Entry
Symbol
TER, TSC13, CER10
Name
very-long-chain enoyl-CoA reductase [EC:
1.3.1.93 ]
Pathway
map01040 Biosynthesis of unsaturated fatty acids
map01110 Biosynthesis of secondary metabolites
Module
M00415 Fatty acid elongation in endoplasmic reticulum
Reaction
R07761 octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
R09449 very-long-chain acyl-CoA:NADP+ oxidoreductase
R10828 very-long-chain acyl-CoA:NADP+ oxidoreductase
Disease
H00768 Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09103 Lipid metabolism
00062 Fatty acid elongation
K10258 TER, TSC13, CER10; very-long-chain enoyl-CoA reductase
01040 Biosynthesis of unsaturated fatty acids
K10258 TER, TSC13, CER10; very-long-chain enoyl-CoA reductase
09180 Brite Hierarchies
09181 Protein families: metabolism
01004 Lipid biosynthesis proteins
K10258 TER, TSC13, CER10; very-long-chain enoyl-CoA reductase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.93 very-long-chain enoyl-CoA reductase
K10258 TER, TSC13, CER10; very-long-chain enoyl-CoA reductase
Lipid biosynthesis proteins [BR:ko01004 ]
Fatty acid synthase
Component type
K10258 TER, TSC13, CER10; very-long-chain enoyl-CoA reductase
BRITE hierarchy
Genes
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Taxonomy UniProt
Reference
Authors
Kohlwein SD, Eder S, Oh CS, Martin CE, Gable K, Bacikova D, Dunn T
Title
Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae.
Journal
Sequence
Reference
Authors
Gable K, Garton S, Napier JA, Dunn TM
Title
Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system.
Journal
Sequence
Reference
Authors
Moon YA, Horton JD.
Title
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.
Journal
Sequence
LinkDB
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