KEGG ORTHOLOGY: K09633

ORTHOLOGY: K09633

Entry

K09633                      KO

Symbol

TMPRSS2

Name

transmembrane protease serine 2 [EC:3.4.21.122]

Pathway

map05164

Influenza A

map05171

Coronavirus disease - COVID-19

map05202

Transcriptional misregulation in cancer

map05215

Prostate cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09633  TMPRSS2; transmembrane protease serine 2
  09162 Cancer: specific types
   05215 Prostate cancer
    K09633  TMPRSS2; transmembrane protease serine 2
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K09633  TMPRSS2; transmembrane protease serine 2
   05164 Influenza A
    K09633  TMPRSS2; transmembrane protease serine 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09633  TMPRSS2; transmembrane protease serine 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.122  transmembrane protease serine 2
     K09633  TMPRSS2; transmembrane protease serine 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K09633  TMPRSS2; transmembrane protease serine 2

Genes

HSA:	7113(TMPRSS2)

PTR:	474007(TMPRSS2)

PPS:	100988626(TMPRSS2)

GGO:	101134135(TMPRSS2)

PON:	100446360(TMPRSS2)

PPYG:

129022654(TMPRSS2)

NLE:	100597416(TMPRSS2)

HMH:	116481528(TMPRSS2)

SSYN:

129483012(TMPRSS2)

MCC:	715138(TMPRSS2)

MCF:	102137447(TMPRSS2)

MTHB:

126950687

MNI:	105472601(TMPRSS2)

CSAB:

103219191(TMPRSS2)

CATY:

105575473(TMPRSS2)

PANU:

101020163(TMPRSS2)

TGE:	112621363(TMPRSS2)

MLEU:

105542593(TMPRSS2)

RRO:	104655126(TMPRSS2)

RBB:	108534725(TMPRSS2)

TFN:	117095813(TMPRSS2)

PTEH:

111526259(TMPRSS2)

CANG:

105520467(TMPRSS2)

CJC:	100407530(TMPRSS2)

SBQ:	101041327(TMPRSS2)

CIMI:

108311235(TMPRSS2)

ANAN:

105713366(TMPRSS2)

CSYR:

103271090(TMPRSS2)

MMUR:

105863085(TMPRSS2)

LCAT:

123630756(TMPRSS2)

ERUF:

138386075(TMPRSS2)

PCOQ:

105806852(TMPRSS2)

OGA:	100961777(TMPRSS2)

MMU:	50528(Tmprss2)

MCAL:

110311360(Tmprss2)

MPAH:

110329806(Tmprss2)

RNO:	156435(Tmprss2)

MCOC:

116086635(Tmprss2)

ANU:	117717665(Tmprss2)

ASYL:

127665871(Tmprss2)

MUN:	110563683(Tmprss2)

CGE:	100764056(Tmprss2)

MAUA:

101843596(Tmprss2)

PLEU:

114685664(Tmprss2)

PMAV:

102926607(Tmprss2)

MORG:

121461865(Tmprss2)

MFOT:

126513582

AAMP:

119824625(Tmprss2)

CNL:	130871546(Tmprss2)

NGI:	103729360(Tmprss2)

HGL:	101715175(Tmprss2)

CPOC:

100731531 100732077(Tmprss2)

CCAN:

109697919(Tmprss2)

DORD:

105993941(Tmprss2)

DSP:	122114297(Tmprss2)

DMER:

138832553(Tmprss2)

PLOP:

125345003 125351440(Tmprss2)

NCAR:

124992941

MMMA:

107136495(Tmprss2)

ITI:	101978577(Tmprss2)

OCU:	100337870(TMPRSS2)

OPI:	101519149(TMPRSS2)

OCZ:	121160638(TMPRSS2)

TUP:	102498265(TMPRSS2)

GVR:	103589282(TMPRSS2)

CFA:	487770(TMPRSS2)

CLUD:

112669156(TMPRSS2)

VVP:	112908022(TMPRSS2)

VLG:	121479456(TMPRSS2)

NPO:	129502198(TMPRSS2)

AML:	100477592(TMPRSS2)

UMR:	103680722(TMPRSS2)

UAH:	113256199(TMPRSS2)

UAR:	123802639(TMPRSS2)

ELK:

111155673

LLV:

125094004

MPUF:

101671765(TMPRSS2)

MNP:	132012416(TMPRSS2)

MLK:	131825395(TMPRSS2)

NVS:	122908278(TMPRSS2)

ORO:	101367564(TMPRSS2)

EJU:	114226418(TMPRSS2)

ZCA:	113918915(TMPRSS2)

MLX:	118026128(TMPRSS2)

NSU:	110571090(TMPRSS2)

LWW:

102731356

FCA:	101096004(TMPRSS2)

PYU:	121035917(TMPRSS2)

PCOO:

112849461(TMPRSS2)

PBG:	122491150(TMPRSS2)

PVIV:

125159128 125175000(TMPRSS2)

LRUF:

124527323

LGF:	123610550(TMPRSS2)

AJU:

106965628

PTG:	102956698(TMPRSS2)

PPAD:

109249809(TMPRSS2)

PUC:

125920702

PLEZ:

122230313(TMPRSS2)

HHV:	120229673(TMPRSS2)

BTA:	511037(TMPRSS2)

BOM:	102273890(TMPRSS2)

BIU:	109560553(TMPRSS2)

BBUB:

102409077(TMPRSS2)

BKE:	129644542(TMPRSS2)

BBIS:

104984961(TMPRSS2)

CHX:	102180351(TMPRSS2)

OAS:	101120216(TMPRSS2)

BTAX:

128053222(TMPRSS2)

CSUM:

138079786(TMPRSS2)

ODA:	120856770(TMPRSS2)

CCAD:

122445361(TMPRSS2)

MREE:

136173573(TMPRSS2)

OVR:	110146872(TMPRSS2)

MBEZ:

129547995(TMPRSS2)

SSC:	100739292(TMPRSS2)

CFR:	102508793(TMPRSS2)

CDK:	105101649(TMPRSS2)

VPC:	102536092(TMPRSS2)

BACU:

103001791(TMPRSS2)

BMUS:

118894571(TMPRSS2)

LVE:	103087272(TMPRSS2)

OOR:	101283194(TMPRSS2)

LALB:

132520733(TMPRSS2)

GMF:	115841461(TMPRSS2)

DDP:	132423938(TMPRSS2)

DLE:	111163868(TMPRSS2)

PCAD:

102982385(TMPRSS2)

PSIU:

116753557(TMPRSS2)

PPHC:

136122290(TMPRSS2)

NASI:

112408620(TMPRSS2)

ECB:	100058498(TMPRSS2)

EPZ:	103563030(TMPRSS2)

EAI:	106829941(TMPRSS2)

MYB:	102243544(TMPRSS2)

MYD:	102759817(TMPRSS2)

MMYO:

118676444(TMPRSS2)

MDT:	132229896(TMPRSS2)

MYUM:

139004274(TMPRSS2)

PKL:	118723981(TMPRSS2)

EFUS:

103289898(TMPRSS2)

MNA:	107543421(TMPRSS2)

DRO:	112306012(TMPRSS2)

SHON:

118984844(TMPRSS2)

AJM:	119048819(TMPRSS2)

PDIC:

114490622(TMPRSS2)

PHAS:

123827961(TMPRSS2)

MMF:	118617278(TMPRSS2)

PPAM:

129074669(TMPRSS2)

HAI:	109372657(TMPRSS2)

RFQ:	117012482(TMPRSS2)

PALE:

102884423(TMPRSS2)

PGIG:

120598749(TMPRSS2)

PVP:	105300585(TMPRSS2)

RAY:	107504925(TMPRSS2)

MJV:	108392412(TMPRSS2)

TOD:	119256719(TMPRSS2)

SARA:

101547383(TMPRSS2)

SFUM:

130028723(TMPRSS2)

SETR:

126025901(TMPRSS2)

LAV:	100655298(TMPRSS2)

TMU:

101349908

ETF:	101649024(TMPRSS2)

DNM:	101419831(TMPRSS2)

MDO:	100016391(TMPRSS2)

GAS:	123242510(TMPRSS2)

SHR:	100918800(TMPRSS2)

AFZ:

127553774

PCW:	110200872(TMPRSS2)

TVP:	118837220(TMPRSS2)

PBRV:

138151414(TMPRSS2)

MLAO:

141506771(TMPRSS2)

OAA:	100080302(TMPRSS2)

TACU:

119940372(TMPRSS2)

GGA:	418528(TMPRSS2)

PCOC:

116241984(TMPRSS2)

MGP:	100548271(TMPRSS2)

CJO:	107323622(TMPRSS2)

TPAI:

128076383(TMPRSS2)

LMUT:

125702987(TMPRSS2)

NMEL:

110403130(TMPRSS2)

APLA:

101793783(TMPRSS2)

AACU:

137857700(TMPRSS2)

ACYG:

106036133(TMPRSS2)

CATA:

118247795(TMPRSS2)

AFUL:

116499862(TMPRSS2)

TGU:	100230865(TMPRSS2)

LSR:	110475860(TMPRSS2)

SCAN:

103815879(TMPRSS2)

PMOA:

120511893(TMPRSS2)

OTC:	121333421(TMPRSS2)

PRUF:

121364476(TMPRSS2)

ATRC:

139591524(TMPRSS2)

GFR:	102038516(TMPRSS2)

FAB:	101814974(TMPRSS2)

OMA:	130250832(TMPRSS2)

PHI:	102107430(TMPRSS2)

PMAJ:

107207522(TMPRSS2)

CCAE:

111927465(TMPRSS2)

CCW:	104686273(TMPRSS2)

CBRC:

103612879(TMPRSS2)

ACOE:

138111083(TMPRSS2)

ETL:	114059207(TMPRSS2)

ZAB:	102074720(TMPRSS2)

ZLE:	135442378(TMPRSS2)

ACHL:

103802759(TMPRSS2)

SVG:	106855753(TMPRSS2)

MMEA:

130578116(TMPRSS2)

HRT:	120765733(TMPRSS2)

SATI:

136358204(TMPRSS2)

CCIC:

134057936(TMPRSS2)

FPG:	101919117(TMPRSS2)

FCH:	102050625(TMPRSS2)

CCRI:

104166215(TMPRSS2)

NNT:	104411463(TMPRSS2)

SHAB:

115604218(TMPRSS2)

ACUN:

113478930(TMPRSS2)

SURA:

141939173(TMPRSS2)

TALA:

104358248(TMPRSS2)

ACHC:

115343872(TMPRSS2)

HALD:

104324965(TMPRSS2)

HLE:	104839795(TMPRSS2)

AGEN:

126053106

HHAR:

128145199(TMPRSS2)

BBUT:

142034005(TMPRSS2)

GCL:

127019564

CSTI:

104550976(TMPRSS2)

LDI:	104353156(TMPRSS2)

MNB:	103773993(TMPRSS2)

DPUB:

104305045(TMPRSS2)

PPUS:

135180206(TMPRSS2)

AVIT:

104281341(TMPRSS2)

BRHI:

104498694(TMPRSS2)

EGZ:	104128256(TMPRSS2)

NNI:	104020153(TMPRSS2)

PCRI:

104025189(TMPRSS2)

PCAO:

104044730(TMPRSS2)

PARX:

142060017(TMPRSS2)

PADL:

103920338(TMPRSS2)

AFOR:

103902091(TMPRSS2)

FGA:	104080880(TMPRSS2)

CBOR:

142074870(TMPRSS2)

GSTE:

104255339(TMPRSS2)

CBOY:

140648103(TMPRSS2)

MAME:

142406311(TMPRSS2)

CLV:	102088037(TMPRSS2)

CNIC:

135991846(TMPRSS2)

MUI:	104539623(TMPRSS2)

PGUU:

104470895(TMPRSS2)

PLET:

104623472(TMPRSS2)

EHS:	104515554(TMPRSS2)

CMAC:

104485234(TMPRSS2)

CUCA:

104059268(TMPRSS2)

TEO:	104380639(TMPRSS2)

BREG:

104643188(TMPRSS2)

GAME:

129207503(TMPRSS2)

OHA:	104327752(TMPRSS2)

ACAR:

104520352

CPEA:

104391216(TMPRSS2)

CVF:	104292052(TMPRSS2)

RTD:	128917784(TMPRSS2)

CRID:

134520166(TMPRSS2)

LMIC:

141749227(TMPRSS2)

AAM:	106494987(TMPRSS2)

AROW:

112971896(TMPRSS2)

NPD:	112959091(TMPRSS2)

TGT:	104565410(TMPRSS2)

DNE:	112996188(TMPRSS2)

SCAM:

104147101(TMPRSS2)

ASN:	102384629(TMPRSS2)

AMJ:	102567247(TMPRSS2)

CPOO:

109305837(TMPRSS2)

GGN:	109302865(TMPRSS2)

PSS:	102447604(TMPRSS2)

CIZ:	142013882(TMPRSS2)

CMY:	102941795(TMPRSS2)

CCAY:

125643446(TMPRSS2)

LKP:	140917391(TMPRSS2)

NDS:	141997313(TMPRSS2)

DCC:	119849988(TMPRSS2)

CPIC:

101943518(TMPRSS2)

TST:	117867839(TMPRSS2)

CABI:

116821857(TMPRSS2)

MRV:	120395666(TMPRSS2)

ACS:	100552320(tmprss2)

ASAO:

132771834(TMPRSS2)

PVT:	110076845(TMPRSS2)

SUND:

121926363(TMPRSS2)

PBI:	103068198(TMPRSS2)

PMUR:

107288318(TMPRSS2)

CTIG:

120319888(TMPRSS2)

TSR:	106548951(TMPRSS2)

PGUT:

117669392(TMPRSS2)

PCAE:

139316661(TMPRSS2)

APRI:

131199708(TMPRSS2)

PTEX:

113444780(TMPRSS2)

NSS:	113416237(TMPRSS2)

VKO:	123029313(TMPRSS2)

PMUA:

114596105(TMPRSS2)

PRAF:

128413037(TMPRSS2)

ZVI:	118085620(TMPRSS2)

HCG:	128348750(TMPRSS2)

GJA:	107112599(TMPRSS2)

STOW:

125432035(TMPRSS2)

EMC:	129326629(TMPRSS2)

XLA:

108707404(tmprss2.8.L) 108707405(tmprss2.9.L) 108707406(tmprss2.10.L) 108707407(tmprss2.11.L) 108707408(tmprss2.12.L) 108707409(tmprss2.13.L) 108707410(tmprss2.14.L) 108707411(tmprss2.15.L) 108707852(tmprss2.1.L) 108707853(tmprss2.4.L) 108709250(tmprss2.13.S) 108709251(tmprss2.14.S) 108709252(tmprss2.1.S) 397830(tmprss2.3.L) 495248(tmprss2.2.L)

XTR:	100380113(tmprss2.13) 100493729(tmprss2.2) 100494702(tmprss2.6) 100494862(tmprss2.5) 100497514(tmprss2.12) 101731505(tmprss2.14) 101731564(tmprss2.7) 101731874(tmprss2.1) 101732176 101732233(tmprss2.15) 105946686(tmprss2.4) 116408581 116408747

NPR:	108787799(TMPRSS2)

RTEM:

120927977(TMPRSS2)

ACAT:

141129305(TMPRSS2)

PADS:

140321589(TMPRSS2)

BBUF:

120994462(TMPRSS2)

DTC:	141091549(TMPRSS2)

PWL:	138248735(TMPRSS2)

MUO:	115470560(TMPRSS2)

GSH:	117359513(TMPRSS2)

DRE:	494080(tmprss2)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122331853(tmprss2)

LROH:

127172318(tmprss2)

GRF:	141299612(tmprss2)

OMC:	131548440(tmprss2)

PPRM:

120483230(tmprss2)

RKG:	130078741(tmprss2)

MAMB:

125262267(tmprss2) 125262699

CIDE:

127521212

CERY:

137028605(tmprss2)

MASI:

127432997 127433616

TROS:

130546206(tmprss2)

TDW:	130412186(tmprss2)

MANU:

129446664(tmprss2)

PDAB:

135743333(tmprss2)

IPU:

108277289

IFU:	128620616(tmprss2)

PHYP:

113544914(tmprss2)

SMEO:

124393362(tmprss2)

TFD:	113650208(tmprss2)

TVC:	132863763(tmprss2)

CGAR:

128545472(tmprss2)

NGRA:

132873852(tmprss2)

TRN:	134332735 134332907

AMEX:

103040418(tmprss2)

CMAO:

118824424(tmprss2)

EEE:	113580720(tmprss2)

CHAR:

116221864

TRU:

115251401

TFS:

130535303

TNG:	GSTEN00005389G001

LCO:	104921149 104930322

NCC:

104945273

TBEN:

117470076 117499972(tmprss2)

CGOB:

115018083 115019120(tmprss2)

PGEO:

117457608 117458162(tmprss2)

GACU:

117551667 117553068(tmprss2)

EMAC:

134871598(tmprss2) 134880381

ELY:

117260112

EFO:	125888886(tmprss2)

PLEP:

121943260 121952833(tmprss2)

SLUC:

116043869 116058173(tmprss2)

ECRA:

117942610 117955246(tmprss2)

ESP:	116672029 116701057(tmprss2)

PFLV:

114552896 114566986

GAT:	120823102(tmprss2) 120825556

PPUG:

119194453 119206982 134102885

AFB:	129091838 129113494(tmprss2)

CLUM:

117741810 117742694(tmprss2)

PSWI:

130191930 130210662

CANA:

137790926 137802660(tmprss2)

CVE:	137870913 137880220(tmprss2)

MSAM:

119895203(tmprss2)

SCHU:

122888380(tmprss2)

EARM:

139285493 139295309(tmprss2)

CUD:	121519012(tmprss2) 121523647

SPUL:

138597446 138604115(tmprss2)

LMIX:

132988515(tmprss2)

HTC:	141791828(tmprss2)

ALAT:

119009941 119031231(tmprss2)

ASTR:

137597094 137606065

PKLU:

139200171 139212943(tmprss2)

MZE:	101479644(tmprss2)

ONL:	100711940(tmprss2) 102076746

OAU:	116330343 116332805(tmprss2)

CSAI:

133459876(tmprss2)

XMA:	102221663(tmprss2)

XCO:

114153509

XHE:

116728835

PRET:

103474389 103476140

PFOR:

103129777(tmprss2)

PLAI:

106951586

PMEI:

106926289 106928683

GAF:	122844745(tmprss2)

PPRL:

129370607(tmprss2)

CVG:	107091376(tmprss2) 107096910

CTUL:

119783852 119788085(tmprss2)

GMU:	124875908(tmprss2)

KMR:	108238135 108247973(tmprss2)

ALIM:

106526502

AOCE:

111583614(tmprss2)

EJA:	138196739(tmprss2) 138197504

BFRE:

138616426 138631613(tmprss2)

MCEP:

125020746(tmprss2)

CSEM:

103377611 103394805(tmprss2)

POV:	109628452(tmprss2) 109634589

SSEN:

122773490 122780185(tmprss2)

SSOE:

131457904(tmprss2) 131462896

HHIP:

117772962 117774363(tmprss2)

HSP:	118105671 118121759(tmprss2)

PPLT:

128439821 128457302(tmprss2)

SMAU:

118299434 118300892(tmprss2)

LCF:	108873777 108894067

SDU:	111222351 111239098

SLAL:

111654567 111663516(tmprss2)

XGL:	120792431 120802388(tmprss2)

HCQ:	109512910 109531175(tmprss2)

SSCV:

125971839 125982682(tmprss2)

SBIA:

133491802(tmprss2) 133504383

PEE:	133405345 133415932(tmprss2)

PTAO:

133467503(tmprss2) 133482295

BPEC:

110169068(tmprss2) 110171889

ENY:	140361120(tmprss2) 140372440

MALB:

109960302 109972884(tmprss2)

BSPL:

114869182(tmprss2)

SJO:	128359830 128371549(tmprss2)

SSCO:

133981029 133994455(tmprss2)

GMH:	115547819 115547820 115561197

SASA:

100195190(tmps2) 106567922(tmprss2)

STRU:

115148918 115154377

OTW:	112228111 112257807

OMY:	110533685(tmprss2) 110537436

OGO:	123998726 124010147(tmprss2) 124028739

ONE:	115105583 115135870

OKI:	109873214 109892116

OKE:	118390120(tmprss2) 118391193

OMM:	135548551 135549198

OCLA:

139419505 139421996

SALP:

111950691

SNH:	120045170 120056522(tmprss2)

SFON:

129817391 129868256

CCLU:

121573596 121578951

ELS:

105030491

OEP:	134029099 134039168(tmprss2)

SFM:	108921358 108932299

PKI:	111844860(tmprss2) 111860770

AANG:

118210127 118235057(tmprss2)

AROT:

135236756 135262759(tmprss2)

CCOG:

133108177(tmprss2)

LOC:	102686194(tmprss2)

PSPA:

121302680(tmprss2)

ARUT:

117407223 117962474

PSEX:

120523297(tmprss2)

LCM:	102364869(TMPRSS2)

CPLA:

CPUN:

SCAU:

LERI:

SCLV:

SPU:

LPIC:

129265717 129272892 129273487

LVG:	121418749 121420324 121421914

AJJ:

PFLL:

AFUN:

BCOO:

PPYR:

SLIU:

OFU:

CSEC:

PVM:	113810655 138863049

PCHN:

125028909

MRJ:

136834063

EAF:

111714608

LSM:	121120075 121130670

RMP:

119170643

VDE:	111253418 111254444

VJA:	111265169 111272259 111272501

GOE:

100902892

UDV:	129220867 129221515 129223971

PMEO:

PVUL:

PCAN:

LSAX:

HRJ:

OED:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

MAEA:

XEN:

Reference

PMID:9325052

Authors

Paoloni-Giacobino A, Chen H, Peitsch MC, Rossier C, Antonarakis SE

Title

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.

Journal

Genomics 44:309-20 (1997)
DOI:10.1006/geno.1997.4845

Sequence

[hsa:7113]

Reference

PMID:18781147

Authors

Narod SA, Seth A, Nam R

Title

Fusion in the ETS gene family and prostate cancer.

Journal

Br J Cancer 99:847-51 (2008)
DOI:10.1038/sj.bjc.6604558

LinkDB

DBGET integrated database retrieval system