KEGG ORTHOLOGY: K06279

ORTHOLOGY: K06279

Entry

K06279                      KO

Symbol

SHC1

Name

SHC-transforming protein 1

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05206

MicroRNAs in cancer

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K06279  SHC1; SHC-transforming protein 1
   04012 ErbB signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04014 Ras signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04072 Phospholipase D signaling pathway
    K06279  SHC1; SHC-transforming protein 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06279  SHC1; SHC-transforming protein 1
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06279  SHC1; SHC-transforming protein 1
   04062 Chemokine signaling pathway
    K06279  SHC1; SHC-transforming protein 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04915 Estrogen signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04917 Prolactin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04926 Relaxin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04935 Growth hormone synthesis, secretion and action
    K06279  SHC1; SHC-transforming protein 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06279  SHC1; SHC-transforming protein 1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K06279  SHC1; SHC-transforming protein 1
   05226 Gastric cancer
    K06279  SHC1; SHC-transforming protein 1
   05214 Glioma
    K06279  SHC1; SHC-transforming protein 1
   05220 Chronic myeloid leukemia
    K06279  SHC1; SHC-transforming protein 1
   05224 Breast cancer
    K06279  SHC1; SHC-transforming protein 1
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K06279  SHC1; SHC-transforming protein 1
  09165 Substance dependence
   05034 Alcoholism
    K06279  SHC1; SHC-transforming protein 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K06279  SHC1; SHC-transforming protein 1
   01522 Endocrine resistance
    K06279  SHC1; SHC-transforming protein 1

Genes

HSA:	6464(SHC1)

PTR:	457351(SHC1)

PPS:	100993361(SHC1)

GGO:	101136424(SHC1)

PON:	100173225(SHC1)

NLE:	100606068(SHC1)

HMH:	116469345(SHC1)

MCC:	718982(SHC1)

MCF:	102142777(SHC1)

MTHB:

126933571

MNI:	105497981(SHC1)

CSAB:

103223899(SHC1)

CATY:

105585292 105585293 105593504(SHC1)

PANU:

101001939(SHC1)

TGE:	112628791(SHC1)

MLEU:

105544828(SHC1)

RRO:	104663483(SHC1)

RBB:	108526812(SHC1)

TFN:	117075160(SHC1)

PTEH:

111543732(SHC1)

CANG:

105502016(SHC1)

CJC:	100390337(SHC1)

SBQ:	101038895(SHC1) 101047748

CIMI:

108292463(SHC1)

CSYR:

103249998(SHC1)

MMUR:

105873192(SHC1)

LCAT:

123634038(SHC1)

PCOQ:

105821872(SHC1)

OGA:	100966694(SHC1)

MMU:	20416(Shc1)

MCAL:

110290710(Shc1)

MPAH:

110320247(Shc1)

RNO:	85385(Shc1)

MCOC:

116093178(Shc1)

ANU:	117706686(Shc1)

MUN:	110551574(Shc1)

CGE:	100758936(Shc1)

MAUA:

101841290(Shc1)

PROB:

127233113(Shc1)

PLEU:

114707889(Shc1)

MORG:

121445583 121450478(Shc1)

MFOT:

126516104

AAMP:

119800744(Shc1)

NGI:	103751254(Shc1)

HGL:	101717434(Shc1)

CPOC:

100734561(Shc1)

CCAN:

109688030(Shc1)

DORD:

105984949(Shc1)

DSP:	122109169(Shc1)

PLOP:

125360001(Shc1)

NCAR:

124982298

MMMA:

107146439 107156736(Shc1)

OCU:

100342812

OPI:	101529134(SHC1)

TUP:	102481002(SHC1)

GVR:	103608197(SHC1)

CFA:	490439(SHC1)

CLUD:

112648956(SHC1)

VVP:	112918897(SHC1)

VLG:	121485053(SHC1)

NPO:	129508769(SHC1)

AML:	100480856(SHC1)

UMR:	103668383(SHC1)

UAH:	113245295(SHC1)

UAR:	123783413(SHC1)

ELK:

111138866

LLV:

125086356

MPUF:

101680880(SHC1)

MNP:	132025921(SHC1)

MLK:	131814353(SHC1)

ORO:	101373821(SHC1)

EJU:	114198628(SHC1)

ZCA:	113933024(SHC1)

MLX:	118013864(SHC1)

NSU:	110573574(SHC1)

LWW:	102738885(SHC1)

FCA:	101092911(SHC1)

PYU:	121015654(SHC1)

PCOO:

112851716(SHC1)

PBG:	122476583(SHC1)

PVIV:

125155101(SHC1)

LRUF:

124521760

PTG:	102949026(SHC1)

PPAD:

109256269(SHC1)

PUC:

125925730

AJU:

106988382

HHV:	120244661(SHC1)

BTA:	507196(SHC1)

BOM:	102265814(SHC1)

BIU:	109553931(SHC1)

BBUB:

102409515(SHC1)

BBIS:

104987424(SHC1)

CHX:	102170926(SHC1)

OAS:	101113548(SHC1)

BTAX:

128044445(SHC1)

ODA:	120855734(SHC1)

CCAD:

122432839(SHC1)

MBEZ:

129541489(SHC1)

SSC:	100156321(SHC1)

CFR:	102524489(SHC1)

CBAI:

105068173(SHC1)

CDK:	105089005(SHC1)

VPC:	102526482(SHC1)

BACU:

103015382(SHC1)

BMUS:

118893636(SHC1)

LVE:	103074885(SHC1)

OOR:	101276908(SHC1)

DLE:	111167062(SHC1)

PCAD:

102991486(SHC1)

PSIU:

116740554(SHC1)

NASI:

112401764(SHC1)

ECB:	100063053(SHC1)

EPZ:	103552865(SHC1)

EAI:	106828516(SHC1)

MYB:	102245916(SHC1)

MYD:	102755241(SHC1)

MMYO:

118669819 118672782(SHC1)

MLF:	102430334(SHC1)

PKL:	118721351(SHC1)

EFUS:

103298913(SHC1)

MNA:	107543890(SHC1)

DRO:	112316734(SHC1)

SHON:

118990179(SHC1)

AJM:	119061761(SHC1)

PDIC:

114488773(SHC1)

PHAS:

123804815(SHC1)

MMF:	118637475(SHC1)

PPAM:

129062405(SHC1)

HAI:	109393422(SHC1)

RFQ:	117014851(SHC1)

PALE:

102894443(SHC1)

PGIG:

120592211(SHC1)

PVP:	105296379(SHC1)

RAY:	107505474(SHC1) 107512423

MJV:	108407280 118972101

TOD:	119235491(SHC1)

SARA:

101553821(SHC1)

SETR:

126020709(SHC1)

LAV:	100653766(SHC1)

TMU:

101358105

ETF:	101638643(SHC1)

DNM:	101438260(SHC1)

MDO:	100016090(SHC1)

GAS:	123244440(SHC1)

SHR:	100926921(SHC1)

AFZ:

127559844

PCW:	110198538 110211965(SHC1)

OAA:	114808180(SHC1)

GGA:	395934(SHC1)

PCOC:

116237337(SHC1)

MGP:	100540048(SHC1)

CJO:	107324486(SHC1)

TPAI:

128078804(SHC1)

LMUT:

125685714(SHC1)

NMEL:

110391258(SHC1)

APLA:

101791792(SHC1)

ACYG:

106048510(SHC1)

CATA:

118258448(SHC1)

AFUL:

116499756(SHC1)

TGU:	100229782(SHC1)

LSR:	110471528(SHC1)

SCAN:

103823958(SHC1)

PMOA:

120498883(SHC1)

OTC:	121332174(SHC1)

PRUF:

121352206(SHC1)

GFR:	102039503(SHC1)

FAB:	101807411(SHC1)

OMA:	130263184(SHC1)

PHI:	102106714(SHC1)

PMAJ:

107214540(SHC1)

CCAE:

111939466(SHC1)

CBRC:

103611255(SHC1)

ETL:	114068431(SHC1)

ZAB:	102064958(SHC1)

ACHL:

103808487(SHC1)

SVG:	106863386(SHC1)

MMEA:

130583217(SHC1)

HRT:	120764204(SHC1)

FPG:	101919976(SHC1)

FCH:	102048929(SHC1)

CLV:	102093713(SHC1)

EGZ:	104127244(SHC1)

NNI:	104012052(SHC1)

PCRI:

104030563(SHC1)

PLET:

104618885(SHC1)

ACUN:

113488759(SHC1)

TALA:

104368486(SHC1)

PADL:

103922288(SHC1)

AFOR:

103905525(SHC1)

ACHC:

115345778(SHC1)

HLE:	104829653(SHC1)

AGEN:

126040820

CCRI:

104169019(SHC1)

CSTI:

104557197(SHC1)

LDI:	104345663(SHC1)

SHAB:

115602564(SHC1)

DPUB:

104310257(SHC1)

CPEA:

104387520(SHC1)

CVF:	104286744(SHC1)

RTD:	128900875(SHC1)

CUCA:

104065074(SHC1)

TEO:	104382695(SHC1)

AAM:

106483710

AROW:

112973269(SHC1)

NPD:	112955215(SHC1)

DNE:	112995804(SHC1)

SCAM:

104147743(SHC1)

ASN:	102376721(SHC1)

AMJ:	106737253(SHC1)

CPOO:

109324765(SHC1)

GGN:	109303877(SHC1)

PSS:	102457971(SHC1)

CMY:	102941809(SHC1)

CCAY:

125625917(SHC1)

DCC:	119847945(SHC1)

CPIC:

101952789(SHC1)

TST:	117888534(SHC1)

CABI:

116830123(SHC1)

MRV:	120390163(SHC1)

ACS:	100566335(shc1)

ASAO:

132764085(SHC1)

PVT:	110081020(SHC1)

SUND:

121915058(SHC1)

PBI:	103049298(SHC1)

PMUR:

107296691(SHC1)

CTIG:

120317081(SHC1)

TSR:	106537474(SHC1)

PGUT:

117658844(SHC1)

APRI:

131186587(SHC1)

PTEX:

113446695(SHC1)

VKO:	123032556(SHC1)

PMUA:

114586090(SHC1)

PRAF:

128404474(SHC1)

ZVI:	118075732(SHC1)

HCG:	128337514(SHC1)

GJA:	107117081(SHC1)

STOW:

125440647(SHC1)

EMC:	129339940(SHC1)

XLA:	108700442(shc1.S) 399198(shc1.L)

XTR:	116406911(shc1)

NPR:	108795195(SHC1)

RTEM:

120920621(SHC1)

BBUF:

120982018(SHC1)

MUO:	115458394(SHC1)

GSH:	117350024(SHC1)

DRE:	323818(shc1)

SRX:	107714692 107723450

SANH:

107673667(shc1) 107677023

SGH:	107582132 107594952(shc1)

CCAR:

109108120

CAUA:

113060226 113116470

CGIB:

127975200 128030709

PTET:

122361104(shc1)

LROH:

127178036(shc1)

OMC:	131522592(shc1)

PPRM:

120484361(shc1)

RKG:	130101945(shc1)

MAMB:

125244114(shc1)

CIDE:

127497924

MASI:

127452900 127453838

TROS:

130557460(shc1)

TDW:	130432343(shc1)

MANU:

129447953(shc1)

IPU:

108265869

IFU:	128607170(shc1)

PHYP:

113542402(shc1)

SMEO:

124384218(shc1)

TFD:	113646702(shc1)

TVC:	132846174(shc1)

AMEX:

103030808(shc1)

CMAO:

118823294(shc1)

EEE:	113590613(shc1)

CHAR:

105891930(shc1)

TRU:	101071954(shc1)

TFS:	130532015(shc1)

TNG:	GSTEN00033961G001

LCO:	104918187(shc1)

NCC:	104962177(shc1)

TBEN:

117480192(shc1)

CGOB:

115020898(shc1)

PGEO:

117460302(shc1)

GACU:

117553868(shc1)

EMAC:

134861829(shc1)

ELY:	117265729(shc1)

EFO:	125892594(shc1)

PLEP:

121945480(shc1)

SLUC:

116049544(shc1)

ECRA:

117946714(shc1)

ESP:	116691703(shc1)

PFLV:

114556600(shc1)

GAT:	120810662(shc1)

PPUG:

119197382(shc1)

AFB:	129109232(shc1)

CLUM:

117745760(shc1)

PSWI:

130212740(shc1)

MSAM:

119897594(shc1)

SCHU:

122882185(shc1)

CUD:	121513974(shc1)

ALAT:

119005783(shc1)

MZE:	101480827(shc1)

ONL:	100704980(shc1)

OAU:	116315698(shc1)

OLA:	101154895(shc1)

OML:	112143897(shc1)

CSAI:

133432211(shc1)

XMA:	102228847(shc1)

XCO:	114140972(shc1)

XHE:	116716789(shc1)

PRET:

103478162(shc1)

PFOR:

103140804(shc1)

PLAI:

106964507(shc1)

PMEI:

106916259(shc1)

GAF:	122830934(shc1)

PPRL:

129358025 129371203(shc1)

CVG:	107088415(shc1)

CTUL:

119786725(shc1)

GMU:	124865598(shc1)

NFU:	107379732(shc1)

KMR:	108241071(shc1)

ALIM:

106529899(shc1)

NWH:	119409401(shc1)

AOCE:

111566077(shc1)

MCEP:

125016060(shc1)

CSEM:

103388227(shc1)

POV:	109633454(shc1)

SSEN:

122774494(shc1)

HHIP:

117776519(shc1)

HSP:	118113543(shc1)

SMAU:

118309118(shc1)

LCF:

108885949

SDU:	111230117(shc1)

SLAL:

111656972(shc1)

XGL:	120783842(shc1)

HCQ:	109521038(shc1)

SSCV:

125975384

SBIA:

133500406(shc1)

PEE:	133401243(shc1)

PTAO:

133479091(shc1)

BPEC:

110162980(shc1) 110173049(shc4)

MALB:

109964107(shc1)

BSPL:

114843588(shc1)

SJO:	128367075(shc1)

SASA:

106575570 106593005

STRU:

115176818 115186485

OTW:	112222667(shc1) 121841079

OMY:	110520788 110536161

OGO:

123998235

ONE:	115122691 115125349

OKI:	109888011 109901647

OKE:	118374980 118382829(shc1)

SALP:

111959065(shc1)

SNH:	120048816 120048880

CCLU:

121542715 121543201

ELS:	105024470(shc1)

SFM:	108925486(shc1)

PKI:	111848307(shc1)

AANG:

118222288(shc1) 118232709

LOC:	102684095(shc1)

PSPA:

121307017(shc1)

ARUT:

117395410(shc1)

PSEX:

120528097(shc1)

LCM:	102356771(SHC1)

HOC:

132808907

LERI:

129715661

PMRN:

116950676 116953603(SHC1)

LRJ:	133354191 133355129(SHC1)

BBEL:

109463526

CIN:

100181792

SCLV:

120342172

SPU:	100892028 578929

APLC:

110990360

SKO:

102802005

DME:	Dmel_CG3715(Shc)

DER:

6545643

DSE:

6605028

DSI:	Dsimw501_GD14181(Dsim_GD14181)

DYA:	Dyak_GE20839

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12075

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108360081 108377307 108383230

AOQ:

129244594

TDA:	119679180 119679182

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109413081 115253778 115257693

CQU:	CpipJ_CPIJ006219

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201490

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128996482 128997003

PHU:	Phum_PHUM387540

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

PVM:	113812518 113830556

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

CSCU:

PTEP:

ABRU:

UDV:	129224423 129227377

SDM:	118200363 118201766

LPOL:

106460297 106464620 106465580

PMEO:

129586995

CEL:	CELE_F54A5.3(shc-1)

CBR:	CBG_05128(Cbr-shc-1)

CRQ:	GCK72_001372

NAI:	NECAME_05438

LOA:	LOAG_17991

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111130165 111130271

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

EPA:

ADF:	107330508 107345345

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

SRE:	PTSG_05060 PTSG_07105

» show all

Reference

PMID:14665640

Authors

Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F

Title

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

Journal

J Biol Chem 279:13224-33 (2004)
DOI:10.1074/jbc.M307456200

Sequence

[hsa:6464]

Reference

PMID:1623525

Authors

Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG

Title

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

Journal

Cell 70:93-104 (1992)
DOI:10.1016/0092-8674(92)90536-L

Sequence

[hsa:6464]

LinkDB

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