KEGG   ORTHOLOGY: K08733
Entry
K08733                      KO                                     
Symbol
APPL1, DIP13A
Name
DCC-interacting protein 13 alpha
Pathway
map04211  Longevity regulating pathway
map04920  Adipocytokine signaling pathway
map05200  Pathways in cancer
map05210  Colorectal cancer
Disease
H00410  Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
  09149 Aging
   04211 Longevity regulating pathway
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
Genes
HSA: 26060(APPL1)
PTR: 460469(APPL1)
PPS: 100995535(APPL1)
GGO: 101126724(APPL1)
PON: 100442490(APPL1)
NLE: 100599415(APPL1)
HMH: 116469192(APPL1)
MCC: 100425753(APPL1)
MCF: 102126071(APPL1)
MTHB: 126948801
MNI: 105482612(APPL1)
CSAB: 103227788(APPL1)
CATY: 105585610(APPL1)
PANU: 101021089(APPL1)
TGE: 112619000(APPL1)
MLEU: 105552676(APPL1)
RRO: 104660203(APPL1)
RBB: 108543582(APPL1)
TFN: 117083029(APPL1)
PTEH: 111534410(APPL1)
CANG: 105515469(APPL1)
CJC: 100389847(APPL1)
SBQ: 101034147(APPL1)
CIMI: 108303557(APPL1)
CSYR: 103274291(APPL1)
MMUR: 105871961(APPL1)
LCAT: 123623370(APPL1)
PCOQ: 105807446(APPL1)
OGA: 100960005(APPL1)
MMU: 72993(Appl1)
MCAL: 110309157(Appl1)
MPAH: 110325445(Appl1)
RNO: 290537(Appl1)
MCOC: 116085385(Appl1)
ANU: 117705146(Appl1)
MUN: 110566349(Appl1)
CGE: 100751324(Appl1)
MAUA: 101824187(Appl1) 106022749
PROB: 127216159(Appl1)
PLEU: 114702126(Appl1)
MORG: 121455088(Appl1)
MFOT: 126511217
AAMP: 119827895(Appl1)
NGI: 103747007(Appl1)
HGL: 101703342(Appl1)
CPOC: 100724445(Appl1)
CCAN: 109681666 109681669
DORD: 105996564(Appl1)
DSP: 122108001(Appl1)
PLOP: 125358562(Appl1)
NCAR: 124968315
MMMA: 107149698(Appl1)
OCU: 100353097
OPI: 101525739(APPL1)
TUP: 102477144(APPL1)
GVR: 103597398(APPL1)
CFA: 484716(APPL1)
CLUD: 112665949(APPL1)
VVP: 112908602(APPL1)
VLG: 121494884(APPL1)
NPO: 129521919(APPL1)
AML: 100463883(APPL1)
UMR: 103675060(APPL1)
UAH: 113257000(APPL1)
UAR: 123798779(APPL1)
ELK: 111143849
LLV: 125078591
MPUF: 101678697(APPL1)
MNP: 132011442(APPL1)
MLK: 131824056(APPL1)
NVS: 122909321(APPL1)
ORO: 101375582(APPL1)
EJU: 114214607(APPL1)
ZCA: 113916861(APPL1)
MLX: 118005760(APPL1)
NSU: 110584833(APPL1)
LWW: 102737588(APPL1)
FCA: 101096960(APPL1)
PYU: 121016816(APPL1)
PCOO: 112852486(APPL1)
PBG: 122487350(APPL1)
PVIV: 125160491(APPL1)
LRUF: 124524439
PTG: 102956094(APPL1)
PPAD: 109279103(APPL1)
PUC: 125929498
AJU: 106967026
HHV: 120238615(APPL1)
BTA: 517850(APPL1)
BOM: 102266894(APPL1)
BIU: 109575959(APPL1)
BBUB: 102414857(APPL1)
BBIS: 104997099(APPL1)
CHX: 102169529(APPL1)
OAS: 101109218(APPL1)
BTAX: 128051748(APPL1)
ODA: 120867954(APPL1)
CCAD: 122424512(APPL1)
MBEZ: 129547950(APPL1)
SSC: 100188978(APPL1)
CFR: 102516958(APPL1)
CBAI: 105079572(APPL1)
CDK: 105089793(APPL1)
VPC: 102543824(APPL1)
BACU: 103012463(APPL1)
BMUS: 118904050(APPL1)
LVE: 103085402(APPL1)
OOR: 101282807(APPL1)
DLE: 111174255(APPL1)
PCAD: 102987883(APPL1)
PSIU: 116761996(APPL1)
NASI: 112400574(APPL1)
ECB: 100058653(APPL1)
EPZ: 103547870(APPL1)
EAI: 106848655(APPL1)
MYB: 102250837(APPL1)
MYD: 102773012(APPL1)
MMYO: 118667962(APPL1)
MLF: 102438518(APPL1)
PKL: 118715098(APPL1)
EFUS: 103290405(APPL1)
MNA: 107531462(APPL1)
DRO: 112301169(APPL1)
SHON: 118983367(APPL1)
AJM: 119039375(APPL1)
PDIC: 114501440(APPL1)
PHAS: 123814267(APPL1)
MMF: 118633236(APPL1)
PPAM: 129088092(APPL1)
HAI: 109377590(APPL1)
RFQ: 117036667(APPL1)
PALE: 102887604(APPL1)
PGIG: 120599524(APPL1)
PVP: 105299855(APPL1)
RAY: 107503389(APPL1)
MJV: 108397387(APPL1)
TOD: 119230351(APPL1)
SARA: 101546914(APPL1)
SETR: 126013203(APPL1)
LAV: 100657434(APPL1)
TMU: 101352321
ETF: 101647519(APPL1)
DNM: 101423339(APPL1)
MDO: 100010013(APPL1)
GAS: 123231748(APPL1)
SHR: 100921499(APPL1)
AFZ: 127550478
PCW: 110195969(APPL1)
OAA: 100089140(APPL1)
GGA: 416002(APPL1)
PCOC: 116238468(APPL1)
MGP: 100547896(APPL1)
CJO: 107319769(APPL1)
TPAI: 128078605(APPL1)
LMUT: 125698636(APPL1)
NMEL: 110404658(APPL1)
APLA: 101798507(APPL1)
ACYG: 106040513
CATA: 118253687(APPL1)
AFUL: 116493000(APPL1)
TGU: 100226921(APPL1)
LSR: 110471716(APPL1)
SCAN: 103817003(APPL1)
PMOA: 120495715(APPL1)
OTC: 121347208(APPL1)
PRUF: 121353012(APPL1)
GFR: 102036365(APPL1)
FAB: 101818861(APPL1)
OMA: 130258312(APPL1)
PHI: 102101270(APPL1)
PMAJ: 107210342(APPL1)
CCAE: 111935108(APPL1)
CCW: 104683267(APPL1)
CBRC: 103614300(APPL1)
ETL: 114057939(APPL1)
ZAB: 102075407(APPL1)
ACHL: 103801356(APPL1)
SVG: 106863584(APPL1)
MMEA: 130577812(APPL1)
HRT: 120758213(APPL1)
FPG: 101918142(APPL1)
FCH: 102055056(APPL1)
CLV: 102087711(APPL1)
EGZ: 104126721(APPL1)
NNI: 104022664(APPL1)
PCRI: 104028766(APPL1)
PLET: 104624779(APPL1)
EHS: 104503133(APPL1)
PCAO: 104044977(APPL1)
ACUN: 113484944(APPL1)
TALA: 104360135(APPL1)
PADL: 103915480(APPL1)
AFOR: 103903287(APPL1)
ACHC: 115353835(APPL1)
HALD: 104313631(APPL1)
HLE: 104834867(APPL1)
AGEN: 126049593
GCL: 127021439
CCRI: 104161806(APPL1)
CSTI: 104551108(APPL1)
CMAC: 104483725(APPL1)
MUI: 104543717(APPL1)
BREG: 104629332(APPL1)
FGA: 104069433(APPL1)
GSTE: 104250578(APPL1)
LDI: 104345343(APPL1)
MNB: 103778456(APPL1)
OHA: 104333184(APPL1)
NNT: 104405447(APPL1)
SHAB: 115614256(APPL1)
DPUB: 104308801(APPL1)
PGUU: 104459133(APPL1)
ACAR: 104525421(APPL1)
CPEA: 104385026(APPL1)
AVIT: 104268548(APPL1)
CVF: 104295918(APPL1)
RTD: 128915544(APPL1)
CUCA: 104068279(APPL1)
TEO: 104373687(APPL1)
BRHI: 104488063(APPL1)
AAM: 106495171(APPL1)
AROW: 112972409(APPL1)
NPD: 112944092(APPL1)
TGT: 104570014(APPL1)
DNE: 112980982(APPL1)
SCAM: 104152737(APPL1)
ASN: 102384706(APPL1)
AMJ: 102573987(APPL1)
CPOO: 109311309(APPL1)
GGN: 109288854(APPL1)
PSS: 102457050(APPL1)
CMY: 102937117(APPL1)
CCAY: 125639506(APPL1)
DCC: 119858323(APPL1)
CPIC: 101950184(APPL1)
TST: 117879847(APPL1)
CABI: 116835736(APPL1)
MRV: 120368545(APPL1)
ACS: 100564640(appl1)
ASAO: 132769285(APPL1)
PVT: 110082404(APPL1)
SUND: 121921287(APPL1)
PBI: 103061921(APPL1)
PMUR: 107297188(APPL1)
CTIG: 120310100(APPL1)
TSR: 106541673(APPL1)
PGUT: 117676834(APPL1)
APRI: 131190783(APPL1)
PTEX: 113452264(APPL1)
NSS: 113418596(APPL1)
VKO: 123034105(APPL1)
PMUA: 114591700(APPL1)
PRAF: 128408330(APPL1)
ZVI: 118080717(APPL1)
HCG: 128344334(APPL1)
GJA: 107107451(APPL1)
STOW: 125428222(APPL1)
EMC: 129327494(APPL1)
XLA: 398493(appl1.S) 398984(appl1.L)
XTR: 100038055(appl1)
NPR: 108786881(APPL1)
RTEM: 120945234(APPL1)
BBUF: 120978492(APPL1)
BGAR: 122944099(APPL1)
MUO: 115471718(APPL1)
GSH: 117351105(APPL1)
DRE: 571540(appl1)
SRX: 107712995 107747534(appl1)
SANH: 107657952 107680550(appl1)
SGH: 107557417(appl1)
CCAR: 109084093
CAUA: 113055449 113110650 113110801
CGIB: 127968329 128022017
PTET: 122353851(appl1)
LROH: 127173387(appl1)
OMC: 131549879(appl1)
PPRM: 120480420(appl1)
RKG: 130071448(appl1)
MAMB: 125256542(appl1)
CIDE: 127522665
MASI: 127426026 127427865
TROS: 130571547(appl1)
TDW: 130410607(appl1)
MANU: 129427522(appl1)
IPU: 108254880
IFU: 128625038(appl1)
PHYP: 113538084(appl1)
SMEO: 124402384(appl1)
TFD: 113656497(appl1)
TVC: 132838055(appl1)
AMEX: 103038259(appl1)
CMAO: 118799486(appl1)
EEE: 113572360(appl1)
CHAR: 105890545(appl1)
TRU: 101078952 115246877
TFS: 130524408(appl1)
TNG: GSTEN00013098G001 GSTEN00033906G001 GSTEN00033909G001
LCO: 104940242(appl1)
NCC: 104951230(appl1)
TBEN: 117497905(appl1)
PGEO: 117446544(appl1)
GACU: 117542256(appl1)
EMAC: 134882827(appl1)
ELY: 117257050(appl1)
EFO: 125891722(appl1)
PLEP: 121960409(appl1)
SLUC: 116051144(appl1)
ECRA: 117943389(appl1)
ESP: 116687987(appl1)
PFLV: 114554199(appl1)
GAT: 120834774(appl1)
PPUG: 119230208(appl1)
AFB: 129105387(appl1)
CLUM: 117731118(appl1)
PSWI: 130207817(appl1)
MSAM: 119882024 119886775(appl1)
SCHU: 122882718(appl1)
CUD: 121507116(appl1)
ALAT: 119022318(appl1)
MZE: 101469918(appl1)
ONL: 100691276(appl1)
OAU: 116329696(appl1)
OLA: 101169445(appl1)
OML: 112140655(appl1)
CSAI: 133448276 133448288
XMA: 102221762(appl1)
XCO: 114135891(appl1)
XHE: 116710260(appl1)
PRET: 103464350(appl1)
PFOR: 103154439(appl1)
PLAI: 106954485(appl1)
PMEI: 106905981(appl1)
GAF: 122833792(appl1)
PPRL: 129372691(appl1)
CVG: 107101713(appl1)
CTUL: 119779866(appl1)
GMU: 124856620(appl1)
NFU: 107385075(appl1)
KMR: 108244943(appl1)
ALIM: 106525043(appl1)
NWH: 119412011(appl1)
AOCE: 111567353 111575770
MCEP: 125007192(appl1)
CSEM: 103386656(appl1)
POV: 109635466(appl1)
SSEN: 122768550(appl1)
HHIP: 117760963(appl1)
HSP: 118104443(appl1)
SMAU: 118308764(appl1)
LCF: 108874777
SDU: 111219333(appl1)
SLAL: 111668209(appl1)
XGL: 120783077(appl1)
HCQ: 109521490(appl1)
SSCV: 125977202
SBIA: 133507094(appl1)
PEE: 133408612(appl1)
PTAO: 133483419(appl1)
BPEC: 110157714(appl1)
MALB: 109966385(appl1)
BSPL: 114855962(appl1)
SJO: 128355194(appl1)
SASA: 106566093(appl1) 106582698
STRU: 115151039 115207383(appl1)
OTW: 112221680 112254175
OMY: 110494736 110527724
OGO: 124003053 124031622
ONE: 115118211 115135595
OKI: 109890816 109899483
OKE: 118388215 118399935
SALP: 111969709 111970772
SNH: 120058468 120065010
CCLU: 121574747 121578340
ELS: 105017453(appl1)
SFM: 108936613(appl1)
PKI: 111837518(appl1)
AANG: 118211332(appl1)
LOC: 102694936(appl1)
PSPA: 121298098(appl1)
ARUT: 117412282 117969221 117970025
PSEX: 120540454(appl1)
LCM: 102354094(APPL1)
CMK: 103176777(appl1)
RTP: 109916002(appl1)
CPLA: 122559017(appl1)
HOC: 132822342(appl1)
LERI: 129704453(appl1)
PMRN: 116949307(APPL1)
LRJ: 133342681(APPL1)
BFO: 118416165
BBEL: 109464972
CIN: 100176004 101243181
SCLV: 120329723 120348559
SPU: 579389
LPIC: 129255681
APLC: 110983942
SKO: 102802648
PVM: 113823119
PJA: 122263283
PCHN: 125034497
PMOO: 119589252
HAME: 121876662
PCLA: 123766201
CQD: 128684543
PTRU: 123513097
ESN: 127010279
MNZ: 135216859
DSV: 119461469
RSAN: 119395906
RMP: 119174246
CSCU: 111619708
PTEP: 107450243
ABRU: 129968863
UDV: 129232754 129234687
SDM: 118194397
LPOL: 106466777
TSP: Tsp_07605
LGI: LOTGIDRAFT_200897
PVUL: 126828797
PCAN: 112571793
BGT: 106051390
GAE: 121367964
HRF: 124136710
HRJ: 124258713
CRG: 105327258
CVN: 111108060
CANU: 128159218
OED: 125657644
MYI: 110461257
PMAX: 117330504
MCAF: 127721683
MMER: 123529996
RPHI: 132739770
DPOL: 127832465
OBI: 106871906
OSN: 115223219
LAK: 106159168 106163145 106172791
AQU: 105314014
 » show all
Reference
PMID:15016378
  Authors
Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M
  Title
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
  Journal
Cell 116:445-56 (2004)
DOI:10.1016/S0092-8674(04)00117-5
  Sequence
[hsa:26060]
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