KEGG ORTHOLOGY: K08888

ORTHOLOGY: K08888

Entry

K08888                      KO

Symbol

MATK

Name

megakaryocyte-associated tyrosine kinase [EC:2.7.10.2]

Pathway

map04722

Neurotrophin signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K08888  MATK; megakaryocyte-associated tyrosine kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08888  MATK; megakaryocyte-associated tyrosine kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08888  MATK; megakaryocyte-associated tyrosine kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  CSK family
   K08888  MATK; megakaryocyte-associated tyrosine kinase

Other DBs

GO:

0004715

Genes

HSA:	4145(MATK)

PTR:	455592(MATK)

PPS:	100992660(MATK)

PON:	100437723(MATK)

NLE:	100588666(MATK)

HMH:	116482876(MATK)

MCC:	100430078(MATK)

MCF:	102136833(MATK)

MTHB:

126942615

MNI:	105485422(MATK)

CSAB:

103233694(MATK)

CATY:

105591792(MATK)

PANU:

100999192(MATK)

TGE:	112612611(MATK)

MLEU:

105530020(MATK)

RRO:	104665434(MATK)

RBB:	108512133(MATK)

TFN:	117076547(MATK)

PTEH:

111520687(MATK)

CANG:

105512825(MATK)

CJC:	100391795(MATK)

SBQ:	101033850(MATK)

CIMI:

108288461(MATK)

MMUR:

105873947(MATK)

LCAT:

123633727(MATK)

PCOQ:

105811872(MATK)

OGA:	100953987(MATK)

MMU:	17179(Matk)

MCAL:

110303229(Matk)

MPAH:

110326441(Matk)

RNO:	60450(Matk)

MCOC:

116076199(Matk)

ANU:	117696508(Matk)

MUN:	110548519(Matk)

CGE:	100764076(Matk)

MAUA:

101843898(Matk)

PROB:

127216554(Matk)

PLEU:

114688376(Matk)

MORG:

121459380(Matk)

MFOT:

126489255

AAMP:

119819512(Matk)

NGI:	103737266(Matk)

HGL:	101718779(Matk)

CPOC:

100729484(Zfr2) 100729756(Matk)

CCAN:

109689678(Matk)

DORD:

105990263(Matk)

DSP:	122119744(Matk)

PLOP:

125348637(Matk)

NCAR:

124968458

OCU:

127485744

OPI:	101520694(MATK)

TUP:	102473036(MATK)

GVR:	103598838(MATK) 103598845(ZFR2)

CFA:	611999(MATK)

CLUD:

112666282(MATK)

VVP:	112935578(MATK)

VLG:	121495840(MATK)

NPO:	129521902(MATK)

AML:	100477232(MATK)

UMR:	103681828(MATK)

UAH:	113242814(MATK)

UAR:	123796825(MATK) 123796850(ZFR2)

ELK:

111161736

LLV:

125086785

MPUF:

101682557(MATK)

MNP:	132009652(MATK)

MLK:	131823301(MATK)

NVS:	122910821(MATK)

ORO:	101378227(MATK)

EJU:	114226143(MATK)

ZCA:	113917429(MATK)

MLX:	118005328(MATK)

NSU:	110593871 123323749

LWW:	102740362(MATK)

FCA:	101099024(MATK)

PYU:	121021404(MATK)

PBG:	122486699(MATK)

PVIV:

125161303(MATK)

LRUF:

124524606

PTG:	102958221(MATK)

PPAD:

109255975

PUC:

125931071

AJU:

113596350

HHV:	120242083(MATK)

BTA:	504668(MATK)

BOM:	102270014(MATK)

BIU:	109560965(MATK)

BBUB:

102401244(MATK)

BBIS:

104979897(MATK)

CHX:	102173735(MATK)

OAS:	101117161(MATK)

BTAX:

128050568(MATK)

ODA:	120864814(MATK)

CCAD:

122440222(MATK)

MBEZ:

129559431(MATK)

SSC:	110255242(MATK)

CFR:	102518648(MATK)

CBAI:

105078201(MATK)

CDK:	105102645(MATK)

VPC:	102537641(MATK)

BACU:

102997639(MATK)

BMUS:

118892170(MATK)

LVE:	103088743(MATK)

OOR:	101285021(MATK)

DLE:	111166211(MATK)

PCAD:

102991843(MATK)

PSIU:

116752083(MATK)

NASI:

112400262(MATK)

ECB:	100146548(MATK)

EPZ:	103544755(MATK)

MYB:	102255224(MATK)

MYD:	102767247(MATK)

MMYO:

118659096(MATK)

MLF:

102430836

PKL:	118731348(MATK)

EFUS:

103294238(MATK)

MNA:	107525635(MATK)

DRO:	112312416(MATK)

SHON:

118984497(MATK)

AJM:	119063773(MATK)

PDIC:

114502386(MATK)

PHAS:

123814215(MATK)

MMF:	118616197(MATK)

PPAM:

129074279(MATK)

HAI:	109388657 109388658

RFQ:	117037760(MATK)

PALE:

102892220(MATK)

PGIG:

120615372(MATK)

PVP:	105300449(MATK)

RAY:	107520080(MATK) 107520099

MJV:	108384781(MATK)

TOD:	119240571(MATK)

SARA:

101543502(ZFR2) 101548513(MATK)

SETR:

126030415(MATK)

LAV:	100669716(MATK)

TMU:

101356971

ETF:	101657160(MATK)

MDO:	100021968(MATK)

GAS:	123232145(MATK)

SHR:	100916088(MATK)

AFZ:

127544963

PCW:	110197456(MATK)

OAA:	100087316(MATK)

GGA:	769076(MATK)

PCOC:

116236178(MATK)

MGP:	100541640(MATK)

CJO:	107325674(MATK)

TPAI:

128090117(MATK)

LMUT:

125684935(MATK)

NMEL:

110389005(MATK)

APLA:

101804889(MATK)

ACYG:

106045705(MATK)

CATA:

118258998(MATK)

AFUL:

116499149(MATK)

TGU:	100229024(MATK)

LSR:	110469459(MATK)

SCAN:

103821887(MATK)

PMOA:

120496400(MATK)

OTC:	121345640(MATK)

PRUF:

121352381(MATK)

GFR:	102041133(MATK)

FAB:	101810082(MATK)

OMA:	130264377(MATK)

PHI:	102104122(MATK)

PMAJ:

107215625(MATK)

CCAE:

111940448(MATK)

CCW:	104696912(MATK)

CBRC:

103620928(MATK)

ETL:	114070575(MATK)

ZAB:	102061514(MATK)

ACHL:

103808582(MATK)

SVG:	106858029(MATK)

MMEA:

130579815(MATK)

HRT:	120763560(MATK)

FPG:	101915284(MATK)

FCH:	102050322(MATK)

CLV:	102096236(MATK)

EGZ:	104125057(MATK)

NNI:	104019613(MATK)

PCRI:

104029142(MATK)

PLET:

104618358(MATK)

EHS:	104503509(MATK)

ACUN:

113489419(MATK)

TALA:

116964231(MATK)

PADL:

103916071(MATK)

AFOR:

103897108(MATK)

ACHC:

115349122(MATK)

HALD:

104310497(MATK)

HLE:	104839799(MATK)

AGEN:

126042083

GCL:

127025539

CCRI:

104169451(MATK)

CSTI:

104551143(MATK)

MUI:	104543024(MATK)

BREG:

104629417(MATK)

FGA:	104075888(MATK)

LDI:	104347887(MATK)

MNB:	103782417(MATK)

OHA:	104333824(MATK)

NNT:	104408037(MATK)

SHAB:

115618242(MATK)

DPUB:

104308580(MATK)

PGUU:

104468795(MATK)

ACAR:

104522936(MATK)

CPEA:

104393884(MATK)

AVIT:

104271981(MATK)

CVF:	104282501(MATK)

RTD:	128900640(MATK)

CUCA:

104062079(MATK)

TEO:

104381872

BRHI:

104499005(MATK)

AAM:

106498527

AROW:

112967617(MATK)

NPD:	112952689(MATK)

TGT:	104574515(MATK)

DNE:	112986260(MATK)

SCAM:

104140867(MATK)

ASN:	102379038(MATK)

AMJ:	102564442(MATK)

CPOO:

109320491(MATK)

GGN:	109294786(MATK)

PSS:	102454008(MATK)

CMY:	102940228(MATK)

CCAY:

125627222(MATK)

DCC:	119848175(MATK)

CPIC:

101932738(MATK)

CABI:

116821437(MATK)

MRV:	120391921(MATK)

XLA:

121399356

XTR:	100494243(matk)

NPR:	108791656(MATK)

BBUF:

120990932(MATK)

MUO:	115480014(MATK)

GSH:	117366085(MATK)

DRE:	567405(matk)

SRX:	107742798(matk) 107753748

SANH:

107702632 107704492

SGH:	107549390 107566337 107580204

CCAR:

109054629 109089497

CAUA:

113039340 113039417

CGIB:

127987440

PTET:

122327367(matk)

LROH:

127153568(matk)

OMC:	131529818(matk)

PPRM:

120486370(matk)

MAMB:

125263334(matk)

CIDE:

127519998

MASI:

127438501 127438823

TROS:

130548307(matk)

TDW:	130429343(matk)

MANU:

129453899(matk)

IPU:

108271073

IFU:	128613834(matk)

PHYP:

113533928(matk)

SMEO:

124391586(matk)

TFD:	113651194(matk)

TVC:	132853927(matk)

AMEX:

103034670(matk)

CMAO:

118819470(matk)

EEE:

113577840

CHAR:

105900935(matk)

TRU:	101078640(matk)

TFS:	130528573(matk)

TNG:	GSTEN00028860G001

LCO:	104924618(matk)

NCC:	104955589(matk)

TBEN:

117495642(matk)

CGOB:

115007634(matk)

PGEO:

117446008(matk)

GACU:

117541128(matk)

EMAC:

134869497(matk)

ELY:	117254381(matk)

EFO:	125896297(matk)

PLEP:

121937803(matk)

SLUC:

116055436(matk)

ECRA:

117950711(matk)

ESP:	116695163(matk)

PFLV:

114561811(matk)

GAT:	120823815(matk)

PPUG:

119217198(matk)

AFB:	129095165(matk)

CLUM:

117729173(matk)

PSWI:

130191521(matk)

MSAM:

119900708(matk)

SCHU:

122877248(matk)

CUD:	121512118(matk)

ALAT:

119028241(matk)

MZE:	101468703(matk)

ONL:	100704856(matk)

OAU:	116323160(matk)

OLA:	101164299(matk)

OML:	112150400(matk)

CSAI:

133457802(matk)

XMA:	102227851(matk)

XCO:	114150842(matk)

XHE:	116725553(matk)

PRET:

103464090(matk)

PFOR:

103138498(matk)

PLAI:

106938522(matk)

PMEI:

106933775(matk)

GAF:	122838612(matk)

PPRL:

129372772(matk)

CVG:	107101117(matk)

CTUL:

119785792(matk)

GMU:	124874307(matk)

NFU:	107393128(matk)

KMR:	108230654(matk)

ALIM:

106511994(matk)

NWH:	119407826(matk)

AOCE:

111586687

MCEP:

125009103(matK)

CSEM:

103393395(matk)

POV:	109625480(matk)

SSEN:

122781225(matk)

HHIP:

117760410(matk)

HSP:	118121483(matk)

SMAU:

118318031(matk)

LCF:

108881351

SDU:	111216945(matk)

SLAL:

111650184(matk)

XGL:	120791346(matk)

HCQ:	109516896(matk)

SSCV:

125976086

PEE:	133406509(matk)

PTAO:

133480589(matk)

BPEC:

110160054(matk)

MALB:

109967443(matk)

BSPL:

114853304(matk)

SJO:	128361466(matk)

SASA:

106573821 106613678

STRU:

115151737 115158148

OTW:	112250783 112252186

OMY:

110524196

OGO:	123997154 123998748(matk)

ONE:	115108224 115109198

OKI:

109902424

OKE:	118388730 118400783

SALP:

111952898 111975841

SNH:	120053758(matk) 120054437

CCLU:

121533619 121576818

ELS:	105011456(matk)

SFM:	108919938(matk)

PKI:	111860139(matk)

AANG:

118224822(matk)

LOC:	102694775(matk)

PSPA:

121301133 121301479

ARUT:

117401440 117962949

PSEX:

120537638(matk)

LCM:	102345317(MATK)

CMK:	103188133(matk)

HOC:	132828811(matk)

LERI:

129710965(matk)

BFO:

BBEL:

SDM:

MMER:

Reference

PMID:8288563

Authors

Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H

Title

Identification and characterization of a novel tyrosine kinase from megakaryocytes.

Journal

J Biol Chem 269:1068-74 (1994)

Sequence

[hsa:4145]

LinkDB

DBGET integrated database retrieval system