KEGG ORTHOLOGY: K10414

ORTHOLOGY: K10414

Entry

K10414                      KO

Symbol

DYNC2H, DNCH2

Name

dynein cytoplasmic 2 heavy chain

Pathway

map04145

Phagosome

map04814

Motor proteins

map04962

Vasopressin-regulated water reabsorption

map05132

Salmonella infection

Disease

H00511

Short rib-polydactyly syndrome

H00751

Asphyxiating thoracic dystrophy

H02157

Short-rib thoracic dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
  09142 Cell motility
   04814 Motor proteins
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
09150 Organismal Systems
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
   04812 Cytoskeleton proteins
    K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Motor proteins
     Dynein complex
      K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
Cilium and associated proteins [BR:ko03037]
Primary cilia and associated proteins
  Dynein and associated proteins
   K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Dyneins
     K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain

Genes

HSA:	79659(DYNC2H1)

PTR:	451515(DYNC2H1)

PPS:	100993677(DYNC2H1)

GGO:	101136193(DYNC2H1)

NLE:	100585639(DYNC2H1)

HMH:	116476867(DYNC2H1)

MCC:	704215(DYNC2H1)

MCF:	101867466(DYNC2H1)

MTHB:

126936259

MNI:	105493700(DYNC2H1)

CSAB:

103248352(DYNC2H1)

CATY:

105588763(DYNC2H1)

PANU:

101003218(DYNC2H1)

TGE:	112606660(DYNC2H1)

MLEU:

105542754(DYNC2H1)

RRO:	104674675(DYNC2H1)

RBB:	108514061(DYNC2H1)

TFN:	117080179(DYNC2H1)

PTEH:

111539980(DYNC2H1)

CANG:

105501185(DYNC2H1)

CJC:	100414677(DYNC2H1)

SBQ:	101050061(DYNC2H1)

CIMI:

108315442(DYNC2H1)

CSYR:

103260634(DYNC2H1)

MMUR:

105874585(DYNC2H1)

LCAT:

123641883(DYNC2H1)

PCOQ:

105822162(DYNC2H1)

OGA:	100952971(DYNC2H1)

MMU:	110350(Dync2h1)

MCAL:

110301164(Dync2h1)

MPAH:

110327347(Dync2h1)

RNO:	65209(Dync2h1)

MCOC:

116073054(Dync2h1)

MUN:	110558093(Dync2h1)

CGE:	100758806(Dync2h1)

MAUA:

101834382(Dync2h1)

PROB:

127216909(Dync2h1)

PLEU:

114708008(Dync2h1)

MORG:

121451516(Dync2h1)

MFOT:

126493283

AAMP:

119810236(Dync2h1)

NGI:	103731613(Dync2h1)

HGL:	101698011(Dync2h1)

CPOC:

100729376(Dync2h1)

DORD:

105980776(Dync2h1)

DSP:	122104147(Dync2h1)

PLOP:

125349529(Dync2h1)

NCAR:

124959762

MMMA:

107145712(Dync2h1)

OCU:

100344127

OPI:	101530192(DYNC2H1)

TUP:

102487405

CFA:	479461(DYNC2H1)

CLUD:

112671432(DYNC2H1)

VVP:	112925909(DYNC2H1)

VLG:	121499433(DYNC2H1)

NPO:	129497194(DYNC2H1)

AML:	100481681(DYNC2H1)

UMR:	103662544(DYNC2H1)

UAH:	113260128(DYNC2H1)

UAR:	123792507(DYNC2H1)

ELK:

111153786

LLV:

125079348

MPUF:

101671576 106007029

MNP:	132029062(DYNC2H1)

MLK:	131834725(DYNC2H1)

NVS:	122912248(DYNC2H1)

ORO:	101367920(DYNC2H1)

EJU:	114211397(DYNC2H1)

ZCA:	113913753(DYNC2H1)

MLX:	118013158(DYNC2H1)

NSU:	110586135(DYNC2H1)

LWW:

102743779

FCA:	101082005(DYNC2H1)

PYU:	121020787(DYNC2H1)

PCOO:

112865897(DYNC2H1)

PBG:	122482894(DYNC2H1)

PVIV:

125176848(DYNC2H1)

LRUF:

124506448

PTG:	102950535(DYNC2H1)

PPAD:

109257514(DYNC2H1)

PUC:

125910710

AJU:

106976475

HHV:	120223082(DYNC2H1)

BTA:	512287(DYNC2H1)

BOM:	102285296(DYNC2H1)

BIU:	109569861(DYNC2H1)

BBUB:

102414258(DYNC2H1)

BBIS:

104987813(DYNC2H1)

CHX:	102171895(DYNC2H1)

OAS:	101118215(DYNC2H1)

BTAX:

128060057(DYNC2H1)

ODA:	120876145(DYNC2H1)

CCAD:

122449476(DYNC2H1)

MBEZ:

129554242(DYNC2H1)

SSC:	100624195(DYNC2H1)

CFR:	102515854(DYNC2H1)

CBAI:

105067590(DYNC2H1)

CDK:	105087164(DYNC2H1)

VPC:	102527058(DYNC2H1)

BACU:

103011204(DYNC2H1)

BMUS:

118899200(DYNC2H1)

LVE:	103075753(DYNC2H1)

OOR:	101269668(DYNC2H1)

DLE:	111167585(DYNC2H1)

PCAD:

102983796(DYNC2H1)

PSIU:

116757600(DYNC2H1)

NASI:

112415755(DYNC2H1)

ECB:	100061459(DYNC2H1)

EAI:	106843122(DYNC2H1)

MYB:	102239745(DYNC2H1)

MYD:	102760102(DYNC2H1)

MMYO:

118664379(DYNC2H1)

MLF:	102418888(DYNC2H1)

PKL:	118712802(DYNC2H1)

EFUS:

103293792(DYNC2H1)

MNA:	107532412(DYNC2H1)

DRO:	112314288(DYNC2H1)

SHON:

119000404(DYNC2H1)

AJM:	119061505(DYNC2H1)

PDIC:

114500120(DYNC2H1)

PHAS:

123805432(DYNC2H1)

MMF:	118627640(DYNC2H1)

PPAM:

129086005(DYNC2H1)

HAI:	109394941(DYNC2H1)

RFQ:	117030540(DYNC2H1)

PALE:

102887147(DYNC2H1)

PGIG:

120599664(DYNC2H1)

PVP:	105297468(DYNC2H1)

RAY:	107520205(DYNC2H1)

MJV:	108402324(DYNC2H1)

TOD:	119242141(DYNC2H1)

SARA:

101552701(DYNC2H1)

SETR:

126016074(DYNC2H1)

LAV:	100656983(DYNC2H1)

TMU:

101361383

ETF:	101654626(DYNC2H1)

DNM:	101412418(DYNC2H1)

MDO:	100011216(DYNC2H1)

GAS:	123241011(DYNC2H1)

SHR:	100915845(DYNC2H1)

AFZ:

127554929

PCW:	110214974(DYNC2H1)

OAA:	100078752(DYNC2H1)

GGA:	418979(DYNC2H1)

PCOC:

116230619(DYNC2H1)

MGP:

104917611

CJO:	107308403(DYNC2H1)

TPAI:

128074796(DYNC2H1)

LMUT:

125689216(DYNC2H1)

NMEL:

110389845(DYNC2H1)

APLA:

101798656(DYNC2H1)

ACYG:

106034161(DYNC2H1)

CATA:

118245885(DYNC2H1)

AFUL:

116493401(DYNC2H1)

TGU:	100229193(DYNC2H1)

LSR:	110470018(DYNC2H1)

SCAN:

103812524(DYNC2H1)

PMOA:

120506591(DYNC2H1)

OTC:	121342507(DYNC2H1)

PRUF:

121364130(DYNC2H1)

GFR:	102045051(DYNC2H1)

FAB:	101806208(DYNC2H1)

OMA:	130251593(DYNC2H1)

PHI:	102111975(DYNC2H1)

PMAJ:

107205077(DYNC2H1)

CCAE:

111923469(DYNC2H1)

CCW:	104690111(DYNC2H1)

CBRC:

103617947(DYNC2H1)

ETL:	114067038(DYNC2H1)

ZAB:	102069045(DYNC2H1)

ACHL:

103799809(DYNC2H1)

SVG:	106859377(DYNC2H1)

MMEA:

130576290(DYNC2H1)

HRT:	120748997(DYNC2H1)

FPG:	101914146(DYNC2H1)

FCH:	102052462(DYNC2H1)

CLV:	102089046(DYNC2H1)

EGZ:	104128902(DYNC2H1)

NNI:	104023066(DYNC2H1)

PLET:

104616240(DYNC2H1)

ACUN:

113477551(DYNC2H1)

TALA:

104368298(DYNC2H1)

PADL:

103915449(DYNC2H1)

AFOR:

103895115(DYNC2H1)

ACHC:

115353229(DYNC2H1)

HALD:

104319046(DYNC2H1)

HLE:	104828446(DYNC2H1)

AGEN:

126048348

GCL:

127029942

CCRI:

104168647(DYNC2H1)

CSTI:

104560637(DYNC2H1)

MUI:	104542800(DYNC2H1)

BREG:

104635463(DYNC2H1)

LDI:	104354427(DYNC2H1)

MNB:	103771388(DYNC2H1)

OHA:	104333062(DYNC2H1)

SHAB:

115603640(DYNC2H1)

DPUB:

104296913(DYNC2H1)

PGUU:

104467611

ACAR:

104532087(DYNC2H1)

CPEA:

104390275(DYNC2H1)

AVIT:

104270027(DYNC2H1)

CVF:	104290320(DYNC2H1)

RTD:	128906187(DYNC2H1)

CUCA:

104064704(DYNC2H1)

TEO:	104380025(DYNC2H1)

BRHI:

104489007(DYNC2H1)

AAM:	106495531(DYNC2H1)

AROW:

112971947(DYNC2H1)

NPD:	112951857(DYNC2H1)

DNE:	112988751(DYNC2H1)

SCAM:

104151768(DYNC2H1)

ASN:	102382793(DYNC2H1)

AMJ:	106736691(DYNC2H1)

CPOO:

109306728(DYNC2H1)

GGN:	109302611(DYNC2H1)

PSS:	102446759(DYNC2H1)

CMY:	102938531(DYNC2H1)

CCAY:

125633968(DYNC2H1)

DCC:	119846515(DYNC2H1)

CPIC:

101950520(DYNC2H1)

TST:	117871166(DYNC2H1)

CABI:

116837659(DYNC2H1)

MRV:	120409058(DYNC2H1)

ACS:	100552062(dync2h1)

ASAO:

132772193(DYNC2H1)

PVT:	110089070(DYNC2H1)

SUND:

121925750(DYNC2H1)

PMUR:

107286362(DYNC2H1)

CTIG:

120313885(DYNC2H1)

TSR:	106544081(DYNC2H1)

PGUT:

117660883(DYNC2H1)

APRI:

131199807(DYNC2H1)

PTEX:

113440483(DYNC2H1)

NSS:	113417309(DYNC2H1)

VKO:	123029391(DYNC2H1)

PMUA:

114595667(DYNC2H1)

PRAF:

128412596(DYNC2H1)

ZVI:	118085657(DYNC2H1)

HCG:	128350213(DYNC2H1)

GJA:	107112035(DYNC2H1)

STOW:

125431110(DYNC2H1)

EMC:	129325703(DYNC2H1)

XLA:	108707571(dync2h1.L)

XTR:	100380107(dync2h1)

NPR:	108795963(DYNC2H1)

RTEM:

120928206(DYNC2H1)

BBUF:

120996392(DYNC2H1)

BGAR:

122930541(DYNC2H1)

MUO:	115469593(DYNC2H1)

GSH:	117362117(DYNC2H1)

DRE:	100332402(dync2h1)

SRX:	107725746(dync2h1)

SANH:

107689594(dync2h1)

CAUA:

113058809 113077241 113094204

CGIB:

128029084

PTET:

122358998

LROH:

127177726

OMC:	131554401(dync2h1)

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113544532(dync2h1)

SMEO:

124394184

TFD:

113637865

TVC:	132857662(dync2h1)

AMEX:

103040540(dync2h1)

CMAO:

118798728

CHAR:

105909270

TRU:	101063436(dync2h1)

TFS:

130535553

LCO:

104920114

TBEN:

117470345

CGOB:

115017949(dync2h1)

PGEO:

117457535

GACU:

117552140

EMAC:

134880536(dync2h1)

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

114550515(dync2h1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

ONL:	100700807(dync2h1)

OAU:

116322966

OLA:	101163989(dync2h1)

OML:

112149163

CSAI:

133441688(dync2h1)

XMA:	102220918(dync2h1)

XCO:	114133207(dync2h1)

XHE:	116707832(dync2h1)

PRET:

103474718(dync2h1)

PFOR:

103146309(dync2h1)

PLAI:

106955566(dync2h1)

PMEI:

106918004(dync2h1)

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:	107380446(dync2h1)

KMR:

108244649

ALIM:

106521481(dync2h1)

AOCE:

111572654(dync2h1)

MCEP:

125013407

CSEM:

103378540(dync2h1)

POV:	109634584(dync2h1)

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:	111224057(dync2h1)

SLAL:

111655294(dync2h1)

XGL:

120792359

HCQ:	109525483(dync2h1)

SSCV:

125972185

SBIA:

133504602(dync2h1)

PEE:	133405600(dync2h1)

PTAO:

133482257(dync2h1)

BPEC:

110174246(dync2h1)

MALB:

109971612(dync2h1)

BSPL:

114867841

SJO:

128360904

STRU:

115206580(dync2h1)

OTW:

112267480

OMY:

110503411

OGO:

124017319

ONE:	115141322(dync2h1)

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:	105024072(dync2h1)

SFM:	108932377(dync2h1)

PKI:	111833830(dync2h1)

AANG:

118209690

LOC:	102694862(dync2h1)

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:	132816449(dync2h1)

LERI:

129698145

PMRN:

116955183(DYNC2H1)

LRJ:	133347767(DYNC2H1)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

APLC:

AJC:	117110427 117121275

SKO:

100375810

DME:	Dmel_CG15148(btv)

DER:

6549278

DSE:

6614513

DSI:	Dsimw501_GD21850(Dsim_GD21850)

DYA:	Dyak_GE13115

DAN:

DSR:

DPO:

DPE:

DMN:

DGR:

DMO:	Dmoj_GI22290

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108360959 108363135

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005887

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

PCF:

PFUC:

VPS:

VCRB:

VVE:

TPRE:

LHT:

LBD:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BANY:

MJU:

NIQ:

VCD:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

PGW:

CFEL:

CCRN:

ACOO:

DVT:

BTAB:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM275890

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_324408

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DFR:

PTEP:

ABRU:

UDV:

SDM:

PMEO:

CEL:	CELE_F18C12.1(che-3)

CBR:	CBG_11853(Cbr-che-3)

CRQ:	GCK72_000056

LGI:	LOTGIDRAFT_209197

PCAN:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

NVE:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_22099

CRE:	CHLRE_06g250300v5

VCN:	VOLCADRAFT_64869(D1bHC)

MIS:	MICPUN_96530(CDHC1B)

MPP:	MICPUCDRAFT_46683(CDHC1B)

MBR:	MONBRDRAFT_26740

TET:	TTHERM_00558310

PTM:	GSPATT00005074001 GSPATT00005076001 GSPATT00027139001 GSPATT00027140001

TBR:	Tb11.02.0030 Tb927.4.560

TBG:	TbgDal_IV310 TbgDal_XI2680

TCR:	507053.209

LMA:	LMJF_27_1750 LMJF_34_4160

LIF:	LINJ_27_1650 LINJ_34_3990

LDO:	LDBPK_271650 LDBPK_343990

LMI:	LMXM_27_1750 LMXM_33_4160

LBZ:	LBRM_20_3790 LBRM_27_1870

LPAN:

LPMP_203930 LPMP_271730

TVA:	TVAG_2v0259030 TVAG_2v0259040

GLA:	GL50803_0093736

» show all

Reference

PMID:19935668

Authors

Kardon JR, Vale RD

Title

Regulators of the cytoplasmic dynein motor.

Journal

Nat Rev Mol Cell Biol 10:854-65 (2009)
DOI:10.1038/nrm2804

Reference

PMID:8666668

Authors

Vaisberg EA, Grissom PM, McIntosh JR

Title

Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.

Journal

J Cell Biol 133:831-42 (1996)
DOI:10.1083/jcb.133.4.831

Sequence

[mmu:110350]

LinkDB

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