KEGG ORTHOLOGY: K07885

ORTHOLOGY: K07885

Entry

K07885                      KO

Symbol

RAB27A

Name

Ras-related protein Rab-27A

Disease

H02022

Griscelli syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07885  RAB27A; Ras-related protein Rab-27A
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07885  RAB27A; Ras-related protein Rab-27A
Membrane trafficking [BR:ko04131]
Exocytosis
  Small GTPases and associated proteins
   Rab GTPases
    K07885  RAB27A; Ras-related protein Rab-27A
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Rab Family
   Rab3/27 [OT]
    K07885  RAB27A; Ras-related protein Rab-27A

Genes

HSA:	5873(RAB27A)

PTR:	453455(RAB27A)

PPS:	100967857(RAB27A)

GGO:	101154058(RAB27A)

PON:	100452648(RAB27A)

NLE:	100598124(RAB27A)

HMH:	116481668(RAB27A)

MCC:	697741(RAB27A)

MCF:	102139672(RAB27A)

MTHB:

126959974

MNI:	105489977(RAB27A)

CSAB:

103245590(RAB27A)

CATY:

105601123(RAB27A)

PANU:

101012967 116268509 116268510

TGE:	112627383(RAB27A)

MLEU:

105544295(RAB27A)

RRO:	104669562(RAB27A)

RBB:	108535438(RAB27A)

TFN:	117070622(RAB27A)

PTEH:

111553654(RAB27A)

CANG:

105510644(RAB27A)

CJC:	100397904(RAB27A)

SBQ:	101052818(RAB27A)

CIMI:

108314464(RAB27A)

CSYR:

103266904(RAB27A)

MMUR:

105881422(RAB27A)

LCAT:

123622951(RAB27A)

PCOQ:

105821395(RAB27A)

OGA:	100957286(RAB27A)

MMU:	11891(Rab27a)

MCAL:

110301597(Rab27a)

MPAH:

110327978(Rab27a)

RNO:	50645(Rab27a)

MCOC:

116072891(Rab27a)

ANU:	117699924(Rab27a)

MUN:	110549121(Rab27a)

CGE:	100767414(Rab27a)

MAUA:

101828460(Rab27a)

PROB:

127231971(Rab27a)

PLEU:

114690495(Rab27a)

MORG:

121466242(Rab27a)

MFOT:

126490806

AAMP:

119809170(Rab27a)

NGI:	103745785(Rab27a)

HGL:	101718718(Rab27a)

CPOC:

100720981(Rab27a)

CCAN:

109683697(Rab27a)

DORD:

105981047(Rab27a)

DSP:	122114501(Rab27a)

PLOP:

125340757(Rab27a)

NCAR:

124978149

MMMA:

107138085(Rab27a)

OCU:

100342983

OPI:	101536467(RAB27A)

TUP:	102488362(RAB27A)

GVR:	103600031(RAB27A)

CFA:	608699(RAB27A)

CLUD:

112675898(RAB27A)

VVP:	112917125(RAB27A)

VLG:	121484750(RAB27A)

NPO:	129506482(RAB27A)

AML:	100484952(RAB27A)

UMR:	103676769(RAB27A)

UAH:	113269646(RAB27A)

UAR:	123801817(RAB27A)

ELK:

111153235

LLV:

125105089

MPUF:

101686754(RAB27A)

MNP:	131999218(RAB27A)

MLK:	131835835(RAB27A)

NVS:	122892944(RAB27A)

ORO:	101363135(RAB27A)

EJU:	114206259(RAB27A)

ZCA:	113909638(RAB27A)

MLX:	118002961(RAB27A)

NSU:	110583834(RAB27A)

LWW:	102732972(RAB27A)

FCA:	101086976(RAB27A)

PYU:	121041733(RAB27A)

PCOO:

112856220(RAB27A)

PBG:	122468618(RAB27A)

PVIV:

125168638(RAB27A)

LRUF:

124508573

PTG:	102970238(RAB27A)

PPAD:

109262957(RAB27A)

PUC:

125910014

AJU:

106988997

HHV:	120219723(RAB27A)

BTA:	618035(RAB27A)

BOM:	102270475 102276951(RAB27A)

BIU:	109565108(RAB27A)

BBUB:

102415102(RAB27A)

BBIS:

104986272(RAB27A)

CHX:	102189041(RAB27A)

OAS:	101122791(RAB27A)

BTAX:

128054395(RAB27A)

ODA:	120853016(RAB27A)

CCAD:

122443579(RAB27A)

MBEZ:

129562777(RAB27A)

SSC:	606749(RAB27A)

CFR:	102506983(RAB27A)

CBAI:

105080483(RAB27A)

CDK:	105088677(RAB27A)

VPC:	102538176(RAB27A)

BACU:

103005425(RAB27A)

BMUS:

118891093(RAB27A)

LVE:	103080402(RAB27A)

OOR:	101269317(RAB27A)

DLE:	111177636(RAB27A)

PCAD:

102996660(RAB27A)

PSIU:

116749032(RAB27A)

NASI:

112415022(RAB27A)

ECB:	100054867(RAB27A)

EPZ:	103566542(RAB27A)

EAI:	106843417(RAB27A)

MYB:	102253766(RAB27A)

MYD:	102768155(RAB27A)

MMYO:

118652142(RAB27A)

MLF:	102439202(RAB27A)

PKL:	118720903(RAB27A)

EFUS:

103287446(RAB27A)

MNA:	107546504(RAB27A)

DRO:	112311850(RAB27A)

SHON:

118992237(RAB27A)

AJM:	119053467(RAB27A)

PDIC:

114493371(RAB27A)

PHAS:

123808743(RAB27A)

MMF:	118619682(RAB27A)

PPAM:

129064233(RAB27A)

HAI:	109394761(RAB27A)

RFQ:	117023657(RAB27A)

PALE:

102879355(RAB27A)

PGIG:

120604616(RAB27A)

PVP:	105294328(RAB27A)

RAY:	107517441(RAB27A)

MJV:	108401119(RAB27A)

TOD:	119238645(RAB27A)

SARA:

101540346(RAB27A)

SETR:

126009295(RAB27A)

LAV:	100662513(RAB27A)

TMU:

101345276

ETF:	101661649(RAB27A)

DNM:	101447357(RAB27A)

MDO:	100020373(RAB27A)

GAS:	123236106(RAB27A)

SHR:	100915283(RAB27A)

AFZ:

127551174

PCW:	110204954(RAB27A)

OAA:	107546796(RAB27A)

GGA:	415410(RAB27A)

PCOC:

116244672(RAB27A)

MGP:	100547180(RAB27A)

CJO:	107318725(RAB27A)

TPAI:

128075650(RAB27A)

LMUT:

125698491(RAB27A)

NMEL:

110403658(RAB27A)

APLA:

101797215(RAB27A)

ACYG:

106033785(RAB27A)

CATA:

118251604(RAB27A)

AFUL:

116493656(RAB27A)

TGU:	100230193(RAB27A)

LSR:	110474211(RAB27A)

SCAN:

103815993(RAB27A)

PMOA:

120509122(RAB27A)

OTC:	121343607(RAB27A)

PRUF:

121354545(RAB27A)

GFR:	102041788(RAB27A)

FAB:	101810061(RAB27A)

OMA:	130257445(RAB27A)

PHI:	102113248(RAB27A)

PMAJ:

107209497(RAB27A)

CCAE:

111934146(RAB27A)

CCW:	104684021(RAB27A)

CBRC:

103621233(RAB27A)

ETL:	114056342(RAB27A)

ZAB:	102065953(RAB27A)

ACHL:

103808355(RAB27A)

SVG:	106851842(RAB27A)

MMEA:

130577024(RAB27A)

HRT:	120758882(RAB27A)

FPG:	101918006(RAB27A)

FCH:	102052300(RAB27A)

CLV:	102089141(RAB27A)

EGZ:	104130893(RAB27A)

NNI:	104017155(RAB27A)

PCRI:

104037958(RAB27A)

PLET:

104615831(RAB27A)

EHS:	104504786(RAB27A)

PCAO:

104052255(RAB27A)

ACUN:

113483926(RAB27A)

TALA:

104356403(RAB27A)

PADL:

103916426(RAB27A)

AFOR:

103893527(RAB27A)

ACHC:

115341413(RAB27A)

HALD:

104312548(RAB27A)

HLE:	104834470(RAB27A)

AGEN:

126043881

GCL:

127020813

CCRI:

104162460(RAB27A)

CSTI:

104555499(RAB27A)

CMAC:

104483197(RAB27A)

MUI:	104546969(RAB27A)

BREG:

104635867(RAB27A)

FGA:	104071750(RAB27A)

GSTE:

104251592(RAB27A)

LDI:	104352189(RAB27A)

MNB:	103771731(RAB27A)

OHA:	104334572(RAB27A)

NNT:	104403655(RAB27A)

SHAB:

115613241(RAB27A)

DPUB:

104309858(RAB27A)

PGUU:

104458986(RAB27A)

ACAR:

104525025(RAB27A)

CPEA:

104385906(RAB27A)

AVIT:

104269050(RAB27A)

CVF:	104287070(RAB27A)

RTD:	128915108(RAB27A)

CUCA:

104061735(RAB27A)

TEO:	104370828(RAB27A)

BRHI:

104493407(RAB27A)

AAM:	106496565(RAB27A)

AROW:

112963629(RAB27A)

NPD:	112952842(RAB27A)

TGT:	104572150(RAB27A)

DNE:	112985831(RAB27A)

SCAM:

104148293(RAB27A)

ASN:	102384009(RAB27A)

AMJ:	106737267(RAB27A)

CPOO:

109308997(RAB27A)

GGN:	109288623(RAB27A)

PSS:	102458798(RAB27A)

CMY:	102941547(RAB27A)

CCAY:

125643917(RAB27A)

DCC:	119862063(RAB27A)

CPIC:

101940024(RAB27A)

TST:	117883642(RAB27A)

CABI:

116834513(RAB27A)

MRV:	120373825(RAB27A)

ACS:	100562326(rab27a)

ASAO:

132762650(RAB27A)

PVT:	110074529(RAB27A)

SUND:

121935202(RAB27A)

PBI:	103054949 103057120(RAB27A)

PMUR:

107283137(RAB27A)

CTIG:

120306533(RAB27A)

TSR:	106542865(RAB27A)

PGUT:

117660930(RAB27A)

APRI:

131184656 131184780

PTEX:

113442136(RAB27A)

NSS:	113421633(RAB27A)

VKO:	123027785(RAB27A)

PMUA:

114584543(RAB27A)

PRAF:

128401659(RAB27A)

ZVI:	118092809(RAB27A)

HCG:	128335160(RAB27A)

GJA:	107117599(RAB27A)

STOW:

125424546(RAB27A)

EMC:	129345834(RAB27A)

XLA:	444290(rab27a.L) 494641(rab27a.S)

XTR:	493339(rab27a)

NPR:	108787878(RAB27A)

RTEM:

120931362(RAB27A)

BBUF:

120985785(RAB27A)

BGAR:

122927642(RAB27A)

MUO:	115459314(RAB27A)

GSH:	117348328(RAB27A)

DRE:	570907(rab27a)

SRX:	107708299(rab27a) 107735066

SANH:

107659079 107662494(rab27a)

SGH:	107554237 107600376

CCAR:

109075764 109110001

CAUA:

113061421 113118086(rab27a)

CGIB:

127934644 127977694

PTET:

122323058(rab27a)

LROH:

127180936(rab27a)

OMC:	131524965(rab27a)

PPRM:

120469337(rab27a)

RKG:	130100450(rab27a)

MAMB:

125253993(rab27a)

CIDE:

127499463

MASI:

127416626 127456049

TROS:

130563321(rab27a)

TDW:	130435260(rab27a)

MANU:

129419450(rab27a)

IPU:

108264641

IFU:	128607098(rab27a)

PHYP:

113534505(rab27a)

SMEO:

124396148(rab27a)

TFD:	113635274(rab27a)

TVC:	132851488(rab27a)

AMEX:

103047190(rab27a)

CMAO:

118818279(rab27a)

EEE:	113584451(rab27a)

CHAR:

122131660(rab27a)

TRU:	101079001(rab27a)

TFS:	130521947(rab27a)

TNG:	GSTEN00017698G001

LCO:	104930377(rab27a)

NCC:	104965836(rab27a)

TBEN:

117471448(rab27a)

CGOB:

115006462(rab27a)

PGEO:

117468137(rab27a)

GACU:

117533311(rab27a)

EMAC:

134863241(rab27a)

ELY:	117246602(rab27a)

EFO:	125904683(rab27a)

PLEP:

121949198(rab27a)

SLUC:

116060660(rab27a)

ECRA:

117947274(rab27a)

ESP:	116690855(rab27a)

PFLV:

114554593(rab27a)

GAT:	120831668(rab27a)

PPUG:

119196362(rab27a)

AFB:	129103191(rab27a)

CLUM:

117728678(rab27a)

PSWI:

130192926(rab27a)

MSAM:

119890426(rab27a) 119896803

SCHU:

122875583(rab27a)

CUD:	121514755(rab27a)

ALAT:

119017599(rab27a)

MZE:	101486365(rab27a)

ONL:	109194169(rab27a)

OAU:	116334601(rab27a)

OLA:	101164788(rab27a)

OML:	112161240(rab27a)

CSAI:

133462559(rab27a)

XMA:	102224590(rab27a)

XCO:	114143357(rab27a)

XHE:	116718314(rab27a)

PRET:

103462533(rab27a)

PFOR:

103153806(rab27a)

PLAI:

106949011(rab27a)

PMEI:

106913985(rab27a)

GAF:	122843463(rab27a)

PPRL:

129364372(rab27a)

CVG:	107100747(rab27a)

CTUL:

119798973(rab27a)

GMU:	124867504(rab27a)

NFU:	107381394(rab27a)

KMR:	108250577(rab27a)

ALIM:

106531878(rab27a)

NWH:	119428392(rab27a)

AOCE:

111577786(rab27a)

MCEP:

125005786(rab27a)

CSEM:

103398351(rab27a)

POV:	109636931(rab27a)

SSEN:

122762772(rab27a)

HHIP:

117759137(rab27a)

HSP:	118113199(rab27a)

SMAU:

118301852(rab27a)

LCF:

108877746

SDU:	111222158(rab27a)

SLAL:

111646234(rab27a)

XGL:	120796190(rab27a)

HCQ:	109525827(rab27a)

SSCV:

125967671

SBIA:

133497882(rab27a)

PEE:	133415107(rab27a)

PTAO:

133474438(rab27a)

BPEC:

110175226(rab27a)

MALB:

109962965(rab27a)

BSPL:

114852057(rab27a)

SJO:	128362876(rab27a)

SASA:

106562223 106587426

STRU:

115167223 115203116(rab27a)

OTW:	112249225 112249226

OMY:	110506555 110526430

OGO:	124033727 124035712(rab27a)

ONE:	115112291 115113671

OKI:	109888084 109895371

OKE:	118359720 118393889

SALP:

111969430 112070516

SNH:	120025280(rab27a) 120056187

CCLU:

121540896 121548288

ELS:	105016307(rab27a)

SFM:	108926710(rab27a) 108929029

PKI:	111845103(rab27a) 111846820

AANG:

118214708 118228531(rab27a)

LOC:	102687621(rab27a)

PSPA:

121294907 121299228

ARUT:

117427718(rab27a) 117429065

PSEX:

120539922(rab27a)

LCM:	102365571(RAB27A)

CMK:	103187225(rab27a)

CPLA:

122541032(rab27a)

HOC:	132834241(rab27a)

LERI:

129712656(rab27a)

PMRN:

116942194 116950616 116953579 116955004

LRJ:	133343902 133354057(RAB27A) 133354320 133355113 133356347

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG14791(Rab27)

DER:

6555633

DSI:	Dsimw501_GD27856(Dsim_GD27856)

DYA:	Dyak_GE16524

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16485

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108371422 108373585

AOQ:

129239505

TDA:	119667175 119671641 119675374

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AAG:

AALB:

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211281

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105382268 105391762

PGW:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM018070

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

DPX:	DAPPUDRAFT_231118

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:	119171552 119171711

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129220242 129234067

SDM:

118182169

LPOL:

106468415

PMEO:

129587656

CEL:	CELE_Y87G2A.4(aex-6)

CBR:	CBG_08034(Cbr-aex-6)

CRQ:	GCK72_003563

NAI:	NECAME_17955

BMY:	BM_BM8312(Bma-aex-6)

LOA:	LOAG_13598

TSP:

Tsp_11219

HRO:	HELRODRAFT_103925

LGI:	LOTGIDRAFT_220613

PVUL:

126816890

PCAN:

112556781

BGT:	106051224 106063677

GAE:	121373131 121373715

HRF:

124115424

HRJ:

124283874

CRG:

105342646

CVN:	111113086 111115551

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:	115222162 115224868

LAK:

106164358

SMM:	Smp_139340

OVI:	T265_05333

EGL:

EGR_06615

NVE:	5498729 5522159

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_50847

» show all

Reference

PMID:17351642

Authors

Jancic C, Savina A, Wasmeier C, Tolmachova T, El-Benna J, Dang PM, Pascolo S, Gougerot-Pocidalo MA, Raposo G, Seabra MC, Amigorena S

Title

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.

Journal

Nat Cell Biol 9:367-78 (2007)
DOI:10.1038/ncb1552

Sequence

[mmu:11891]

Reference

PMID:18812475

Authors

Menasche G, Menager MM, Lefebvre JM, Deutsch E, Athman R, Lambert N, Mahlaoui N, Court M, Garin J, Fischer A, de Saint Basile G

Title

A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.

Journal

Blood 112:5052-62 (2008)
DOI:10.1182/blood-2008-02-141069

Sequence

[hsa:5873]

LinkDB

DBGET integrated database retrieval system