KEGG ORTHOLOGY: K05703

ORTHOLOGY: K05703

Entry

K05703                      KO

Symbol

FYN

Name

tyrosine-protein kinase Fyn [EC:2.7.10.2]

Pathway

map04071

Sphingolipid signaling pathway

map04072

Phospholipase D signaling pathway

map04360

Axon guidance

map04380

Osteoclast differentiation

map04510

Focal adhesion

map04520

Adherens junction

map04611

Platelet activation

map04650

Natural killer cell mediated cytotoxicity

map04660

T cell receptor signaling pathway

map04664

Fc epsilon RI signaling pathway

map04725

Cholinergic synapse

map05020

Prion disease

map05130

Pathogenic Escherichia coli infection

map05416

Viral myocarditis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
   04071 Sphingolipid signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05703  FYN; tyrosine-protein kinase Fyn
   04520 Adherens junction
    K05703  FYN; tyrosine-protein kinase Fyn
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05703  FYN; tyrosine-protein kinase Fyn
   04650 Natural killer cell mediated cytotoxicity
    K05703  FYN; tyrosine-protein kinase Fyn
   04660 T cell receptor signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
   04664 Fc epsilon RI signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
  09156 Nervous system
   04725 Cholinergic synapse
    K05703  FYN; tyrosine-protein kinase Fyn
  09158 Development and regeneration
   04360 Axon guidance
    K05703  FYN; tyrosine-protein kinase Fyn
   04380 Osteoclast differentiation
    K05703  FYN; tyrosine-protein kinase Fyn
09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05703  FYN; tyrosine-protein kinase Fyn
  09164 Neurodegenerative disease
   05020 Prion disease
    K05703  FYN; tyrosine-protein kinase Fyn
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05703  FYN; tyrosine-protein kinase Fyn
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05703  FYN; tyrosine-protein kinase Fyn
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05703  FYN; tyrosine-protein kinase Fyn
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05703  FYN; tyrosine-protein kinase Fyn
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SRC family
   K05703  FYN; tyrosine-protein kinase Fyn
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05703  FYN; tyrosine-protein kinase Fyn
Endocytosis
  Lipid raft mediated endocytosis
   Flotillin-dependent endocytosis
    K05703  FYN; tyrosine-protein kinase Fyn

Other DBs

GO:

0004715

Genes

HSA:

2534(FYN)

PTR:	462944(FYN)

PPS:	100971932(FYN)

GGO:	101143006(FYN)

PON:	100439712(FYN)

NLE:	100585303(FYN)

HMH:	116471050(FYN)

MCC:	574214(FYN)

MCF:	102126878(FYN)

MTHB:

126953590

MNI:	105492092(FYN)

CSAB:

103240563(FYN)

CATY:

105581387(FYN)

PANU:

101003717(FYN)

TGE:	112622714(FYN)

MLEU:

105532442(FYN)

RRO:	104668854(FYN)

RBB:	108512073(FYN)

TFN:	117096942(FYN)

PTEH:

111547323(FYN)

CANG:

105506747(FYN)

CJC:	100391434(FYN)

SBQ:	101051746(FYN)

CIMI:

108289728(FYN)

CSYR:

103261354(FYN)

MMUR:

105864918(FYN)

LCAT:

123633175(FYN)

PCOQ:

105809082(FYN)

OGA:	100954541(FYN)

MMU:	14360(Fyn)

MCAL:

110302997(Fyn)

MPAH:

110326389(Fyn)

RNO:	25150(Fyn)

MCOC:

116074574(Fyn)

ANU:	117724160(Fyn)

MUN:	110561016(Fyn)

CGE:	100772355(Fyn)

MAUA:

101834635(Fyn)

PROB:

127215149(Fyn)

PLEU:

114696882(Fyn)

MORG:

121449300(Fyn)

MFOT:

126499043

AAMP:

119821217(Fyn)

NGI:	103749533(Fyn)

HGL:	101721279(Fyn)

CPOC:

100728124(Fyn)

CCAN:

109695356(Fyn)

DORD:

105998151(Fyn)

DSP:	122108458(Fyn)

PLOP:

125357194(Fyn)

NCAR:

124988460

MMMA:

107154658(Fyn)

OCU:

100339741

OPI:	101517134(FYN)

TUP:	102498676(FYN)

GVR:	103596898(FYN)

CFA:	475032(FYN)

CLUD:

112658623(FYN)

VVP:	112925186(FYN)

VLG:	121489350(FYN)

NPO:	129513108(FYN)

AML:	100470931(FYN)

UMR:	103676988(FYN)

UAH:	113264721(FYN)

UAR:	123792961(FYN)

ELK:

111158275

LLV:

125103208

MPUF:

101676005(FYN)

MNP:	132018370(FYN)

MLK:	131833494(FYN)

NVS:	122903454(FYN)

ORO:	101362244(FYN)

EJU:	114209890(FYN)

ZCA:	113927359(FYN)

MLX:	118001612(FYN)

NSU:	110583670(FYN)

LWW:	102731161(FYN)

FCA:	101085720(FYN)

PYU:	121029911(FYN)

PCOO:

112862059(FYN)

PBG:	122489876(FYN)

PVIV:

125165365(FYN)

LRUF:

124528746

PTG:	102956260(FYN)

PPAD:

109263555(FYN)

PUC:

125937963

AJU:

106968910

HHV:	120245246(FYN)

BTA:	527263(FYN)

BOM:	102284015(FYN)

BIU:	109563811(FYN)

BBUB:

102416287(FYN)

BBIS:

105000638(FYN)

CHX:	102179673(FYN)

OAS:	101109363(FYN)

BTAX:

128053552(FYN)

ODA:	120862488(FYN)

CCAD:

122422629(FYN)

MBEZ:

129561305(FYN)

SSC:	791125(FYN)

CFR:	102506492(FYN)

CBAI:

105077134(FYN)

CDK:	105099211(FYN)

VPC:	102538350(FYN)

BACU:

103012275(FYN)

BMUS:

118905159(FYN)

LVE:	103071829(FYN)

OOR:	101279266(FYN)

DLE:	111164732(FYN)

PCAD:

102974010(FYN)

PSIU:

116763801(FYN)

NASI:

112396968(FYN)

ECB:	102149085(FYN)

EPZ:	103547543(FYN)

EAI:	106847048(FYN)

MYB:	102242533(FYN)

MYD:	102751410(FYN)

MMYO:

118660684(FYN)

MLF:	102422740(FYN)

PKL:	118705144(FYN)

EFUS:

103302295(FYN)

MNA:	107540684(FYN)

DRO:	112297021(FYN)

SHON:

119000185(FYN)

AJM:	119044480(FYN)

PDIC:

114493972(FYN)

PHAS:

123821592(FYN)

MMF:	118620959(FYN)

PPAM:

129067708(FYN)

HAI:	109384758(FYN)

RFQ:	117020052(FYN)

PALE:

102896849(FYN)

PGIG:

120608606(FYN)

PVP:	105295260(FYN)

RAY:	107506307(FYN)

MJV:	108396080(FYN)

TOD:	119252791(FYN)

SARA:

101538710(FYN)

SETR:

126005876(FYN)

LAV:	100675535(FYN)

TMU:

101340362

ETF:	101664321(FYN)

DNM:	101414233(FYN)

MDO:	100022459(FYN)

GAS:	123246567(FYN)

SHR:	100923088(FYN)

AFZ:

127562100

PCW:	110222880(FYN)

OAA:	100073798(FYN)

GGA:	396294(FYN)

PCOC:

116240704(FYN)

MGP:

100543914

CJO:	107311849(FYN)

TPAI:

128078435(FYN)

LMUT:

125688914(FYN)

NMEL:

110397033(FYN)

APLA:

101799525(FYN)

ACYG:

106032576(FYN)

CATA:

118243877(FYN)

AFUL:

116488312(FYN)

TGU:	100228220(FYN)

LSR:	110484642(FYN)

SCAN:

103818548(FYN)

PMOA:

120511405(FYN)

OTC:	121341412(FYN)

PRUF:

121359270(FYN)

GFR:	102037765(FYN)

FAB:	101807629(FYN)

OMA:	130251463(FYN)

PHI:	102103534(FYN)

PMAJ:

107202142(FYN)

CCAE:

111927157(FYN)

CCW:	104691303(FYN)

CBRC:

103619269(FYN)

ETL:	114062026(FYN)

ZAB:	102066840(FYN)

ACHL:

103806255(FYN)

SVG:	106854997(FYN)

MMEA:

130589058(FYN)

HRT:	120749766(FYN)

FPG:	101924310(FYN)

FCH:	102057542(FYN)

CLV:	102095466(FYN)

EGZ:	104131981(FYN)

NNI:	104011133(FYN)

PCRI:

104025302(FYN)

PLET:

104616558(FYN)

EHS:	104511549(FYN)

PCAO:

104047175(FYN)

ACUN:

113477834(FYN)

TALA:

104364969(FYN)

PADL:

103918980(FYN)

AFOR:

103907054(FYN)

ACHC:

115349460(FYN)

HALD:

104314525(FYN)

HLE:	104828171(FYN)

AGEN:

126046044

GCL:

127015009

CCRI:

104155433(FYN)

CSTI:

104561792(FYN)

CMAC:

104477914(FYN)

MUI:	104545088(FYN)

BREG:

104636234(FYN)

FGA:	104083477(FYN)

GSTE:

104256104(FYN)

LDI:	104346930(FYN)

MNB:

103771119

OHA:	104332676(FYN)

NNT:	104406532(FYN)

SHAB:

115609359(FYN)

DPUB:

104296617(FYN)

PGUU:

104459183(FYN)

ACAR:

104529146(FYN)

CPEA:

104398294(FYN)

AVIT:

104273700(FYN)

CVF:	104294054(FYN)

RTD:	128906782(FYN)

CUCA:

104062740(FYN)

TEO:

104383972

BRHI:

104492111(FYN)

AAM:	106489691(FYN)

AROW:

112965972(FYN)

NPD:	112948451(FYN)

TGT:	104569805(FYN)

DNE:	112995135(FYN)

SCAM:

104149054(FYN)

ASN:	102384418(FYN)

AMJ:	102574913(FYN)

CPOO:

109311945(FYN)

GGN:	109299590(FYN)

PSS:	102464071(FYN)

CMY:	102935370(FYN)

CCAY:

125634270(FYN)

DCC:	119852788(FYN)

CPIC:

101949716(FYN)

TST:	117875019(FYN)

CABI:

116820271(FYN)

MRV:	120400558(FYN)

ACS:	100559709(fyn)

ASAO:

132760877(FYN)

PVT:	110085313(FYN)

SUND:

121921756(FYN)

PBI:	103062202(FYN)

PMUR:

107287161(FYN)

CTIG:

120311563(FYN)

TSR:	106540113(FYN)

PGUT:

117660862(FYN)

APRI:

131193515(FYN)

PTEX:

113455319(FYN)

NSS:	113411559(FYN)

VKO:	123021493(FYN)

PMUA:

114594054(FYN)

PRAF:

128410447(FYN)

ZVI:	118082130(FYN)

HCG:	128349676(FYN)

GJA:	107118444(FYN)

STOW:

125430582(FYN)

EMC:	129327107(FYN)

XLA:	373609(fyn.L) 379812(fyn.S)

XTR:	100488004(fyn)

NPR:	108790091(FYN)

RTEM:

120937220(FYN)

BBUF:

120998271(FYN)

BGAR:

122933715(FYN)

MUO:	115458730 115467344(FYN)

GSH:	117358198(FYN)

DRE:	373872(fyna) 574422(fynb)

SRX:	107750405 107751750 107755004 107755790

SANH:

107670246(fyn) 107680776 107693124 107704353

SGH:	107548254 107564973 107565451 107583469

CCAR:

109050311 109107918 109113279

CAUA:

113060715 113063512 113079400 113091729 113121280(fyn)

CGIB:

127938329 127976426 127983895 128031367

PTET:

122324527(fynb) 122362363(fyna)

LROH:

127180013(fyna) 127182733(fynb)

OMC:	131523357(fyna) 131526727(fynb)

PPRM:

120467769 120479329(fyna)

RKG:	130085043(fynb) 130101435(fyna)

MAMB:

125268483(fyna) 125277709(fynb)

CIDE:

127498876 127502076

MASI:

127410012 127411024 127415824 127455434

TROS:

130560603(fyna) 130566005(fynb)

TDW:	130434919(fynb) 130436957(fyna)

MANU:

129417623(fyna)

IPU:	108255503(fynb) 108270342

IFU:	128612628(fyna) 128618003

PHYP:

113525201(fyn) 113533722

SMEO:

124389707 124400918(fynb)

TFD:	113651260(fyna) 113661162(fynb)

TVC:	132852929(fyna) 132854468(fynb)

AMEX:

103026055(fyn) 103043249

CMAO:

118816039(fynb) 118823428(fyna)

EEE:	113586228 113590638

CHAR:

105894860(fynb) 105908235(fyna)

TRU:	101063191 101070253(fyn)

TFS:	130516640(fynb) 130540072(fyna)

TNG:	GSTEN00010460G001 GSTEN00031972G001 GSTEN00031974G001

LCO:	104922928(fyn) 104931606

NCC:	104960495(fyn)

TBEN:

117478273(fyna) 117498357(fynb)

CGOB:

115003857(fyn) 115027270

PGEO:

117439700(fynb) 117467933(fyna)

GACU:

117540611(fyna) 117557151

EMAC:

134877131(fynb) 134881806(fyna)

ELY:	117267269 117270652(fynb)

EFO:	125897173(fynb) 125901027(fyna)

PLEP:

121953490(fyna) 121955340(fynb)

SLUC:

116040292(fynb) 116057484(fyna)

ECRA:

117935692(fyna) 117961942(fynb)

ESP:	116669655 116679832 116705947(fyn)

PFLV:

114546343 114572774(fyn)

GAT:	120807866(fynb) 120832872(fyna)

PPUG:

119194835(fynb) 119227856(fyna)

AFB:	129103992(fyna) 129107629(fynb)

CLUM:

117725380(fyna) 117727069(fynb)

PSWI:

130201611(fyna) 130202304(fynb)

MSAM:

119908832(fynb) 119910684

SCHU:

122862053 122862803(fynb)

CUD:	121520950(fynb) 121526271(fyna)

ALAT:

119004876(fyna) 119012483(fynb)

MZE:	101474799 101479859(fyn)

ONL:	100690757(fyn) 100691175

OAU:	116317251(fynb) 116326099(fyna)

OLA:	101157019 101167011

OML:	112146402 112158419(fynb)

CSAI:

133418321(fynb) 133461874(fyna)

XMA:	102233390 102237794

XCO:	114134301 114158470

XHE:	116709199 116734021

PRET:

103458010 103458742

PFOR:

103140737(fyn) 103155051 103155058

PLAI:

106937692 106958585(fyn)

PMEI:

106903328 106906671 106925409

GAF:	122824832(fynb) 122846276

PPRL:

129365599 129369217(fynb)

CVG:	107092365(fyn) 107096191

CTUL:

119775236(fyna) 119790784(fynb)

GMU:	124855451 124881897(fynb)

NFU:	107392150 107396024(fyn)

KMR:	108236545 108248899(fynb)

ALIM:

106518449 106529781

NWH:

119427356

AOCE:

111563357(fyn) 111573260

MCEP:

124998801(fynB) 125023380(fynA)

CSEM:

103378673 103380632(fyn)

POV:	109632533(fyn) 109636463

SSEN:

122783072 122783855(fynb)

HHIP:

117755525(fyna) 117758609(fynb)

HSP:	118099251(fynb) 118115949(fyna)

SMAU:

118286547(fyna) 118290098(fynb)

LCF:	108875026(fyna) 108899306(fynb)

SDU:	111225278 111235770(fyn)

SLAL:

111651009 111672913(fyn)

XGL:	120788557(fynb) 120795636(fyna)

HCQ:	109517462 109524890

SSCV:

125981014 125990179

SBIA:

133496377 133513789(fyna)

PEE:	133412411 133417419

PTAO:

133468221 133487934(fyna)

BPEC:

110153632

MALB:

109968046 109968087(fyn)

BSPL:

114849057(fyna) 114849390(fynb)

SJO:	128375535(fyna) 128376708(fynb)

SASA:

100306819(fyn) 106571317

STRU:

115190053 115194124

OTW:	112217528 112250060

OMY:	110522145 110529523

OGO:	123990674 123995010

ONE:	115107673 115139501

OKI:	109866316 109900669

OKE:	118386809 118398743

SALP:

111954280 111972516

SNH:	120019668 120024183

CCLU:

121549004 121552964

ELS:	105017971(fyn)

SFM:	108921798 108929301(fyn)

PKI:	111843036(fyn) 111857866

AANG:

118229663(fynb) 118233373

LOC:	102696359(fyn)

PSPA:

121315478 121317572

ARUT:

117403304 117410990

PSEX:

120525553(fynb)

LCM:	102354666(FYN)

CMK:

RTP:

CPLA:

HOC:

PMRN:

LRJ:

BFO:

BBEL:

SCLV:

LPIC:

129279895 129280386 129280453 129281046

AJC:

NVL:

PJA:

PMOO:

HAME:

PTRU:

BGT:	106050182 106059250

CRG:

CVN:

CANU:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115209142 115227602 115228262

LAK:

106171164

SMM:	Smp_136300 Smp_172200

EGL:

EGR_09507

HSY:

130653749

AQU:	100631421 100633614 100635873 100636000 100638702 100640218 109584853 109584989

» show all

Reference

PMID:7822789

Authors

Rigley K, Slocombe P, Proudfoot K, Wahid S, Mandair K, Bebbington C

Title

Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.

Journal

J Immunol 154:1136-45 (1995)

Sequence

[hsa:2534]

LinkDB

DBGET integrated database retrieval system