KEGG ORTHOLOGY: K08683

ORTHOLOGY: K08683

Entry

K08683                      KO

Symbol

HSD17B10

Name

3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]

Pathway

map00280

Valine, leucine and isoleucine degradation

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Reaction

R04203

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase

Disease

H00925

2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
   05022 Pathways of neurodegeneration - multiple diseases
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
    1.1.1.178  3-hydroxy-2-methylbutyryl-CoA dehydrogenase
     K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Mitochondrial ribonuclease P
    K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of breast cancer cells
   K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase

Other DBs

GO:	0003857 0047015

Genes

HSA:	3028(HSD17B10)

PTR:	465649(HSD17B10)

PPS:	100971848(HSD17B10)

GGO:	101130538(HSD17B10)

PON:	100459385(HSD17B10)

NLE:	100594310(HSD17B10)

HMH:	116811708(HSD17B10)

MCC:	700018(HSD17B10)

MCF:	102123916(HSD17B10)

MTHB:

126946552

MNI:	105493784(HSD17B10)

CSAB:

103232017(HSD17B10)

CATY:

105576369(HSD17B10)

PANU:

101012016(HSD17B10)

TGE:	112616408(HSD17B10)

MLEU:

105532263(HSD17B10)

RRO:	104663370(HSD17B10)

RBB:	108520302(HSD17B10)

TFN:	117078288(HSD17B10) 117091873

PTEH:

111531744(HSD17B10)

CANG:

105514907(HSD17B10)

CJC:	100402832(HSD17B10)

SBQ:	101039788(HSD17B10)

CIMI:

108295447(HSD17B10)

CSYR:

103253700(HSD17B10)

MMUR:

105861240

LCAT:

123628032(HSD17B10) 123635438

PCOQ:

105823442(HSD17B10)

OGA:	100940377(HSD17B10)

MMU:	15108(Hsd17b10)

MCAL:

110286767(Hsd17b10)

MPAH:

110313838(Hsd17b10)

RNO:	63864(Hsd17b10)

MCOC:

116089853(Hsd17b10)

ANU:	117694035(Hsd17b10)

MUN:	110540816(Hsd17b10)

CGE:	100757689(Hsd17b10)

MAUA:

101837486(Hsd17b10)

PROB:

127217690(Hsd17b10) 127231134

PLEU:

114683399 114702840(Hsd17b10)

MORG:

121443092 121445568(Hsd17b10)

MFOT:

126494035

AAMP:

119804867(Hsd17b10) 119819446

NGI:	103747316(Hsd17b10)

HGL:	101712281(Hsd17b10)

CPOC:

100718814(Hsd17b10)

CCAN:

109702046(Hsd17b10)

DORD:

106000637(Hsd17b10)

DSP:	122112017(Hsd17b10)

PLOP:

125344092(Hsd17b10)

NCAR:

124972561

MMMA:

107159874(Hsd17b10)

OCU:

100342235

OPI:	101529823(HSD17B10)

TUP:	102491700(HSD17B10)

GVR:	103592126(HSD17B10)

CFA:	480930(HSD17B10)

CLUD:

112673073(HSD17B10)

VVP:	112911953(HSD17B10)

VLG:	121482238(HSD17B10)

NPO:	129518320(HSD17B10)

AML:	100483379(HSD17B10)

UMR:	103675231(HSD17B10)

UAH:	113247518(HSD17B10)

UAR:	123793530(HSD17B10)

ELK:

111139811

LLV:

125092362

MPUF:

101693030(HSD17B10)

MNP:	132007269(HSD17B10)

MLK:	131822124(HSD17B10)

NVS:	122894392 122896272(HSD17B10) 122916941

ORO:	101369544(HSD17B10)

EJU:	114200638(HSD17B10)

ZCA:	113931211(HSD17B10)

MLX:	117998525(HSD17B10)

NSU:	110588558(HSD17B10)

LWW:	102733441(HSD17B10)

FCA:	101090672(HSD17B10)

PYU:	121024801(HSD17B10)

PCOO:

112870930(HSD17B10)

PBG:	122477514(HSD17B10)

PVIV:

125157292(HSD17B10)

LRUF:

124522283

PTG:	102956982(HSD17B10)

PPAD:

109260276(HSD17B10)

PUC:

125931707

AJU:

106985377

HHV:	120222963(HSD17B10)

BTA:	281809(HSD17B10)

BOM:	102284367(HSD17B10)

BIU:	109555307(HSD17B10)

BBUB:

102403269(HSD17B10)

BBIS:

105000965(HSD17B10)

CHX:	102182021(HSD17B10)

OAS:	101119880(HSD17B10)

BTAX:

128070049(HSD17B10)

ODA:	120851531 120854550 120860174 120882164(HSD17B10)

CCAD:

122434299(HSD17B10)

MBEZ:

129564227(HSD17B10)

SSC:	100524293(HSD17B10)

CFR:	102504376(HSD17B10) 102511542

CBAI:

105081500(HSD17B10)

CDK:	105096695(HSD17B10)

VPC:	102531602(HSD17B10)

BACU:

103010500(HSD17B10)

BMUS:

118889266(HSD17B10)

LVE:	103085758(HSD17B10)

OOR:	101287041(HSD17B10)

DLE:	111170779(HSD17B10)

PCAD:

102982939(HSD17B10)

PSIU:

116747313(HSD17B10)

NASI:

112408416(HSD17B10)

ECB:	100060335(HSD17B10)

EPZ:	103542953(HSD17B10)

EAI:	106822166(HSD17B10)

MYB:

102241897

MYD:	102751672(HSD17B10)

MMYO:

118653717(HSD17B10) 118659315

MLF:	102417112(HSD17B10)

PKL:	118706130 118706176 118714042(HSD17B10)

EFUS:

103294936 103301347(HSD17B10)

MNA:	107542354(HSD17B10)

DRO:	112322468(HSD17B10)

SHON:

118978337(HSD17B10)

AJM:	119055505(HSD17B10)

PDIC:

114505044(HSD17B10)

PHAS:

123814830(HSD17B10)

MMF:	118635833(HSD17B10)

PPAM:

129064545(HSD17B10) 129075737

HAI:	109396389(HSD17B10)

RFQ:	117021353(HSD17B10)

PALE:

102882756(HSD17B10)

PGIG:

120593567(HSD17B10)

PVP:	105307806(HSD17B10)

RAY:	107506614(HSD17B10)

MJV:	108393376(HSD17B10)

TOD:	119246140(HSD17B10)

SARA:

101554831(HSD17B10)

SETR:

125999256(HSD17B10)

LAV:	100676457(HSD17B10)

TMU:

101360197

ETF:	101643918 101654022(HSD17B10)

DNM:	101437023 101443695(HSD17B10)

MDO:	100019657(HSD17B10)

GAS:	123253957(HSD17B10)

SHR:	100918332(HSD17B10)

AFZ:

127542698

PCW:	110201063(HSD17B10)

OAA:	100081790(HSD17B10)

GGA:	425758(HSD17B10)

PCOC:

116240178(HSD17B10)

MGP:	100540780(HSD17B10)

NMEL:

110391433(HSD17B10)

LSR:	110482653(HSD17B10)

PMOA:

120503076(HSD17B10)

OTC:	121340067(HSD17B10)

PRUF:

121362366(HSD17B10)

OMA:	130262830(HSD17B10)

PHI:	102108549(HSD17B10)

PMAJ:

107199346(HSD17B10)

CCW:	120412192(HSD17B10)

CBRC:

103617130(HSD17B10)

SVG:	106864400(HSD17B8)

MMEA:

130586734(HSD17B10)

HRT:	120748218(HSD17B10)

FPG:	101922240(HSD17B10)

FCH:	102045831(HSD17B10)

ACHC:

115338221(HSD17B10)

HLE:	104834323(HSD17B10)

AGEN:

126035190

SHAB:

115603483(HSD17B10)

PGUU:

104460485(HSD17B10)

CVF:	104291634(HSD17B10)

CUCA:

104067759(HSD17B10)

AROW:

112972653(HSD17B10)

NPD:	112946761(HSD17B10)

DNE:	112985485(HSD17B10)

ASN:	102377997(HSD17B10)

AMJ:	102559608(HSD17B10)

CMY:	102935413(HSD17B10)

CCAY:

125628021(HSD17B10)

DCC:	119847007(HSD17B10)

CPIC:

101946623(HSD17B10)

CABI:

116818886(HSD17B10)

MRV:	120388542(HSD17B10)

ACS:	100566347(hsd17b10)

ASAO:

132767863(HSD17B10)

PVT:	110089193(HSD17B10)

SUND:

121922707(HSD17B10)

PBI:	103051793(HSD17B10)

PMUR:

107284213(HSD17B10)

CTIG:

120311302(HSD17B10)

PGUT:

117675536(HSD17B10)

APRI:

131192205(HSD17B10)

PTEX:

113443230(HSD17B10)

NSS:	113417676(HSD17B10)

VKO:	123030114(HSD17B10)

PMUA:

114588150(HSD17B10)

PRAF:

128404927(HSD17B10) 128406171

ZVI:	118097678(HSD17B10)

HCG:	128344203(HSD17B10)

GJA:	107117365(HSD17B10)

EMC:	129346280(HSD17B10)

XLA:	108699982(hsd17b10.S) 446903(hsd17b10.L)

XTR:	549265(hsd17b10)

NPR:	108797529(HSD17B10)

RTEM:

120913022(HSD17B10)

BBUF:

121009152(HSD17B10)

BGAR:

122946398(HSD17B10)

MUO:	115463597(HSD17B10)

GSH:	117349060(HSD17B10)

DRE:	450078(hsd17b10)

SRX:	107737644 107741341

SANH:

107656989 107672063(hsd17b10)

SGH:	107560905 107562460

CAUA:

113069104(hsd17b10) 113094765

CGIB:

127944159 128011065

PTET:

122329266(hsd17b10)

LROH:

127155270(hsd17b10)

OMC:	131532057(hsd17b10)

PPRM:

120463755(hsd17b10)

RKG:	130081712(hsd17b10)

MAMB:

125260492(hsd17b10)

CIDE:

127505258

MASI:

127419442 127420442

TROS:

130544981(hsd17b10)

TDW:	130409300(hsd17b10)

MANU:

129431225(hsd17b10)

IPU:	100528090(hsd17b10)

IFU:	128619628(hsd17b10)

PHYP:

113530295(hsd17b10)

SMEO:

124398597(hsd17b10)

TFD:	113642024(hsd17b10)

TVC:	132862612(hsd17b10)

AMEX:

103024621(hsd17b10)

CMAO:

118822580(hsd17b10)

EEE:	113575440(hsd17b10)

CHAR:

105894129(hsd17b10)

TFS:	130529577(hsd17b10)

TNG:	GSTEN00023338G001

LCO:	104928358(hsd17b10)

TBEN:

117483467(hsd17b10) 117483479 117483535

CGOB:

115011423(hsd17b10)

PGEO:

117449563(hsd17b10)

GACU:

117562352(hsd17b10)

EMAC:

134871417(hsd17b10)

ELY:	117258246(hsd17b10)

EFO:	125891170(hsd17b10)

PLEP:

121947111(hsd17b10)

SLUC:

116059325(hsd17b10)

ECRA:

117948109(hsd17b10)

ESP:	116692997(hsd17b10)

PFLV:

114559071(hsd17b10)

GAT:	120829460(hsd17b10)

PPUG:

119223392(hsd17b10)

AFB:	129100181(hsd17b10)

CLUM:

117733173(hsd17b10) 117733856

PSWI:

130199841(hsd17b10)

MSAM:

119905089(hsd17b10)

SCHU:

122882575(hsd17b10)

CUD:	121517639(hsd17b10)

ALAT:

119022692(hsd17b10)

MZE:	101486814(hsd17b10)

ONL:	100708936(hsd17b10)

OAU:	116309184(hsd17b10)

OLA:	101170516(hsd17b10)

OML:	112159416(hsd17b10)

CSAI:

133456220(hsd17b10)

XMA:	102219644(hsd17b10) 111608152

XCO:	114141158(hsd17b10)

XHE:	116717817(hsd17b10) 116717849 116720286

PRET:

103467892(hsd17b10)

PFOR:

103130892(hsd17b10)

PLAI:

106960803(hsd17b10)

PMEI:

106932965(hsd17b10)

GAF:	122835328(hsd17b10)

PPRL:

129377107(hsd17b10)

CVG:	107088734(hsd17b10)

CTUL:

119799317(hsd17b10)

GMU:	124877059(hsd17b10)

NFU:	107390369(hsd17b10)

KMR:	108230534(hsd17b10)

ALIM:

106511017(hsd17b10)

NWH:	119416676(hsd17b10)

MCEP:

125023683(hsd17b10)

CSEM:

103385214(hsd17b10)

POV:	109646243(hsd17b10)

SSEN:

122761722(hsd17b10)

HHIP:

117765000(hsd17b10)

HSP:	118111521(hsd17b10)

SMAU:

118316978(hsd17b10)

LCF:

108875474

SDU:	111235061(hsd17b10)

SLAL:

111644152(hsd17b10)

XGL:	120803441(hsd17b10)

HCQ:	109523116(hsd17b10)

SSCV:

125989420

SBIA:

133505115(hsd17b10)

PEE:	133396423(hsd17b10)

PTAO:

133477268(hsd17b10)

BPEC:

110175804(hsd17b10)

MALB:

109951871(hsd17b10)

BSPL:

114859022(hsd17b10)

SJO:	128357055(hsd17b10)

SASA:

100196585(hsd17b10)

STRU:

115168753(hsd17b10)

OTW:	112221480(hsd17b10)

OMY:	110492729(hsd17b10)

OGO:	124045434(hsd17b10)

ONE:

115126100

OKI:	109885832(hsd17b10)

OKE:

118360242

SALP:

112075320(hsd17b10)

SNH:	120037698(hsd17b10)

CCLU:

121546823(hsd17b10)

ELS:	105013512(hsd17b10)

SFM:	108918316(hsd17b10)

PKI:	111857098(hsd17b10)

AANG:

118207783(hsd17b10)

PSPA:

121305366(hsd17b10)

PSEX:

120542716(hsd17b10)

LCM:	102359593(HSD17B10)

RTP:	109920085(hsd17b10)

CPLA:

122542360(hsd17b10)

HOC:	132809036(hsd17b10)

PMRN:

116952231(HSD17B10)

LRJ:	133355481 133355602

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG7113(scu)

DER:

6550269

DSE:

6614820

DSI:	Dsimw501_GD17383(Dsim_GD17383)

DYA:	Dyak_GE17707

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14682

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108371357 108376016

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	5571801 5571804

AALB:

109427471 109427473 109427541 115253538 115253659 115269370

CQU:	CpipJ_CPIJ014285 CpipJ_CPIJ014286

CPII:

120420167 120420202

CNS:	116340896 116341640 116347922 116347923 116348465 116348677 116352597

BCOO:

119077639 119083641

AME:	725274 726590

ALAB:

122710550 122711460

ADR:	102670881 102673042

AFLR:

100867464 100871693

BIM:	100744954 100745932

BBIF:

117206297 117207552 117207654

BVK:	117233088 117236101

BVAN:

117153343 117156912

BTER:

100642257 100652075 100652169

BAFF:

126917491 126917492 126917494 126922587

BPYO:

122569073 122569811 122572480 122572547

BPAS:

132907124 132916712

FVI:	122535016 122535905

CCAL:

108632372

OBB:	114872622 114881413

OLG:	117607659 117609087

MGEN:

117223643 117223858

NMEA:

116425158 116425159 116425336

CGIG:

122395028 122399651

SOC:	105205705 120356835

MPHA:

105840130

AEC:	105144619 105147099

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:	106789194 106791582

PFUC:

122524227 122525451 122525452

VPS:	122634700 122634701

VCRB:

124430227 124430228

VVE:	124954848 124954849

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:	103575367 103575716

CGLO:

123267606 123270676

FAS:

105264291

DAM:	107042858 107047511 107047998

AGIF:

122853371 122855531 122855533 122856582

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109539142 109542618 109543344 109546870

SOY:	115885943 115885955 115888479

AGRG:

126735339 126739758 126743681

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206141 KGM_207362

BANY:

112048026 112053858

MJU:	123876904 123880125

NIQ:	126776519 126780464

VCD:	124538772 124543010

MCIX:

123664193 123668706

PMAC:

106719897 106721132

PPOT:

106103284 106104281

PXU:	106113640 106116574

PRAP:

110993036 111000559

PBX:	123710398 123718779

PNAP:

125053857 125062863

ZCE:	119828938 119835635

CCRC:

123700762 123705454

LSIN:

126975470 126978561

AAGE:

121735759 121738572

HAW:	110371359 110373884

HZE:	124640969 124645237

TNL:	113494026 113499310 113499443

SLIU:

111348796 111360581

OFU:	114354109 114357052

PXY:	105381601 105382604

PGW:	126379862 126380374

CFEL:

113381984 113382094 113382095

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM489260

FOC:	113210867 113214822

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_299789

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128697141 128697161

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:	124490400 124498538 124499261

CSCU:

111628029 111640538

PTEP:

107443400 107443407 107444042 107444043

ABRU:

129963812 129964069 129964070

UDV:	129217412 129217414 129217417

SDM:	118183746 118187370 118193954 118193955 118193956

LPOL:

106462667

PMEO:

129583335 129583377 129584270 129584271 129586187 129589768 129589791 129589810 129589832 129592188 129598566

CEL:	CELE_F01G4.2(ard-1)

CBR:	CBG_06017(Cbr-ard-1)

CRQ:	GCK72_014065 GCK72_014228

NAI:	NECAME_03624

BMY:	BM_BM3137(Bma-ard-1.1) BM_BM3231(Bma-ard-1.2)

LOA:	LOAG_02590 LOAG_02591

HRO:	HELRODRAFT_62336

LGI:	LOTGIDRAFT_130767 LOTGIDRAFT_130874

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105337727 105349048

CVN:	111106365 111108694 111109578 111109751

CANU:

128157694 128159502 128161110

OED:	125655895 125656946

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_151030

SHX:	MS3_00007148

OVI:	T265_14188

EGL:

EGR_00218

NVE:	5516466 5516467

EPA:	110234807 110234808

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_22420 TRIADDRAFT_51183

AQU:

100642054

SSL:	SS1G_12339

BFU:	BCIN_05g06820

MBE:

MBM_06971

PSCO:

LY89DRAFT_690741

GLZ:	GLAREA_10926

HIR:	HETIRDRAFT_410926

PSQ:	PUNSTDRAFT_54939

GTR:	GLOTRDRAFT_128483

ABP:	AGABI1DRAFT119037(AGABI1DRAFT_119037)

MRR:	Moror_1115 Moror_1116

WSE:	WALSEDRAFT_66965 WALSEDRAFT_66966

MBR:	MONBRDRAFT_35161

SRE:	PTSG_09481

TET:	TTHERM_00085280 TTHERM_00085290 TTHERM_00085300 TTHERM_00085310

FCY:	FRACYDRAFT_229426

TPS:	THAPS_263178(HCD1)

PIF:	PITG_05542

PSOJ:

PHYSODRAFT_284787

SPAR:

SPRG_04958

MLQ:	ASQ50_13255

AMAA:

AMAD:

AMAI:

AMAG:

ALN:	AS19_06730

ADI:

B5T_03344

AXE:

P40_15700

APAC:

S7S_05705

GPB:	HDN1F_11030(hadH2)

VIG:	BKP57_16440

VPN:	A21D_02478(fabG_5)

SALE:

SLP:

PBRO:

Reference

PMID:9338779

Authors

Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D

Title

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.

Journal

Nature 389:689-95 (1997)
DOI:10.1038/39522

Sequence

[hsa:3028]

LinkDB

DBGET integrated database retrieval system