KEGG ORTHOLOGY: K07359

ORTHOLOGY: K07359

Entry

K07359                      KO

Symbol

CAMKK2

Name

calcium/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]

Pathway

map04140

Autophagy - animal

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04920

Adipocytokine signaling pathway

map04921

Oxytocin signaling pathway

map04936

Alcoholic liver disease

map05034

Alcoholism

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
   04921 Oxytocin signaling pathway
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
  09149 Aging
   04211 Longevity regulating pathway
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
09160 Human Diseases
  09165 Substance dependence
   05034 Alcoholism
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.17  Ca2+/calmodulin-dependent protein kinase
     K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  CAMKK family
   K07359  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2

Other DBs

GO:

0004683

Genes

HSA:	10645(CAMKK2)

PTR:	452320(CAMKK2)

PPS:	100989349(CAMKK2)

GGO:	101147428(CAMKK2)

PON:	100459439(CAMKK2)

NLE:	100590503(CAMKK2)

HMH:	116477793(CAMKK2)

MCC:	699685(CAMKK2)

MCF:	101866264(CAMKK2)

MTHB:

126930629

MNI:	105495499(CAMKK2)

CSAB:

103239530(CAMKK2)

CATY:

105590963(CAMKK2)

PANU:

101018841(CAMKK2)

TGE:	112634222(CAMKK2)

MLEU:

105527937(CAMKK2)

RRO:	104666273(CAMKK2)

RBB:	108529638(CAMKK2)

PTEH:

111537867(CAMKK2)

CANG:

105516340(CAMKK2)

CJC:	100393687(CAMKK2)

SBQ:	101046431(CAMKK2)

CIMI:

108315123(CAMKK2)

CSYR:

103262348(CAMKK2)

MMUR:

105880914(CAMKK2)

LCAT:

123626079(CAMKK2)

PCOQ:

105825619(CAMKK2)

OGA:	100958613(CAMKK2)

MMU:	207565(Camkk2)

MCAL:

110294191(Camkk2)

MPAH:

110339044(Camkk2)

RNO:	83506(Camkk2)

MCOC:

116068376(Camkk2)

ANU:	117697635(Camkk2)

MUN:	110545324(Camkk2)

CGE:	100765904(Camkk2)

MAUA:

101830359(Camkk2)

PROB:

127216076(Camkk2)

PLEU:

114704555(Camkk2)

MORG:

121446232(Camkk2)

MFOT:

126504174

AAMP:

119824700(Camkk2)

NGI:	103739072(Camkk2)

HGL:	101723556(Camkk2)

CPOC:

100716041(Camkk2)

CCAN:

109687748 109699538(Camkk2)

DORD:

105990681(Camkk2)

DSP:	122098568(Camkk2)

PLOP:

125349143(Camkk2)

NCAR:

124990307

MMMA:

107156420(Camkk2)

OCU:	100350689 127488422

OPI:	101535145(CAMKK2)

TUP:	102493235(CAMKK2)

GVR:	103588689(CAMKK2)

CFA:	486263(CAMKK2)

CLUD:

112676516(CAMKK2)

VVP:	112935239(CAMKK2)

VLG:	121475308(CAMKK2)

NPO:	129507648(CAMKK2)

AML:	100465808(CAMKK2)

UMR:	103661273(CAMKK2)

UAH:	113266952(CAMKK2)

UAR:	123779287(CAMKK2)

ELK:

111156362

LLV:

125081965

MPUF:

101690172(CAMKK2)

MNP:	132023135(CAMKK2)

MLK:	131811889(CAMKK2)

NVS:	122903449(CAMKK2)

ORO:	101366735(CAMKK2)

EJU:	114219018(CAMKK2)

ZCA:	113912412(CAMKK2)

MLX:	118018448(CAMKK2)

NSU:	110588219(CAMKK2)

LWW:	102738691(CAMKK2)

FCA:	101097674(CAMKK2)

PYU:	121010458(CAMKK2)

PCOO:

112870127(CAMKK2)

PBG:	122470201(CAMKK2)

PVIV:

125148894(CAMKK2)

LRUF:

124518313

PTG:	102971870(CAMKK2)

PPAD:

109277678(CAMKK2)

PUC:

125914197

AJU:

106967543

HHV:	120235137(CAMKK2)

BTA:	509084(CAMKK2)

BOM:	102275357(CAMKK2)

BIU:	109571288(CAMKK2)

BBUB:

102395241(CAMKK2)

BBIS:

104989679(CAMKK2)

CHX:	102173026(CAMKK2)

OAS:	101103267(CAMKK2)

BTAX:

128062604(CAMKK2)

ODA:	120871048(CAMKK2)

CCAD:

122423763(CAMKK2)

MBEZ:

129542224(CAMKK2)

SSC:	100157312(CAMKK2)

CFR:	102504832(CAMKK2)

CBAI:

105080624(CAMKK2)

CDK:	105102506(CAMKK2)

VPC:	102538414(CAMKK2)

BACU:

103001613(CAMKK2)

BMUS:

118906968(CAMKK2)

LVE:	103090099(CAMKK2)

OOR:	101281422(CAMKK2)

DLE:	111186858(CAMKK2)

PCAD:

102992365(CAMKK2)

PSIU:

116738742(CAMKK2)

NASI:

112408747(CAMKK2)

ECB:	100058510(CAMKK2)

EPZ:	103541408(CAMKK2)

EAI:	106842289(CAMKK2)

MYB:	102250560(CAMKK2)

MYD:	102752773(CAMKK2)

MMYO:

118678237(CAMKK2)

MLF:	102421841(CAMKK2)

PKL:	118725458(CAMKK2)

EFUS:

103287031(CAMKK2)

MNA:	107529560(CAMKK2)

DRO:	112310895(CAMKK2)

SHON:

118991080(CAMKK2)

AJM:	119048763(CAMKK2)

PDIC:

114509708(CAMKK2)

PHAS:

123820940(CAMKK2)

MMF:	118640013(CAMKK2)

PPAM:

129087112(CAMKK2)

HAI:	109386090(CAMKK2)

RFQ:	117017317(CAMKK2)

PALE:

102884660(CAMKK2)

PGIG:

120616083(CAMKK2)

PVP:	105289204(CAMKK2)

RAY:

107515245

MJV:	108384598(CAMKK2)

TOD:	119245010(CAMKK2)

SARA:

101546726(CAMKK2)

SETR:

126030591(CAMKK2)

LAV:	100670181(CAMKK2)

TMU:

101347848

ETF:	101640292(CAMKK2)

DNM:	101412193(CAMKK2)

MDO:	100021014(CAMKK2)

GAS:	123256858(CAMKK2)

SHR:	100923665(CAMKK2)

AFZ:

127545450

PCW:	110196822(CAMKK2)

OAA:	100090388(CAMKK2)

GGA:	396405(CAMKK2)

PCOC:

116228617(CAMKK2)

MGP:	100543732(CAMKK2)

CJO:	107321118(CAMKK2)

TPAI:

128084636(CAMKK2)

LMUT:

125701876(CAMKK2)

NMEL:

110406318(CAMKK2)

APLA:

101791374(CAMKK2)

ACYG:

106031146(CAMKK2)

CATA:

118257239(CAMKK2)

AFUL:

116495973(CAMKK2)

TGU:	100229492(CAMKK2)

LSR:	110471760(CAMKK2)

SCAN:

103818321(CAMKK2)

PMOA:

120509614(CAMKK2)

OTC:	121338948(CAMKK2)

PRUF:

121364993(CAMKK2)

GFR:	102039537(CAMKK2)

FAB:	101814961(CAMKK2)

OMA:	130259708(CAMKK2)

PHI:	102113121(CAMKK2)

PMAJ:

107211609(CAMKK2)

CCAE:

111936387(CAMKK2)

CCW:	104688834(CAMKK2)

CBRC:

103616026(CAMKK2)

ETL:	114054952(CAMKK2)

ZAB:	102062312(CAMKK2)

ACHL:

103810655(CAMKK2)

SVG:	106852398(CAMKK2)

MMEA:

130580334(CAMKK2)

HRT:	120760410(CAMKK2)

FPG:	101918977(CAMKK2)

FCH:	102054552(CAMKK2)

CLV:	102085783(CAMKK2)

EGZ:	104130144(CAMKK2)

NNI:	104020820(CAMKK2)

PCRI:

104024407(CAMKK2)

PLET:

104618219(CAMKK2)

EHS:	104513712(CAMKK2)

PCAO:

104052835(CAMKK2)

ACUN:

113486072(CAMKK2)

TALA:

104357787(CAMKK2)

PADL:

103914558(CAMKK2)

AFOR:

103902795(CAMKK2)

ACHC:

115345422(CAMKK2)

HALD:

104310721(CAMKK2)

HLE:	104840898(CAMKK2)

AGEN:

126040767

GCL:

127022737

CCRI:

104169580(CAMKK2)

CSTI:

104552732

CMAC:

104477999(CAMKK2)

MUI:	104545141(CAMKK2)

BREG:

104629561(CAMKK2)

FGA:	104081679(CAMKK2)

GSTE:

104256117(CAMKK2)

LDI:	104347776(CAMKK2)

MNB:	103772409(CAMKK2)

OHA:	104339357(CAMKK2)

NNT:	104408159(CAMKK2)

SHAB:

115614311(CAMKK2)

DPUB:

104308397(CAMKK2)

PGUU:

104469698(CAMKK2)

ACAR:

104529005(CAMKK2)

CPEA:

104389440(CAMKK2)

AVIT:

104270964(CAMKK2)

CVF:	104282205(CAMKK2)

RTD:	128916915(CAMKK2)

CUCA:

104058829(CAMKK2)

TEO:	104383395(CAMKK2)

BRHI:

104501007(CAMKK2)

AAM:

106497653

AROW:

112962578(CAMKK2)

NPD:	112945817(CAMKK2)

TGT:	104567206(CAMKK2)

DNE:	112991878(CAMKK2)

ASN:	102376499(CAMKK2)

AMJ:	102562709(CAMKK2)

CPOO:

109312975(CAMKK2)

GGN:	109290602(CAMKK2)

PSS:	102462475(CAMKK2)

CMY:	102932730(CAMKK2)

CCAY:

125622916(CAMKK2)

DCC:	119843718(CAMKK2)

CPIC:

101944835(CAMKK2)

TST:	117887972(CAMKK2)

CABI:

116836786(CAMKK2)

MRV:	120386239(CAMKK2)

ACS:

103281581

ASAO:

132781638(CAMKK2)

PVT:	110083818(CAMKK2)

SUND:

121916476(CAMKK2)

PBI:	103057354(CAMKK2)

PMUR:

107286967(CAMKK2)

CTIG:

120316796(CAMKK2)

TSR:	106554949(CAMKK2)

PGUT:

117672149(CAMKK2)

APRI:

131185577(CAMKK2)

PTEX:

113448688(CAMKK2)

NSS:	113424925(CAMKK2)

VKO:	123028584(CAMKK2)

PMUA:

114586157(CAMKK2)

PRAF:

128404341(CAMKK2)

ZVI:	118075764(CAMKK2)

HCG:	128337878(CAMKK2)

GJA:	107115910(CAMKK2)

EMC:	129341033(CAMKK2)

XLA:	108707162(camkk2.S) 108716832(camkk2.L)

XTR:	100135108(camkk2)

NPR:	108787841(CAMKK2)

RTEM:

120933561(CAMKK2)

BBUF:

120988576(CAMKK2)

BGAR:

122924541(CAMKK2)

MUO:	115479677(CAMKK2)

GSH:	117365865(CAMKK2)

DRE:

101884909

SRX:	107736868 107739694

SANH:

107662592 107675640(camkk2)

SGH:	107584526(camkk2) 107600874

CCAR:

109054844

CAUA:

113038812 113064135 113074545

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00009545G001

LCO:

104934788

NCC:	104945410 104945421

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

103147626(camkk2)

PLAI:

106948094(camkk2)

PMEI:

106918312(camkk2)

GAF:

122819178

PPRL:

129366495

CVG:	107100370(camkk2)

CTUL:

119772045

GMU:

124872922

NFU:	107397234(camkk2)

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110174159(camkk2)

MALB:

109965640

BSPL:

114866400

SJO:

128380574

SASA:

106563118 106566234(camkk2)

STRU:

115159654(camkk2) 115203998

OTW:	112219945 112230923

OMY:	110509723 110523513

OGO:	124006669 124049032

ONE:	115121817 115125722

OKI:	109868078 109874137

OKE:	118373623 118385363

SALP:

111961692(camkk2) 111963963

SNH:	120021641 120026006

CCLU:

121541608 121582589

ELS:

105014838

SFM:	108932973(camkk2)

PKI:	111842083(camkk2)

AANG:

118206983

LOC:	102693525(camkk2)

PSPA:

121297617 121299840

ARUT:

117426702 117428187

PSEX:

120540935

LCM:	102352086(CAMKK2)

CMK:

RTP:

CPLA:

HOC:

LERI:

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG17698(CG17698)

DER:

6544497

DSE:

116801021

DSI:	Dsimw501_GD27369(Dsim_GD27369)

DYA:	Dyak_GE19469

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23982

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109402816 109422598 115259223

CQU:	CpipJ_CPIJ013523

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

MDL:

AGIF:

CCIN:

NLO:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

OTU:	111416957 111422363

BMOR:

101735336

BMAN:

114246292

MSEX:

115448919

DPL:	KGM_207133

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

API:

DNX:

AGS:

RMD:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM510570

TPAL:

ZNE:

CSEC:

IEL:

FCD:

DPX:	DAPPUDRAFT_308627

DMK:	116932052 116933691 123474707

DPZ:

PVM:

PJA:

PMOO:

HAME:

CQD:

PTRU:

HAZT:

EAF:	111708970 111715518

LSM:

TCF:

PPOI:

DSV:

RSAN:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

PMEO:

NAI:	NECAME_15838

HRO:	HELRODRAFT_67876

LGI:	LOTGIDRAFT_104050

PVUL:

PCAN:

BGT:

GAE:

HRF:

MMER:

RPHI:

OBI:

LAK:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

ALY:

CRB:

CSAT:

104726644 104737996 104762163

BNA:

BOE:

TCC:

DZI:

POP:

PEU:	105126135 105134996

VVI:

100251930

SOT:

102605033

NTA:	107772774 107778951

NSY:

NTO:

NAU:

DCR:

PDA:

EGU:	105033409 105053481

ATR:

18444257

SMO:	SELMODRAFT_119400

VCN:	VOLCADRAFT_58122(stpk3) VOLCADRAFT_82610 VOLCADRAFT_96321

MNG:

MNEG_6785

CSL:	COCSUDRAFT_28987

CVR:	CHLNCDRAFT_22362

OTA:	OT_ostta20g00790

MIS:	MICPUN_82799

MPP:	MICPUCDRAFT_34898(JGI:MicpuC2_34898)

GSL:	Gasu_10230

CCP:	CHC_T00008485001 CHC_T00008624001 CHC_T00008896001

SEUB:

DI49_1798

YLI:	YALI0B17556g

SLB:	AWJ20_2900(TOS3)

NCR:	NCU06177(camk-3)

NTE:	NEUTE1DRAFT81254(NEUTE1DRAFT_81254)

SMP:	SMAC_05352

PAN:	PODANSg5202

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2118787

MTM:	MYCTH_2305058

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_1686

SSCK:

SPSK_03044

FGR:	FGSG_06940

FPU:	FPSE_04784

FPOA:

FPOAC1_010688

FVN:	FVRRES_11691

FVR:	FVEG_08256

FOX:	FOXG_01878

NHE:	NECHADRAFT_79164

FFC:	NCS54_00570600

FKR:	NCS57_00608500

FMU:	J7337_002706

TRE:	TRIREDRAFT_119679

TRR:	M419DRAFT_135365

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_05462

PTKZ:

JDV02_001018

VAL:	VDBG_06889

VDA:	VDAG_05950

CFJ:	CFIO01_12630

CLUP:

CLUP02_03269

CHIG:

CH63R_02344

SAPO:

SAPIO_CDS7692

ELA:	UCREL1_8706

PFY:	PFICI_08107

SSL:	SS1G_00591

BFU:	BCIN_03g02460(Bccmk3)

MBE:

MBM_03623

PSCO:

LY89DRAFT_731120

GLZ:	GLAREA_07108

AFM:	AFUA_5G05980

ACT:	ACLA_009260

NFI:	NFIA_037150

AOR:	AO090009000663

ANG:	An17g01865

AFV:	AFLA_010708

ALUC:

AKAW2_70803S

ACHE:

ACHE_20466S

APUU:

APUU_70402A

PCS:	N7525_008567

PDP:	PDIP_22670

POU:	POX_e06287

TMF:	EYB26_004562

TRG:	TRUGW13939_07995

CIM:	CIMG_06216

CPW:	CPC735_027550

URE:	UREG_04168

PBL:	PAAG_12379(PAAG_07342)

PBN:	PADG_05840

ABE:

ARB_06991

TVE:

TRV_00332

AJE:	HCAG_03012

BGH:	BDBG_08518

PNO:	SNOG_09198

PTE:

PTT_17806

BZE:	COCCADRAFT_94886

BSC:	COCSADRAFT_34577

BOR:	COCMIDRAFT_102812

AALT:

CC77DRAFT_147769

ARAB:

EKO05_0002994

ZTR:	MYCGRDRAFT_74837

PFJ:	MYCFIDRAFT_137805(CAMKK)

FFU:	CLAFUR5_07025

CBET:

CB0940_09389

BCOM:

BAUCODRAFT_69308

NPA:	UCRNP2_6831

TML:	GSTUM_00005199001

CNE:

CNH01420

CNB:

CNBL1380

CNG:	CNAG_05484

CGI:	CGB_L1480C

CDEU:

CNBG_4379

TASA:

A1Q1_04309

CCAC:

CcaHIS019_0106670(CcaverHIS019_0106670)

UMA:	UMAG_04755

PFP:	PFL1_04277

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00856

PTRC:

PtA15_17A300 PtA15_1A628

PSTR:

Pst134EA_000349 Pst134EA_030565

MLR:	MELLADRAFT_91015

ACAN:

ACA1_170640

TET:	TTHERM_00440630 TTHERM_00715820

PTM:	GSPATT00000508001 GSPATT00003805001 GSPATT00015086001 GSPATT00017952001 GSPATT00022204001 GSPATT00031823001 GSPATT00032564001 GSPATT00033871001 GSPATT00037754001 PTMB.47c

AAF:	AURANDRAFT_63657

PIF:	PITG_08358 PITG_17390

PSOJ:

PHYSODRAFT_478412 PHYSODRAFT_555042

SPAR:

SPRG_05310 SPRG_06934 SPRG_07462 SPRG_12696 SPRG_14742

EHX:	EMIHUDRAFT_458573

GTT:	GUITHDRAFT_116188

NGR:	NAEGRDRAFT_69658 NAEGRDRAFT_71673

» show all

Reference

PMID:12935886

Authors

Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R

Title

Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

Journal

FEBS Lett 550:57-63 (2003)
DOI:10.1016/S0014-5793(03)00817-2

Sequence

[hsa:10645]

LinkDB

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