KEGG ORTHOLOGY: K05718

ORTHOLOGY: K05718

Entry

K05718                      KO

Symbol

ITGAL, CD11a

Name

integrin alpha L

Pathway

map04015

Rap1 signaling pathway

map04514

Cell adhesion molecules

map04613

Neutrophil extracellular trap formation

map04650

Natural killer cell mediated cytotoxicity

map04670

Leukocyte transendothelial migration

map04810

Regulation of actin cytoskeleton

map05144

Malaria

map05150

Staphylococcus aureus infection

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05323

Rheumatoid arthritis

map05416

Viral myocarditis

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05718  ITGAL, CD11a; integrin alpha L
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05718  ITGAL, CD11a; integrin alpha L
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K05718  ITGAL, CD11a; integrin alpha L
   04650 Natural killer cell mediated cytotoxicity
    K05718  ITGAL, CD11a; integrin alpha L
   04670 Leukocyte transendothelial migration
    K05718  ITGAL, CD11a; integrin alpha L
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05718  ITGAL, CD11a; integrin alpha L
   05169 Epstein-Barr virus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K05718  ITGAL, CD11a; integrin alpha L
  09174 Infectious disease: parasitic
   05144 Malaria
    K05718  ITGAL, CD11a; integrin alpha L
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05718  ITGAL, CD11a; integrin alpha L
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05718  ITGAL, CD11a; integrin alpha L
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05718  ITGAL, CD11a; integrin alpha L
   04515 Cell adhesion molecules
    K05718  ITGAL, CD11a; integrin alpha L
   04090 CD molecules
    K05718  ITGAL, CD11a; integrin alpha L
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K05718  ITGAL, CD11a; integrin alpha L
Cell adhesion molecules [BR:ko04515]
Integrins
  Integrin alpha subunits
   K05718  ITGAL, CD11a; integrin alpha L
CD molecules [BR:ko04090]
Proteins
  K05718  CD11a, ITGAL; integrin, alpha L

Genes

HSA:	3683(ITGAL)

PTR:	454045(ITGAL)

PPS:	100968171(ITGAL)

GGO:	101139540(ITGAL)

PON:	100451665(ITGAL)

NLE:	100600240(ITGAL)

HMH:	116470180(ITGAL)

MCC:	711945(ITGAL)

MCF:	102117706(ITGAL)

MTHB:

126944173

MNI:	105483005(ITGAL)

CSAB:

103231906(ITGAL)

CATY:

105599804(ITGAL)

PANU:

101022225(ITGAL)

TGE:	112614061(ITGAL)

MLEU:

105541493(ITGAL)

RRO:	104681602(ITGAL)

RBB:	108535405(ITGAL)

TFN:	117087649(ITGAL)

PTEH:

111525635(ITGAL)

CANG:

105505725(ITGAL)

CJC:	100390790(ITGAL)

SBQ:	101049788(ITGAL)

CIMI:

108293872(ITGAL)

CSYR:

103260120(ITGAL)

MMUR:

105871080(ITGAL)

LCAT:

123632733(ITGAL)

PCOQ:

105823192(ITGAL)

OGA:	100963323(ITGAL)

MMU:	16408(Itgal)

MCAL:

110299482(Itgal)

MPAH:

110338926(Itgal)

RNO:	308995(Itgal)

MCOC:

116103005(Itgal)

ANU:	117710925(Itgal)

MUN:	110548001(Itgal)

CGE:	100770691(Itgal)

MAUA:

101830558(Itgal)

PROB:

127228383(Itgal)

PLEU:

114704367(Itgal)

MORG:

121457663(Itgal)

MFOT:

126515909

AAMP:

119799932(Itgal)

NGI:	103726419(Itgal)

HGL:	101723643(Itgal)

CPOC:

100713143(Itgal)

CCAN:

109683028(Itgal)

DORD:

105982178(Itgal)

DSP:	122096293(Itgal)

PLOP:

125341191(Itgal)

NCAR:

124970604

MMMA:

107146950(Itgal)

OCU:

100356927

OPI:	101536679(ITGAL)

TUP:	102469543(ITGAL)

GVR:	103609616(ITGAL)

CFA:	489905(ITGAL)

CLUD:

112640092(ITGAL)

VVP:	112929237(ITGAL)

VLG:	121487568(ITGAL)

NPO:	129520158(ITGAL)

AML:	100464009(ITGAL)

UMR:	103657863(ITGAL)

UAH:	113267681(ITGAL)

UAR:	123784641(ITGAL)

ELK:

111162178

LLV:

125090875

MPUF:

101689018(ITGAL)

MNP:	132026714(ITGAL)

MLK:	131819303(ITGAL)

NVS:	122895632 122895665

ORO:	101370679(ITGAL)

EJU:	114214543(ITGAL)

ZCA:	113932959(ITGAL)

MLX:	117999594(ITGAL)

NSU:	110589962(ITGAL)

LWW:	102726508(ITGAL)

FCA:	101085940(ITGAL)

PYU:	121022236(ITGAL)

PCOO:

112856284(ITGAL)

PBG:	122471448(ITGAL)

PVIV:

125154132(ITGAL)

LRUF:

124517784

PTG:	102951540(ITGAL)

PPAD:

109259024(ITGAL)

PUC:

125928080

AJU:

106979092

HHV:	120242213(ITGAL)

BTA:	281874(ITGAL)

BOM:	102281951(ITGAL)

BIU:	109578145(ITGAL)

BBUB:

102412430(ITGAL)

BBIS:

104986661(ITGAL)

CHX:	102172115(ITGAL)

OAS:	641296(ITGAL)

BTAX:

128070817(ITGAL)

ODA:	120876507(ITGAL)

CCAD:

122433358(ITGAL)

MBEZ:

129545532(ITGAL)

SSC:	733681(ITGAL)

CFR:	102519794(ITGAL)

CBAI:

105082804(ITGAL)

CDK:	105102736(ITGAL)

VPC:	102529371(ITGAL)

BACU:

103015686(ITGAL)

BMUS:

118881949(ITGAL)

LVE:	103086254(ITGAL)

OOR:	101278885(ITGAL)

DLE:	111182142(ITGAL)

PCAD:

102973622

PSIU:

116739681(ITGAL)

NASI:

112399447(ITGAL)

ECB:	100065508(ITGAL)

EPZ:	103547219(ITGAL)

EAI:	106831918(ITGAL)

MYB:	102245292(ITGAL)

MYD:	102754113(ITGAL)

MMYO:

118656453(ITGAL)

MLF:	102436734(ITGAL)

PKL:	118704833(ITGAL)

EFUS:

103296258(ITGAL)

MNA:	107541988(ITGAL)

DRO:	112304654(ITGAL)

SHON:

118997404(ITGAL)

AJM:	119041144(ITGAL)

PDIC:

114508204(ITGAL)

PHAS:

123825537(ITGAL)

MMF:	118641577(ITGAL)

PPAM:

129078038(ITGAL)

HAI:	109374220(ITGAL)

RFQ:	117019780(ITGAL)

PALE:

102879417(ITGAL)

PGIG:

120620083(ITGAL)

PVP:	105304532(ITGAL)

RAY:	107515868(ITGAL)

MJV:	108399261(ITGAL)

TOD:	119233334 119241739(ITGAL)

SARA:

101541898(ITGAL)

SETR:

126029883(ITGAL)

LAV:	100658239(ITGAL)

TMU:

101355641

ETF:	101663621(ITGAL)

DNM:	101429504(ITGAL)

MDO:	100017790(ITGAL)

GAS:	123249604(ITGAL)

SHR:	100932849(ITGAL)

AFZ:

127563043

PCW:	110223126(ITGAL)

OAA:	100090742(ITGAL)

PCOC:

AFUL:

CCW:

MMEA:

AGEN:

SHAB:

ASN:

AMJ:	102574904(ITGAL)

PSS:	102448841(ITGAL)

CMY:	102935120(ITGAL)

CCAY:

125638525(ITGAL)

DCC:	119856495(ITGAL)

CPIC:

101951426(ITGAL)

CABI:

116827359(ITGAL)

MRV:

120403129

ACS:	103280821(itgal)

ASAO:

132777775(ITGAL)

PVT:	110090083(ITGAL)

SUND:

121932713(ITGAL)

PBI:

103063786

PMUR:

107296625 107298566

CTIG:

120302299(ITGAL)

TSR:	106549614(ITGAL)

PGUT:

117666797(ITGAL)

APRI:

131196557(ITGAL)

PTEX:

113443637(ITGAL)

NSS:	113421720(ITGAL)

VKO:	123032238(ITGAL)

PMUA:

114581671(ITGAL)

PRAF:

128400852(ITGAL)

ZVI:	118094285(ITGAL)

HCG:	128329479(ITGAL)

GJA:	107111209(ITGAL)

STOW:

125444311

EMC:	129338513(ITGAL)

XLA:

108701717

XTR:	100495488(itgal)

RTEM:

120923930

BBUF:

121008517

BGAR:

122923973

MUO:	115474140(ITGAL)

GSH:	117361514(ITGAL)

DRE:	557935(zmp:0000001082)

SRX:

SANH:

SGH:

CCAR:

CAUA:

113046531 113047355 113047432 113079484 113082501 113083287 113100656 113100658 113121251

CGIB:

127949404 127949421 127952380 128018302(zmp:0000001082)

PTET:

122355466(zmp:0000001082)

LROH:

127158770 127161238 127170715 127170786(zmp:0000001082)

OMC:	131536069 131539366 131548848

PPRM:

120486175 120486178

RKG:	130097405(zmp:0000001082) 130097410

MAMB:

125263216 125263221

CIDE:

127509582(zmp:0000001082)

MASI:

127445098

TROS:

130552426(zmp:0000001082)

TDW:	130440388(zmp:0000001082)

MANU:

129438408 129438414 129438417 129438423 129438428 129438892 129443788(zmp:0000001082)

IPU:	108258823(zmp:0000001082)

IFU:	128601868 128601957

PHYP:

113524847

SMEO:

124377932(zmp:0000001082)

TFD:	113636950 113636962 125139423

TVC:	132839269(zmp:0000001082)

CMAO:

118804034(zmp:0000001082) 118804043

EEE:

113568533

CHAR:

105895766 105897349 105905690

TRU:

101074990

TFS:	130527282(zmp:0000001082)

LCO:	104920395 104920396

NCC:

104956319

TBEN:

117481746(zmp:0000001082)

CGOB:

115012242

PGEO:

117445942(zmp:0000001082)

GACU:

117562518(zmp:0000001082)

EMAC:

134864968(zmp:0000001082)

ELY:	117255965(zmp:0000001082)

EFO:	125885606(zmp:0000001082)

PLEP:

121941905(zmp:0000001082)

SLUC:

116039546(zmp:0000001082)

ECRA:

117951450

ESP:

116701381

PFLV:

114567024

GAT:	120825683(zmp:0000001082)

PPUG:

119218207(zmp:0000001082)

AFB:	129095973(zmp:0000001082)

CLUM:

117730405(zmp:0000001082)

PSWI:

130190349(zmp:0000001082)

MSAM:

119899752(zmp:0000001082) 119899876

SCHU:

122872828(zmp:0000001082) 122872830

CUD:	121508224(zmp:0000001082)

ALAT:

119011524 119011746(zmp:0000001082)

MZE:	101466075 101467624 112429989

ONL:	100708169 100708437 109202376

OAU:	116320255 116331498 116331532

OLA:	101154755 101175215

OML:	112141038 112157039(zmp:0000001082) 112157043

CSAI:

133446894(zmp:0000001082)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122829053(zmp:0000001082)

PPRL:

129367123(zmp:0000001082)

CVG:

107085482

CTUL:

119779344(zmp:0000001082)

GMU:	124869166(zmp:0000001082)

NFU:

107397049

KMR:	108251354(zmp:0000001082)

ALIM:

106526910

NWH:	119423048(zmp:0000001082)

AOCE:

MCEP:

CSEM:

POV:

SSEN:

122770722(zmp:0000001082)

HHIP:

117759924 117771419

HSP:

118104052

SMAU:

118313260(zmp:0000001082)

LCF:	108884539 108884542

SDU:	111217895 111217925

SLAL:

111660400 111660426

XGL:	120800190(zmp:0000001082) 120800192

HCQ:	109521850(itgal)

SSCV:

125969506(zmp:0000001082)

SBIA:

133506456(zmp:0000001082)

PEE:	133404655(zmp:0000001082)

PTAO:

133477456(zmp:0000001082)

BPEC:

110173840 110173876

MALB:

109956782

BSPL:

114854067(zmp:0000001082) 114854134

SJO:	128374609(zmp:0000001082)

SASA:

106564936 106564975 106588084 106588086

STRU:

115177964 115177966 115208661 115208663

OTW:	112222413 112245515 112245641 121838644

OMY:	110485921 110485924 110493647 110493648

OGO:	124003356 124003357 124015537 124016328

ONE:	115103783 115142565 115142567

OKI:	109865735 109882882 109883864 116355440

OKE:	118365716 118389237 118389238

SALP:

111982324

SNH:	120022762 120027434 120032973

CCLU:

121534000 121534001 123486173 123486174

ELS:

105021449

SFM:

108933547

PKI:

111850807

AANG:

118220357(zmp:0000001082)

LOC:	102690798(itgal)

PSPA:

121306811(zmp:0000001082)

» show all

Reference

PMID:2537322

Authors

Larson RS, Corbi AL, Berman L, Springer T

Title

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

Journal

J Cell Biol 108:703-12 (1989)
DOI:10.1083/jcb.108.2.703

Sequence

[hsa:3683]

Reference

PMID:23726040

Authors

Knight JM, Lee SH, Roberts L, Smith CW, Weiss ST, Kheradmand F, Corry DB

Title

CD11a polymorphisms regulate TH2 cell homing and TH2-related disease.

Journal

J Allergy Clin Immunol 133:189-97.e1-8 (2014)
DOI:10.1016/j.jaci.2013.03.049

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