KEGG ORTHOLOGY: K09027

ORTHOLOGY: K09027

Entry

K09027                      KO

Symbol

XBP1

Name

X box-binding protein 1

Pathway

map04141

Protein processing in endoplasmic reticulum

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05017

Spinocerebellar ataxia

map05022

Pathways of neurodegeneration - multiple diseases

map05417

Lipid and atherosclerosis

Disease

H01653

Bipolar disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09027  XBP1; X box-binding protein 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K09027  XBP1; X box-binding protein 1
   05012 Parkinson disease
    K09027  XBP1; X box-binding protein 1
   05014 Amyotrophic lateral sclerosis
    K09027  XBP1; X box-binding protein 1
   05017 Spinocerebellar ataxia
    K09027  XBP1; X box-binding protein 1
   05022 Pathways of neurodegeneration - multiple diseases
    K09027  XBP1; X box-binding protein 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K09027  XBP1; X box-binding protein 1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K09027  XBP1; X box-binding protein 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09027  XBP1; X box-binding protein 1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K09027  XBP1; X box-binding protein 1

Genes

HSA:	7494(XBP1)

PTR:	458735(XBP1)

PPS:	100975787(XBP1)

GGO:	101152414(XBP1)

PON:	100432230(XBP1)

NLE:	100593978(XBP1)

HMH:	116459428(XBP1)

MCC:	713863(XBP1)

MCF:	102122252(XBP1)

MTHB:

126963975

MNI:	105487280(XBP1)

CSAB:

103223125(XBP1)

CATY:

105575685(XBP1)

PANU:

101017284(XBP1)

TGE:	112632740(XBP1)

MLEU:

105550732(XBP1)

RRO:	104659033(XBP1)

RBB:	108517565(XBP1)

TFN:	117096137(XBP1)

PTEH:

111525377(XBP1)

CANG:

105506618(XBP1)

CJC:	100406291(XBP1)

SBQ:	101051328(XBP1)

CIMI:

108283240(XBP1)

CSYR:

103273582(XBP1)

MMUR:

105870895(XBP1)

LCAT:

123625801(XBP1)

PCOQ:

105810198(XBP1)

OGA:	100960586(XBP1)

MMU:	22433(Xbp1)

MCAL:

110305540(Xbp1)

MPAH:

110330475(Xbp1)

RNO:	289754(Xbp1)

MCOC:

116069833(Xbp1)

ANU:	117712939(Xbp1)

MUN:	110546119(Xbp1)

CGE:	100689062(Xbp1)

MAUA:

101823789(Xbp1) 101833227

PROB:

127233638(Xbp1)

PLEU:

114693991(Xbp1)

MORG:

121436588(Xbp1)

MFOT:

126500785

AAMP:

119811524(Xbp1)

NGI:	103734968(Xbp1)

HGL:	101714834 101723083(Xbp1)

CPOC:

100719734(Xbp1)

CCAN:

109690244(Xbp1)

DORD:

105984314(Xbp1)

DSP:	122097163(Xbp1)

PLOP:

125348985(Xbp1)

NCAR:

124991760

MMMA:

107154590(Xbp1)

OCU:	100339940 100357982

OPI:	101536694(XBP1)

TUP:	102502358(XBP1)

GVR:	103588209(XBP1)

CFA:	477532(XBP1)

CLUD:

112676769(XBP1)

VVP:	112906911(XBP1)

VLG:	121475808(XBP1)

NPO:	129508383(XBP1)

AML:	100471419(XBP1)

UMR:	103659239(XBP1)

UAH:	113245005(XBP1)

UAR:	123788139(XBP1)

ELK:

111160084

LLV:

125081642

MPUF:

101682738(XBP1)

MNP:	132023300(XBP1)

MLK:	131811244(XBP1)

NVS:	122896017 122903290(XBP1)

ORO:	101385284(XBP1)

EJU:	114225225(XBP1)

ZCA:	113913021(XBP1)

MLX:	118018617(XBP1)

NSU:	110592433(XBP1)

LWW:	102741207(XBP1)

FCA:	101092150(XBP1)

PYU:	121022649(XBP1)

PCOO:

112870154(XBP1)

PBG:	122470426(XBP1)

PVIV:

125149180(XBP1)

LRUF:

124518371

PTG:	102961098(XBP1)

PPAD:

109253547(XBP1)

PUC:

125914494

AJU:

106985439

HHV:	120227864(XBP1)

BTA:	541236(XBP1)

BOM:	102267259(XBP1)

BIU:	109571020(XBP1)

BBUB:

102404909 102408041(XBP1)

BBIS:

104980220(XBP1)

CHX:	102184460(XBP1)

OAS:	100037692(XBP1)

BTAX:

128062235(XBP1)

ODA:	120871478(XBP1)

CCAD:

122421504(XBP1)

MBEZ:

129542397(XBP1)

SSC:	100217386(XBP1)

CFR:	102510269(XBP1)

CBAI:

105066108(XBP1)

CDK:	105099473(XBP1)

VPC:	102534541(XBP1)

BMUS:

118906778(XBP1)

OOR:	101288279(XBP1)

DLE:	111162721(XBP1)

PCAD:

102985576(XBP1)

PSIU:

116738813(XBP1)

NASI:

112415136(XBP1)

ECB:	100059209(XBP1)

EPZ:	103554117(XBP1)

EAI:	106827572(XBP1)

MYB:	102252117(XBP1)

MYD:	102767486(XBP1)

MMYO:

118678214(XBP1)

MLF:	102424434(XBP1)

PKL:	118725347(XBP1)

EFUS:

103286875(XBP1)

MNA:	107526248(XBP1)

DRO:	112310648(XBP1)

SHON:

118991255(XBP1)

AJM:	119055161(XBP1)

PDIC:

114509452(XBP1)

PHAS:

123811000(XBP1)

MMF:	118640291(XBP1)

PPAM:

129087130(XBP1)

HAI:	109383072(XBP1)

RFQ:	117017386(XBP1)

PALE:

102882851(XBP1)

PGIG:

120601994(XBP1)

PVP:	105300938(XBP1)

RAY:	107520486(XBP1)

MJV:	108408450(XBP1)

TOD:	119244810(XBP1)

SARA:

101550010(XBP1)

SETR:

126030755(XBP1)

LAV:	100665921(XBP1)

TMU:

101354466

ETF:	101654999(XBP1)

DNM:	101422727(XBP1)

MDO:	100030619(XBP1)

GAS:	123232427(XBP1)

SHR:	100933113(XBP1)

AFZ:

127545638

PCW:	110215243(XBP1)

OAA:	100077370(XBP1)

GGA:	416918(XBP1)

PCOC:

116228509(XBP1)

MGP:	100543846(XBP1)

CJO:	107321230(XBP1)

TPAI:

128083882(XBP1)

LMUT:

125701812(XBP1)

NMEL:

110406519(XBP1)

APLA:

119718550(XBP1)

ACYG:

106043879(XBP1)

CATA:

118257557(XBP1)

AFUL:

116496335(XBP1)

TGU:	100225681(XBP1)

LSR:	110478215(XBP1)

SCAN:

103818106(XBP1)

PMOA:

120509708(XBP1)

OTC:	121338940(XBP1)

PRUF:

121364911(XBP1)

GFR:	102038226(XBP1)

FAB:	101810196(XBP1)

OMA:	130259823(XBP1)

PHI:	102111268(XBP1)

PMAJ:

107211677(XBP1)

CCAE:

111936480(XBP1)

CCW:	104688792(XBP1)

CBRC:

103616089(XBP1)

ETL:	114061527(XBP1)

ZAB:	102074476(XBP1)

ACHL:

103803140(XBP1)

SVG:	106852405(XBP1)

MMEA:

130579626(XBP1)

HRT:	120760615(XBP1)

FPG:	101915480(XBP1)

FCH:	102047579(XBP1)

CLV:	102095307(XBP1)

EGZ:	104122586(XBP1)

NNI:	104015778(XBP1)

PLET:

104627699(XBP1)

EHS:	104504931(XBP1)

PCAO:

104041709(XBP1)

ACUN:

113486258(XBP1)

TALA:

104357551(XBP1)

PADL:

103922653(XBP1)

AFOR:

103901866(XBP1)

ACHC:

115346212(XBP1)

HALD:

104316385(XBP1)

HLE:	104840810(XBP1)

AGEN:

126040683

GCL:

127023026

CCRI:

104156249(XBP1)

CSTI:

104558936(XBP1)

MUI:	104539924(XBP1)

FGA:	104071663(XBP1)

LDI:	104342891(XBP1)

SHAB:

115614790(XBP1)

DPUB:

104309058(XBP1)

ACAR:

104530200(XBP1)

CPEA:

104388062(XBP1)

CVF:	104289439(XBP1)

RTD:	128917246(XBP1)

CUCA:

104068491(XBP1)

TEO:	104381520(XBP1)

BRHI:

104494069(XBP1)

AAM:	106492738 106492739

AROW:

112968875(XBP1)

NPD:	112945164(XBP1)

TGT:	104566537(XBP1)

DNE:	112990124(XBP1)

SCAM:

104142408(XBP1)

ASN:	102380131(XBP1)

AMJ:	102575369(XBP1)

CPOO:

109312969(XBP1)

GGN:	109290638(XBP1)

PSS:	102462347(XBP1)

CMY:	102939054(XBP1)

CCAY:

125623032(XBP1)

DCC:	119843563(XBP1)

CPIC:

101954056(XBP1)

TST:	117888185(XBP1)

CABI:

116816394(XBP1)

MRV:	120386470(XBP1)

ACS:	103282887(xbp1)

ASAO:

132780927(XBP1)

PVT:	110083427(XBP1)

SUND:

121917955(XBP1)

PBI:	103065771(XBP1)

PMUR:

107287284(XBP1)

CTIG:

120316808(XBP1)

TSR:	106548512(XBP1)

PGUT:

117672317(XBP1)

APRI:

131185752(XBP1)

PTEX:

113448647(XBP1)

NSS:	113423948(XBP1)

VKO:	123021473(XBP1)

PMUA:

114586709(XBP1)

PRAF:

128403626(XBP1)

ZVI:	118076134(XBP1)

HCG:	128337766(XBP1)

GJA:	107123922(XBP1)

STOW:

125442524(XBP1)

XLA:	380215(xbp1.L)

XTR:	407858(xbp1)

NPR:	108800514(XBP1)

RTEM:

120932778(XBP1)

BBUF:

120988506(XBP1)

BGAR:

122924586(XBP1)

MUO:	115479710(XBP1)

GSH:	117365278(XBP1)

DRE:	140614(xbp1)

CGIB:

128013555

PTET:

122345744(xbp1)

LROH:

127165345(xbp1)

OMC:	131541727(xbp1)

PPRM:

120470303(xbp1)

RKG:	130099267(xbp1)

MAMB:

125267377(xbp1)

CIDE:

127512839

TROS:

130550508(xbp1)

TDW:	130420181(xbp1)

MANU:

129439769(xbp1)

IPU:

108255948

IFU:	128599137(xbp1)

PHYP:

113537021(xbp1)

SMEO:

124380878(xbp1)

TFD:	113653363(xbp1)

TVC:	132854593(xbp1)

AMEX:

103047551(xbp1)

CMAO:

118827137(xbp1)

EEE:	113583387(xbp1)

CHAR:

122131066(xbp1)

TRU:	654272(xbp1)

TFS:	130526145(xbp1)

TNG:	GSTEN00029066G001

LCO:	104920672(xbp1)

NCC:	104960857(xbp1)

TBEN:

117472674(xbp1)

CGOB:

115013203(xbp1)

PGEO:

117452730(xbp1)

GACU:

117552081(xbp1)

EMAC:

134873728(xbp1)

ELY:	117253006(xbp1)

EFO:	125890143(xbp1)

PLEP:

121944422(xbp1)

SLUC:

116054067(xbp1)

ECRA:

117945322(xbp1)

ESP:	116690292(xbp1)

PFLV:

114555329(xbp1)

GAT:	120830973(xbp1)

PPUG:

119225297(xbp1)

AFB:	129101131(xbp1)

CLUM:

117736609(xbp1)

PSWI:

130196482(xbp1)

MSAM:

119891735(xbp1) 119898408

SCHU:

122876514(xbp1)

CUD:	121510425(xbp1)

ALAT:

119019112(xbp1)

MZE:	101480626(xbp1)

ONL:	100695162(xbp1)

OAU:	116325834(xbp1)

OLA:	101157780(xbp1)

OML:	112148615(xbp1)

CSAI:

133451486(xbp1)

XMA:	102236159(xbp1)

XCO:	114154693(xbp1)

XHE:	116729908(xbp1)

PRET:

103469857(xbp1)

PFOR:

103134937(xbp1)

PLAI:

106939483(xbp1)

PMEI:

106908071(xbp1)

GAF:	122828669(xbp1)

PPRL:

129366202(xbp1)

CVG:	107091970(xbp1)

CTUL:

119788772(xbp1)

GMU:	124877146(xbp1)

NFU:	107386234(xbp1)

KMR:	108242736(xbp1)

ALIM:

106536617(xbp1)

NWH:	119413175(xbp1)

AOCE:

111581888(xbp1)

MCEP:

125012326(xbp1)

CSEM:

103397862

SSEN:

122770173(xbp1)

HHIP:

117767786(xbp1)

HSP:	118114900(xbp1)

SMAU:

118313521(xbp1)

LCF:

108901516

SDU:	111227347(xbp1)

SLAL:

111663093(xbp1)

XGL:	120805826(xbp1)

HCQ:	109513466(xbp1)

SSCV:

125994117

SBIA:

133499760(xbp1)

PEE:	133400198(xbp1)

PTAO:

133475795(xbp1)

BPEC:

110172081(xbp1)

MALB:

109973998(xbp1)

BSPL:

114862839(xbp1)

SJO:	128364125(xbp1)

SASA:

100846957(xbp1)

OTW:	112248872(xbp1)

OMY:	110526029(xbp1)

OKE:	118393544(xbp1)

SALP:

111973651 111974231

SNH:	120043919(xbp1)

CCLU:

121584626(xbp1)

ELS:	105014054(xbp1)

SFM:

108925673

PKI:

111849892

AANG:

118206891(xbp1)

LOC:	102698044(xbp1)

PSPA:

121297317

ARUT:

117426296 117427761

PSEX:

120540568(xbp1)

LCM:	102351750(XBP1)

CMK:	103182222(xbp1)

CPLA:

122562756(xbp1)

HOC:	132827167(xbp1)

LERI:

129709297(xbp1)

PMRN:

116936854 116939140

LRJ:	133348448(XBP1)

BFO:

118425763

BBEL:

109465328

CIN:	778793(xbpa)

SCLV:

SPU:

LPIC:

APLC:

SKO:

DME:	Dmel_CG9415(Xbp1)

DER:

6547724

DSE:

6615310

DSI:	Dsimw501_GD11567(Dsim_GD11567)

DYA:	Dyak_GE12171

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20807

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ005730

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200164

BANY:

NIQ:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

CLEC:

HHAL:

HVI:

MQU:

PHU:	Phum_PHUM437880

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_314438

PCHN:

PMOO:

HAME:

PTRU:

ESN:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DFR:

CSCU:

ABRU:

UDV:

SDM:

LPOL:

106471711 106478215 106478265

PMEO:

129596100

CEL:	CELE_R74.3(xbp-1)

CBR:	CBG_20165(Cbr-xbp-1)

CRQ:	GCK72_008914

NAI:	NECAME_10616

LOA:	LOAG_10234

HRO:	HELRODRAFT_193172

LGI:	LOTGIDRAFT_232105

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106156947 106156951

SMM:	Smp_044770

SHX:	MS3_00010817(XBP1)

OVI:	T265_08225

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130654449 130656565

TAD:	TRIADDRAFT_64159

AQU:

100636782

» show all

Reference

PMID:11779464

Authors

Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K

Title

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

Journal

Cell 107:881-91 (2001)
DOI:10.1016/S0092-8674(01)00611-0

Sequence

[hsa:7494]

Reference

PMID:2321018

Authors

Liou HC, Boothby MR, Finn PW, Davidon R, Nabavi N, Zeleznik-Le NJ, Ting JP, Glimcher LH

Title

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.

Journal

Science 247:1581-4 (1990)
DOI:10.1126/science.2321018

LinkDB

DBGET integrated database retrieval system