KEGG ORTHOLOGY: K10409

ORTHOLOGY: K10409

Entry

K10409                      KO

Symbol

DNAI1

Name

dynein axonemal intermediate chain 1

Pathway

map04814

Motor proteins

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00564

Primary ciliary dyskinesia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    K10409  DNAI1; dynein axonemal intermediate chain 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K10409  DNAI1; dynein axonemal intermediate chain 1
   05016 Huntington disease
    K10409  DNAI1; dynein axonemal intermediate chain 1
   05022 Pathways of neurodegeneration - multiple diseases
    K10409  DNAI1; dynein axonemal intermediate chain 1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K10409  DNAI1; dynein axonemal intermediate chain 1
   04812 Cytoskeleton proteins
    K10409  DNAI1; dynein axonemal intermediate chain 1
Cilium and associated proteins [BR:ko03037]
Motile cilia and associated proteins
  Dynein arm
   K10409  DNAI1; dynein axonemal intermediate chain 1
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     K10409  DNAI1; dynein axonemal intermediate chain 1

Genes

HSA:	27019(DNAI1)

PTR:	465060(DNAI1)

PPS:	100972569(DNAI1)

GGO:	101153747(DNAI1)

PON:	100456621(DNAI1)

NLE:	100583045(DNAI1)

HMH:	116475381(DNAI1)

MCC:	701307(DNAI1)

MCF:	102142147(DNAI1)

MTHB:

126937387

MNI:	105485688(DNAI1)

CSAB:

103219265(DNAI1)

CATY:

105590058(DNAI1)

PANU:

101007991(DNAI1)

TGE:	112607941(DNAI1)

MLEU:

105539669(DNAI1)

RRO:	104680004(DNAI1)

RBB:	108542180(DNAI1)

TFN:	117099047(DNAI1)

PTEH:

111536841(DNAI1)

CANG:

105517820(DNAI1)

CJC:	100393712(DNAI1)

SBQ:	101040116(DNAI1)

CIMI:

108314195(DNAI1)

CSYR:

103273431(DNAI1)

MMUR:

105874348(DNAI1)

LCAT:

123646197(DNAI1)

PCOQ:

105819705(DNAI1)

OGA:	100958127(DNAI1)

MMU:	68922(Dnai1)

MCAL:

110292390(Dnai1)

MPAH:

110338758(Dnai1)

RNO:	500442(Dnai1)

MCOC:

116095842(Dnai1)

ANU:	117708621(Dnai1)

MUN:	110547115(Dnai1)

CGE:	100754021(Dnai1)

MAUA:

101836467(Dnai1)

PROB:

127224538(Dnai1)

PLEU:

114703235(Dnai1)

MORG:

121458437(Dnai1)

MFOT:

126509909

AAMP:

119826060(Dnai1)

NGI:	103741572(Dnai1)

HGL:	101703186(Dnai1)

CPOC:

100722355(Dnai1)

CCAN:

109681896(Dnai1)

DORD:

105993333(Dnai1)

DSP:	122123974(Dnai1)

PLOP:

125355993(Dnai1)

NCAR:

124964088

MMMA:

107147649(Dnai1)

OCU:

100349624

OPI:	101525254(DNAI1)

TUP:	102490260(DNAI1)

GVR:	103606452(DNAI1)

CFA:	474749(DNAI1)

CLUD:

112649679(DNAI1)

VVP:	112927537(DNAI1)

VLG:	121496196(DNAI1)

NPO:	129494571(DNAI1)

AML:	100480789(DNAI1)

UMR:	103667109(DNAI1)

UAH:	113260653(DNAI1)

UAR:	123781205(DNAI1)

ELK:

111145979

LLV:	125082978 125083962

MPUF:

101679241(DNAI1)

MNP:	132024650(DNAI1)

MLK:	131812422(DNAI1)

NVS:	122916913(DNAI1)

ORO:	101369360(DNAI1)

EJU:	114218180(DNAI1)

ZCA:	113934787(DNAI1)

MLX:	118018151(DNAI1)

NSU:	110581741(DNAI1)

LWW:

102747374

FCA:	101083042(DNAI1)

PYU:	121034593(DNAI1)

PCOO:

112855026(DNAI1)

PBG:	122475088(DNAI1)

PVIV:

125150257(DNAI1)

LRUF:

124525942

PTG:	102966898(DNAI1)

PPAD:

109252020(DNAI1)

PUC:

125918965

AJU:

106975826

HHV:	120241756(DNAI1)

BTA:	524709(DNAI1)

BOM:	102275642(DNAI1)

BIU:	109563189(DNAI1)

BBUB:

102398598(DNAI1)

BBIS:

104988692(DNAI1)

CHX:	102170421(DNAI1)

OAS:	101122250(DNAI1)

BTAX:

128052653(DNAI1)

ODA:	120860305 120866428

CCAD:

122432044(DNAI1)

MBEZ:

129557367(DNAI1)

SSC:	100625977(DNAI1)

CFR:	102521975(DNAI1)

CBAI:

105078851(DNAI1)

CDK:	105085591(DNAI1)

VPC:	102545874(DNAI1)

BACU:

103018106(DNAI1)

BMUS:

118896317(DNAI1)

LVE:	103077438(DNAI1)

OOR:	101269561(DNAI1)

DLE:	111163109(DNAI1)

PCAD:

102986780(DNAI1)

PSIU:

116755482(DNAI1)

NASI:

112405438(DNAI1)

ECB:	100068649(DNAI1)

EPZ:	103564362(DNAI1)

EAI:	106841398(DNAI1)

MYB:	102257657(DNAI1)

MYD:	102775219(DNAI1)

MMYO:

118667712(DNAI1)

MLF:	102426736(DNAI1)

PKL:	118716390(DNAI1)

EFUS:

103286465(DNAI1)

MNA:	107544881(DNAI1)

DRO:	112304534(DNAI1)

SHON:

118979797(DNAI1)

AJM:	119053855(DNAI1)

PDIC:

114497528(DNAI1)

PHAS:

123820111(DNAI1)

MMF:	118629755(DNAI1)

PPAM:

129078474(DNAI1)

HAI:	109371754(DNAI1)

RFQ:	117031770(DNAI1)

PALE:

102894839(DNAI1)

PGIG:

120612964(DNAI1)

PVP:	105306431(DNAI1)

RAY:	107502815(DNAI1)

MJV:	108395469(DNAI1)

TOD:	119231318(DNAI1)

SARA:

101538143(DNAI1)

SETR:

126005601(DNAI1)

LAV:	100674508(DNAI1)

TMU:

101360738

ETF:	101641029(DNAI1)

DNM:	101430916(DNAI1)

MDO:	100028940(DNAI1)

GAS:	123249127(DNAI1)

SHR:	100913750(DNAI1)

AFZ:

127540912

PCW:	110194544(DNAI1)

OAA:	100084774(DNAI1)

GGA:	431654(DNAI1)

PCOC:

116239234(DNAI1)

CJO:	107305769(DNAI1)

TPAI:

128074351(DNAI1)

LMUT:

125686617(DNAI1)

NMEL:

110389290(DNAI1)

APLA:

101803329(DNAI1)

ACYG:

106045168(DNAI1)

CATA:

118257683(DNAI1)

AFUL:

116500478(DNAI1)

TGU:	100223289(DNAI1)

LSR:	110484185(DNAI1)

SCAN:

108962796(DNAI1)

PMOA:

120500084(DNAI1)

OTC:	121345289(DNAI1)

PRUF:

121350473(DNAI1)

GFR:	102037629(DNAI1)

FAB:	101812005(DNAI1)

OMA:	130264660(DNAI1)

PHI:	102111661(DNAI1)

PMAJ:

107198360(DNAI1)

CCAE:

111941117(DNAI1)

CCW:	104686730(DNAI1)

CBRC:

103623864(DNAI1)

ETL:	114060144(DNAI1)

ZAB:	102073200(DNAI1)

SVG:	106859051(DNAI1)

MMEA:

130575638(DNAI1)

HRT:	120765286(DNAI1)

FPG:	101921452(DNAI1)

FCH:	102047959(DNAI1)

CLV:	102092733(DNAI1)

EGZ:	104133874(DNAI1)

NNI:	104017551(DNAI1)

ACUN:

113489585(DNAI1)

TALA:

116960491(DNAI1)

PADL:

103925917(DNAI1)

AFOR:

103906365(DNAI1)

ACHC:

115337421(DNAI1)

HALD:

104316255(DNAI1)

HLE:	104829786(DNAI1)

AGEN:

126035967

GCL:

127027802

CSTI:

104557342

MUI:	104548285(DNAI1)

GSTE:

104258460(DNAI1)

OHA:	104336820(DNAI1)

SHAB:

115619334(DNAI1)

DPUB:

104307815(DNAI1)

PGUU:

104461580(DNAI1)

CPEA:

104385364(DNAI1)

CVF:	104290637(DNAI1)

RTD:	128903088(DNAI1)

CUCA:

104056568(DNAI1)

AAM:	106493679(DNAI1)

AROW:

112974599(DNAI1)

DNE:	112987802(DNAI1)

SCAM:

104152015(DNAI1)

ASN:	102370966(DNAI1)

AMJ:	102575157(DNAI1)

CPOO:

109307670(DNAI1)

GGN:	109297961(DNAI1)

PSS:	102447674(DNAI1)

CMY:	102930732(DNAI1)

CCAY:

125637470(DNAI1)

DCC:	119855874(DNAI1)

CPIC:

101932245(DNAI1)

TST:	117879531(DNAI1)

CABI:

116827865

MRV:	120407711(DNAI1)

ACS:	100557518(dnai1)

ASAO:

132766812(DNAI1)

PVT:	110080484(DNAI1)

SUND:

121924163(DNAI1)

PBI:

103055634

CTIG:

120313462(DNAI1)

APRI:

131192640(DNAI1)

VKO:	123030237(DNAI1)

PMUA:

114606200(DNAI1)

PRAF:

128423725(DNAI1)

ZVI:	118077314(DNAI1)

HCG:	128345136(DNAI1)

EMC:	129334223(DNAI1)

XLA:	444304(dnai1.L)

XTR:	100144946(dnai1)

NPR:	108799591(DNAI1)

RTEM:

120924641(DNAI1)

BBUF:

120991297(DNAI1)

BGAR:

122930753 122938256

MUO:	115462824(DNAI1)

GSH:	117356406(DNAI1)

DRE:	555705(dnai1.2) 570363(dnai1.1)

SRX:	107708341 107708344(dnai1)

SANH:

107661189(dnai1) 107686904

SGH:	107565384(dnai1) 107573459

CCAR:

109106846(dnai1)

CAUA:

CGIB:

PTET:

LROH:

OMC:	131528179 131528304

PPRM:

120490618

RKG:	130102295(dnai1.2) 130102298

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

129423690(dnai1.2)

IPU:	108279323(dnai1.2)

IFU:	128622355(dnai1.2)

PHYP:

113535447(dnai1)

SMEO:

124398248(dnai1.2)

TFD:	113646437(dnai1.2)

TVC:	132859568(dnai1.2)

AMEX:

103036091(dnai1)

CMAO:

118820055(dnai1.2)

EEE:	113573729(dnai1)

CHAR:

105902480(dnai1.2)

TRU:	101069460(dnai1)

TFS:	130524591(dnai1.2)

LCO:	104921058(dnai1)

NCC:	104965625(dnai1)

TBEN:

117486483 117486484

CGOB:

115008796(dnai1)

PGEO:

117446120

GACU:

117561868(dnai1.2)

EMAC:

134882254(dnai1.2)

ELY:	117257242(dnai1.2)

EFO:	125886391(dnai1.2)

PLEP:

121954329(dnai1.2)

SLUC:

116034383(dnai1.2)

ECRA:

117943989(dnai1.2)

ESP:	116687386(dnai1)

PFLV:

114554641(dnai1)

GAT:	120835844(dnai1.2)

PPUG:

119194188(dnai1.2)

AFB:	129106179(dnai1.2)

CLUM:

117731212(dnai1.2)

PSWI:

130191272(dnai1.2)

MSAM:

119886734(dnai1.2)

SCHU:

122868988(dnai1.2)

CUD:	121506746(dnai1.2)

ALAT:

119020944(dnai1.2)

MZE:	101484202(dnai1)

ONL:	100707071(dnai1)

OAU:	116326530(dnai1.2)

OLA:	101175474(dnai1)

OML:	112144811(dnai1.2)

CSAI:

133446428(dnai1.2)

XMA:	102235026(dnai1)

XCO:	114135562(dnai1)

XHE:	116711061(dnai1)

PRET:

103464981(dnai1)

PFOR:

103139611(dnai1)

PLAI:

106958224(dnai1)

PMEI:

106915062(dnai1)

GAF:	122834440(dnai1.2)

PPRL:

129354310(dnai1.2)

CVG:	107087985(dnai1)

CTUL:

119775699

GMU:	124856359(dnai1.2)

NFU:	107385494(dnai1) 107389817

KMR:	108239861(dnai1.2)

ALIM:

106518403(dnai1)

NWH:	119412220(dnai1.2)

AOCE:

111578407(dnai1)

MCEP:

125006576(dnai1.2)

CSEM:

103386228(dnai1)

POV:	109628975(dnai1) 109632430

SSEN:

122768399(dnai1.2) 122768493

HHIP:

117760521 117761691(dnai1.2)

HSP:	118104885(dnai1.2) 118120755

SMAU:

118309343(dnai1.2)

LCF:	108899693(dnai1.2)

SDU:	111221927(dnai1)

SLAL:

111670931(dnai1)

XGL:	120783028(dnai1.2)

HCQ:	109522528 109522529

SSCV:

125976721 125976723

SBIA:

133507110 133507111

PEE:	133408902(dnai1.2) 133409271

PTAO:

133484090(dnai1.2) 133484183

MALB:

109955933(dnai1)

BSPL:

114855261(dnai1.2)

SJO:	128355813(dnai1.2)

SASA:

106565387(dnai1)

STRU:

115208026(dnai1)

OTW:	112215633(dnai1.2)

OMY:	110494145(dnai1.2)

OGO:	124003697(dnai1.2)

ONE:	115143017(dnai1)

OKI:	109893975(dnai1)

OKE:	118388185(dnai1.2)

SALP:

111964783(dnai1)

SNH:	120021412(dnai1.2)

CCLU:

121575103(dnai1.2)

ELS:	105017063(dnai1)

SFM:	108930012 108933514 108933516

PKI:	111857760(dnai1)

AANG:

118212160(dnai1.2)

LOC:	102698121(dnai1)

PSPA:

121306756(dnai1.2) 121309148

ARUT:

117403777 117404066

PSEX:

120532768(dnai1.2)

LCM:	102366067(DNAI1)

CMK:	103180972(dnai1.2)

RTP:	109913551(dnai1.2)

CPLA:

122544682(dnai1.2)

HOC:	132820280(dnai1.2)

LERI:

129695402(dnai1.2)

PMRN:

116942091(DNAI1)

LRJ:	133343659(DNAI1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG9313(CG9313)

DER:

6547646

DSE:

6615277

DSI:	Dsimw501_GD11552(Dsim_GD11552)

DYA:	Dyak_GE12154

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21066

DAZ:

DNV:

DHE:

DVI:

BOD:

BDR:

RZE:

AOQ:

TDA:	119674636 119683636

MDE:	101888011 131801668

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ000996

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:	105277375 105281843 105287122

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214667A

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105380210 105387171

PGW:

126374628

CFEL:

113362979

CCRN:

123297896

API:	100163264 100163892

DNX:	107167829 107167894

AGS:	114126206 114128646

RMD:	113553842 113559885

ACOO:

126833136 126834463

DVT:

126899094

BTAB:

109034729

DCI:	103504985 108252457

CLEC:

106664018 106666629

HHAL:

106684286

NLU:

111050885

HVI:	124355441 124373576

MQU:

128997338

PHU:	Phum_PHUM591980 Phum_PHUM591990

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_310944

DMK:

116916497

DPZ:

124328715

PVM:	113800519 113800605 113808286 113810258 113814302 113814665 113820233 113828769

PJA:	122244781 122247667 122254633 122254634 122262655 122264229

PCHN:

125025180 125025502 125025596 125034460 125034924 125034998 125043063

HAME:

121858548 121865499 121868197 121868693 121873170 121874159

PCLA:

123755126 123757931 123764188 123765904 123765974 123771540

CQD:	128687135 128692290 128703745 128703824

PTRU:

123499125 123499146 123503208 123511100

ESN:	126991060 127001528 127008307

MNZ:	135208707 135208710 135218341

HAZT:

108677252

EAF:	111698905 111699294 111701180

LSM:

TCF:

PPOI:

CSCU:

PTEP:

ABRU:

UDV:

SDM:	118189563 118192877 118204275

LPOL:

106471990

PMEO:

129590289

HRO:	HELRODRAFT_162705 HELRODRAFT_71864

LGI:	LOTGIDRAFT_166491

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111129376 111129377

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:	106870528 106875787

OSN:	115231087 115232642

LAK:

106169100

SMM:	Smp_167040

SHX:	MS3_00006752(DNAI1)

OVI:	T265_02269 T265_12527

NVE:

5507639

EPA:

110243167

ATEN:

116287389

ADF:	107329639 107345962

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130641069 130644136

TAD:	TRIADDRAFT_22484

AQU:

100635812

CRE:	CHLRE_12g536550v5

VCN:	VOLCADRAFT_81277

CSL:	COCSUDRAFT_67673

CVR:	CHLNCDRAFT_21762

APRO:

F751_3440

MIS:	MICPUN_83829(ODA9)

MPP:	MICPUCDRAFT_50559(ODA-IC1)

MBR:	MONBRDRAFT_32485

SRE:	PTSG_10104

PFA:	PF3D7_0922000

PFD:	PFDG_03083

PFH:	PFHG_01347

PREI:

PRSY57_0920000

PGAB:

PGSY75_0922000

PYO:	PY17X_0826200

PCB:	PCHAS_0823200

PBE:	PBANKA_0822900

PVV:	PVVCY_0802030 PVVCY_0802040

PKN:	PKNH_0720000

PVX:	PVX_099515

PMAL:

PMUG01_07033500

PREL:

PRELSG_0719600

BBIG:

BBBOND_0401170

TGO:	TGME49_209300

TET:	TTHERM_00487150

PTM:	GSPATT00020363001 GSPATT00022952001 GSPATT00023599001

SMIN:

v1.2.033314.t1(symbB.v1.2.033314.t1)

TPS:	THAPSDRAFT_13149(DIC2)

AAF:	AURANDRAFT_30500

PIF:	PITG_03878

PSOJ:

PHYSODRAFT_470453

SPAR:

SPRG_12000

GTT:	GUITHDRAFT_119182 GUITHDRAFT_95510

TBR:	Tb11.02.2640

TBG:	TbgDal_XI5640

TCR:	507669.70 507857.60

LMA:	LMJF_24_0280

LIF:	LINJ_24_0270

LDO:	LDBPK_240270

LMI:	LMXM_24_0280

LBZ:	LBRM_24_0280

LPAN:

LPMP_240270

NGR:	NAEGRDRAFT_78637

TVA:	TVAG_2v0401040

GLA:	GL50803_0033218

» show all

Reference

PMID:10577904

Authors

Pennarun G, Escudier E, Chapelin C, Bridoux AM, Cacheux V, Roger G, Clement A, Goossens M, Amselem S, Duriez B

Title

Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.

Journal

Am J Hum Genet 65:1508-19 (1999)
DOI:10.1086/302683

Sequence

[hsa:27019]

LinkDB

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