjp1a)

PPRM:

120459093(tjp1b) 120475995(tjp1a)

RKG:	130079605(tjp1a) 130099343(tjp1b)

MAMB:

125247762(tjp1b) 125264727(tjp1a)

CIDE:

127507778 127515277

MASI:

127434806 127435738 127437405 127455528

TROS:

130551642(tjp1b) 130562312(tjp1a)

TDW:	130413796(tjp1b) 130418355(tjp1a)

MANU:

129434497(tjp1b) 129442893(tjp1a)

IPU:	108259232(tjp1a) 108274984(tjp1b)

IFU:	128602860(tjp1a) 128617688(tjp1b)

PHYP:

113530062(tjp1) 113540846

SMEO:

124380202(tjp1a) 124392805(tjp1b)

TFD:	113647378(tjp1a) 113659990(tjp1b)

TVC:	132838937(tjp1a) 132856835(tjp1b)

AMEX:

103023057 103025779

CMAO:

118811706(tjp1b) 118817421(tjp1a)

EEE:	113576698 113581762

CHAR:

105892343(tjp1b) 105906243(tjp1a)

TRU:	101069449 101073904

TFS:	130520579(tjp1a) 130535888(tjp1b)

TNG:	GSTEN00017845G001 GSTEN00025602G001

LCO:	104919257 104940591

NCC:	104952246 104960119(tjp1)

TBEN:

117471860(tjp1a) 117491376(tjp1b)

CGOB:

115006417 115009291

PGEO:

117447860(tjp1b) 117467047(tjp1a)

GACU:

117538858(tjp1b) 117546946(tjp1a)

EMAC:

134862923(tjp1a) 134876280(tjp1b)

ELY:	117258110(tjp1a) 117262742(tjp1b)

EFO:	125881656 125888108(tjp1b)

PLEP:

121949670(tjp1b) 121950953

SLUC:

116034026(tjp1a) 116038332(tjp1b)

ECRA:

117949611(tjp1b) 117951061(tjp1a)

ESP:	116675814 116693851

PFLV:

114559767 114560133

GAT:	120809555(tjp1b) 120812329 120831136(tjp1a)

PPUG:

119196644(tjp1b) 119198791(tjp1a)

AFB:	129107730(tjp1b) 129108618(tjp1a)

CLUM:

117732189(tjp1b) 117748531(tjp1a)

PSWI:

130192633(tjp1a) 130194721(tjp1b)

MSAM:

119889744(tjp1a) 119890020 119893804(tjp1b)

SCHU:

122874741(tjp1b) 122878499(tjp1a)

CUD:	121507464(tjp1a) 121514714(tjp1b)

ALAT:

119017649(tjp1a) 119024323(tjp1b)

MZE:	101471045 101477899

ONL:	100697056 100698737

OAU:	116326685(tjp1b) 116327182(tjp1a)

OLA:	101160233 101166369

OML:	112151703(tjp1b) 112160469(tjp1a)

CSAI:

133444110(tjp1b) 133461462(tjp1a)

XMA:	102216933 102224296

XCO:	114136837 114142496

XHE:	116718091 116731862

PRET:

103462420 103466442

PFOR:

103139421 103155700(tjp1)

PLAI:

106937846 106961235

PMEI:

106906403 106919352(tjp1)

GAF:	122821978(tjp1a) 122834977(tjp1b)

PPRL:

129359229(tjp1b) 129369379(tjp1a)

CVG:	107087409 107090929(tjp1)

CTUL:

119782720(tjp1a) 119787358(tjp1b)

GMU:	124867541(tjp1a) 124882391(tjp1b)

NFU:	107381456 107388620(tjp1)

KMR:	108230036(tjp1b) 108251409(tjp1a)

ALIM:

106526830(tjp1) 106530660

NWH:	119416336(tjp1b) 119422076

AOCE:

111572856 111577702

MCEP:

125005994(tjp1a) 125015362(tjp1b)

CSEM:

103378762 103380472(tjp1)

POV:	109624378 109624981

SSEN:

122761378(tjp1b) 122778464(tjp1a)

HHIP:

117753942(tjp1a) 117762931(tjp1b)

HSP:	118110064(tjp1b) 118116632(tjp1a)

SMAU:

118301950(tjp1a) 118314712(tjp1b)

LCF:	108876659(tjp1b) 108889662(tjp1a)

SDU:	111229539 111238329

SLAL:

111654818 111658534

XGL:	120791782(tjp1a) 120792999(tjp1b)

HCQ:	109507607 109514326

SSCV:

125967144 125971361

SBIA:

133498515(tjp1a) 133502746(tjp1b)

PEE:	133399182(tjp1a) 133402435(tjp1b)

PTAO:

133470620(tjp1a) 133478565(tjp1b)

BPEC:

110169754 110173088

MALB:

109963765 109972560

BSPL:

114851841(tjp1a) 114857079(tjp1b)

SJO:	128359311(tjp1b) 128363179(tjp1a)

SASA:

106561768 106562151 106584727(tjp1) 106587244

STRU:

115167354 115192877 115196557 115202998

OTW:	112235723 112249136(tjp1a) 112257767(tjp1b)

OMY:	100750227 110500877(tjp1b) 110506437 110522713

OGO:	124031591 124033821 124035800

ONE:	115112174 115113578 115117279

OKI:	109874465 109885810 109895444 109898230

OKE:	118358799 118362304 118378188 118394150(tjp1a)

SALP:

111969103 111974518

SNH:	120025359 120046404(tjp1a) 120051673(tjp1b) 120065974

CCLU:

121540688 121548341 121559826 121568189

ELS:	105015751(tjp1) 106024783

SFM:	108926720 108931159

PKI:	111835101 111846729

AANG:

118215021 118227177

LOC:	102686200(tjp1)

PSPA:

121294726 121299175

ARUT:

117428010 117429450

LCM:	102359541(TJP1)

CMK:	103188819(tjp1a)

CPLA:

122542509(tjp1a)

HOC:	132834831(tjp1a)

LERI:

129713634(tjp1a)

PMRN:

116939131 116941894

LRJ:	133343847 133346580

BFO:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG43140(pyd)

DER:

6552588

DSE:

6607184

DSI:	Dsimw501_GD20836(Dsim_GD20836)

DYA:	Dyak_GE24813

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22708

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ007474

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:	119828883 119828933

CCRC:

123700750

LSIN:

126977821

AAGE:

121736135

HAW:	110376792(pyd)

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM359090

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_308707

DMK:

DPZ:

PVM:

PJA:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111698218 111705513

LSM:

121121966

PPOI:

119100455 119101398 119103110

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:	118187631 118190059

LOA:	LOAG_00393

TSP:

Tsp_11165

HRO:	HELRODRAFT_176655

LGI:	LOTGIDRAFT_234130

PVUL:

PCAN:

BGT:

GAE:

HRJ:

CRG:

OED:

MYI:

PMAX:

MMER:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_137910

OVI:	T265_11076

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

TAD:	TRIADDRAFT_60291

» show all

Reference

PMID:21240187

Authors

Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M

Title

Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration.

Journal

EMBO J 30:665-78 (2011)
DOI:10.1038/emboj.2010.353

Reference

PMID:8395056

Authors

Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C, Anderson JM

Title

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

Journal

Proc Natl Acad Sci U S A 90:7834-8 (1993)
DOI:10.1073/pnas.90.16.7834

Sequence

[hsa:7082]

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