KEGG ORTHOLOGY: K06463

ORTHOLOGY: K06463

Entry

K06463                      KO

Symbol

FCGR3, CD16

Name

low affinity immunoglobulin gamma Fc receptor III

Pathway

map04145

Phagosome

map04380

Osteoclast differentiation

map04613

Neutrophil extracellular trap formation

map04650

Natural killer cell mediated cytotoxicity

map04666

Fc gamma R-mediated phagocytosis

map05140

Leishmaniasis

map05150

Staphylococcus aureus infection

map05152

Tuberculosis

map05322

Systemic lupus erythematosus

Disease

H00080

Systemic lupus erythematosus

H00090

NK cell defects

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04666 Fc gamma R-mediated phagocytosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Membrane trafficking [BR:ko04131]
Endocytosis
  Phagocytosis
   Fc receptors
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
CD molecules [BR:ko04090]
Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III

Other DBs

GO:

0019770

Genes

HSA:	2214(FCGR3A) 2215(FCGR3B)

PTR:	457457 745350

PPS:

100975908

GGO:	101129837 101143892

PON:

100453994

NLE:

101176357

HMH:

116473327

MCC:	720006(FCGR3)

MCF:	102140945(FCGR3A)

MNI:

105498220

CSAB:

103223675

CATY:

105589237

PANU:

100126738(FCGR3A)

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

SBQ:

CIMI:

108293621(FCGR3A)

CSYR:

103256411

MMUR:

105873562

LCAT:

123635228(FCGR3A)

PCOQ:

105806406

OGA:

100959197

MMU:	246256(Fcgr4)

MCAL:

110299183

MPAH:

110322271

RNO:	116591(Fcgr2a) 304966(Fcgr3a)

MCOC:

ANU:

MUN:

CGE:

MAUA:

101822472(Fcgr4)

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

105996451(Fcgr3a)

DSP:	122109327(Fcgr3a)

PLOP:

125359220

NCAR:

124993198

MMMA:

107147461

OCU:	100337909 100338913

OPI:	101522313 118758563

TUP:	102499391(FCGR3B)

GVR:

CFA:

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:	122918083 122918084

ORO:

101363133

EJU:

114210408

MLX:	118014023(FCGR3A)

NSU:

110588140

LWW:

102735873

FCA:	493677(FCGR3A)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

109276673(FCGR3A)

PUC:

125925566

AJU:

106986773

HHV:	120241040(FCGR3A)

BTA:	281766(FCGR3A)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:	100192433(FCGR3A)

BTAX:

128044373

CCAD:

122430259

MBEZ:

129540804

SSC:	397684(FCGR3B)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:	101270000 125964005

DLE:

PCAD:

PSIU:

NASI:

ECB:

EPZ:	103540860(FCGR3A)

EAI:	106828032 106831116

MYB:	102247789(FCGR3B)

MYD:	102754425(FCGR3A)

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

123818273(FCGR3A)

MMF:	118637098(FCGR3A)

PPAM:

129082082

HAI:

109392302

RFQ:	117014648(FCGR3A)

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:	101360005 101360268

ETF:

DNM:

MDO:

GAS:

SHR:	100924138(FCGR3B)

AFZ:

127563000

PCW:

110209910

OAA:	100091501 103169645

XTR:

OAU:

XMA:

XCO:

CVG:	107102744 107104144 107104434

POV:

109646743

SALP:

112072649 112080255

» show all

Reference

PMID:2526846

Authors

Ravetch JV, Perussia B

Title

Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

Journal

J Exp Med 170:481-97 (1989)
DOI:10.1084/jem.170.2.481

Sequence

[hsa:2214 2215]

Reference

PMID:25816339

Authors

Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B

Title

Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.

Journal

PLoS One 10:e0121788 (2015)
DOI:10.1371/journal.pone.0121788

LinkDB

DBGET integrated database retrieval system